Divya Shaji

• PhD
• Kyoto University

Alzheimer’s disease (AD) is a neurological disease, and its signs and symptoms appear slowly over time. Although current Alzheimer’s disease treatments can alleviate symptoms, they cannot prevent the disease from progressing. To accurately diagnose and treat Alzheimer’s disease, it is therefore necessary to establish effective methods for diagnosis...

Coronavirus disease 2019 (COVID-19) is a pandemic first identified in China and rapidly transmitted to other countries all over the world. The lack of effective vaccines and treatments against COVID-19 causes its devastating aftermath. Therefore, it is urgently required to identify effective and safe treatments for COVID-19 and a variety of studies...

Alzheimer's disease (AD), one of the most common neurodegenerative diseases, is a major factor contributing to cognitive impairment in older adults. Current therapeutic treatments can only relieve the symptoms of AD, but they cannot stop the progression of the disease because it takes a long time for clinical symptoms to manifest. Therefore, it is...

The novel coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide, and new drug treatments for COVID-19 are urgently required. To find the potential inhibitors against the main protease (Mpro) of SARS-CoV-2, we investigated the inhibitory potential of naturally occurring compou...

The novel coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide, and new drug treatments for COVID-19 are urgently required. To find the potential inhibitors against main protease (Mpro) of SARS-CoV-2, we investigated the inhibitory potential of naturally occurring compounds...

Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV-2) is a rapidly spreading virus that appeared at the end of 2019 in Wuhan, China. To date, there is no effective treatment for COVID-19. Aloe vera is a widely used medicinal plant and its antiviral activities are well documented. A molecular docking approach was employed in this study to iden...

Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV-2) is a rapidly spreading virus that appeared at the end of 2019 in Wuhan, China. To date, there is no effective treatment for COVID-19. Aloe vera is a widely used medicinal plant and its antiviral activities are well documented. A molecular docking approach was employed in this study to iden...

This paper proposes natural drug candidate compounds for the treatment of coronavirus disease 2019 (COVID-19). We investigated the binding properties between the compounds in the Moringa oleifera plant and the main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 using molecular docking and ab initio fragment molecular orbital cal...

div>COVID-19 which is caused by the virus SARS-CoV-2, has now been declared a global pandemic by the World Health Organization. At present, no specific vaccines or drugs are available to treat COVID-19. Therefore, there is an urgent need for the identification of novel drug lead compounds to treat COVID-19. The SARS-CoV-2 main protease (Mpro also...

COVID-19 which is caused by the virus SARS-CoV-2, has now been declared a global pandemic by the World Health Organization. At present, no specific vaccines or drugs are available to treat COVID-19. Therefore, there is an urgent need for the identification of novel drug lead compoundsto treat COVID-19. The SARS-CoV-2 main protease (Mpro also known...

Aims To identify natural inhibitors against MCT8 for Allan-Herndon-Dudley Syndrome. Background Monocarboxylate transporter 8 (MCT8) is a Thyroid hormone (TH) transporter which is highly expressed in liver and brain. Mutations in the MCT8 gene (SLC16A2) cause a syndrome of psychomotor retardation in humans, known as Allan–Herndon–Dudley syndrome (A...

Background: Urolithiasis is the process of forming stones in the kidney, bladder, and/or urinary tract. It has been reported that kidney stones are the third most common disorder among urinary diseases. At present, surgical procedures and Extracorporeal Shock Wave Lithotripsy (ESWL) are commonly employed for the treatment of Urolithiasis. The majo...

Monocarboxylate transporter-8 (MCT8) is a specific thyroid hormone transporter, essential for the uptake of thyroid hormone into target tissues. Mutations in the MCT8 gene have been identified as the cause of Allan-Herndon-Dudley syndrome (AHDS). It has been reported that soy isoflavones influence thyroid hormone system and can interact with thyroi...

Intrinsically Disordered Proteins (IDPs) lack a stable, three-dimensional structure under physiological conditions, yet they exhibit numerous biological activities. Protean segments (ProSs) are the functional regions of intrinsically disordered proteins that undergo disorder-to-order transitions upon binding to their partners. Example ProSs collect...

Proteins that lack a well-defined conformation under native conditions are referred to as intrinsically disordered proteins. When interacting with partner proteins, short regions in disordered proteins can undergo disorder-to-order transitions upon binding; these regions are called protean segments (ProSs). It has been indicated that interactions o...