Dominiek Maes

Dominiek Maes
Ghent University | UGhent · Department of Obstetrics, Reproduction and Herd Health

DVM, MSc, MS, PhD, Dipl ECVPH, Dipl ECPHM

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560
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Publications

Publications (560)
Article
Full-text available
Background Dam-to-piglet transmission plays an important role in the epidemiology of enzootic pneumonia on farms. Although Mycoplasma hyopneumoniae ( M. hyopneumoniae ) infections in breeding animals are often subclinical, their control could have a positive effect on M. hyopneumoniae infection levels in fattening pigs. This study investigated the...
Article
Full-text available
The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) induces apoptosis in different organs. Angiotensin II (Ang II) is the main effector of the renin-angiotensin system and participates in apoptosis. Thus, this study aimed to investigate changes in piglet serum Ang II levels following intradermal (ID) and intramuscular (IM) vaccination w...
Article
Mycoplasma hyopneumoniae remains one of the most problematic bacterial pathogens for pig production. Despite an abundance of observational and laboratory testing capabilities for this organism, diagnostic interpretation of test results can be challenging and ambiguous. This is partly explained by the chronic nature of M. hyopneumoniae infection and...
Article
Full-text available
Background Piglet perinatal and pre-weaning mortality is a welfare problem causing economic losses in pig production. In this study, the effects of housing and management interventions on the economic result of sow enterprises representing six European countries (Belgium, Denmark, Finland, Germany, The Netherlands and Spain) were tested. Interventi...
Poster
Full-text available
Introduction Swine dysentery (SD) caused by Brachyspira hyodysenteriae (B. hyodysenteriae) results in substantial economic losses in swine-producing countries worldwide. Outbreaks of SD caused concern in Belgium, given the sudden rise of cases that were admitted to the laboratory Animal Health Care Flanders in 2018-2020. Furthermore, it was feare...
Article
Full-text available
Reduced and responsible antimicrobial use leads to a lower risk of developing antimicrobial resistance. Raised Without Antibiotics (RWA) is a certification label that is recognized in only a few countries, and it is often unclear what the specific criteria and characteristics of RWA farms are. The objectives of this study were to describe the crite...
Article
Full-text available
Mycoplasma (M.) hyopneumoniae interacts with the respiratory microbiota and facilitates colonization of other pathogens. The present study investigated the pulmonary and nasal microbiota of M. hyopneumoniae-infected and M. hyopneumoniae-free pigs. Sixty-six pigs from three commercial herds were selected at the end of the finishing phase: 44 origina...
Article
Porcine reproductive and respiratory syndrome virus (PRRSV) induces apoptosis through the activation of death receptors, including cell-surface Fas receptor. The aim of this study was to investigate the impact of intradermal (ID) and intramuscular (IM) vaccination with a commercial PRRSV-modified live vaccine in piglets on Fas-related apoptosis. Th...
Article
Full-text available
Background The breeding population is very important in pig herds, for productivity, health and profitability. Replacement of breeding animals can be accomplished by own rearing of breeding gilts or by purchasing them. Purchasing breeding gilts is a hazardous event in terms of biosecurity and introduction of pathogens into a farm. However, in liter...
Article
Full-text available
Mycoplasma hyopneumoniae ( M. hyopneumoniae ) is one of the primary agents involved in the porcine respiratory disease complex, economically one of the most important diseases in pigs worldwide. The pathogen adheres to the ciliated epithelium of the trachea, bronchi, and bronchioles, causes damage to the mucosal clearance system, modulates the immu...
Article
Full-text available
Background Porcine ear necrosis (PEN) in pigs is characterized by a blue to black discoloration of the tip or margin of the ear followed by necrosis. The present study investigated the prevalence of PEN in a Belgian pig farm with PEN problems in nursery pigs, the effect of a mycotoxin detoxifier added to the feed on PEN prevalence, and the impact o...
Poster
Full-text available
Swine dysentery (SD) caused by Brachyspira hyodysenteriae (B. hyodysenteriae) results in substantial economic losses in swine producing countries worldwide. Outbreaks of SD caused concern in Belgium, given the sudden rise of cases that were admitted to the laboratory Animal Health Care Flanders. Furthermore, it was feared that treatment with antimi...
Article
Full-text available
The use of antimicrobials in animal production is under public debate, mainly due to the risk of transfer of resistance to pathogenic bacteria in humans. Therefore, measures have been taken during the last few decades to reduce antibiotic usage in animals, for instance, by national monitoring programmes and by improving animal health management. Al...
Article
Full-text available
Mycoplasma hyopneumoniae is the primary agent of enzootic pneumonia in pigs. Although cell mediated immunity (CMI) may play a role in protection against M. hyopneumoniae, its transfer from sows to their offspring is poorly characterized. Therefore, maternally-derived CMI was studied in piglets from vaccinated and non-vaccinated sows. The potential...
Preprint
Full-text available
The use of antimicrobials in animal production is under public debate, mainly due to the risk of transfer of resistance to pathogenic bacteria in humans. Therefore, measures have been taken during the last decades to reduce antibiotic usage in animals, for instance by national monitoring programmes and by improving animal health management. Althoug...
Article
Full-text available
Direct detection of Mycoplasma hyopneumoniae through molecular tools is a growing trend for early diagnosis, highlighting the importance of knowing M. hyopneumoniae dynamics in the respiratory tract upon infection. This study focused on monitoring the infection level and its effects in different anatomic sites of the respiratory tract of experiment...
Article
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The etiology of Postpartum dysgalactia syndrome (PDS) includes stress οn preparturition and constipation associated with low water intake or low fiber intake. The aim of this study was to investigate the effects of a raw crude fibre concentrate (Arbocel ®) on sow's metabolism and performance. 100 sows from a farm suffering from PDS, were divided in...
Article
Infections with Mycoplasma hyopneumoniae (Mhyo), Mycoplasma hyorhinis (Mhr) and Mycoplasma flocculare (Mfloc) are common in swine. However, the degree of co-infections and the correlations between these mycoplasma co-infection and the severity of macroscopic lung consolidation lesions (MLCL) have not yet been explored in Brazil.The objectives were...
Chapter
This book contains 14 chapters that discuss the genetics, epidemiology, prevalence, pathogenesis, clinical signs, diagnosis, treatment, prevention and control of Mycoplasma infections in pigs. Chapter 1 discusses the phylogenetics and classification of Mycoplasma species in pigs; Chapter 2 describes the genomic diversity and antigenic variation of...
Chapter
This book contains 14 chapters that discuss the genetics, epidemiology, prevalence, pathogenesis, clinical signs, diagnosis, treatment, prevention and control of Mycoplasma infections in pigs. Chapter 1 discusses the phylogenetics and classification of Mycoplasma species in pigs; Chapter 2 describes the genomic diversity and antigenic variation of...
Article
Since the introduction in Georgia in 2007 of an African swine fever (ASF) genotype 2 virus strain, the virus has rapidly spread to both Western European and Asian countries. It now constitutes a major threat for the global swine industry. The ongoing European transmission cycle has been related to the ‘wild boar habitat’ with closed transmission ev...
Article
Porcine ear necrosis (PEN) is a condition that mainly occurs in intensive pig production systems and mostly affects piglets after weaning. The syndrome manifests itself with lesions on the pinna, which can heal or become more severe resulting in partial loss of the ear. The pathogenesis of the condition is not fully known. Three different hypothese...
Chapter
This chapter focuses on the epidemiology, transmission routes, and biosecurity measures of bacterial diseases in pigs and poultry raised in intensive production systems. Bacterial pathogens are highly prevalent in these systems and cause major animal health, welfare, and production problems. There are numerous transmission routes by which bacterial...
Chapter
Bacterial diseases in pigs cause major health, welfare, and performance problems. They are also responsible for the high usage of antimicrobials and therefore contribute to the problem of antimicrobial resistance. This chapter discusses the control of a selected number of bacterial pathogens that are economically very important for the pig industry...
Article
Full-text available
Neonatal piglets lack immunoglobulins at birth. Sufficient colostrum intake (CI) and immunoglobulin absorption are essential for an appropriate passive transfer of immunity via the colostrum. Most methods to measure immunoglobulins in serum of piglets are labour-intensive, expensive or imprecise and not designed for on-farm use. The present diagnos...
Article
Full-text available
Postpartum dysgalactia syndrome (PPDS) is a major economic problem in modern sow farms. General treatment of PPDS consists of the use of oxytocin to promote milk ejection and non-steroidal anti-inflammatory drugs (NSAIDs) to alleviate inflammatory processes. So far, studies investigated the use of a single administration of NSAIDs after parturition...
Article
Full-text available
Neonatal diarrhea in piglets may cause major losses in affected pig herds. The present study used random high-throughput RNA sequencing (metagenomic next generation sequencing, mNGS) to investigate the virome of sows from a farm with persistent neonatal piglet diarrhea in comparison to two control farms without diarrhea problems. A variety of known...
Article
Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia, a chronic respiratory disease, causing significant economic losses. Results from the 2015-2016 MycoPath pan-European antimicrobial susceptibility monitoring survey of M. hyopneumoniae are presented. In total, 147 M. hyopneumoniae porcine isolates from Belgium, France, Ge...
Article
Full-text available
Dietary fibre (DF) is implicated in gastrointestinal health of weaned piglets, either through its physiochemical properties, through modulation of gut microbiota and (or) improved gut integrity. We aimed to study the effect of DF enriched supplemental diets fed to suckling piglets (‘creep feed’) on health and performance after weaning when challeng...
Article
This study presents a case of clubbed down syndrome in conventional broilers. During the first week of life, severe growth retardation was observed in approximately 25% of the flock. The growth retarded chicks weighed only 45 g and showed a typical feather disorder which was most apparent on their abdomen and was defined in literature as typical fo...
Article
Full-text available
Background: Brachyspira infections are causing major losses to the pig industry and lead to high antimicrobial use. Treatment of Brachyspira (B.) hyodysenteriae infections may be problematic due to the high level of antimicrobial resistance. The present study implemented and evaluated farm-specific eradication programmes for B. hyodysenteriae in 1...
Article
A multifactorial approach using environmental, performance, health and welfare parameters was used to investigate the numerous associations of ventilation throughout three consecutive fattening batches (08/2015 to 12/2016) in a farrow-to-finish commercial pig farm in Belgium. Two fattening pig units were used, unit A (1256 pigs) with mechanical ven...
Article
Vaccinating pigs against Salmonella Typhimurium (ST) might be a way to control ST infections at farm level and reduce human infections. Two main issues have to be addressed before such a mandatory vaccination program can be implemented: the effective reduction of attributable human incidence has to be demonstrated and all socio-economic barriers im...
Article
Full-text available
Background: Conventional broilers are currently one of the most efficient protein converters. Although decades of progress in genetic selection and feed formulation have lead to high standards of efficient broiler production, still a lot of variability is found between farms and between successive flocks. The aim of this study was to investigate r...
Article
Full-text available
Feed conversion ratio ( FCR ) in grow-finishing pigs is one of the most important determinants of pig farm profitability and production efficiency. In its simplest form, FCR represents the amount of feed used per unit weight gain of the pig. Yet, this approach entails various limitations hampering its practical applicability such as availability of...
Article
Introduction of infectious agents (e.g. African swine fever) in a farm could have severe implications beyond the farm level. Among the solutions required to minimize the risk of disease introduction and spread, the strengthening of biosecurity is a priority. Yet, although the pig fattening (finishing) herds comprise 41.2% of the pig herds on a Euro...
Article
Mycoplasma hyopneumoniae (M. hyopneumoniae) is the primary agent of enzootic pneumonia, a chronic and economically important respiratory disease of pigs. Control and prevention of M. hyopneumoniae infections can be accomplished by optimization of management and housing conditions, and by vaccination. The present paper summarizes the current knowled...
Article
Full-text available
In order to reduce antimicrobial use in pig production, the consequences of insufficient biosecurity and welfare problems need to be known. This study aimed to investigate associations between the number of antimicrobial treatments per fattening pig, and biosecurity, indicators for animal welfare as well as the prevalence of lesions at slaughter. T...
Article
Despite the importance of swine intestinal health, there are no easy‐to‐use and cost‐efficient methods to evaluate it under field conditions for sows. To provide some indication about intestinal health, pH of faeces could be used but reference values for the currently high‐performing commercial sow breeds are missing. In response, faecal pH of heal...
Article
Full-text available
Fear and environmental stressors may negatively affect the welfare of farm animals such as pigs. The present study investigated the effects of music and positive handling on reproductive performance of sows ( n = 1014; parity 1 to 8) from a commercial pig farm practicing a batch farrowing system. Every 2 weeks, 56 sows were moved from the gestation...
Article
Coccidiosis in broiler chickens, caused by infection with Eimeria spp. remains one of the most economically important production diseases. Development of a genetic biomarker panel of sub-clinical infection would be an important biological tool for the management of broiler flocks. We analysed expression of MicroRNAs (miRNAs) to determine the potent...
Article
Subclinical Salmonella Typhimurium infections occur frequently in pigs and constitute a major risk for human salmonellosis. With the currently available control measures, Salmonella Typhimurium infections in pigs remain difficult to control. Vaccination has been proposed to be an effective tool to control infections at farm level. In the current st...
Article
Full-text available
Abstract Mycoplasma hyopneumoniae and Mycoplasma hyorhinis are two phylogenetically related species colonizing the respiratory tract of pigs but differing in pathogenicity, the basis of which is not well resolved. We hypothesize that genes belonging to the species-specific portion of the genome and being non-essential during ideal laboratory growth...
Article
Full-text available
Background: Commercial pre-weaning diets are formulated to be highly digestible and nutrient-dense and contain low levels of dietary fibre. In contrast, pigs in a natural setting are manipulating fibre-rich plant material from a young age. Moreover, dietary fibre affects gastrointestinal tract (GIT) development and health in older pigs. We hypothe...
Article
Full-text available
Abstract New vaccine formulations that include novel strains of Mycoplasma hyopneumoniae and innovative adjuvants designed to induce cellular immunity could improve vaccine efficacy against this pathogen. The aim of this experimental study was to assess the efficacy of three experimental bacterin formulations based on M. hyopneumoniae field strain...
Article
Full-text available
The majority of livestock in high-income countries is raised in intensive production systems, with pigs being one of the most important food-producing animals. Worldwide, pork accounts for approximately 35% of all meat production. Intensive pig production is characterized by a high biological and economic productivity with a simultaneously low inpu...
Article
Claw lesions have a multifactorial origin and may affect sow welfare and farm profitability. However, estimating the precise impact is hampered by several factors that interfere with the accuracy of claw lesion assessment. The objective of this study was to determine the impact of observer, scoring condition and claw cleanliness on claw lesion scor...
Preprint
Background Conventional broilers are currently one of the most efficient protein converters. Although decades of progress in genetic selection and feed formulation have lead to high standards of efficient broiler production, still a lot of variability is found between farms and between successive flocks. The aim of this study was to investigate ris...
Article
The present study investigated the prevalence of uroliths in fattening pigs and assessed the composition of these urinary tract concrements. In total, 2,432 urinary bladders were sampled in the slaughterhouse and checked for abnormal content. Urinary samples were analysed microscopically, and samples of the urinary bladder wall were tested for hist...
Article
Door de toenemende druk op de economische marges in de varkenshouderij neemt het belang van efficiënter produceren toe. De grootste kost bij het afmesten van vleesvarkens is het voeder, met een gemiddeld aandeel van ongeveer 75% in de totale afmestkosten (Departement Landbouw en Visserij). De voederkosten hangen af van de voederprijzen, maar ook va...
Article
Full-text available
We characterized five different vaccine candidates and a commercial vaccine in terms of safety, immunogenicity and using a systems vaccinology approach, with the aim to select novel vaccine candidates against Mycoplasma hyopneumoniae. Seven groups of six M. hyopneumoniae-free piglets were primo-and booster vaccinated with the different experimental...
Article
Mycoplasma hyopneumoniae (M. hyopneumoniae) is the etiologic agent of enzootic pneumonia in swine, a prevalent chronic respiratory disease worldwide. Mycoplasma hyopneumoniae is a small, self‐replicating microorganism that possesses several characteristics allowing for limited biosynthetic abilities, resulting in the fastidious, host‐specific growt...
Article
Subclinical infections with Salmonella Typhimurium occur frequently in pigs. They constitute a risk for human salmonellosis and are difficult to control with currently available control measures. Vaccination against Salmonella Typhimurium in pigs can be an effective tool to control Salmonella infections at farm level. In the present study, the effi...
Article
Vaccination of pigs against Salmonella Typhimurium (S. Typhimurium) can be effective for the control of Salmonella infections at the farm level and reduce the risk of Salmonella contamination in the food chain. However, vaccination may interfere with herd serological status in serology-based Salmonella monitoring programs. The present study investi...
Article
Objective Treatment of inflammation and pain management is an important topic in the welfare of pigs. It is very difficult for veterinary practitioners to choose the most appropriate product for a certain problem. This review aims to summarise and discuss the characteristics of different non-steroidal anti-inflammatory drugs (NSAIDs), as well as pa...
Article
Full-text available
Claw lesions and lameness in sows are important problems in the industry as they impair sow welfare and result in economic losses. Available scoring techniques to detect claw lesions are all limited in terms of collecting data during all reproductive phases and recording all claws. The Mobile Claw Scoring Device (MCSD) was designed to address these...
Chapter
Full-text available
Mammary growth is a major determinant of potential sow milk yield. Estrogens are important for mammogenesis in growing gilts, as evidenced by the increased rate of mammary development occurring at puberty. Mammary gland involution involves losses of over two‐thirds of the parenchymal mass and cells present on the day of weaning. Lactogenesis is the...
Chapter
This chapter presents relevance, etiology, public health, epidemiology, pathogenesis, clinical signs, lesions, diagnosis, immunity, prevention and control of Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Mycoplasma hyosynoviae, and Other mycoplasma spp in swine. Mycoplasma hyopneumoniae causes enzootic pneumonia (EP) and is an important primary p...
Article
Full-text available
This study investigated Mycoplasma hyopneumoniae colonisation and lung lesions at slaughter in pigs from vaccinated (V) and non-vaccinated (NV) sows, in two herds (A and B). In each herd, two sow batches were V against M. hyopneumoniae with a commercial bacterin at six and three weeks before farrowing and two sow batches remained NV. From each sow...
Chapter
The book Biosecurity in Animal Production and Veterinary Medicine is the first compilation of both fundamental aspects of biosecurity practices, and specific and practical information on the application of the biosecurity measures in different animal production and animal housing settings. This book has 19 chapters, starting with a general introduc...
Article
Full-text available
Miniature pigs, like the Vietnamese pot-bellied pig and the Kunekune, are the most popular hobby pig breeds. Despite their popularity, the knowledge of their health and management is still scarce. They have an exemplary sense of smell and hearing, possess good adaptability and are easy to handle. A well-ventilated shelter space with an area for rec...
Article
Full-text available
Background A dedicated program to monitor for freedom of several economically important diseases is present within most of the breeding companies that currently deliver high health breeding animals to their customers. Serology is therefore the preferential approach in order to screen for most of these diseases, including Mycoplasma hyopneumoniae (M...