Dmitriy BerilloKazakh National Medical University · Department of Pharmacy
Dmitriy Berillo
PhD
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53
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873
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Citations since 2017
Introduction
Additional affiliations
November 2018 - November 2019
September 2016 - September 2018
April 2015 - October 2015
Publications
Publications (53)
The past several decades have illustrated an enormous interest in noble metal nanoparticles for their superior catalytic activity, however, their industrial use is very restricted due to inefficient recovery leading to potential contamination of products and the environment. Immobilised nanoparticles illustrate promising results for scaling up proc...
Bioremediation is a key process for reclaiming polluted soil and water by the use of biological agents. A commonly used approach aims to neutralise or remove harmful pollutants from contaminated areas using live microorganisms. Generally, immobilised microorganisms rather than planktonic cells have been used in bioremediation methods. Activated car...
Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied b...
Despite their conventional and widespread use, oral and intravenous routes of drug administration face several limitations. In particular, orally administered drugs undergo enzymatic degradation in the gastrointestinal tract and first-pass metabolism in the liver, which tend to decrease their bioavailability. Intravenous infusions of medications ar...
Un unsolvable issue of a significant number increase of drug multi resistant strains of microorganisms including Mycobacterium tuberculosis force researchers for continuous design novel pharmaceuticals.
The purpose of the study is the establishment of the correlation between the structure of novel heterocyclic hydrazide derivatives and their biolog...
The present study deals with the synthesis and characterization of a polymer composite based on an unsaturated ester loaded with 5 wt.% triclosan, produced by co-mixing on an automated hardware system. The polymer composite’s non-porous structure and chemical composition make it an ideal material for surface disinfection and antimicrobial protectio...
Despite the variety of synthetic drugs existing on the
pharmaceutical market, the search for novel sources of biologically active
compounds for the production of more effective and safe drugs remains relevant.
The path from the creation of a molecule to a drug is very long and can be interrupted at any stage due to insufficient efficiency or ide...
Pollution of the aquatic environment by halogen derivatives widely used as antiseptic compounds, as well as chemicals for various industrial purposes, is significant. Existing systems of bioremediation poorly solve the problem of eliminating pollution. This paper discusses the preparation of novel macroporous chitosan-based cryogels with in situ-im...
The use of natural biopolymers as a core material to produce cell-laden scaffolds has been recognized and extensively utilized for tissue engineering purposes due to their advantageous biocompatibility and tunable biodegradation rate. The morphology and average pore size play, however, a major role in biological processes affecting cell proliferati...
The present study describes the synthesis of a novel type of harmine derivatives, containing substituent at the C-8 position and their physicochemical characterization by FTIR, NMR, and elemental analysis. Computer simulation of the interaction of harmine and its derivatives (Z)-8-(1-hydrazonoethyl)-7-methoxy-1-methyl-9H-pyrido[3,4-b]indole and 8-{...
The conservative fission products 137Cs and 90Sr are of concern when present in groundwater, as they present a radiological hazard to organisms and can be transported long distances from their source. To provide an interceptive permeable reactive barrier (PRB) solution which accommodates the throughflow of groundwater whilst removing 137Cs+ and 90S...
Background and Objectives: Providing a proper quality control of drugs is essential for efficient treatment of various diseases minimizing the possible side effects of pharmaceutical active substances and potential impurities. Recent in vitro and in vivo studies have shown that certain heavy metalloids and metals interfere with protein folding of n...
The manufacturing of sanitary and household furniture on a large scale with inherently antimicrobial properties is an essential field of research. This work focuses on the synthesis of polymer composites based on the unsaturated polyester of resin loaded with 5 wt.%-Triclosan produced by a co-mixing approach on automated technological complex with...
Rumex confertus belongs to the genus Rumex and is classified as an invasive parasitic plant in agriculture. Despite other Rumex species being widely used in herbal medicine due to their antimicrobial, antioxidant, antitumor, and anti-inflammatory effects, there are almost no information about the potential of Rumex confertus for the treatment of va...
The effectiveness of an amphoteric cryogel (AAC) as an oral sorbent (enerosorbent) for the treatment of acute poisoning of small animals (rats) with heavy metals (HMs) was studied in in vivo experiments. The morphological structure of the cryogel was examined using scanning electron microscopy/energy-dispersive X-ray analysis and confocal microscop...
We investigated the water sorption properties of macroporous cryogels of gelatine (Gel) and dextran dialdehyde (DDA) prepared via cryogelation at 260 K and following the freeze drying processes. Water vapour sorption isotherms for aerogels were studied at 293 K by two independent methods: static-gravimetric and dynamic vapour sorption (DVS) over a...
Urea sensors based on electrodes in direct contact with the medium have limited long-term stability when exposed to complex media. Here, we present a urea biosensor based on urease immobilized in an alginate polymer, buffered at pH 6, and placed in front of a newly developed fast and sensitive CO2 microsensor, where the electrodes are shielded by a...
In this study amphoteric cryogels were synthesized by the use of free-radical co-polymerization of acrylate-based precursors (methacrylic acid and 2-acrylamido-2-methyl-1-propansulfonic acid) with allylamine at different ratios. The physico-chemical characteristics of the cryogels were examined using SEM/EDX, FT-IR, XPS and zeta potential measureme...
Mercury is a toxic element, which can be found in air, water and soil in several inorganic and organic forms. Mercury pollution comes from a variety of industrial sources, including vinyl-chloride industry, pulp and paper, fertilizers, pharmaceuticals, gold mining and cement production. Gels have increasingly attracted the interest over the past de...
Macroporous scaffolds composed of chitosan (CHI), hydroxyapatite (HA), heparin (Hep), and polyvinyl alcohol (PVA) were prepared with a glutaraldehyde (GA) cross-linker by cryogelation. Addition of PVA to the reaction mixture slowed down the formation of a polyelectrolyte complex (PEC) between CHI and Hep, which allowed more thorough mixing, and res...
The physical and chemical attributes of cryogels, such as the macroporosity, elasticity, water permeability and ease of chemical modification have attracted strong research interest in a variety of areas, such as water purification, catalysis, regenerative medicine, biotechnology, bioremediation and biosensors. Cryogels have shown high removal effi...
In this study novel silver-modified cryogels were synthesized and applied for the removal of iodide from aqueous solutions. The co-allylamine-methacrylic acid-DMAAm-BisAAm (AAC) and co-allylamine-2-acrylamido-2-methyl-1-propansulfonic acid-DMAAm-BisAAm (SAC) cryogels were decorated with silver by one-step ion-exchange technique and characterized by...
Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chito...
The aim of this study was to develop and test a non-diffusion limited, high cell density bioreactor for biodegradation of various phenol derivatives. The bioreactor was obtained using a straightforward one-step preparation method using cryostructuration and direct cross-linking of bacteria into a 3D structured (sponge-like) macroporous cryogel comp...
Immobilisation of bacteria on or into a polymer support is a common method for the utilisation of bacteria as biocatalysts for many biotechnological, medical and environmental applications. The main challenge in this approach is the time taken for the formation of stable biofilms, and the typically low percentage of bacterial cells present on or in...
In this work, amphoteric cryogels based on N,N-dimethyl acrylamide, methacrylic acid and allylamine, crosslinked by N,N-methylenebisacrylamide were synthesized by free-radical polymerization in cryo-conditions. The synthesized cryogels were used for the removal of cadmium ions from aqueous solutions under different pH values. The chemical structure...
3D-macroporous chitosan-based scaffolds (cryogels) were produced via growth of metal-polymer coordinated complexes and electrostatic interactions between oppositely charged groups of chitosan and metal ions under subzero temperatures. A mechanism of reduction of noble metal complexes inside the cryogel walls by glutaraldehyde is proposed, which pro...
The chitosan and gelatine are commonly used biopolymers for the tissue engineering applications. In the previous methods for the cryogels synthesis, multistep preparation methods using toxic cross-linking agents such as glutaraldehyde are reported. Here, we present a two-step preparation method of gelatin macroporous cryogels and one-step preparati...
Изобретение относится к амфотерным полимерам, а именно к макропористым амфотерным
гидрогелям на основе метакриловой кислоты, акриламида, аллиламина и бисакриламида (или
полиэтиленгликольдиакрилата), обладающим высокой степенью сорбции по отношению к ионам
переходных металлов, в частности меди, никеля, кобальта и железа.
Получение новых, ранее не о...
http://www.journals.elsevier.com/biotechnology-reports/most-cited-articles/
An analytical method is presented, combining novel microcontact imprinting technique and capacitive biosensor technology for the detection of BSA. Glass cover slips were used for preparation of protein stamps. The microcontact-BSA imprinted gold electrodes were prepared in...
Following the development of the idea of octupolar molecules as nonlinear optical materials a variety of compounds have been reported. Trans-porphyrins have a great potential to self-order into octupolar symmetry. Nonlinear optical properties can be tuned by using strong donor-acceptor groups in porphyrins as well as extention of conjugation. Here...
In this study, a novel method of preparation of cryogels based on oxidised dextran (Ox.D) and gelatin (Gel) without sodium borohydride is proposed. The physico-chemical properties of obtained hydrogels were investigated. It was found that the stability of cryogels Ox.D–Gel is significantly depended on pH, and mechanical properties were improved aft...
To download free full-text http://krastsvetmet.ru/images/catalog/pmc/articles/4HAuCI4.pdf or
http://pubs.acs.org/doi/abs/10.1021/bm5003834
One of the purposes of the project was to develop the method of preparation of 3D macroporous hydrogel with a structure of interconnected pores by the use of non covalent interactions. The combination of chitosa...
In this study, a novel method of preparation of cryogels based on oxidised dextran (Ox.D) and gelatin (Gel) without sodium borohydride is proposed. The physico-chemical properties of obtained hydrogels were investigated. It was found that the stability of cryogels Ox.D–Gel is significantly depended on pH, and mechanical properties were improved aft...
Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectr...
Applications of immobilized biocatalysts in both research and industry require highly active catalysts,
preferably at a low cost. In this study, cryogels with high catalyst density were produced through cryostructuration of whole Escherichia coli (E.coli) cells. Prepared cryogels are macroporous materials composed of metabolically active cells cros...
Applications of immobilized biocatalysts in both research and industry require highly active catalysts,
preferably at a low cost. In this study, cryogels with high catalyst density were produced through cryostructuration of whole Escherichia coli (E.coli) cells. Prepared cryogels are macroporous materials composed of metabolically active cells cros...
In this study a new way to produce supermacroporous protein structures was investigated. Enzyme-mediated cross-linking of gelatin or casein was performed in a partly frozen state, which yielded stable, protein-based cryogels. The reaction kinetics for the formation of cryogels were found to be fairly slow, most likely due to the low temperature (-1...
Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectr...
A series of macroporous amphoteric cryogels based on allylamine, methacrylic acid and acrylamide were synthesized by radical copolymerization of monomers in cryoconditions. The average molar composition of amphoteric cryogels was found from the potentiometric and conductimetric titration curves. The morphology of cryogels was evaluated by SEM. Cryo...
In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibrils of assembled dipeptides a...
Objects of research are β-[N-piperidyl-( and N-morpholyl-)] propane acids hydrazides, α-[N-piperidyl-( and N-morpholyl-)]propane acids nitriles and their derivatives as the substances potentially possessing practically useful properties. In order to obtain biologically effective compounds with given properties a synthesis of new derivatives β-amino...
In the current work a protective properties of the compounds are synthesized and researched. Protective properties by an electrochemical method of record of polarizing and capacitor curves are investigated. The protective effect for cathodic and anodic processes was determined. Calculation of partial effects of inhibition (kinetic, blocking, power...
The synthesis of 2-methyl-3-(N-piperidyl)-propane acid thiosemicarbazide and its derivatives were investigated. The cyclization reaction of 2-methyl-3-(N- piperidyl)-propane acid thiosemicarbazide into a corresponding 2-amino-5[α-methyl-β-(N-piperidyl)ethylene]-1,3,4-thiodiazole was performed in acidic conditions. The treatment of the thiosemicarba...
In the current work, the synthesis of 2-methyl-3-(N-morpholyl)-propionic acid hydrazide and their derivatives are curried out. The condensation reaction of 2-methyl-3-(N-morpholyl)-propionic acid hydrazide with various aromatic aldehydes and cyclic ketons catalyzed by piperidine in ethanol solution was studied. The chemical structures of new compou...
http://bulletin.chemistry.kz/index.php/kaznu/article/view
In this study the synthesis of 2-methyl-3-(N-piperidyl)-propane acid hydrazide and its derivatives were studied. The condensation reaction of 2-methyl-3-(N- piperidyl)-propane acid hydrazide with aromatic aldehydes (p-nitrobenzaldehyde,p-hydroxybenzaldehyde, benzaldehyde, m-pyridyl benzaldeh...
The synthesis of a-aminopropionic acid (2-methyl-2-N-methylaminopropionitrile, 2-methyl-2-N-benzylpropionitrile, 2-methyl-2-N-diethylaminopropan acid) nitriles and their derivatives have been carried out. The reaction of alkylation and acylation of a-aminonitriles was performed. The treatment of obtained nitriles with allylbromide and benzyl chlori...
http://bulletin.chemistry.kz/index.php/kaznu/article/view
In the present work, the synthesis of a-aminopropionic acid (2-methyl-2-N-piperidylpropan acid, 2-methyl-2-N-morphoylpropan acid, 2-methyl-2-N-diethylaminopropan acid) nitriles and their derivatives are discussed. The reaction of condensation of heterocyclicamines with acetonecyanehydrine in...
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Projects (4)
We are pleased to invite you to contribute to a collection of research papers (Special Issue "Advances in Cryogels" Journal Gels) related to novel methods of cryogel preparation, new approaches of physical characterisation and chemical modification of cryogel surface, molecular imprinted(MIP) cryogels, separation of biomolecules using via ligand exchange mechanism (chelation) and ion exchange; nano and microparticles elimination, macroporous hydrogels acceptable for selective or nonselective extraction of noble metal ions; smart porous polymers based on inter and or polyelectrolyte complexes. Methods of preparation of composite cryogels composed of metal nanoparticles or metal oxide nanoparticles and polymers; usage of nontoxic modified cross-linking agents for synthesis of biocompatible scaffolds for biomedical application. Smart cryogels utilized for desalination of water. Research areas may include (but not limited to) the following: Composite cryogels with given properties for biosensing; cryogels for efficient radionuclides separation or extraction; cryogels polymer-metal systems for catalysis. Cryogels as a drug delivery system https://www.mdpi.com/journal/gels/special_issues/advances_cryogels?fbclid=IwAR0shEdz1dfax5UFS-XjJvoV2OYQwP-DewHsZVa4ShMkKEsknuSntH3xoUk
Dear Colleagues,
This issue contains a collection of research papers related to heavy metal removal via ligand exchange mechanism (chelation) and ion exchange; polymeric systems acceptable for selective or nonselective extraction of noble metal ions from diluted solutions using smart polymers (molecular imprinted polymers, polymeric membranes, polyelectrolytes). Topics:
Methods of extraction of metal nanoparticles or metal oxide nanoparticles
Nontoxic modified cross-linked polymers for the selective removal of harmful ions from biological fluids
Methods of regeneration of polymeric systems, as well as methods of utilization of polymers after the adsorption of metals
Smart polymers used for the desalination of sea water
Effect of adsorption of metals on mechanical properties of polymers
Polymers with given properties applicable for efficient radionuclides separation or extractionhttps://www.mdpi.com/journal/polymers/special_issues/cross_link_poly_metal_removal
Improvement of viability of immobilized Nitrate/nitrite reducing bacteria in the bio-chamber for sensor
