Dmitry Shvarev

Dmitry Shvarev
Universität Osnabrück | UOS · FB 5 Biologie/Chemie

PhD

About

14
Publications
1,159
Reads
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57
Citations
Citations since 2017
14 Research Items
57 Citations
2017201820192020202120222023051015
2017201820192020202120222023051015
2017201820192020202120222023051015
2017201820192020202120222023051015
Additional affiliations
September 2020 - present
Universität Osnabrück
Position
  • PostDoc Position
July 2019 - August 2020
Max Planck Institute of Biophysics
Position
  • PostDoc Position
Description
  • Cryo-EM analysis of ABC transporters.
October 2016 - November 2016
Paris Descartes, CPSC
Position
  • Researcher
Description
  • Recombinant protein expression and purification.
Education
September 2015 - June 2019
University of Tuebingen
Field of study
  • Biology, Microbiology
September 2010 - June 2015
Lomonosov Moscow State University
Field of study
  • Immunology, Biochemistry

Publications

Publications (14)
Article
Full-text available
Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival and requires HOPS, a conserved heterohexameric tethering complex. On the membranes to be fused, HOPS binds small membrane-associated GTPases and assembles SNAREs for fusion, bu...
Preprint
Full-text available
Lysosomes are of central importance in cellular recycling, nutrient signaling and endocytosis, are tightly connected to autophagy and the invasion of pathogenic bacteria and viruses. Lysosomal fusion events are fundamental to cell survival and require HOPS, a conserved heterohexameric tethering complex. HOPS recognizes and binds small membrane-asso...
Article
ATP-binding cassette (ABC) transporters are widely present molecular machines that transfer substrates across the cell membrane. ABC transporters are involved in numerous physiological processes and are often clinical targets. Structural biology is fundamental to obtain the molecular details underlying ABC transporter function and suggest approache...
Article
Acid stress is an environmental problem for plants and fresh water cyanobacteria like the filamentous, heterocyst forming species Anabaena sp. PCC 7120 (hereafter Anabaena sp.). Heterocyst differentiation, cell-cell communication, and nitrogen fixation has been deeply studied in this model organism, but little is known about the cellular response o...
Article
Full-text available
The nitrogenase complex in the heterocysts of the filamentous freshwater cyanobacterium Anabaenasp. PCC 7120 fixes atmospheric nitrogen to allow diazotrophic growth. The heterocyst cell envelope protects the nitrogenase from oxygen and consists of a polysaccharide and a glycolipid layer that are formed by a complex process involving the recruitment...
Article
The filamentous heterocyst‐forming cyanobacterium Anabaena sp. PCC 7120 is an important model organism for studying cell differentiation, nitrogen fixation, and photosynthesis. This cyanobacterium possesses a high number of membrane transporters. Not much is known about the roles of the membrane transporters, especially the ATP‐binding cassette (AB...
Article
The filamentous, photosynthetic cyanobacterium Anabaena sp. PCC 7120 can be considered as a true multicellular bacterium. Along the filament of cells, nitrogen fixation is spatially separated from the incompatible process of oxygenic photosynthesis by the formation of specialized heterocysts in a semiregular pattern. Heterocyst development involves...
Preprint
Full-text available
The nitrogenase complex in the heterocysts of the filamentous freshwater cyanobacterium Anabaena sp. PCC 7120 fixes atmospheric nitrogen to allow diazotrophic growth. The heterocyst cell envelope protects the nitrogenase from oxygen and consists of a polysaccharide and a glycolipid layer that are formed by a complex process involving the recruitmen...
Article
Full-text available
Anabaena sp. PCC 7120 is a filamentous cyanobacterium able to fix atmospheric nitrogen in semi-regularly spaced heterocysts. For correct heterocyst function, a special cell envelope consisting of a glycolipid layer and a polysaccharide layer is essential. We investigated the role of the genes hgdB and hgdC, encoding domains of a putative ABC transp...
Article
Two hundred genes or 3% of the known or putative protein-coding genes of the filamentous freshwater cyanobacterium Anabaena sp. PCC 7120 encode domains of ATP-binding cassette (ABC) transporters. Detailed characterization of some of these transporters (14 - 15 importers and 5 exporters) has revealed their crucial roles in the complex lifestyle of t...

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