Divakar Goli

Divakar Goli
Indian Pharmaceutical Association

M.Pharm, PhD

About

124
Publications
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Publications

Publications (124)
Article
Full-text available
One bacterial isolate Bacillus pumilus out of hundred and twenty-eight screened for tolerance against Pb, Cd, Ba, Cr, Fe, Cu, and F was found to be resistant against all. Hence it was selected up for detail study. Only Bacillus sp. could stand up against Cr and upto 700 ppm removing nearly 86% of Cr at neutral pH. Chemical analysis was carried out...
Article
Full-text available
One bacterial isolate Bacillus pumilus out of hundred and twenty-eight screened for tolerance against Pb, Cd, Ba, Cr, Fe, Cu, and F was found to be resistant against all. Hence it was selected up for detail study. The isolate could stand up against F- upto 1000 ppm. Shifting the pH from 7 to 6, an increase in de-fluoridation was observed i.e. 46% t...
Article
Full-text available
One bacterial isolate Bacillus pumilus out of hundred and twenty-eight screened for tolerance against Pb, Cd, Ba, Cr, Fe, Cu, and F was found to be resistant against all. Hence it was selected up for detail study. The Bacillus sp. could stand up to 900 ppm of Pb and remove nearly 96% of Pb at neutral pH. Subjecting to a change in pH nearly 45% of m...
Article
Full-text available
Thirty halophilic bacteria were isolated from the soil of Karwar mangrove regions, Karnataka. These were examined for the production of pigments, antibiotic and proteolytic activities. KA16SPiv produced fluorescent green pigment and KA16SK2HS produced pink pigment. The optimal pigment production was at pH 8, 37°. Pigments are extractable in chlorof...
Article
Full-text available
Novel lipid nanoparticulates (NCs) were developed by a combined approach of precipitation and complexation with an aim to improve the solubility, stability and targeting efficiency of glimepiride (GLP). GLP NCs were prepared by precipitation process using PEG 20000 and further complexed with phospholipon90G (P90G). The NCs were evaluated for physic...
Article
Full-text available
Background: The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in the south and southeast tropical Asia. Turmeric an Indian yellow gold and universal spice is described in Ayurveda, an ancient treatise on longevity and quality life for the treatment of various inflammatory disorders. The oral bioavailab...
Article
Full-text available
The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in south and southeast tropical Asia. The rhizome is coined as the most useful part of the plant and a staple in all cooking and treatment of medicinal purposes include antioxidant, anti-viral, anti-bacterial, anti-fungal, anti-carcinogenic, anti-mutagen...
Article
The objective of the study was to develop optimized formulation of In-situ gel of Brimonidine tartarate (BT), anti-glaucoma agent using Ion activated polymer; Gelrite as gelling agent, kappa carrageenan as mucoadhesive agent and Hydroxy Propyl Methyl Cellulose (HPMC E50) as release retardant polymer. The 23 factorial design was employed to optimize...
Article
Objective: The goal of this study was to develop and characterize an ion-activated in situ gel-forming brimonidine tartrate, solution eye drops containing xanthan gum as a mucoadhesive polymer.Method: Sol-gel formulation was prepared using gellan gum as an ion-activated gel-forming polymer, xanthan gum as mucoadhesive agent, and hydroxypropyl methy...
Article
Quinolinic acid (QUIN) is a well-known neuroactive metabolite of tryptophan degradation pathway or kynurenine pathway. The QUIN is involved in the development of several toxic cascades which leads to the neuronal degeneration processes. The QUIN-induced toxicity is also responsible for the impairment of the motor function and motor learning ability...
Article
Al exposure causes an alteration in the several ions in the body and causes toxicity. Such as apoptosis, oxidative stress, disruption in neuronal transport, mitochondrial damage, excitotoxicity, generation of inflammatory mediators, and microglial activation. These multiple mechanisms lead to the several neurodegenerative diseases, including sporad...
Article
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Article
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Background: Curcumin constitutes 80% of the curcuminoids (4-5%) of the rhizomes of Curcuma longa L. and saffron. This polyphenol regulates various targets through direct interaction or modulation of gene expression. Despite well documented clinical benefits in colon disorders and safety profile, curcumin has limited pharmaceutical role owing to red...
Research
Full-text available
Our present research aimed to perform a detailed behavioral characterization of caffeine-induced seizure activity in zebrafish. Epileptic activity was observed by immersing individuals in different concentrations of caffeine solution at 250, 350, and 500 mg/l, respectively. Higher concentrations of caffeine rapidly induced intense behavioral activi...
Article
Cross-linked guar gum microparticles of curcumin were prepared for controlled release by emulsion gelation method using glutaraldehyde as cross-linking agent. Morphology and surface characteristics of the formulations were assessed by scanning electron microscopy. Particle size of the guar gum microparticles was determined by optical microscopy. Th...
Article
Our present research aimed to perform a detailed behavioral characterization of caffeine-induced seizure activity in zebrafish. Epileptic activity was observed by immersing individuals in different concentrations of caffeine solution at 250, 350, and 500 mg/l, respectively. Higher concentrations of caffeine rapidly induced intense behavioral activi...
Article
Microbial pectinases currently occupy a place of prominence among biocatalysts owing to their capability to catalyze a diversity of reactions in aqueous and non-aqueous media. Specific action of these enzymes has initiated remarkable attention among industrialists and researchers. Pectinases from a large number of fungal and a few bacterial sources...
Research
Full-text available
The present research is to explore the anti-anxiety property of novel synthesized pyrimidine derivative in zebra fish. We have investigated the anti-anxiety property of synthesized drug in different anti-anxiety model, trapezoid, light and dark and open field. LC50 value for drug was found as 5.5 mg/l. The dose are selected as in different concentr...
Research
Full-text available
This study was designed to evaluate the possible anti-hyperlipidemic and antioxidant effect of hydroalcoholic leaves extract of Ixora coccinea L. in triton (400 mg/kg, bw) and cafeteria diet induced hyperlipidemic rats. Hydroalcoholic leaves extract of Ixora coccinea was evaluated for antihyperlipidemic activity in tritonand cafeteria diet induced...
Book
This new volume provides exhaustive knowledge on a wide range of natural products and holistic concepts that have provided promising in the treatment of leishmaniasis. Including the major natural therapies as well as traditional formulations, over 300 medicinal plants and 150 isolated compounds that are reported to have beneficial results in the tr...
Article
Full-text available
Pravastatin Sodium has a cholesterol lowering agent. It has shorter half-life and undergoes first-pass metabolism. Frequent dose is required in case of conventional dosage form. The purpose of the study is to formulate and evaluate microcapsules containing Pravastatin Sodium by complex with cholestyramine resins coated with Eudragit RLPO and Eudrag...
Article
Full-text available
Stroke is a major cause of death and disability worldwide. The resulting burden on the society continues to grow, with increase in the incidence of stroke. Oxidative stress has been involved in the pathogenesis of several neurological diseases including acute stroke.Focal and global cerebral ischemia represents diseases that are common in the human...
Article
In present study, we formulated RT loaded PLGA-Soya lecithin-Tween 80 NPs, for the treatment of Alzheimer's disease (AD). After formulation we optimized formulation by Response Surface Methodology (RSM) using 32 factorial design. PLGA-Soya lecithin-Tween 80 nanoparticles were synthesized by modified nanoprecipitation technique combined with self as...
Article
Full-text available
Gmelina arborea roxb commonly known as ‘Gambhari’ tree, the various parts of the plants are widely used in diarrhoea, anti-pyretic, thirst, anemia, leprosy, ulcers, consumption, strangury and vaginal discharges. We tested the cytotoxic potential of Gmelina arborea roxb in HL-60 cells. Aqueous Extract of Gmelina arborea roxb (AEGA) was tested at the...
Article
Full-text available
The objective of the present study was to develop double layered tablets of lornoxicam, a highly potent non-steroidal anti-inflammatory drug. Double layered tablets compris of fast release layer and a sustained release layer, anticipating the rapid drug release that starts in the stomach rapidly alleviate the symptoms and continuous in the intestin...
Article
The predominance of drug-resistant pathogens have extended the devotion of pharmaceutical and scientific communities towards potential antimicrobial agents from plant derived sources. The present research work has commenced to study the antimicrobial activity of the methanolic extract of Boerhavia diffusa L. roots against slaughterhouse isolate Bac...
Article
Full-text available
A RP-HPLC method was developed for simultaneous estimation of Paracetamol (PCM), Cetirizine (CTZ) and Pseudoephedrine (PSEDN) for bulk drug and marketed tablet formulation using Phenomenex Luna C 18 column (250 mm × 4.6 mm id, 5 µm) and a mobile phase of Acetonitrile: 0.025 mM Potassium Dihydrogen orthophosphate + one drop of Triethylamine in every...
Article
Full-text available
The present study evaluated some neuropharmacological activities of ethanolic extract of Fumaria officinalis linn. (Fumaraciae) in experimental animal models. Fumaria officinalis (FO) (at 100,200 and 500 mg/kg body weight, i.p.) was evaluated for muscle relaxants activity by using Rota rod, Traction test and fall off time is, muscle relaxants are r...
Article
Full-text available
Objectves: The objective of our present research investigation was to evaluate the effectiveness of the aquatic white/black plus maze model to evaluate the efficacy of different treatment drugs on zebra fish behavior studies. Methods: Animals were divided into three groups each containing six animals. The first two groups were pretreated with lower...
Research
Full-text available
The research investigation was designed to find the behavior of zebra fish when it was exposed into unfamiliar atmosphere. The animals were divided into three different groups containing 6 zebra fishes. After pretreatment with high and low dose of Midazolam, two groups were undergone an exposure of unknown environment by immersing into novel dive t...
Research
Full-text available
The present study evaluated some neuropharmacological activities of ethanolic extract of Fumaria officinalis linn. (Fumaraciae) in experimental animal models. Fumaria officinalis (FO) (at 100,200 and 500 mg/kg body weight, i.p.) was evaluated for muscle relaxants activity by using Rota rod, Traction test and fall off time is, muscle relaxants are r...
Article
Full-text available
The present study was undertaken to evaluate anticonvulsant activity of ethanolic extract of Fumaria officinalis in experimental animal. The anticonvulsant activity of ethanolic extract of Fumaria officinalis (100, 200 and 500 mg/kg, p.o.) in mice was assessed by using maximum electroshock seizure (MES) test, Pentylenetetrazol (PTZ), and Picrotoxin...
Article
Full-text available
Article
Aimed to formulate, optimize (using CCD design) and characterize PLGA-CS-Tween 80 nanoparticles, of the drug Rivastigmine Tartrate (RT), for the treatment of Alzheimer's disease (AD). The pharmacodynamics performance of the nanoparticles (NPs) were evaluated for brain targeting and memory improvement in Aluminium chloride treated model using Morris...
Research
Full-text available
The present study was undertaken to evaluate anticonvulsant activity of ethanolic extract of Fumaria officinalis in experimental animal. The anticonvulsant activity of ethanolic extract of Fumaria officinalis (100, 200 and 500 mg/kg, p.o.) in mice was assessed by using maximum electroshock seizure (MES) test, Pentylenetetrazol (PTZ), and Picrotoxin...
Research
Full-text available
Objectves: The objective of our present research investigation was to evaluate the effectiveness of the aquatic white/black plus maze model to evaluate the efficacy of different treatment drugs on zebra fish behavior studies. Methods: Animals were divided into three groups each containing six animals. The first two groups were pretreated with lower...
Article
Buccoadhesive compacts of lercanidipine HCl showed better drug control release property during in vitro drug release studies. Optimized formulation of buccoadhesive compacts (FLCR2) was subjected to pharmacokinetic evaluation with an objective to evaluate their rate controlling efficiency and drug release by in vivo method using rabbits. Bilayered...
Article
Full-text available
Pain is a common and distressing feature of many diseases such as tumour, surgical procedures, physical trauma, noxious chemical stimulation etc. It is mostly a warning signal and primarily protective but excessive pain can lead to other side effects such as sweating, apprehension, nausea and palpitation. Preliminary phytochemical investigations of...
Research
Full-text available
Pain is a common and distressing feature of many diseases such as tumour, surgical procedures, physical trauma, noxious chemical stimulation etc. It is mostly a warning signal and primarily protective but excessive pain can lead to other side effects such as sweating, apprehension, nausea and palpitation. Preliminary phytochemical investigations of...
Research
Full-text available
In present study preliminary phytochemical investigations of different extracts of leaves of Fumaria officinalis Linn. were done. The petroleum ether extract contains phytosterols, saponins and fixed oils. The chloroform extract contains proteins. The ethanolic extract contains carbohydrates, saponins, flavonoids, phytosterols, tannins and phenolic...
Article
Full-text available
Controlled release drug delivery systems are gaining popularity. One of the attractive methods for modified drug delivery systems preferably controlled type is ion-exchange resins as carriers for such systems. Ion-exchange resinates of drugs can help in reducing the dose. Reduced fluctuations in blood and tissue concentrations and maintenance of dr...
Data
Full-text available
This work has been undertaken for the screening and isolation of fibrinolytic protease producing mesophilic bacteria from ten soil samples, collected from slaughter houses various regions of Bangalore and used to screen for fibrinolytic protease production by using fibrin plate assay. In the present study, an attempt was made to isolate efficient f...
Article
Full-text available
A novel fibrinolytic protease from a newly mutated Bacillus cereus GD55 was isolated and characterized for the fibrinolytic activity. The fibrinolytic protease was purified by ammonium sulphate fractionation (70%) and subjected to chromatographic methods like Sephadex G-50, DEAE–Sephadex A-50 columns. The purified enzyme has an approximately 31kDa...
Article
Fullerenes or buckyballs are a new allotrope of carbon characterized by a closed-cage structure. The chemical and physical properties of fullerenes have been important topic in the field of research and development. Buckeyballs and carbon nanotubes have opened the door to a vast range of carbon-based materials with some extremely useful properties....
Article
Full-text available
A novel fibrinolytic protease from a newly mutated Bacillus cereus GD55 was isolated and characterized for the fibrinolytic activity. The fibrinolytic protease was purified by ammonium sulphate fractionation (70%) and subjected to chromatographic methods like Sephadex G-50, DEAE –Sephadex A-50 colums. The purified enzyme has an approximately 31kDa...
Data
This work has been undertaken to enhance the production of industrially important fibrinolytic protease by subjecting indigenous fibrinolytic protease producing Bacillus cereus to strain improvement by random mutagenesis using ultra-violet (UV) irradiation, ethyl methane sulfonate (EMS) and ethidium bromide treatment. Mutants were screened on the b...
Data
This study aims to fabricate and optimize mouth dissolving tablets prepared by direct compression to not only have sufficient mechanical strength/hardness to withstand manual handling, but also have a rapid disintegration time. This research was to develop fast dissolving tablets of pioglitazone. Tablets containing pioglitazone, β-Cyclodextrin and...
Article
Full-text available
The main objective of the study was to determine the neuroprotective effect of allopurinol and nimesulide against the cerebral ischemic reperfusion injury in diabetic and nondiabetic rats. MTERIALS AND METHODS: In this study, Wistar albino rats of either sex weighing 150-250 g were procured from authorized suppliers. Rats were anesthetized by givin...
Data
This work has been undertaken for the Screening and isolation of Keratinase producing strains of Bacteria were carried out from Ten soil samples, collected from various regions of Bangalore and used to screen for Keratinase production by using feather powder agar plate assay. In the present study, an attempt was made to isolate efficient Keratinase...
Article
OBJECTIVES: The main objective of the study was to determine the neuroprotec-tive effect of allopurinol and nimesulide against the cerebral ischemic reperfusion injury in dia-betic and nondiabetic rats. MATERIALS AND METHODS: In this study, Wistar albino rats of either sex weighing 150-250 g were procured from authorized suppliers. Rats were anesth...
Article
Full-text available
Compacts containing the drug layer were developed by direct compression method using combination of polymers (HPMC and Carbopol 934P) and ethyl cellulose as an impermeable backing layer to release the drug in a unidirectional way toward the mucosa, thus avoiding loss of drug due to wash out by saliva. Formulations were evaluated for precompressiona...
Article
The cost of fibrinolytic protease (GD kinase) production may be significantly decreased by using inexpensive carbon substrates like agricultural residues. The optimization of different physical parameters such as various substrates, initial moisture level, pH, substrate particle size, incubation temperature, inoculum size, incubation period and che...
Data
The antibacterial activity of the plant parts extracts (stem, root, leaf, flower and whole plant) of Azadirachta indica was studied against Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris (Gram-negative), Bacillus subtilis and Staphylococcus aureus (Gram-positive) by the agar well diffusion method. The ethanol and methanolic extracts d...
Data
The antibacterial activity of the plant parts extracts (stem, root, leaf, flower and whole plant) of Azadirachta indica was studied against Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris (Gram-negative), Bacillus subtilis and Staphylococcus aureus (Gram-positive) by the agar well diffusion method. The ethanol and methanolic extracts d...
Data
The antibacterial activity of the plant parts extracts (stem, root, leaf, flower and whole plant) of Azadirachta indica was studied against Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris (Gram-negative), Bacillus subtilis and Staphylococcus aureus (Gram-positive) by the agar well diffusion method. The ethanol and methanolic extracts d...