
Domenico GuarinoUniversity of Paris-Saclay · Research
Domenico Guarino
Doctor of Philosophy
About
12
Publications
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174
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Introduction
Additional affiliations
November 2018 - January 2021
October 2013 - February 2015
Publications
Publications (12)
The thalamus is the brain’s central relay station, orchestrating sensory processing and cognitive functions. However, how thalamic function depends on internal and external states, is not well understood. A comprehensive understanding would necessitate the integration of single cell dynamics with their collective behavior at population level. For t...
The thalamus is the brain’s central relay station, orchestrating sensory processing and cognitive functions. However, how thalamic function depends on internal and external states, is not well understood. A comprehensive understanding would necessitate the integration of single cell dynamics with their collective behavior at population level. For t...
In the early visual system, corticothalamic feedback projections greatly outnumber thalamocortical feedforward projections. Extensive experimental and modeling work has been devoted to the functional impact of the feedforward pathway, but the role of its denser feedback counterpart remains elusive. Here, we propose a novel unifying framework where...
Cortical events of correlated neuronal firing are thought to underlie sensorimotor and associative functions. In the dominant theory, events are attractors of cortical dynamics, pulled by strong mutual connections between recurrently active – core – neurons. Here, we exhaustively measured core connectivity, using a unique dataset with co-registered...
Abstract of poster presentation at OCNS-2017
Each time there is an interaction with the environment, we select one among many, equally possible, actions. How is it done? In the classical view, to access motor resources, many cortical action plans compete in the basal ganglia: a set of subcortical neuron populations, whose output constantly inhibits specific thalamic targets. In the basal gang...
One of the current challenges in computational neuroscience is not only to build high fidelity models of brain structures reflecting their biological complexity, but also to test them with as broad a range of measures and stimulation conditions as possible. The need to repetitively perform such tests on a model under development, and the increasing...
Neuroscientists use many different software tools to acquire, analyze and visualize electrophysiological signals. However, incompatible data models and file formats make it difficult to exchange data between these tools. This reduces scientific productivity, renders potentially useful analysis methods inaccessible and impedes collaboration between...
The benefits of capturing the output of neurophysiology laboratories in structured databases are potentially very large, both in improved data management within a laboratory and in easier and more effective sharing of data, whether with close collaborators or in public databases. However, at present the task of systematically annotating every exper...
Many problems arise during simulation software development regarding how data is represented in memory, which affect both creation and management of simulated structures. Indeed, managing data movement from disk storage to active memory, with all its low level software design challenges, is one of the most important problems, dramatically rising in...