Domenico Guarino

Domenico Guarino
University of Paris-Saclay · Research

Doctor of Philosophy

About

12
Publications
3,963
Reads
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174
Citations
Additional affiliations
November 2018 - January 2021
French National Centre for Scientific Research
Position
  • PostDoc Position
October 2013 - February 2015
French National Centre for Scientific Research
Position
  • PhD Student

Publications

Publications (12)
Article
Full-text available
The thalamus is the brain’s central relay station, orchestrating sensory processing and cognitive functions. However, how thalamic function depends on internal and external states, is not well understood. A comprehensive understanding would necessitate the integration of single cell dynamics with their collective behavior at population level. For t...
Preprint
Full-text available
The thalamus is the brain’s central relay station, orchestrating sensory processing and cognitive functions. However, how thalamic function depends on internal and external states, is not well understood. A comprehensive understanding would necessitate the integration of single cell dynamics with their collective behavior at population level. For t...
Preprint
Full-text available
In the early visual system, corticothalamic feedback projections greatly outnumber thalamocortical feedforward projections. Extensive experimental and modeling work has been devoted to the functional impact of the feedforward pathway, but the role of its denser feedback counterpart remains elusive. Here, we propose a novel unifying framework where...
Preprint
Cortical events of correlated neuronal firing are thought to underlie sensorimotor and associative functions. In the dominant theory, events are attractors of cortical dynamics, pulled by strong mutual connections between recurrently active – core – neurons. Here, we exhaustively measured core connectivity, using a unique dataset with co-registered...
Article
Full-text available
Each time there is an interaction with the environment, we select one among many, equally possible, actions. How is it done? In the classical view, to access motor resources, many cortical action plans compete in the basal ganglia: a set of subcortical neuron populations, whose output constantly inhibits specific thalamic targets. In the basal gang...
Conference Paper
One of the current challenges in computational neuroscience is not only to build high fidelity models of brain structures reflecting their biological complexity, but also to test them with as broad a range of measures and stimulation conditions as possible. The need to repetitively perform such tests on a model under development, and the increasing...
Article
Full-text available
Neuroscientists use many different software tools to acquire, analyze and visualize electrophysiological signals. However, incompatible data models and file formats make it difficult to exchange data between these tools. This reduces scientific productivity, renders potentially useful analysis methods inaccessible and impedes collaboration between...
Conference Paper
Full-text available
The benefits of capturing the output of neurophysiology laboratories in structured databases are potentially very large, both in improved data management within a laboratory and in easier and more effective sharing of data, whether with close collaborators or in public databases. However, at present the task of systematically annotating every exper...
Conference Paper
Full-text available
Many problems arise during simulation software development regarding how data is represented in memory, which affect both creation and management of simulated structures. Indeed, managing data movement from disk storage to active memory, with all its low level software design challenges, is one of the most important problems, dramatically rising in...

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