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Dobrin Konstantinov

Dobrin Konstantinov
University Hospital "Queen Johanna-ISUL", Sofia, Bulgaria · Pediatric Oncohematology Department

MD, PhD

About

52
Publications
2,918
Reads
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57
Citations
Additional affiliations
June 2004 - present
Specialized Children's Oncohaematology Hospital
Specialized Children's Oncohaematology Hospital
Position
  • Professor (Associate)
October 2000 - June 2004
Specialized Children's Oncohaematology Hospital
Specialized Children's Oncohaematology Hospital
Position
  • Professor (Assistant)
April 1990 - October 2000
University Hospital "Queen Johanna"
Position
  • Professor (Assistant)

Publications

Publications (52)
Article
What is known and objectives: Intravenous (IV) replacement therapy with plasma derived or recombinant factor VIII (FVIII) and factor IX concentrates is the mainstay for treatment of patients with haemophilia A and B. Therefore, the current therapy is particularly dependent on the presence of a secure IV access especially in case of emergency. Case...
Article
Full-text available
Over the last 20 years (from Oct 1997 to Oct 2017) a total of 309 hematopoietic stem cell transplantations of bone marrow, peripheral stem cells and cord blood have been performed in 278 patients (children and adults) in Children's Oncohemato-logical Clinic in Sofia. There were 85 allogeneic transplantations in 82 patients and 195 patients received...
Article
While thiopurine antimetabolites are drugs, widely used in treating a variety of acute conditions, they also have a relative-lynarrow therapeutic range. Their dosage is specifically tailored to the nosological unit and adapted with consideration to the specific tolerance as needed. Pharmacogenetic.specificity is one of the main factors that predete...
Article
Thiopurine antimetabolites include 6-Mercaptopurine (6-MP), 6-Thioguanine (6-TG), and Azathioprine (AZA). They are widely used in the treatment of acute lymphoblastic leukemia as well as other neoplastic and autoimmune diseases, and to help prevent organ rejection of transplants. Thiopurine-S-methyltransferase (TPMT), is a key enzyme in catabolisin...
Article
Joint bleeds represent the most common clinical presentation of Haemophilia. Each upcoming joint bleed triggers a pathologic chain that ultimately leads to arthropathic changes. The assessment and follow-up of haemophilic arthropathy is of a great importance for the right management of patients. The newest understandings on the pathogenesis of haem...
Article
Chemotherapy-inducing febrile neutropenia is, a serious side effect of the treatment of malignant diseases and a major risk factor for the morbidity and mortality from infections in this patient group (children and adults). One way to reduce the frequency of incidents of febrile.neutropenia is a prophylactic use of colony-stimulating factors (CSF)...
Article
Full-text available
Research has exposed cancer to be a heterogeneous disease with a high degree of inter-tumoral and intra-tumoral variability. Individual tumors have unique profiles, and these molecular signatures make the use of traditional histology-based treatments problematic. The conventional diagnostic categories, while necessary for care, thwart the use of mo...
Article
For the period 2009-2015 in Pediatric Oncohaematological Hospital-Sofia three patients with poorly differentiated nasopharyngeal carcinoma were treated and followed up. All children from that seria were boys and at time of diagnosis were 16,14,14 years old. They all were high risk cases because of the local widespread disease with neck lymph node m...
Article
Full-text available
We report a rare case of cerebellar degeneration as a paraneoplastic syndrome in an 8-year-old boy with Hodgkin lymphoma that presented during first-line treatment. Antibodies against Purkinje cells (anti-Tr antibodies) were detected in the serum of the patient. After successful treatment of the lymphoma, the cerebellar symptoms resolved partially....
Article
Primary immunodeficiencies are rare diseases with frequency of about 1/2000 children. Disorders in humural immunity combined B-cell and T-cell, phagocytic or complement abnormalities are the most common types. Children with such disorders tend to have infections caused by unusual agents with a very severe and recurrent course of the diseases. Very...
Article
Here are presented and discussed two cases of children at risk with advanced neoplastic diseases. Given the progressive move and the proven resistance of the disease in the patients it creates a need to solve a number of medical, psychosocial and legal problems. The medico-social case involves targeting at-risk children to use social service for th...
Article
Objective: The current report comprises the all cases of factor XIII deficiency that have been diagnosed, followed and treated in the last 10 years (2004-2014) in the three centers for pediatric hematology in Bulgaria. Methods: Retrospective analysis of 4 cases has been perfomed. Data variables include age, sex.clinical presentation, PT, aPTT, plat...
Article
For ten years, were studied 143 children suffering from lymphoma, of which 70 with Hodgkin's disease (Morbus Hodgkin - MH) and 73 with non-Hodgkin's Lymphoma (Non Hodgkin Lymphoma - NHL). Of these, 52 are girls and 91 boys. Age from 2 to 18 years. Initial ultrasonography was performed before initiating therapy with ex-post controls in the early sta...
Conference Paper
Full-text available
CD39+ T regulatory cells as a biomarker of immune reconstitution after allogeneic stem cell transplantation. Maya Yordanova1, Maria Nikolova2, Boryana Avramova1, Dobrin Konstantinov1 1Transplantation Unit, Specialized Children’s Hospital for Onco-hematological Diseases, Sofia, 2 Reference Immunological Laboratory, National Center for Infectious and...
Article
Introduction: After continuous improved clinical outcomes in Hodgkin's disease, the psychological adaptation is essential. The aim of the study is to analyze some of the basic parameters, involved in the construction of self-survival of the patient of the disease, and also the attitudes, summarizing the elements of: relation to the disease and to t...
Article
Paraneoplastic overproduction of a vasoactive intestinal peptid from tumors with sympathic nervous system origin is a very rare clinical presentation. The authors present a rare case of a 1 year 8 months old boy with a high risk neuroblastoma with bone metastasis. At the time of treatment induction the clinical picture was presented with biochemica...
Article
Full-text available
The incidence rate of tuberous sclerosis is 1/6000 newborn infants every year. It is the most common neurocutaneus syndrome after neurofibromatosis. Germ cell mutations of TSC1 and TSC2 tumorsupressor genes are the factors responsible for that disease and it is characterised with formations of multiple hamartomas in whole part of the human body and...
Article
We report on the case of an 10-year-old boy with ALL, who rapidly developed severe lactic acidosis as an early presentation of his 2-nd hematologic relapse. Complication was successfully treated with chemotherapy after correct diagnosis of the underlying condition. Revue of the literature and possible explanation of the pathophysiology of this rare...
Article
Full-text available
This paper describes the successful mobilization of peripheral blood stem cells for autologous transplantation in three children with malignant diseases by using plerixafor (Mozobil; Genzyme Corporation, Cambridge, MA) and granulocyte-colony stimulating factor (G-CSF) after failed previous mobilizations. A median sixfold increase in the number of c...
Article
Full-text available
To compare the survival of patients with poor prognosis Ewing's sarcoma family tumors (EFT) after conventional and myeloablative chemotherapy treated at our hospital in a period of 25 years. Fifty-seven patients were treated between 1985 and 2010. The patients were separated into 3 groups. Group A included patients (n=20) treated with conventional...
Article
Between April 2005 and June 2007 in the pediatric transplantation unit - Sofia, Bulgaria 15 hematopoietic stem cell transplantations (HSCT - 13 peripheral and 2 - bone marrow) were performed by 14 patients (pts) with poor prognostic leukemia, aged median 21 years (8-55): 4 with acute myeloid leukemia (AML), 9 - acute lymphoblastic leukemia (ALL), 1...
Article
The contemporary treatment of patients with severe and very severe acquired aplastic anemia (SAAA) consist of allogeneic hemopoietic stem cell transplantation (HSCT) or immunosuppressive therapy with antithymocyte globulin (ATG), Cyclosporine A and Prednisolone in patients without donors for transplantation. We present the outcome of the patients t...
Article
We present a ten-years experience of the SBALDOHZ - Sofia, with hematopoietic stem cell transplantations (HSCT). Between October 1997 and July 2007, 139 patients on the average age 23, 5 years (3-65) undergoing HSCT - 36 allogeneic and 115 autologous. The allogeneic transplantation are carry out in patients with hematological diseases, whereas auto...
Conference Paper
Objective: The risk of adverse events after allogeneic haematopoietic stem cell transplantation (HSCT) using major ABO-blood group incompatibility graft had to be investigated. Materials and Methods: Within the last 2 years altogether 7 major ABO incompatible HSCT were performed in 6 patients (pts) at the transplantation unit of SBALDOHZ. Мedian a...
Article
Full-text available
Purpose: Stage IV-S neuroblastoma with metastatic dissemination to liver (Pepper's syndrome) is a very rare finding in infants. Our aim was to present patients with this syndrome with good prognosis. Methods: During 2003-2004 3 infants (2 boys and 1 girl) with stage IV-S neuroblastoma, with liver metastasis were diagnosed and treated in our institu...
Article
Full-text available
Purpose: Stage IV-S neuroblastoma with metastatic dissemination to liver (Pepper’s syndrome) is a very rare finding in infants. Our aim was to present patients with this syndrome with good prognosis. Methods: During 2003-2004 3 infants (2 boys and 1 girl) with stage IV-S neuroblastoma, with liver metastases were diagnosed and treated in our institu...
Article
To assess the outcome of patients with refractory or relapsed solid tumors treated with myeloablative chemotherapy followed by autologous peripheral blood stem cell transplantation. From October 1997 to March 2006, 38 transplantations were performed in 32 patients (19 children and 13 adults, 20 men and 12 women, median age 18.5 years, range 3 - 59)...
Article
Full-text available
Liver tumors are rare - below 1% of all malignancies in childhood. For the period 1991-2003. Ю children with hepatoblastoma have been treated. Males : females - 4:1. Under 2 years : over 11 years of age -9:1. Fetal: embrional anaplastic histological types- 2:2:1. Right: le ft: multifocal involvement of both lobes - 4:3:3 All children had surgical t...
Article
Allogeneic transplantation of hemopoietic stem cells from HLA-matched sibling is the best curative treatment option for many patients with hematological malignancies, despite of the risk of transmission of some serious donor's diseases and of the donor's complications in harvesting. The authors report a case of allogeneitc peripheral blood stem cel...
Article
Liver tumors are rare - below 1% of all malignancies in childhood. For the period 1991-2003, 10 children with hepatoblastoma have been treated. Males: females - 4:1. Under 2 years: over 11 years of age - 9:1. Fetal: embrional: anaplastic histological types-2:2:1. Right: left: multifocal involvement of both lobes - 4:3:3. All children had surgical t...
Article
This disease, also called kala-azar, is caused by species of Leishmania (L. donovani complex, L. chagasi, L. infantum) that disseminate hematogenously, infecting macrophages in virtually any organ, but particularly in the liver, spleen, bone marrow, and lymph nodes. The infection is zoonotic in most areas. Dogs and other carnivores are the most com...
Article
Different aspects of the problems during psychological consultation of patients with malignant diseases and their families are discussed. An empirical data on frequency, contents and components of family-therapeutic interventions are shown. The experience with liaison orientated pediatric oncological practice and with family psychotherapy is shared...
Article
Toxocariasis is a parasitic disease usually caused by T. canis by ingesting soil contaminated with eggs in animal excrements. The disease manifests itself as visceral larval migrans (VLM) and ocular larval migrans (OLM). Signs and symptoms of VLM may vary from an asymptomatic state with mild eosinophilia to a severe and potentially fatal disorder....
Article
Polycythemia exists when the red blood cell count, the hemoglobin level, and the total red blood cell volume all exceed the upper limits of normal. In postpubertal children, a hemoglobin > 16 g/dL and a total red blood cell mass >35 mL/kg indicate polycythemia. Measurement of the total red blood cell volume by radioisotopic techniques is essential...
Article
The results of psychological examination of personality in 12 children and adolescents (age ranging between 4 and 14 years), with Non-Hodgkin's lymphoma are shown. The usage of drawing projective tests is preferred as to follow the dynamics of therapy influence on child's mentality and the psychological problems in period of remission. The attentio...
Article
Langerhans histiocytosis, although rare disease, may be found in all age groups and has variety of clinical appearances, mostly depending on sites of affect. A case, presenting with some of "cardinal" features of the disease is described. A chronological sequence of the evolution, diagnosis and therapy results are offered. The international accepte...
Article
Cutaneus manifestations in leukemia are rare phenomena, especially among young patients. The diverse phenotypic characteristic of the dermal infiltrative changes, in combination with or without other organ or systemic appearance, make diagnostic precision in separate cases very difficult. The description of clinical characteristics of 4 cases, with...
Article
Full-text available
A case with Philadelphia (Ph) -positive Acute myeloid leukemia (AML) in a child is reported. Though a rare finding, literature review shows its important informative value concerning diagnosis, type of the disease, therapeutic control, follow-up and prognosis. A future plan for the treatment of this particular case is proposed.
Article
Anaemic states are one of the commonest diagnostic problems in the everyday practice of a pediatrician. Despite the fact that most of the cases are 'genuine' blood diseases, it is not rare to find anaemia to be the debut of or cause to find out a systemic disease. The wide variety of diagnostic possibilities imposes the need of diagnostic approach....
Article
In its prevalence neuroblastoma (NB) is the fourth malignant tumor in children after leucaemia, malignant lymphoma and cerebral tumors. Specific sites for metastases are known, i.e. bones, bone marrow, lymph nodes, liver, skin are more frequently affected than the lung and the central nervous system. Cytogenetics, molecular biology, immunocytology...
Article
Full-text available
After analyzing nonsatisfactory therapeutic results in the 1970s and early 1980s, the 81-01 treatment protocol of the Dana-Farber Cancer Institute was initiated in 1987 in the Children's Oncohaematology Clinic in Sofia, Bulgaria. Two hundred thirty patients were enrolled with a period of observation of a minimum of 14 and a maximum of 97 months; th...
Article
The data from 24 cases of children with AIHA diagnosed and treated in Children's Oncohematology Clinic in Sofia, Bulgaria, between 1979-1996 are retrospectively analyzed. Four patients were classified as secondary(symptomatic) AIHA (LED-1 case, Wiskott-Aldrich-1, AIH-2). The rest were patients with idiopathic forms. Among the latter 16 of the patie...

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Project (1)
Project
The ability to design therapies based on molecular information from the disease tissue and from the make up of the individual depends on the ability to incorporate as much of the available molecular and biological information as possible. This necessitates an ability to consolidate, cross-reference and prioritize the vast amounts of 'omics' information available in the numerous online genomic and proteomic databases and protein-protein interaction networks. This project is committed to devising tools for physicians and researchers using Complex Sociotechnical Systems (CSTS), and maximizing the power of mathematics, physics and artificial intelligence in medicine for interpretation of molecular information.