Domenico Lombardo

Domenico Lombardo
Italian National Research Council | CNR · Istituto per Processi Chimico Fisici - Messina (Italy)

PhD

About

81
Publications
23,164
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2,337
Citations
Additional affiliations
January 2001 - March 2017
Italian National Research Council
Position
  • Group Leader

Publications

Publications (81)
Article
Full-text available
Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical composition variability, and ease of preparation, as well as their large variety of structural properties, liposomes have been employed in a large variety of nanomedicine and...
Article
Owing to the amphiphilic nature of their constituent molecules, binary mixtures of pure liquid surfactants are usually characterized by enhanced nano-segregation and thus can exhibit interesting transport properties and complex macroscopic behavior. In this ambit it was recently shown by Turco Liveri et al. (J. Mol. Liq. 263 (2018) 274–281) that mi...
Article
Full-text available
Ionic liquids (ILs) are liquid materials at room temperature with an ionic intrinsic nature. The electrostatic interactions therefore play a pivotal role in dictating their inner structure, which is then expected to be far from the traditional pattern of classical simple liquids. Therefore, the strength of such interactions and their long-range eff...
Article
Full-text available
This paper reports the analysis of the intramolecular OH stretching band obtained by Fourier Transform Infrared (FTIR) spectroscopy measurements. In order to characterize the effect of montmorillonite on the properties of Bovine Serum Albumin (BSA) the two-state model is adopted for the analysis of the OH stretching band. We assume that the OH stre...
Article
Full-text available
The investigation of the structural features in biological membranes represents a central topic in many aspects of biological science. It involves the study of the collective behavior of a great number of interacting macromolecules, while the study of the structure-function relationship require the observation and calculation of a large number of k...
Article
Owing to the amphiphilic nature of their constituent molecules, binary mixtures of pure liquid surfactants are usually characterized by enhanced nano-segregation and thus can exhibit interesting transport properties and complex macroscopic behavior. In this ambit it was recently shown by Turco Liveri et al. (J. Mol. Liq. 263 (2018) 274–281) at room...
Article
Full-text available
This paper reports the analysis of the intramolecular OH stretching band obtained by Fourier Transform Infrared (FTIR) spectroscopy measurements. In order to characterize the effect of montmorillonite on the properties of Bovine Serum Albumin (BSA) the two-state model is adopted for the analysis of the OH stretching band. We assume that the OH stre...
Article
Full-text available
Scattering techniques represent non-invasive experimental approaches and powerful tools for the investigation of structure and conformation of biomaterial systems in a wide range of distances, ranging from the nanometric to micrometric scale. More specifically, small-angle X-rays and neutron scattering and light scattering techniques represent well...
Article
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The involvement of metal ions within the self-assembly spontaneously occurring in surfactant-based systems gives additional and interesting features. The electronic states of the metal, together with the bonds that can be established with the organic amphiphilic counterpart, are the factors triggering new photophysical properties. Moreover, the ava...
Article
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Asphalt concretes are materials used worldwide. It is well-known that in such materials the minor component, the bitumen, plays the most important role since it binds the high fraction (>95%) of inorganic macrometer-sized particles ensuring a coherent material fit for uses in road pavement. Additives can be used to increase the overall rheological...
Article
Amphiphiles play a pivotal role in the area of self-assembled structures and interesting additional features can be obtained if metal ions are involved. In this ambit, the development of smart materials benefits from the availability of stimuli-responsive supramolecular amphiphile assemblies where the disassembly back-processes has an inherently ba...
Article
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Materials self-assembly represents a key strategy for the design and fabrication of nanostructured systems and has become a fundamental approach for the construction of advanced nanomaterials [...]
Article
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Experimental findings obtained by FTIR and Raman spectroscopies on montmorillonite-water mixtures at three concentration values are presented. To get some insight into the hydrogen bond network of water within the montmorillonite network, FTIR and Raman spectra have been collected as a function of time and then analyzed following two complementary...
Article
Full-text available
In this paper, we survey recent advances in the self-assembly processes of novel functional platforms for nanomaterials and biomaterials applications. We provide an organized overview, by analyzing the main factors that influence the formation of organic nanostructured systems, while putting into evidence the main challenges, limitations and emergi...
Article
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The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β...
Article
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Magnetically-induced birefringence is usually low in molecular liquids owing to the low magnetic energy of molecules with respect to the thermal one. Despite this, it has been found that a mixture of dibutyl phosphate and propylamine at propylamine molar ratio (X) around 0.33 surprisingly gives an intense effect (∆n/λ ≈ −0.1 at 1 Tesla). In this pa...
Article
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A mesoporous silica-based drug delivery device potentially useful for bone-specific drug delivery has been designed, developed and characterized starting from MSU-type mesoporous silica. The proposed system consists of a Mesoporous Silica Nanoparticles (MSN) based vehicle, presenting Alendronate as targeting function for bone tissue while ibuprofen...
Article
The self-assembly process in water solution of amphiphilic polydimethylsiloxane-b-polyethyleneoxide (PDMS-PEO) diblock copolymer was investigated by means of Small Angle X-rays Scattering (SAXS) experiments in the concentration region below (and near) the critical micellar concentration (c.m.c.=0.007 g/cm3). In the highly diluted region, at the cop...
Article
Full-text available
In recent years, the development of novel approaches for the formation of lipid nano-formulations for efficient transport of drug molecules in living systems offers a wide range of biotechnology applications. However, despite the remarkable progress in recent methodologies of synthesis that provide a wide variety of solutions concerning the liposom...
Article
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The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This art...
Article
Interactions of charged nanoparticles with model bio-membranes provide important insights about the soft interaction involved and the physico-chemical parameters that influence lipid bilayers stability, thus providing key features of their cytotoxicity effects onto cellular membranes. With this aim, the self-assembly processes between polyamidoamin...
Article
Binary mixtures of liquid surfactants, owing to the amphiphilic nature of the molecules involved, can exhibit nano-segregation and peculiar transport properties. The amphiphilicity, and consequently the resulting self-assembly, can be tuned by changing the length of the alkyl chains and the nature of the polar head group. So, in the present study,...
Article
Inorganic/organic hybrid materials composed by iron atoms bonded to an alkyl phosphate can be easily synthesized by mixing at 110 °C iron chlorides with tri-alkyl phosphates. Since structural information on these products are lacking and taking into account that lithium/iron organic hybrid materials are important in lithium ion battery technology w...
Article
Full-text available
The development of smart nanocarriers for the delivery of therapeutic drugs has experienced considerable expansion in recent decades, with the development of new medicines devoted to cancer treatment. In this respect a wide range of strategies can be developed by employing liposome nanocarriers with desired physico-chemical properties that, by expl...
Article
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Pure surfactant liquids and their binary mixtures, owing to the amphiphilic nature of the molecules involved, can exhibit nano-segregation and peculiar transport properties. The structural and dynamic properties of Octanoic acid (OA)/bis(2-ethylhexyl) amine (BEEA) liquid mixtures at various compositions have been studied by Wide Angle X-Ray Scatter...
Article
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Amphiphiles are synthetic or natural molecules with the ability to self-assemble into a wide variety of structures including micelles, vesicles, nanotubes, nanofibers, and lamellae. Self-assembly processes of amphiphiles have been widely used to mimic biological systems, such as assembly of lipids and proteins, while their integrated actions allow...
Article
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Dendrimers are highly branched macromolecules obtained by stepwise controlled, reaction sequences. The ability to be designed for specific applications makes dendrimers unprecedented components to control the structural organization of matter during the bottom-up synthesis of functional nanostructures. For their applications in the field of biotech...
Article
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The spectroscopic properties and liquid structure of pure tri-n-butyl phosphate (TBP) and FeCl3/TBP solutions have been investigated by Uv-Vis and Raman spectroscopies, X-ray diffraction and conductometry. Uv-Vis and Raman spectra, supported by conductometric measurements, consistently indicate that the solubilized salt is present mostly as TBP n [...
Article
Small angle neutron scattering (SANS) and dynamic light scattering (DLS) were used to study different aggregation states in sodium deoxycholate (NaDC)-phosphatidylcholine systems at T = 60 degrees C. Size and shape of the aggregates investigated as a function of the NaDC bile salt concentration (at the constant DPPC concentration of 6 mM) indicate...
Article
Full-text available
Small angle neutron scattering (SANS), neutron diffraction and X-ray powder diffraction were used to investigate influence of N-stearoyl phytosphingosine (CER[NP]) and alpha-hydroxy-N-stearoyl phytosphingosine (CER[AP]) on the internal structure and hydration of DMPC membrane in fully and partly hydrated states at T = 30 A degrees C. Application of...
Article
We describe the hydrothermal synthesis of zeolite Linde type A (LTA) submicrometer particles using a water-soluble amphiphilic block copolymer of poly(dimethylsiloxane)-b-poly(ethylene oxide) as a template. The formation and growth of the intermediate aggregates in the presence of the diblock copolymer have been monitored by small-angle X-ray scatt...
Article
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We present a study which illustrates the modeling of the Particle Scattering Structure Factor from Small Angle X-ray Scattering (SAXS) data. The studied sample was a poly(amidoamine) Pamam dendrimers in water solution. The intra-particle form factor P(q) has been analyzed employing an inverse Fourier transformation which allows to obtain the partic...
Article
Full-text available
In this paper a novel hybrid approach to synthesise composite nanoparticles is presented. It is based on the laser ablation of a bulk target (Yb) immersed in a reversed micellar solution which contains nanoparticles of a different host material (TiO2 nanoparticles) previously synthesised by chemical method. This approach thus exploits the advantage...
Article
A Small Angle X-ray Scattering (SAXS) investigation has been performed to study the self-assembly process generated by the addition of a low generation G1.5 polyamidoamine dendrimer during the zeolite LTA formation process. The presence of a condensed cationic Na+ charge all around the dendrimers, which is responsible for the intense electrostatic...
Article
Surfactant-coated ytterbium nanoparticles were produced by Nd:YAG laser ablation of a Yb bulk target immersed in sodium bis(2-ethylhexyl)sulfosuccinate (AOT)/n-heptane micellar solution. In our experimental conditions, as highlighted by IR spectroscopy, AOT molecules are not decomposed by the intense laser pulses but play a pivotal role in the stab...
Article
Here we report on the temperature dependence of the density and refractive index of alkyl-sulfate room temperature ionic liquids (RTIL): 1-ethyl-3-methylimidazolium n-alkyl-sulfate, [C2mim][CnOSO3] (n=2, 4, 6, 8). Moreover an X-ray scattering structural study on the salts’ morphology is presented, highlighting the existence of nano-scale structural...
Article
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We describe the synthesis of porous spherical nanoaggregates derived by the controlled growth of zeolite LTA on a poliamidoamine (Pamam) dendrimer acting as nano-template. The presence of a strong condensed cationic Na+ charge all around the dendrimers, which is responsible for the intense electrostatic inter-particle interaction potential, stimula...
Article
Full-text available
We describe the synthesis of porous spherical nanoaggregates derived by the controlled growth of zeolite LTA on a poliamidoamine (Pamam) dendrimer acting as nano-template. The presence of a strong condensed cationic Na + charge all around the dendrimers, which is responsible for the intense electrostatic inter-particle interaction potential, stimul...
Article
A structural investigation in water solution of the sodium carboxylate-terminated (generation G3.5) Tomalia-type poly(amidoamine) dendrimers has been performed by means of the small angle X-ray scattering (SAXS) technique. A long-range intermolecular interaction, revealed by the presence of sharp peaks in SAXS spectra, gives evidence of a considera...
Article
We describe the formation of a spherical complex driven by the incorporation of aluminosilicate in a dendrimer charged surface. By using a carboxyl-terminated dendrimer species as a macromolecular template for zeolite formation, we detected the formation of porous, stable, and nearly monodisperse spherical aggregates with an average radius of R = 3...
Article
Morphological transition in a mixed system of the dimyristoylphosphatidylcholine (DMPC)/sodium cholate (NaC) has been investigated by small-angle scattering of neutron (SANS) and X-ray (SAXS). Structural investigation, performed as a function of temperature and NaC concentration, show that the system containing 15mM DMPC and 6mM NaC reveals a stron...
Article
We present the results of a small angle neutron scattering investigation on a unilamellar DMPC vesicle system during the application of a magnetic field. The presence of the strong magnetic field, elongate the vesicles along the field and cause a change in the shape of the particles. This circumstance is caused by the presence of a small anisotropy...
Article
The neutron scattering length density across the membrane is simulated on the basis of fluctuated model of lipid bilayer. The use of a separated form factors method has been applied for the identification of the structural features of the polydispersed unilamellar DMPC vesicle system. The hydration of vesicle is described by sigmoid distribution fu...
Chapter
We report the results of quasi-elastic light scattering experiments in dense AOT microemulsions in the stable phase of water in oil, for different concentration (water volume fractions φ) and temperatures. In order to study the system dynamics, the measurements of the density-density correlation function are performed above and below the percolatio...
Chapter
The phase separation process in a one-phase microemulsions has been examined in an unstable region above its lower cloud point temperature by light-scattering measurements. The three time stages of the spinodal decomposition, i.e., early, intermediate, and late, has been observed. The scaling behavior of the peak in the structure factor, and the sc...
Article
The interaction between the anionic 5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,23H-porphyrin (TPPS) and cationic vesicles formed by heptakis(2-omega-amino-O-oligo(ethylene oxide)-6-hexylthio)-beta-cyclodextrin (SC6CDNH2) has been investigated in detail through a combination of elastic light scattering (ELS), quasi-elastic light scattering (QELS), z...
Article
Full-text available
The association properties in water solution of poly(dimethylsiloxane)-b-poly(ethyleneoxide) diblock copolymer was investigated by static and dynamic light scattering in a wide range of concentrations and temperatures. The presence of a long hydrophilic poly(ethyleneoxide) (PEO) chain causes a weak tendency to microphase separation of the system wh...
Article
The amphiphilic character in water of a novel class of chemically modified cyclodextrins has been investigated by means of small-angle X-ray scattering and light scattering. The introduction ofhydrophilic oligo(ethylene glycol) onto the secondary side of heptakis[6-alkylthio-6-deoxy-2-oligo(ethylene glycol)]-beta-cyclodextrins produces an enhanced...
Article
The entanglement process between water-soluble 5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,23H-porphine and the amphiphilic cyclodextrin (CD) heptakis(2-omega-amino-O-oligo(ethylene oxide)-6-hexylthio)-beta-CD and the occurrence of various species at different porphyrin:CD ratios were studied by a combination of UV/Vis absorption, fluorescence aniso...
Article
We study an attractive micellar system for which the percolation curve terminates near the critical point. We have studied such an intriguing situation by means of scattering (elastic and dynamical) and viscoelasticity experiments. Obtained data are accounted by considering in a proper way the fractal clustering processes typical of percolating sys...
Article
Full-text available
A new model of separated form factors is proposed for the evaluation of small-angle neutron scattering curves from large unilamellar vesicles. The validity of the model was checked by comparison to the model of a hollow sphere. The model of separated form factors and the hollow-sphere model give reasonable agreement in the evaluation of vesicle par...
Article
We detect in a tri-block co-polymer micellar system an ergodic-to-nonergodic-to-ergodic transition, as a function of temperature, in a range of concentrations, by photon correlation measurements. The shear viscosity is also shown to jump two order of magnitude at these transition temperatures. Surprisingly, the structure factor as measured by small...
Article
In this work, we study the internal density distribution in a dendrimer or “starburst polymers” system at different generations. We have used different techniques like small angle X-ray scattering, quasi-elastic light scattering and a Molecular dynamics simulation. Obtained data, compared with the literature ones, proposed that lower generation den...
Article
In this work, we study a copolymer-micellar system characterized by clustering processes due to a short-range attractive interaction. This originates a percolation process and a new type of kinetic glass transition. We have studied these intriguing dynamical situations by means of an extensive set of light scattering and viscoelasticity experiments...
Article
The possibility to use sucrose solutions as medium for X-ray and neutron small-angle scattering experiments has been explored for dimyristoylphosphatidylcholine (DMPC) vesicles and mixed DMPC/C_(12)E_(8) aggregates. The influence of sucrose concentration on phospholipid vesicles size and polydispersity has been investigated by complimentary X-ray a...
Article
The small-angle X-ray and neutron scattering, time resolved X-ray small-angle and wide-angle diffraction coupled with differential scanning calorimetry have been applied to the investigation of unilamellar and multilamellar dimyristoylphosphatidylcholine vesicles in sucrose buffers with sucrose concentrations from 0% to 60%. Sucrose buffer decrease...
Article
Full-text available
The formation of spherical and monodisperse small unilamellar vesicles is observed upon temperature jumps in a mixed system composed of a phospholipid (dimyristoylphosphatidylcholine) and a bile salt (sodium cholate) in an aqueous buffer. In order to enhance the X-ray contrast of the system a mixed water/sucrose buffer is used. The spontaneous form...
Article
Full-text available
Small angle light and X-ray scattering and scaling concepts are used to explore the intra- and inter-molecular structure of two different classes of new materials: dendritic polymer and porphyrins systems. Whereas porphyrins in water are characterized, depending on their concentration and ionic strength, by the built-up of extended clusters, dendri...