
Domenic Vincent CicchettiYale University | YU · Child Study Center, Biometry, and Psychiatry
Domenic Vincent Cicchetti
Ph.D
About
292
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Introduction
Additional affiliations
January 1988 - June 1995
Education
September 1955 - April 1965
University of CT
Field of study
- Social Psychology and Biostatistics
Publications
Publications (292)
Early identification of autism spectrum disorder (ASD) is regarded as crucial for swift access to early intervention and, subsequently, better outcomes later in life. However, current instruments miss large proportions of children who later go on to be diagnosed with ASD, raising a question of what these instruments measure. The present study utili...
Here we address the earlier published review by Øien et al. (J Autism Dev Disord, https://doi.org/10.1007/s10803-018-3686-7, 2018) and the subsequent comments by Zucker and VanderLaan (J Autism Dev Disord, https://doi.org/10.1007/s10803-018-3748-x, 2018). The current commentary is a response to the corrections put forth by the latter authors where...
In this systematic map review, we aimed (1) at identifying studies including the co-occurrence of autism spectrum disorders (ASD) and gender dysphoria (GD) between 1946 and 2018, and (2) to present the papers included in this systematic map review to provide authors in the field of GD, sexuality and ASD with an important database of studies focusin...
Published research often address aspects related to “statistical significance” but fail to address the clinical and practical importance and meaning of results. Our main objectives in this article are to investigate the merit of common measures of Effect Size in statistical research and to highlight the importance of the simple Relative Risk ratio....
OBJECTIVES
We compared sex-stratified developmental and temperamental profiles at 18 months in children screening negative for autism spectrum disorder (ASD) on the Modified Checklist for Autism in Toddlers (M-CHAT) but later receiving diagnoses of ASD (false-negative group) versus those without later ASD diagnoses (true-negative group).
METHODS
W...
A substantial oenological literature exists on opinions of experts and neophytes as they relate to opinions about the quality of wines (Ashenfelter and Quandt, 1998; Cicchetti, 2004; Lindley, 2006). These opinions can be contrasted with factual binary questions about wine: Is it oaked? Does it contain sulfites? Is it filtered? Is the grape varietal...
Wine judges were randomly selected from the membership of the American Association of Wine Economists (AAWE) to participate in a blind triplicate tasting of two South African varietals: one Sauvignon Blanc and one Pinotage; as well as a blind tasting of a single pouring of five additional Sauvignon Blanc wines and five additional Pinotage wines. It...
Cohen's (Educ Psychol Meth. 1960;23:37-40) kappa statistic has been criticized recently for providing low chance-corrected coefficients (<0.40) despite high levels of examiner agreement (e.g., ≥85%). The AC1 statistic (Series. 2002;2:1-9; BMC Med Res Methodol. 2013;13:61), the alpha statistic (J Clin Epidemiol. 1996;49:775-782), the B statistic (BM...
In this study, we examined the frequency of sensory-related issues as reported by parents in a large sample of school-age adolescents and adults with autism/autism spectrum disorder (ASD) [1] as compared to a group of individuals receiving similar clinical evaluations for developmental/behavioral difficulties but whose final diagnoses were not on t...
In an earlier article, the authors assessed the clinical significance of each of 19 Clinician Administered PTSD Scale items and composite scores (CAPS-1) [1] when 12 clinicians evaluated a Vietnam era veteran. A second patient was also evaluated by the same 12 clinicians and used for cross-validation purposes [2]. The objectives of this follow-up r...
A univariate analysis of 88 covariates was undertaken and 46 of them reached statistical significance at an acceptable level of p < 0.05. The multivariable analysis exhibited a significant negative relationship between ICH and hypertension. The improvement among ICH patients having hypertension was found to be 0.5 with the p=0.001, ARR=0.5, 95% C.I...
In an earlier investigation, the authors assessed the reliability of the ADI-R when multiple clinicians evaluated a single case, here a female 3 year old toddler suspected of having an autism spectrum disorder (Cicchetti et al. in J Autism Dev Disord 38:764-770, 2008). Applying the clinical criteria of Cicchetti and Sparrow (Am J Men Def 86:127-137...
The purpose of this research was to compare the ratings of 237 2009 Bordeaux wines by Jancis Robinson (JR) and Robert Parker (RP). Results indicate that the level of agreement was 81.77% as compared to an expected agreement of 80.92%. This produced a chance-corrected agreement level of only 4%. Though statistically significant at a level of 0.02, t...
In the rating of 184 2004 Bordeaux wines, Jancis Robinson (JR) and Robert Parker (RP) showed: complete agreement on only 71/184 or 39% of the wines; for 110 of the remaining 119 wines, RP assigned a higher rating than JR. RP scored: 51 wines as EXCELLENT that JR rated as ABOVE AVERAGE; 38 as ABOVE AVERAGE that JR scored as AVERAGE; 19 as EXCELLENT...
MacleanNatalie: Red, White, and Drunk All Over: A Wine Soaked Journey from Grape to Glass. Bloomsburg Publishers, New York, 2006, 279 pp., ISBN 13: 978-2-58234, $23.95 - Volume 4 Issue 2 - Domenic V. Cicchetti
KramerMatt: Making Sense of Italian Wine: Discovering Italy's Greatest Wines and Best Values. Running Press, Philadelphia, PA, 2006, 280 pp., ISBN – 13: 978-0-7624-2230-2, $24.95 - Volume 2 Issue 1 - Domenic V. Cicchetti
The author examined critically three beliefs of S.S. Stevens pertaining to his quadripartite system of scales of measurement: (1) There are four scales of measurement in common usage (2) These scales and the scientific disciplines that use them can be incrementally graded for levels of reliability and validity or accuracy such that: Nominal scale v...
Los analizadores de hematología ofrecen varios parámetros que se pueden obtener de maneras distintas, en conformidad con el modelo o la marca de los mismos. En el presente trabajo se estudian dos equipos automatizados, analizadores Coulter STKS y Sysmex XE-2100D, y se evalúan de manera comparativa los parámetros del eritrograma en 383 personas eleg...
The main diagnostic features of autism spectrum disorders (ASD) are defined in terms of qualitative impairments in social
interaction, communication, and a pattern of restricted interests or repetitive behaviors. However, the particular constellation
of symptoms, number, frequency, and severity differs from individual to individual. For some, an en...
Hematology analyzers provide several parameters that can be obtained in a distinct way, in accordance with the model or brand name. In the present work, two automated hematology equipment Coulter STKS and Sysmex XE-2100D analyzers are studied, evaluating, in a comparative way, the erythrogram parameof 383 individuals, chosen randomly at the Hospita...
The author examined critically three beliefs of S.S. Stevens pertaining to his quadripartite system of scales of measurement: (1) There are four scales of measurement in common usage (2) These scales and the scientific disciplines that use them can be incrementally graded for levels of reliability and validity or accuracy such that: Nominal scale v...
The objectives of this report are: (a) to trace the theoretical roots of the concept clinical significance that derives from Bayesian thinking, Marginal Utility/Diminishing Returns in Economics, and the "just noticeable difference", in Psychophysics. These concepts then translated into: Effect Size (ES), strength of agreement, clinical significance...
The editors of this book recently described the development and application of an “evaluative method” for assessing evidence-based
practices (EBP) in Autism (Reichow et al. 2008). The major results of this investigation, which were presented at the International
Meeting for Autism Research (Reichow et al. 2007) indicated that the method produced hi...
Autism spectrum disorders (ASDs) have been increasingly diagnosed in recent years and carries with it far reaching social and financial implications. With this in mind, educators, physicians, and parents are searching for the best practices and most effective treatments. But because the symptoms of ASDs span multiple domains (e.g., communication an...
Manual reticulocyte counts were examined under light microscopy, using the property whereby supravital stain precipitates residual ribosomal RNA versus the automated flow methods, with the suggestion that in the latter there is greater precision and an ability to determine both mature and immature reticulocyte fractions. Three hundred and forty-one...
The relationship between adaptive functioning and autism symptomatology was examined in 1,089 verbal youths with ASD examining results on Vineland-II, IQ, and measures of ASD severity. Strong positive relationships were found between Vineland subscales and IQ. Vineland Composite was negatively associated with age. IQ accounted a significant amount...
The Prudhoe Cognitive Function Test (PCFT) directly measures the cognitive abilities of people with intellectual impairment. This study examined the relationship between this instrument and the Kaufman Brief Intelligence Test (K-BIT) and two shorter versions of the same scale. High correlations between the verbal and performance sections of the K-B...
The objective of this research is to devise a reliable and accurate scoring algorithm for awarding medals at a major U.S. wine competition that was described earlier by Hodgson (2008). The new algorithm is comprised of a two-tiered method that considers an award on the basis of a total medal score averaged across four judges per each evaluated wine...
A neoplasia cervical constitui um problema de saude publica em âmbito mundial, estimando-se que seja a terceira mais comum na populacao feminina. Na realizacao do exame de Papanicolaou, principal instrumento para a deteccao de anormalidades epiteliais, deve-se buscar formas de reduzir as variacoes, atraves do aprofundamento e uniformizacao de crite...
The objective of this investigation was to assess the inter-examiner reliability of PTSD symptomatology by 12 clinical examiners who evaluated independently a single-case Vietnam-Era veteran, using videotaped clinician interviews with The Clinician Administered PTSD Scale-1 (CAPS-1). A second patient was utilized for cross-validation purposes. Data...
A consistent result in the evaluation of group-delivered intervention to promote social reciprocity in children with PDDs is that outcome data are inconclusive. Lack of robust evidence of efficacy confounds understanding of these interventions and their value to the field. It is conceivable that the construct of impaired social reciprocity in PDD p...
Randomised controlled trials are difficult to carry out in high security prisons and very few have succeeded. We describe here a randomised controlled trial of early versus late assessment for the pilot phase of the new DSPD programme for dangerous and severe personality disorder, which assessed prisoners (n = 75) at baseline, then six months, and...
Domenic V Cicchetti1, Arnold F Cicchetti21Yale Home Office, North Branford, CT, USA; 2Consulting Specialist of Wine, Director of National Accounts, Wine Warehouse, San Anselmo, CA, USAAbstract: The authors studied seven wine rating scales judged to be useful for the wine producer, consumer, or oenologic researcher: (1) My Wine Rating scale; (2) the...
Reticulocyte counts are widely used in laboratories to evaluate bone marrow erythropoietic activity and have great diagnostic and prognostic importance in the treatment of anemias. Reticulocytes are supravitally stained with new methylene blue or brilliant cresyl blue, which highlight the characteristic aspect of the reticulum visible by light micr...
The objectives of this paper are (1) to broaden the concept and importance of differentiating statistical significance from clinical or practical significance that was introduced in a recent oenologie application that appeared in this Journal (Cicchetti, 2007); (2) to highlight the major contribution of Economics to the clinical-statistical signifi...
Using data deriving from the Paris 1976 blind wine tastings of notable French and American Chardonnays, in the first tasting, and of notable French Bordeaux and American Cabernets in the second tasting, it is discovered that the same five of 11 tasters were the most reliable or consistent ones in both wine competitions. We discuss the very importan...
Although research in autism has grown more sophisticated, the gap between research knowledge and applicability of research in real world settings has grown. There have been a number of different reviews of evidence-based practices of treatments for young children with autism. Reviews which have critically evaluated the empirical evidence have not f...
In a two-part article, we discuss both from a personal-experiential and empirical-objective perspective, the oenologic issues of judgments of wine quality, and the need to produce a balanced and consistent appreciation of wine tasting, whether one be an experienced wine connoisseur, an aficionado, or someone who simply enjoys a wine of one's choice...
To examine the validity of the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS), a new observational method for assessing preschool disruptive behavior.
A total of 327 behaviorally heterogeneous preschoolers from low-income environments comprised the validation sample. Parent and teacher reports were used to identify children with clini...
To examine the reliability of the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS), a new observational method for assessing preschool disruptive behavior.
The DB-DOS is a structured clinic-based assessment designed to elicit clinically salient behaviors relevant to the diagnosis of disruptive behavior in preschoolers. Child behavior is...
Background It is often useful to ascertain whether adults have moderate to profound intellectual disability (approximate IQ < 50; developmental age <108 months) when deciding whether to refer to specialist or mainstream services. The aim of the present study was to develop a simple measure to estimate moderate to profound intellectual disability in...
The authors assessed the reliability of the Autism Diagnostic Interview (ADI-R). Seven Clinical Examiners evaluated a three and one half year old female toddler suspected of being on the Autism Spectrum. Examiners showed agreement levels of 94-96% across all items, with weighted kappa (K(w)) between .80 and .88. They were in 100% agreement on 74% o...
Thirty-seven children 15-25 months of age received clinical diagnoses of autism spectrum disorder (ASD) and were re-evaluated two years later. All subjects were judged to have retained a diagnosis of ASD at the follow-up evaluation. Communication scores for the group as a whole during the first visit were significantly lower than nonverbal IQ. Howe...
In low- and middle-income countries, methods for clinicians to address difficulties in language, social-emotional, cognitive, behavioral, or neuromotor development during early childhood are lacking. To fill this gap, we designed, in Turkey, the Guide for Monitoring Child Development, which aims to aid clinicians in monitoring and supporting child...
Pages 108-117 of the current issue of Pediatric and Developmental Pathology contain a landmark interobserver investigation of some of the vagaries and vicissitudes involved in the nosological assessment of 6 histological features of childhood brain tumors. Doctor Gilles and his clinical research colleagues are to be commended for their conceptualiz...
Although there are many rating scales recording the incidence and intensity of violence there are none that are specifically concerned with the measurement and assessment of severe violence.
To develop a scale sensitive to variation centred on severe violence, establish its normative values, test its feasibility, and assess its reliability and vali...
Purpose
This study tests the hypothesis that toddlers with autism spectrum disorders (ASD) will show differences from contrast groups in preferences for attending to speech.
Method
This study examined auditory preferences in toddlers with ASD and matched groups of (a) typical age-mates, (b) age-mates with nonautistic developmental disabilities, an...
The author distinguishes between the clinical and statistical meaning of varying levels of intertaster reliability for the 11 judges who evaluated 10 Chardonnays (6 American and 4 French) in the heralded 1976 Paris wine competition. Four wines showed levels of weighted kappa values (<0.40), that are considered poor by established biostatistical cri...
Surgery for intractable temporal lobe epilepsy usually controls seizures and improves health-related quality of life (HRQOL), but some patients experience continued seizures, memory decline, or both. The relative impact of these unfavorable outcomes on HRQOL has not been described.
We studied seizure control, memory change, and HRQOL among 138 pati...
The relationship between adaptive functioning (ability) and autism symptomatology (disability) remains unclear, especially for higher functioning individuals with autism spectrum disorder (ASD). This study investigates ability and disability using the Vineland and Autism Diagnostic Observation Schedule (ADOS), respectively, in two clinical samples...
We investigated the relationship between somatostatin-like immunoreactivity (SSLI) and interictal spikes (IIS) in human temporal lobe epileptic tissue. IIS counted manually from depth electrode recordings obtained preoperatively were expressed as spike frequency in anterior, middle, and posterior portions of hippocampus. SSLI was determined by radi...
Clinicians and researchers use brief instruments, such as the Mini Mental State Examination (MMSE) and the Telephone Interview for Cognitive Status (TICS), to measure cognitive functioning in patients with cerebral aneurysms. MMSE and TICS scores are often dichotomized to classify patients as cognitively impaired or not. Frequently, after an initia...
In the author's earlier research, five quite reliable and six quite unreliable subsets of tasters were identified, from among the full sample of eleven wine tasters, at the heralded 1976 Paris blind Chardonnay and Bordeaux/Cabernets wine competitions. This study shows quite conclusively that the consistent tasters and the inconsistent ones provided...
We focus upon several broad issues that are of concern to clinicians and clinical researchers in the areas of biobehavioral and biomedical research, including, but not limited to, the fields of psychiatry, psychology, neuropsychology, and neurology. These issues are the critical reassessment of S. S. Stevens' quadripartite conceptualization of scal...
To develop an assessment of bed need that was as little affected by personal bias as possible.
The Bed Requirement Inventory (BRI) is an eight-point scale designed to identify the appropriate use of an acute psychiatric bed. This is completed by a member of the ward staff, usually a nurse, and takes 5 minutes to fill in. The reliability, validity a...
To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change.
Forty-eight children (5 years to 16 years, 5 months) who showed behavioral improvement during acute treatment with rispe...
Shriberg et al. [Shriberg, L. et al. (2001). Journal of Speech, Language and Hearing Research, 44, 1097-1115] described prosody-voice features of 30 high functioning speakers with autistic spectrum disorder (ASD) compared to age-matched control speakers. The present study reports additional information on the speakers with ASD, including associatio...
This paper presents the clinical/developmental framework underlying a new diagnostic observational tool, the Disruptive Behavior Diagnostic Observation Schedule (DB-DOS). The special importance of observation for clinical assessment during the preschool period is delineated. The developmental rationale for a multi-dimensional assessment of disrupti...
The cross-cultural applicability of the concept of posttraumatic stress was investigated by assessing symptom frequency and levels of comorbid psychopathology in adolescents from the United States and Russia.
A self-report survey was conducted in representative samples of 2,157 adolescents 14 to 17 years old from urban communities of the United Sta...
To compare three methods of data collection on case ascertainment of past chlamydia or gonorrhea diagnoses.
Data collection for 361 adolescent females between 1998 and 2000 included: 1) face-to-face interviews; 2) computerized and paper medical record reviews; and 3) chlamydia and gonorrhea reports to the state health department. Statistical method...
The author discusses reliability research designs and data analytic strategies that are required in future wine competitions. The sources of variations that are identified and need to be controlled in order to increase both the reliability and, to the extent possible, accuracy of wine tasting evaluations derive from two literature sources, wine res...
The author revisits the heralded 1976 Paris blind tasting of US Cabernets and French Bordeaux. The conclusion reported in 1976, 1999, 2001 and 2003 was that the Americans won the competition outright. This conclusion derives from a non-parametric analysis of the data that converts wine rating scores to ranks, thereby producing invalid results. The...
Our purpose in this report is to evaluate scientifically that body of literature relating the effects of prenatal and postnatal exposure to polychlorinated biphenyls (PCBs) upon neurobehavioral, health-related, and cognitive deficits in neonates, developing infants, children, and adults. The data derive from seven cohorts: six cohorts of mothers an...
In this paper we address the points raised by groups of scientists who were invited to respond to our initial critique of polychlorinated biphenyl (PCB) research in this special issue. In that article, we applied six objective criteria to more than two decades of published PCB research and concluded that much of the research was badly flawed. The P...
The purpose of this study is to provide a microanalysis of differences in adaptive functioning seen between well-matched groups of school-aged children with autism and those diagnosed as having Pervasive Developmental Disorder-Not Otherwise Specified, all of whom functioned in the mild to moderate range of intellectual impairment. Findings indicate...
There are no specific instruments for rating dependent personality, although this may be an important subject in clinical practice, where knowledge of dependent personality features may influence treatment.
To develop a simple self-rating questionnaire for dependent personality features and compare the findings in two groups, one with and one witho...
To examine the reliability and validity of the 42-item Brief Infant-Toddler Social and Emotional Assessment (BITSEA), a screener for social-emotional/behavioral problems and delays in competence.
Parents in a representative healthy birth cohort of 1,237 infants aged 12 to 36 months completed the Infant-Toddler Social and Emotional Assessment (ITSEA...
Significant resources are used for acute illnesses in children. Identifying predictors of resource use can focus interventions to reduce this use.
To determine the relative effects of maternal, infant, social milieu, and demographic characteristics, the mother-child interaction, and perception of illness severity on the use of resources during acut...
Few data are available concerning the trajectories of mental and motor development across time for cocaine-exposed children compared with others. Findings are presented from individual group curve analyses of the mental and motor development measured by the Bayley Scales of Infant Development-II (BSID-II) on repeated visits from 3 through 36 months...
The concurrent validity of the Leiter International Performance Scale (Leiter) and Leiter International Performance Scale-Revised (Leiter-R) was examined in a sample of children with autism who could not be assessed with more traditional measures of intelligence (e.g., the Wechsler scales). The sample consisted of 26 children ranging in age from 4...
In this study, specific consideration is given to a role for the thalamus in autism.
A volumetric analysis of the thalamus was conducted using magnetic resonance imaging, based on segmentation of continuous 1.2 mm(3) coronal images. The sample consisted of 12 high-functioning individuals with autism, mean age of 21.0 years (SD = 10.4) and mean IQ o...
The Global Assessment of Function (GAF) scale is widely used in adult psychiatric practice and research but it has not often been used in learning disability, which is inherently more complex.
To evaluate the reliability of GAF in the assessment of learning disability.
GAF reliability was tested by simultaneous multiple rating of unselected case vi...
Originally published in Contemporary Psychology: APA Review of Books , 2002, Vol 47(4), 449-452. The reviewer states that this book (see record 2000-08524-000 ) seeks to provide a compendium of both parametric and nonparametric statistical approaches that will be of interest and useful to both those with a very restricted knowledge of statistics, a...