Djanggan Sargowo

• University of Brawijaya

Background: Caspase-1 (reflects NOD-like receptor protein 3 inflammasome activity), transforming growth factor-β (TGF-β), and Galectin-3 play significant roles in post-AMI fibrosis and inflammation. Recently, colchicine was shown to dampen inflammation after AMI; however, its direct benefit remains controversial. Objectives: This study aimed to ana...

While the beneficial effects of colchicine on inflammation and infarcted myocardium have been documented, its impact on cardiac fibroblast activation in the context of MI remains unknown. This study aimed to investigate the effect of colchicine on the regulation of NLRP3 inflammasome activation and IL-1β expression in fibroblasts. The 3T3 fibroblas...

Background/Objectives: ST-segment elevation acute coronary syndrome (STE-ACS) represents a significant global health challenge, with cardiac remodeling and fibrosis critically affecting recovery after percutaneous coronary intervention (PCI). Colchicine, known for its anti-inflammatory effects, may regulate key fibrotic markers such as Procollagen...

Background: Caspase-1 (reflects NOD-like receptor protein 3 inflammasomes activity), transforming growth factor-β (TGF-β), and Galectin-3 play significant role in post-AMI fibrosis and inflammation. Recently, colchicine was shown to dampen inflammation after AMI, however, its direct benefit remains controversial. Objectives. This study aimed to ana...

Background/Objectives: ST-segment elevation myocardial infarction (STEMI) represents a significant global health challenge, with cardiac remodelling and fibrosis critically affecting recovery after reperfusion therapy. Colchicine, known for its anti-inflammatory effects, has been shown to significantly increase Interleukin-10 (IL-10) levels, partic...

Long exposure of cardiovascular risk factor were correlated with vascular aging due to interaction of oxidative stress or inflammation exposure leading alteration of vascular adaptation. Garcinia Mangostana Periparpium extract has been reported to display antioxidant effect and immunomodulatory properties. The current research was undertaken to exp...

Background: Cardiometabolic disease (CMD) describes a metabolic condition often associated with cardiovascular disease. It has been revealed that the Ganoderma lucidum polysaccharide peptide (GLPP) possesses anti-inflammatory and antioxidant qualities. Objective: This study aimed to find out how GLPP affected oxidative stress, inflammation, and lef...

Cardiovascular complications are a common manifestation of acute phase and chronic phase of coronavirus disease 2019 (COVID-19) infection. Complications include cardiomyopathy, myocardial infarction, arrhythmias, heart failure, and deep venous thrombosis. Imaging is widely used in patients with suspected myocardial injury or myocarditis. Because of...

BACKGROUND: The current biomarker diagnostic modality for acute coronary syndrome (ACS), cardiac troponin, has several limitations. Emerging studies showed that micro-RNA (miR)-133a was released from infarcted heart to circulation, yet the diagnostic value of miR-133a in ACS demonstrated a conflicting result. Therefore, this study was conducted to...

Agaricus blazei Murill has been known as a mushroom with medicinal properties, such as its efficacy in maintaining the immune system and other metabolic processes. The main polysaccharide found in A. blazei, is b-glucan. This study aims to quantify and compare b-glucan content in A. blazei compared with the medicinal mushrooms Ganoderma sp. and Ple...

Background: Inflammation plays a critical role in myocardial infarction as a critical process in the development of heart failure, involving the development of cardiac fibrosis. Colchicine is a well-established anti-inflammatory drug, but its scientific application in controlling post-acute myocardial infarction (AMI) inflammatory processes has not...

Background: Patients with chronic venous insufficiency (CVI) undergo a standard puncture below the knee to access the great saphenous vein (GSV) for endovenous laser ablation (EVLA). However, in some cases, getting a puncture below the knee is difficult; a puncture above the knee to access the incompetent saphenous vein is another option. Objective...

Background: Inflammatory plays critical role in myocardial infarction as a critical process in the development of heart failure, involving the development of cardiac fibrosis. Colchicine is a well-established anti-inflammatory drug, but its scientific application in controlling post-acute myocardial infarction remodelling processes has not been est...

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), characterized by inflammation and steatosis, is one of the metabolic problems that trigger serious complications. Statin is usually used for NAFLD therapy, however, statin intolerance and resistance reduce the effectiveness of NAFLD treatment. Therefore, this study was conducted to develop the...

Background: Surveillance in high-risk pregnancies is inconsistent. The carefully calculated identification of associated preeclampsia risk factors is promising for use as a basis for the early management of pregnant women at risk. The aims of this study was to develop a risk index for determining preeclampsia in pregnant women with high risk. Metho...

Background: Tobacco smoke exposure induces intima-media thickness by reducing nitric oxide and increasing adhesive molecule activity, with circulating cotinine serving as a marker; we hypothesize a correlation between monocyte chemoattractant protein-1 (MCP-1) and carotid intima-media thickness (cIMT) in active male smokers. Material and Methods: W...

Cardiovascular diseases remain a major cause of morbidity and mortality worldwide. Cardiovascular diseases associated with metabolic disorders are collectively referred to as Cardiometabolic Diseases (CMDs). Oxidative stress and inflammation are key contributors to the development and progression of CMDs. Antioxidants and anti-inflammatory agents h...

Background Foam cells are markers of atherosclerosis and characterise advanced atherosclerotic plaque, stimulated by inflammation caused by high lipid levels in macrophages. The combination of decaffeinated coffee and green tea extract (DCGTE) has been suggested to have a role in foam cell inhibition. Objective We investigated the inhibiting role o...

The preeclampsia etiology is unclearly understood, becoming considerable concern as an aging-related disease. Accelerated prematurity of cell death associated with decreased Sirtuin (SIRT)1 activity. This study was designed to estimate the SIRT1 serum profile in high-risk pregnancies to preeclampsia development probability. This study was conducted...

Background: Recent studies have shown that arterial stiffness is a strong predictor of cardiovascular events and all-cause mortality, with CAVI (Cardio-Ankle Vascular Index) as a non-invasive arterial stiffness testing method in daily practice. Objective: This study was conducted to examine the relationship between smoking -as a risk factor for art...

Background: Foam cells, the markers of early atherosclerosis and characterise the advanced atherosclerotic plaque, are stimulated by inflammation due to the excess of lipid in macrophages. The combination of decaffeinated coffee and green tea extract (DCGTE) has been suggested to have a role in foam cell inhibition. Objective : to investigate the r...

Type A Aortic intramural haematoma (IMH), a variant form of classic aortic dissection, has been accepted as an increasingly recognised and potentially fatal entity of acute aortic syndrome.It is a very dangerous, fatal, and emergency condition. It is very important to recognize the symptoms of acute aortic syndrome related to appropriate management...

Although positive association between fermented vegetables intake with the risk of coronary heart disease (CHD) has increased attention nowadays, the metabolite profiling and the mechanism of action are still elusive. This study designed to investigate the secondary metabolites, hypolipidemic, and anti-atherogenic effect of mixed vegetable fermenta...

Downregulation of circulating EPCs survival affects the ability to maintain and repair the endothelium as a key feature in vascular homeostasis.The current study intends to describe the intracellular protein profile after chronic asymmetric dimethylarginine (ADMA) exposure using the immunofluorescence technique. Human EPCs as targeted cells were pu...

Background: Central vein stenosis (CVS) is common in hemodialysis patients and is caused by the implantation of cardiac intravascular devices, venous access, and limited vascular access. The effect may develop until an arteriovenous fistula (AVF) or graft is established in the ipsilateral arm or forearm for hemodialysis. Arm edema, significant veno...

A 28-year-old male wasaadmittedto hospitalwwith chief complaint chestadiscomfort. There were symptoms of dyspnea on effort and palpitation before. He had a history of alcoholics for more than five years. The ECG showed frequent Premature Ventricular Complex (PVC) and recommended to have ambulatory Holter monitoring with conclusion frequent monomorp...

Cardiovascular disease, which affects more than half of all diabetics, is the leading cause of morbidity and mortality in patients with type 1 and type 2 Diabetes Mellitus (DM). Around 55% of diabetes patients are thought to have it, in comparison to 2-4% of the general population. A significant risk factor for the development of Coronary Artery Di...

BACKGROUND: Obesity has been widely reported to be associated with loss of kidney function. The efficacy of β-1,3/1,6-D-glucan as a traditional medicine for the improvement of inflammation and vascular status in obesity has known. However, there have been no further studies that prove the effect of β-1,3/1,6-D-glucan in inhibiting kidney injury as...

Ipomoea batatas L purple variant is a natural source of bioactive compounds with strong antioxidant activity and has long been used in folk medicine. This study aimed to evaluate the active compounds, antioxidant, and anti-inflammatory activities of Ipomoea batatas L purple variant leaf extract in rats fed a high-fat diet. The presence of active co...

p16INK4a (CDKN2A) represent as primary cell-cycle regulation, which arranges the moment of continued or interrupt cell proliferation. Cells expressing p16INK4a accumulate in aging tissue and age-related accumulation DNA damage, yet their physiologic compensated effects in human peripheral blood mononuclear cells (PBMNCs) after different stress indu...

Objectives: Cardiovascular diseases, especially atherosclerosis, are the leading cause of human mortality in Indonesia. Ipomoea batatas (L.) is a food plant used in Indonesian traditional medicine to treat cardiovascular diseases and related conditions. We assessed the anti-atherosclerotic activity of the aqueous extract of I. batatas leaves in a...

Background Pregnant women with Marfan’s syndrome needed multidisciplinary approach to evaluate pregnancy status, fetal and maternal outcome. Marfan’s syndrome was an inherited autosomal dominant with mutation of fibrillin-I (FBN1) gene. Pregnant woman with MFS can lead to aortic dissection. It’s increase 23% of maternal mortality and 35% of fetal d...

Background Acute aortic dissection is a life threatening condition that remains a challenge to diagnose and treat. 67% patients was presented with Acute type A aortic dissection (ATAAD) and often accompanied with some complications. Case Summary A 40-year-old male with risk factor hypertension was presented with sudden sharp tearing-like chest pai...

Background: Foam cells are markers of atherosclerosis and characterise advanced atherosclerotic plaque, stimulated by inflammation caused by high lipid levels in macrophages. The combination of decaffeinated coffee and green tea extract (DCGTE) has been suggested to have a role in foam cell inhibition. Objective : we investigated the inhibiting rol...

Background Pregnant women with Marfan’s syndrome needed multidisciplinary approach to evaluate pregnancy status, fetal and maternal outcome. Marfan’s syndrome was an inherited autosomal dominant with mutation of fibrillin-I (FBN1) gene. Pregnant woman with MFS can lead to aortic dissection. It’s increase 23% of maternal mortality and 35% of fetal d...

Background Acute aortic dissection is a life threatening condition that remains a challenge to diagnose and treat. 67% patients was presented with Acute type A aortic dissection (ATAAD) and often accompanied with some complications. Case Summary A 40-year-old male with risk factor hypertension was presented with sudden sharp tearing-like chest pai...

Background: Global Public Health Burden of Heart Failure reported the growing prevalence of heart failure which is 64.3 million affected in 2020 worldwide with half of the case classified as Heart Failure Preserved Ejection Fraction (HFpEF). It is well known that someone who has been diagnosed with heart failure will have a poorer 􏰼􏰞􏰏􏰦􏰝􏰊􏰗 􏰓􏰒 􏰦􏰝􏰒􏰋􏰷􏰽...

Background: Heart Failure prevalence was raising as one of the most Objective: to find the correlation of New York Heart Association Functional Class in heart failure patient with Depression Method: This cross-sectional study recruited 342 patients diagnosed with HF with previously for more than 3 months, at dr. Saiful Anwar General Hospital during...

Background : The benefit of PCI to improve quality of life (QoL) in chronic coronary syndrome (CCS) is still unclear. Objectives : This study aimed to assess the benefit of percutaneous coronary intervention (PCI) in improving QoL among CCS patients receiving OMT. Methods : We conducted a retrospective cohort study. CCS patients who underwent coron...

Background : Acute aortic syndrome (AAS) is a potentially fatal disease involving the acute disruption of the aortic wall. Several conditions, such as intramural hematoma (IMH), aortic dissection (AD), penetrating atherosclerotic ulcer (PAU), as well as high mortality rates, are associated with this disease. Hypertension is an essential risk factor...

Background: Acute heart failure (AHF) is a significant clinical problem, which has a high prevalence, mortality, and rehospitalization. Congestion is critical in the pathogenesis of AHF, which is also a predictor of mortality and rehospitalization in patients with AHF. Objective: Knowing the effect of adding a %Total body water (TBW) test detected...

Background : The risk of adverse cardiovascular events remains substantial and may vary significantly among STEMI patients. Echocardiography is the recommended diagnostic tool in predicting outcomes. This study purposed to assess the prognostic role of the combination of LAVI/a’ ratio and E/e’ in STEMI patients who received percutaneous coronary in...

Background: Despite the advances of current optimal treatment of atherosclerotic disease, the incidence of events after acute coronary syndrome (ACS) remains high. Colchicine, with its well-established pleiotropic anti-inflam- matory effects, may inhibit NLRP3 inflammasome, a key mediator in atherosclerosis-associated inflammation (AAI) thus reduci...

BACKGROUND: Atrial fibrillation (AF) could be triggered by inflammation and oxidative stress. Ganoderma lucidum has an active substance in the form of β-glucan that can reduce inflammatory process and oxidative stress in rats. The objective of this study was to evaluate the effect of Ganoderma lucidum polysaccharide peptide (GLPP) in paroxysmal AF...

Objective: Endothelial dysfunction is the primary initial step for atherogenesis in cardiovascular disease. Stable angina pectoris is a stable form of cardiovascular disease that profoundly alters Endothelial Progenitor Cells (EPC) and Circulating Endothelial Cells (CEC). Both CEC and EPC have a significant role as native homeostasis biomarker of e...

Introduction: Uncomplicated type B aortic dissections have been traditionally treated with medication therapy. While it may provide good short-term results, longterm prognosis may be less favorable. With improvements in endovascular repair and the potential risk of disease progression, thoracic endovascular aortic repair (TEVAR) has been considered...

Background : Myocardial blush grade (MBG) is an angiographic parameter to describe the adequacy of myocardial reperfusion. The correlation between myocardial blush and the clinical outcome following chronic total occlusion (CTO) recanalization is still unclear. Our study aimed to investigate the impact of myocardial blush after CTO recanalization o...

High levels of total cholesterol can worsen the condition of ischemic heart failure. Polysaccharide peptide (PsP) is a capsule of Ganoderma lucidum extract. This study aims to measure changes in total cholesterol levels in patients with ischemic heart failure before and after the administration of PSP and Placebo and to analyze differences in decre...

Background : Rheumatic heart disease (RHD) contributed to a large number of proportion amoung cardiovascular problems in developing county, especially Indonesia. Secondary prophylaxis method using intramuscular injection of Benzathin Penicillin-G (BPG) has been known as the most effective strategy in the prevention of RHD. However, whether this pre...

Background : Garcinia mangostana L. has been extensively used for years as antioxidant and anti-inflammation. However, its role in the context of endothelial disease was lacking. Objectives : To assess the effect of add-on G. mangostana L. extracts on endothelial dysfunction in type 2 diabetes subjects with high-risk Framingham score, compared to p...

BACKGROUND: Critical limb ischemia (CLI) is a terminal stage of peripheral arterial disease (PAD), in the absence of intervention, may lead to lower extremity amputation or death. In cases where medical management is not effective or severe cases of PAD, endovascular and surgical interventions are indicated. 2 Endovascular interventions become a fi...

Background : Angiotensin-converting enzyme inhibitors (ACEI) should be titrated to the optimal dose for adequate inhibition of the Renin-Angiotensin-Aldosterone system (RAAS). The up-titration of ACEI to the optimal doses during in-hospital treatment is challenging. Objectives : This study aimed to investigate whether the use of optimal dose of ACE...

Atherosclerosis is a disease caused by an inflammatory response which involved the interaction between endothelial cells, macrophages and lymphocytes, and is closely related to IL-17 regulation. This study is important to investigate the activity of Agaricusblazei in modulating the immunological activity based on the profile of CD4+IL-17+, CD8+IL-1...

[This corrects the article DOI: 10.2147/VHRM.S205996.].

Introduction The increasing blood glucose level due to insulin resistance which occurs in diabetes mellitus (DM) may cause vascular damage. This study aims to prove the effect of the polysaccharide peptide (PsP) Ganoderma lucidum on improving vascular damage through an increase of circulating endothelial cells and circulating endothelial cells (CEC...

Background. Hypercholesterolemia is a major classic risk factor for cardiovascular disease, but there are 35%-40% cases of cardiovascular patients have a normal cholesterol levels. Lp-PLA2 is an enzyme that produced and secreted by macrophages as a response to the lipid peroxide formation, especially the platelet activating factor compound and phos...

Background: Extract of Ganoderma lucidum Mycelium containing β-1,3/1,6-D-Glucan has shown to possess beneficial effects on cardiovascular diseases. Objective: To examine the effectiveness of β-1,3/1,6-D-Glucan (GLME) consumption to reduced blood pressure (BP) & inflammation in patients with hypertension. Material and Methods: A randomized, double-b...

High free radical can induce oxidative stress, inflammation, and endothelial dysfunction in atherosclerosis. PsP of Ganoderma lucidum that proven as an effective anti inflammation, antioxidants, anti endothelial dysfunction and no toxicity in animal model in previous studies. This study aims to prove the role of PsP of Ganoderma lucidum as a potent...

The metabolic syndrome is a group of conditions that include dyslipidemia, hypertension and increased plasma blood sugar. The metabolic syndrome itself, is a risk factor for atherosclerosis, which can develop into a form of complication such as STEMI-NSTEMI. Signs of inflammation occur from the beginning to the development of atherosclerosis. As fo...

Individuals with metabolic syndrome have an increased risk of cardiovascular disease such as coronary heart disease. With the occurrence of a metabolic syndrome consisting of dyslipidemia, hypertension and type 2 diabetes mellitus, inflammation of the endothelial wall activates proinflammatory molecules such as IL-1, IL-6 and hsCRP and decreases th...

Sel Progenitor Endotel (EPC) merupakan kelompok sel yang memiliki kekuatan angiogenik yang kemudian dikenal sebagai pilihanpengobatan seluler untuk mengimbas perbaikan lapisan intima pembuluh darah. Berdasarkan beberapa kajian sebelumnya, jumlahEPC di pasien angina pektoris stabil lebih rendah dibandingkan dengan individu yang sehat. Di samping itu...

Background and Objective: Dyslipidemia has been established as major risk factor contribute to atherosclerosis. One of emerging theory contribute to atherosclerosis is involvement of lipoprotein-associated phospholipase A2 (Lp-PLA2). Darapladib as inhibitor Lp-PLA2 have pro and contra about it is effect in atherosclerosis inhibition. This study aim...

BACKGROUND: Type 2 Diabetes Mellitus (DM) is one of dominant factors in cardiovascular deaths and induces endothelial dysfunction. A definite sign of endothelial dysfunction is foam cells formation derived from oxidized LDL. This study was conducted to determine effect of Polysaccharides Peptides (PsP) Ganoderma lucidum to foam cell counts and lipi...

The purpose of the present study was to provide evidence of the potential of Agaricus blazei Murill extract as atheroprotective agent. The study was conducted with 25 male mice (Mus musculus) divided into five groups consisting of five mice in each group. Three doses of Agaricus blazei Murill extract: D1 (100 mg/kg body weight), D2 (200 mg/kg body...

Aim: To acknowledge the nature of correlation between apolipoprotein B concentrations and LDL cholesterol levels in patients with stable angina pectoris and also to show that the ratio of apoB/apoA-I may be a promising predictor for the risk of cardiovascular disease. Methods: This is an observational study with cross-sectional approach of 34 patie...

p> Objective : There are many unknown safety for consumption in a compound of medicinal plants, one of them is polysaccharide peptide (PSP) of the extract of Ganoderma lucidum. Polysaccharide peptide (PSP) from Ganoderma lucidum mushroom extract is a bioactive substances found in the mushroom that is expected to be a drug that is safe for consumpti...

Research Background. Stroke as brain vascular disorder that can be ruptured vascular commonly referred to as a bleeding stroke or ischemic stroke may be due to cerebral arterial thrombosis as a final impact the progression of atherosclerosis, especially in the area of branching blood vessels. Atherogenesis related to endothelial dysfunction as a co...

Background : Heart disease is the leading cause of death for both men and women, but heart disease is preventable and controllable. Ganoderma lucidum is widely used as traditional medicine for centuries particularly in China, Japan, and Korea. Previous study showed antioxidative activity of polysaccharide peptide (PsP) from Genoderma lucidum. Objec...

BACKGROUND In cardiovascular medicine, Garcinia mangostana has been used as an antioxidant to inhibit oxidation of low density lipoproteins and as an antiobesity agent. The effect of Garcinia mangostana on hyperlipidemia is unknown. The aim of this study was to evaluate the effect of an ethanolic extract of Garcinia mangostana pericarp on lipid pro...

Background: Ganoderma lucidum, commonly referred to as Lingzhi in China, is a fungus that has been widely used through the centuries for the general promotion of health and longevity in Asian countries. Aims and Objective: To determine the effects of subchronic exposure of PSP G. lucidum on renal function and renal histopathology feature in Rattus...

Background: Coronary artery disease is one of the leading causes of morbidity and mortality in the world. Plaque atherosclerosis is a major role in this condition. The current study evaluated anti-inflammatory of polysaccharide peptide (ganodermalucidum) in atherosclerotic rats. Objective: This study aimed to evaluate polysaccharide peptide (PsP) o...

This study aimed to investigate whether methanolic extract of Scurrula atropurpurea (BL.) Dans. able to diminisihed oxidative stress in hypertensive rats. This study subjected rats to DOCA-induced hypertension. The experimental design: I. Sham group, II. Hypertensive group (administered by DOCA-salt at dosage of 10 mg/KgBW). III-V. The groups recei...

Background: The heart is a vital organ of the body. Although it is not a common target organ, this organ can be damaged by various chemical substances. Ganodermalucidumis a polysaccharide peptide which has antioxidant and anti-inflammatory properties to inhibit the progressivity of atherosclerosis as a cardiovascular disease related to oxidative st...

Background: Diabetes Mellitus (DM) is a major independent risk factor for cardiovascular disease (CVD) that oxidative stress plays key role for diabetescomplication vascular. Antioxidant agent is needed to attenuate the oxidative stress. Objective: This study aimed to evaluate polysaccharide peptide (PsP) of the extract of Ganoderma lucidum as an a...

Background: Atherogenesis is an inflammation process, begin with accumulation of oxidized LDL and formation of foam cells. Lingzhi (Ganoderma lucidum) is a woody mushroom, widely consumed as traditional medicine in the belief that it lowers risk of heart diseases and boosts the immune system. Objective: To evaluate the effects of polysaccharide pep...

Background: Polysaccharide Peptide (Ganoderma lucidum) are antioxidants and anti-inflammatory that is effective in inhibiting the progression of atherosclerosis as cardiovascular disease are very closely linked to the incidence of oxidative stress and inflammatory processes. Research before this proved the ability to significantly reduce the levels...

We evaluated the effect of short-acting long diuretics (Furosemide) on heart rate and blood pressure in patients with Forrester Hemodynamic Subset I-III Acute Decompensated Heart Faiure (ADHF). Fourty-one patients with mild Forrester Hemodynamic Subset I-III ADHF received furosemide (40 to 60 mg/day) in the first few days of admission. We performed...

Background: Diabetes Mellitus (DM) is a risk factor equivalent to Coronary Artery Disease (CAD). DM with hyperglycemia and insulin resistance enhances inflammation in vascular wall that accelerates atherosclerosis. Inflammatory cytokines are involved in both these diseases either DM or CAD. Anti-inflammation agent is needed to attenuate the inflamm...

Background: Ganodermalucidum was developed as a comprehensive approach for cardiovascular diseases. Efforts to develop polysaccharide peptide(Ganodermalucidum) as antioxidant and antiinflammation in previous studies had proved its ability to significantly reduce the level of MDA, hs-CRP, H2O2, total cholesterol, and foam cell and also increase the...

Background: Ganoderma lucidum has been used as a traditional oriental medicine as a therapeutic treatment of cardiovascular diseases. It has been proved that in the study of development efforts of polysaccharide peptide (PsP) as an antioxidant and anti-inflammatory. Objective: To assess the safety profiles of PsP Ganoderma lucidum through testing t...

Background: Clinical and experimental studies strongly indicate that hypertension is a major factor in coronary heart disease, stroke, and renal insufficiency. It has been hypothesized that oxidative stress plays a pivotal role in the pathogenesis of hypertension. Excessive reactive oxygen species has emerged as a central common pathway that may in...

Background: Gonoderma lucidum is claimed to have beneficial health effects, and is developing into a comprehensive form of treatment against cardiovascular disease. Previous studies have successfully proven Ganoderma lucidum polysaccharides peptide ability as an antioxidant and anti-inflammatory agent whereby reducing levels of MDA, hs-CRP, H2O2, t...

Background: High prevalence of diabetes mellitus (DM) in the world is one of the leading cardiovascular risk factor that associated with high morbidity and mortality. Atherosclerotic heart disease is one of the major cardiovascular disease related to DM from the current study. Polysaccharide peptide, extract from Ganodermalucidum, a popular medicin...

This research aims to find out the levels of xanthone in mangosteen pericarp extract (MPE) and to prove the ability of xanthone in modulating the activity of paraoxonase-1 (PON-1), reduce oxidized-low density lipoprotein (ox-LDL) and increase the levels of acetylcholinesterase (AChE) serum in animal model with organophosphat subchronic and subcutan...

Atherosclerosis is chronic inflammatory process triggered by oxidative stress. Oxidative stress can increase hydrogen peroxide (H2O2) level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (PVAT), foam cells, and atherosclerotic plaque. Antioxidant is needed to control negative effects of oxidativ...

B ACKGROUND: Acute myocardial infarction (AMI) is one of cardiovascular diseases with high morbidity and mortality rates. Novel biomarkers that can detect accurately acute coronary syndrome (ACS) at early stage, are necessary to improve current strategies and/or to identify subjects who are at risk. Fibrinogen and high-sensitivity C-reactive protei...

The current study evaluated the effect of subchronic toxicity of Ganoderma lucidum Polysaccharides peptide (PsP) to liver physiology and histopatology in rats. The 80 rats were randomly divided into four groups male and four groups female (10 rats per group): Three PsP treated group: 300, 600, 1200 mg/KgBW, and one normal control group. Aspartate a...

Endothelial progenitor cells (EPCs) clinical applications have been well reported. However, due to low number of EPCs that could be isolated, EPCs expansion study became one of the main focuses. Some optimized mediums to culture EPCs were currently available. However, the proliferation signaling pathway is not clearly disclosed yet. Peripheral bloo...

Atherosclerosis, a vascular disturbance, occurs as a result of oxidation of low density lipoprotein (LDL) deposition which later forms plaque. Its risk factor is hyperglycemia, a certain risk factor of vascular damage which happens in Diabetes Mellitus (DM) Type 2. Oxidative stress such as hydrogen peroxide (H2O2) increases within the condition of...

Background Oxidative stress in atherosclerosis produces H2O2 and triggers the activation of nuclear factor kappa beta (NF-κB) and increase of inducible nitric oxide synthase (iNOS). The formation of vasa vasorum occurs in atherosclerosis. Vasa vasorum angiogenesis is mediated by VEGFR-1 and upregulated by hypoxia-inducible factor-1α (HIF-1α). The n...

To know whether Scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (EPCs) in hypertensive rats. The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive gr...

BACKGROUND: A population of circulating Endothelial Progenitor Cells (EPCs) has been reported to play important role in maintaining endothelial function and integrity. Since EPCs culture is crucial and an optimized medium is currently available. Therefore we conducted a study to investigate whether stable angina subjects peripheral blood-derived EP...