Diwen Yang

Diwen Yang
University of Toronto | U of T · Department of Physical and Environmental Sciences at Scarborough

Master of Science

About

9
Publications
774
Reads
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64
Citations
Citations since 2016
9 Research Items
64 Citations
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2016201720182019202020212022010203040
2016201720182019202020212022010203040

Publications

Publications (9)
Article
Increases in the global use of plastics have caused concerns regarding potential adverse effects on human health. Plastic products contain hundreds of potentially toxic chemical additives, yet the exact chemicals which drive toxicity currently remain unknown. In this study, we employed nontargeted analysis and in vitro bioassays to identify the tox...
Preprint
Full-text available
Environmental obesogens can cause adverse health effects through activation of peroxisome proliferator-activated nuclear receptor γ (PPARγ). However, only a small portion of PPARγ ligands in the environment have been discovered to date, due to the co-occurrence of thousands of compounds. In this study, protein Affinity Purification with Nontargeted...
Article
Full-text available
Background: Thousands of per- and polyfluoroalkyl substances (PFAS) with diverse structures have been detected in the ambient environment. Apart from a few well-studied PFAS, the structure-related toxicokinetics of a broader set of PFAS remain unclear. Objectives: To understand the toxicokinetics of PFAS, we attempted to characterize the metabol...
Article
Evaluating interspecies toxicity variation is a long-standing challenge for chemical hazard assessment. This study developed a quantitative interspecies thermal shift assay (QITSA) for in situ, quantitative, and modest-throughput investigation of chemical-protein interactions in cell and tissue samples across species. By using liver fatty acid bind...
Article
Significance Secondary organic aerosol (SOA) causes various adverse health outcomes, but identification of the toxic components remains infeasible for current methodology due to the existence of hundreds of unknown chemical components. In this study, we established a platform to tackle this challenge by combining atmospheric flow reactor, proteomic...
Article
More than 1000 per- and polyfluoroalkyl substances (PFASs) have been discovered by nontarget analysis (NTA), but their prioritization for health concerns is challenging. We developed a method by incorporating size-exclusion column co-elution (SECC) and NTA, to screen PFASs binding to human liver fatty acid binding protein (hL-FABP). Of 74 PFASs ass...
Article
Brominated azo dyes (BADs) have been identified as predominant indoor brominated pollutants in daycare dust, thus their potential health risk to children is of concern. However, the toxicities of BADs remain elusive. In this study, the toxicokinetics of two predominant BADs, Disperse Blue 373 (DB373) and Disperse Violet 93 (DV93), and their suspect...

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