Dolores López-Presa

Dolores López-Presa
Hospital de Santa Maria · Serviço de Anatomia Patológica

MD

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45
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Introduction
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Publications

Publications (45)
Article
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Some locally advanced pelvic bone tumors are deemed unresectable and, as such, not suitable for curative surgery. In this setting, treatment options are generally limited and not unanimous, with decisions being made on an individual basis after multidisciplinary discussion. Ultimately, and notwithstanding the bright prospects raised by novel therap...
Article
Full-text available
The microenvironment of pituitary adenomas (PAs) includes a range of non-tumoral cells, such as immune and stromal cells, as well as cell signaling molecules such as cytokines, chemokines and growth factors, which surround pituitary tumor cells and may modulate tumor initiation, progression, invasion, angiogenesis and other tumorigenic processes. T...
Article
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Mucosal melanoma accounts for 1% of all melanomas. It is more aggressive than cutaneous melanoma, and local excision provides the best disease-free survival. The vast majority of patients eventually develop metastases, with a metastatic pattern independent of the primary tumor site. While studies show that BRAF and KIT inhibitors have a role in the...
Article
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A 68 year-old female presents with an ulcerated mass of the 5th digit, with rapid growth during the previous month to surgery. The mass was excised and covered with a 4th dorsal metacarpal artery perforator flap. The histologic analysis was compatible with the diagnosis of fibro-osseous pseudotumor of the digit.
Article
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We present the case of a 32-year-old man with a diagnosis of type-III osteogenesis imperfecta who developed a telangiectatic osteosarcoma in the proximal right tibia. An above-knee amputation was performed and after one-year follow-up, pulmonary metastatic lesions were detected on the thoracic CT scan. Palliative chemotherapy was proposed and to da...
Article
Schwannoma is a benign encapsulated nerve sheath tumor composed of Schwann cells, that may arise anywhere along the course of a nerve. Cutaneous schwannomas, associated with peripheral nerves, usually present as a slow-growing well-circumscribed nodule, localized in the dermis or subcutaneous tissue. They are generally asymptomatic; however, they m...
Article
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Introduction: A primary malignant giant-cell tumor of bone (PMGCT) is an extremely rare disease and usually presents with a better prognosis than its secondary counterpart does (secondary malignant giant-cell tumor of bone or SMGCT). Case Report: We present a case of a highly atypical PMGCT of the proximal left tibia, with extremely fast progressi...
Article
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Biological therapies, including anti-TNF (tumor-necrosis-factor) agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this...
Article
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Background Anemia can compromise therapeutic outcomes in cancer. The aim of this study was to evaluate hemoglobin (Hb) levels as a prognostic factor in locally advanced head and neck squamous cell carcinoma (HNSCC) treated with concurrent chemoradiotherapy (cCRT). Methods Retrospective evaluation of patients with HNSCC treated with cCRT. Primary a...
Article
Case: A 60-year-old man presented with left hip pain, and a radiograph showed reduced joint space. During the surgical procedure for a total hip replacement, a proximal femur mass was identified and biopsy was subsequently interpreted as grade 2 chondrosarcoma. A wide resection was needed, but he developed local recurrence after 2 years and was tr...
Article
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Introduction Schwannomas—Schwann cells–originating tumors—may develop in many locations. However, primary schwannomas arising within lymph nodes are extremely rare, with only a few cases described to this date in the English literature. For the intranodal location, most of the cases are described in the abdominal cavity. In these cases, clinicians...
Article
Objectives: To investigate whether the balance of blood T follicular helper (Tfh) and Foxp3+ T follicular regulatory (Tfr) cells can inform on ectopic lymphoid neogenesis and disease activity in primary Sjögren's syndrome (SS). Methods: We prospectively recruited 56 patients with clinical suspicion of SS, 16 of which subsequently fulfilled Ameri...
Article
Chronic kidney disease (CKD) commonly evolves with disturbances in mineral and bone metabolism, currently defined as CKD-MBD. Management strategies have progressed over the years, but our knowledge regarding evaluation and treatment is still sparse. Herein, we describe a rare case of a hemodialysis patient with apparently fairly controlled hyperpar...
Poster
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In dedifferentiated osseous neoplasms two distinct constituents may be observed: a low-grade well differentiated sarcoma and a high-grade undifferentiated sarcoma, the latter dictating the overall prognosis. We present two cases of dedifferentiated bone tumours.
Poster
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Hospital de Santa Maria (Lisbon, Portugal) is a tertiary healthcare institution and teaching hospital with a distinguished Ophthalmology Department. We present our experience through a 10 year-long period.
Poster
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Composite lymphoma is a rare entity defined as the synchronous coexistence of two or more distinct lymphomas within the same tissue, customarily described in excised specimens. We present 3 cases diagnosed in core needle biopsy (CNB) samples throughout the past 7 years in our institution.
Article
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Key Clinical Message Hemophagocytic lymphohistiocytosis (HLH) should be considered in the differential diagnosis of adult patients with white matter disease. Brain involvement can be life‐threatening and should prompt aggressive therapy. Even after HLH remission, the possibility of subsequent deterioration due to emergence of an aggressive intravas...
Article
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Solitary bone plasmacytomas are part of a wide range of monoclonal neoplasms that share a common progenitor in the B lymphocyte lineage. In their particular case, a single bone lesion is found, most frequently on the axial skeleton, having evidence of no other osteolytic lesions or systemic involvement. Diagnosis can sometimes prove to be difficult...
Article
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Introduction: The leiomyosarcoma of the inferior vena cava (IVC) is a rare clinical entity, although it represents the most common malignant tumor of the venous system. Level II IVC tumors (supra-renal) are the most frequent and those who have a better prognosis for the development of symptoms earlier. Case report: The authors report a case of IVC...
Article
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Parathyroid carcinoma is an extremely rare cause of hyperparathy-roidism. Histologic diagnosis may be challenging. DAB, male aged 66 was submitted to subtotal gastrectomy because of a localized gastric adenocarcinoma (intestinal type). A mild primary hyperparathy-roidism was simultaneously found. Calcium oxalate nephrolithiasis was diagnosed 16 yea...
Article
Squash cytology (SC) is a very useful procedure during neurosurgical intraoperative consultation (IOC), and it is especially recommended for the evaluation of soft tumors or tumors that are highly cellular (just the characteristics of pediatric central nervous system [CNS] tumors). The aim of this review is to familiarize pathologists with the rang...
Article
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Purpose To report a rare case of lacrimal gland carcinoma ex pleomorphic adenoma (Ca ex PA) with chronic B-cell lymphocytic leukemia (B-CLL) infiltration in a patient without a previous diagnosis of B-CLL. Patient and methods We report a 66-year-old woman who presented with recent worsening of a long-standing right eye proptosis. Sequential orbita...
Conference Paper
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Objective: In our community, high-risk HPV (HR-HPV) subtype 16 is the most frequent, and associated with a greater progression to carcinoma. Our goal is to investigate the distribution of HR-HPV infection in our experience. Method: Between January 2012 and March 2014, HR-HPV testing (extraction and PCR in Roche’s cobas® 4800 automated system, with...
Conference Paper
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Objective: Pap test is an important tool in the detection of cervical lesions, mainly squamous lesions. In literature, the concordance rate (CR) between a positive diagnosis for squamous lesion (ASCUS, ASC-H, LSIL, HSIL and Squamous cell carcinoma (SCC)) and the histologic findings in biopsy and/or conization varies greatly. Our goal was to evaluat...
Poster
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Carcinoma de células de Merkel: un caso raro de metastatización intestinal
Article
The clinical case of a 39 years old female is reported, with the diagnosis of tumor of the right kidney extending into the infra-hepatic vena cava, assuming the shape of a floating thrombus. The patient underwent right radical nephrectomy, followed by resection of the intra caval tumor. Both the procedure and post operative course were uneventfull....
Article
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Carcinoma with thymus-like differentiation (CASTLE) is a rare malignant epithelial tumor which arises on soft tissue of the neck or thyroid gland. It is important to differentiate CASTLE from primary or metastatic squamous cell carcinoma of head and neck, and from squamous cell thyroid carcinoma, because it has a different prognosis. CD5 immunoreac...
Poster
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Introdução: O cistadenoma seroso microquístico do pâncreas (CSMP) é um tumor quístico benigno. Os múltiplos pequenos quistos e uma cicatriz paracentral são característicos e permitem suspeitar macroscopicamente desta entidade. Menos frequentes são as variantes oligoquística e macroquística. Foram descritos seis casos de uma variante sólida ou adeno...
Article
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To study the role of fine needle aspiration cytology (FNAC) in the diagnosis of cutaneous and subcutaneous endometriosis. We present 7 cases of endometriosis in abdominal wall, inguinal region and perineum diagnosed by FNAC. All cases were confirmed with histologic follow-up. Cytologic and histologic material was prepared using standard methods. Th...