Dmitri Toren

Dmitri Toren
Ben-Gurion University of the Negev | bgu · Shraga Segal Department of Microbiology and Immunology

Ph.D.
I’m a researcher working to better understand the biology of aging, autoimmune diseases, and cultured meat development.

About

34
Publications
2,658
Reads
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900
Citations
Citations since 2016
26 Research Items
755 Citations
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2016201720182019202020212022050100150
Introduction
I’m a research scientist working to better understand the biology of aging, autoimmune diseases, and cultured meat. Currently, I’m working on a few challenging projects in the private sector and academia, including a potential treatment for autoimmune diseases, automation of lifespan experiments, and aging gene signatures.
Additional affiliations
March 2013 - present
Ben-Gurion University of the Negev
Position
  • PhD Student
October 2010 - present
Ben-Gurion University of the Negev
Position
  • Research Assistant
Description
  • General and Organic Chemistry, Organic Chemistry, Cell Molecular Biology, Biology of Aging, Bioinformatics, Microbiology, Pathology
Education
October 2010 - July 2013
Ben-Gurion University of the Negev
Field of study
  • Life Science, Medical Science

Publications

Publications (34)
Article
Full-text available
Mitochondria are the only organelles in the animal cells that have their own genome. Due to a key role in energy production, generation of damaging factors (ROS, heat), and apoptosis, mitochondria and mtDNA in particular have long been considered one of the major players in the mechanisms of aging, longevity and age-related diseases. The rapidly in...
Article
One important question in aging research is how differences in genomics and transcriptomics determine the maximum lifespan in various species. Despite recent progress, much is still unclear on the topic, partly due to the lack of samples in nonmodel organisms and due to challenges in direct comparisons of transcriptomes from different species. The...
Article
Full-text available
Interventional studies on genetic modulators of longevity have significantly changed gerontology. While available lifespan data are continually accumulating, further understanding of the aging process is still limited by the poor understanding of epistasis and of the non-linear interactions between multiple longevity-associated genes. Unfortunately...
Article
Full-text available
One of the important questions in aging research is how differences in transcriptomics are associated with the longevity of various species. Unfortunately, at the level of individual genes, the links between expression in different organs and maximum lifespan (MLS) are yet to be fully understood. Analyses are complicated further by the fact that ML...
Article
Full-text available
Genetic manipulations can ameliorate the aging process and extend the lifespan of model organisms. The aim of this research was to identify novel genetic interventions that promote both lifespan and healthspan, by combining the effects of multiple longevity-associated gene inactivations in C. elegans. For this, the individual and combined effects o...
Preprint
Full-text available
Age-related pathologies are so widely presented in old age that in most cases they are hardly distinguishable at the molecular level from the so-called "normal" aging. Both aging and age-related diseases are characterized by a wide range of transcriptional and epigenetic changes that underlie the physiological or pathological phenotype, with plenty...
Article
Full-text available
If somatic stem cells would be able to maintain their regenerative capacity over time, this might, to a great extent, resolve rejuvenation issues. Unfortunately, the pool of somatic stem cells is limited, and they undergo cell aging with a consequent loss of functionality. During the last decade, low molecular weight compounds that are able to indu...
Article
Full-text available
Tissue fibrosis is a major driver of pathology in aging and is involved in numerous age-related diseases. The lungs are particularly susceptible to fibrotic pathology which is currently difficult to treat. The mouse bleomycin-induced fibrosis model was developed to investigate lung fibrosis and widely used over the years. However, a systematic anal...
Chapter
Health and pathologies are multifactorial states characterizing how well biological systems function in a range of conditions and facing various stressors. Depending on how flexible the definition of a state is, systems may have multiple healthy and stable states. However, keeping homeostasis requires parameters dynamically fluctuating within a phy...
Preprint
Full-text available
Interventional studies on genetic modulators of longevity have significantly changed gerontology. While available lifespan data is continually accumulating, further understanding of the aging process is still limited by the poor understanding of epistasis and of the non-linear interactions between multiple longevity-associated genes. Unfortunately,...
Preprint
Full-text available
One important question in aging research is how differences in genomics and transcriptomics determine maximum lifespan in various species. Despite recent progress, much is still unclear on the topic, partly due to the lack of samples in non-model organisms and due to challenges in direct comparisons of transcriptomes from different species. The nov...
Article
Full-text available
Background: Gray whale, Eschrichtius robustus (E. robustus), is a single member of the family Eschrichtiidae, which is considered to be the most primitive in the class Cetacea. Gray whale is often described as a “living fossil”. It is adapted to extreme marine conditions and has a high life expectancy (77 years). The assembly of a gray whale genome...
Article
Full-text available
In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR's main functionalities, highlighting new additions and improvements. H...
Preprint
Full-text available
In spite of a growing body of research and data, human ageing remains a poorly understood process. To facilitate studies of ageing, over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), which are now the leading online resource for biogerontologists. In this update, we present HAGR’s main functionalities, including new additions...
Article
Full-text available
Does the longevity phenotype offer an advantage in wound healing (WH)? In an attempt to answer this question, we explored skin wound healing in the long-lived transgenic αMUPA mice, a unique model of genetically extended life span. These mice spontaneously eat less, preserve their body mass, are more resistant to spontaneous and induced tumorigenes...
Article
Full-text available
Does the longevity phenotype offer an advantage in wound healing (WH)? In an attempt to answer this question, we explored skin wound healing in the long‐lived transgenic αMUPA mice, a unique model of genetically extended life span. These mice spontaneously eat less, preserve their body mass, are more resistant to spontaneous and induced tumorigenes...
Article
Full-text available
The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing. HAGR features now several databases with high-quality manually curated data: (i) GenAge, a database of genes associated with ageing in humans and model organisms;...
Article
Full-text available
Recent studies have uncovered the links between aging, rejuvenation and polar protein transport in the budding yeast Saccharomyces cerevisiae. Here, we examined a still unexplored possibility for co-regulation of polar mRNA transport and lifespan. To monitor the amount and distribution of mRNA-containing granules in mother and daughter cells, we us...

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