Diu Nguyen

Diu Nguyen
Memorial Sloan Kettering Cancer Center | MSKCC · Molecular Pharmacology

Research Scholar

About

15
Publications
4,076
Reads
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1,045
Citations
Citations since 2017
13 Research Items
1014 Citations
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2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
Additional affiliations
August 2013 - September 2013
Heritagesummers school
Position
  • Tutor
Description
  • Design and teach the course "An introduction to Molecular Biology" for highschool students.
October 2010 - November 2016
University of Oxford
Position
  • Fellow
Description
  • Research focus: Biological functions of the chromatin remodeler ATRX (Alpha-thalassemia Mental Retardation Syndrome protein)
June 2009 - July 2010
Massachusetts Institute of Technology
Position
  • MSc internship
Description
  • Research focus: identifying target genes of miR-125b that is overexpressed in a rare leukemia with a chromosomal translocation.
Education
October 2010 - October 2014
University of Oxford
Field of study
  • Molecular Genetics
June 2009 - July 2010
Massachusetts Institute of Technology
Field of study
  • Biomedical Research
August 2008 - September 2010
Vrije Universiteit Amsterdam
Field of study
  • Biomolecular Sciences

Publications

Publications (15)
Article
Somatic missense mutations of BTG1 are exclusive to germinal center (GC)-derived B cell lymphomas (~12% of DLBCLs) and are most prevalent in ABC-DLBCL (p=0.0184 vs GCB-DLBCL), particularly in the MCD/cluster 5 subtype, which features extranodal dissemination and unfavorable outcome. However, the relevance, mechanism of action and biological contrib...
Article
RNA binding proteins (RBPs) have been increasingly recognized as an important class of regulators of normal and malignant hematopoiesis. However, the exact function and underpinning mechanisms of the RBPs that govern hematopoietic stem cells (HSCs) remains poorly characterized. We had previously identified SYNCRIP as a critical RBP that controls le...
Article
RNA binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be dysregulated in hematological malignancies. Here, we identify the RBP RBMX and its retrogene RBMXL1 to be required for murine and human myeloid leukemogenesis. Using murine conditional knockout models, we determined that Rbmxl1 is functionally redund...
Article
Full-text available
RNA-binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be dysregulated in hematological malignancies. Here we identify the RBP RNA-binding motif protein, X-linked (RBMX; also known as hnRNPG), and its retrogene RBMXL1 to be required for murine and human myeloid leukemogenesis. RBMX and RBMXL1 were overexpre...
Article
Mutations and aberrant expression of RNA binding proteins (RBPs) have recently been found to contribute to leukemia development (Prieto and Kharas, CSH, 2020). Previously we have identified the RBP RBMX (RNA binding motif protein, X-linked) in our shRNA in vivo screen using murine MLL-AF9 driven leukemia (Prieto et al, ASH abstract 2018). Here we u...
Article
Full-text available
The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to globally map the mRNA targets of the RBP MSI2 in mammalian adult normal and malignant stem cells. We reveal a unique MUSASHI-2 (MSI2...
Article
Full-text available
Stem cells balance cellular fates through asymmetric and symmetric divisions in order to self-renew or to generate downstream progenitors. Symmetric commitment divisions in stem cells are required for rapid regeneration during tissue damage and stress. The control of symmetric commitment remains poorly defined. Using single-cell RNA sequencing (scR...
Article
Acute myeloid leukemia (AML) is characterized by a block in the development of myeloid cells, often due to dysregulation of genes involved in key processes including self-renewal, proliferation, and differentiation. Somatic mutations and aberrant expression of RNA binding proteins (RBPs) have recently been found to be important in hematological mal...
Article
The RNA binding protein (RBP) MSI2 has been demonstrated to regulate the self-renewal activity and differentiation program of normal hematopoietic stem and progenitor cells (HSPCs), as well as leukemic stem cells (LSCs) (Kharas et al, Nature Medicine 2010, Park et al, 2013 Journal of Experimental Medicine, Park et al JCI 2015). Yet, the extent of M...
Article
N 6-methyladenosine (m6A) is a nucleotide modification in mRNA that is required for the acquisition of cell fate in embryonic stem cells. Recent studies have indicated that methylation writers can act as both oncogenes and tumor suppressor genes. Here we show that m6A is a critical regulator of myeloid differentiation of human hematopoietic stem an...
Article
Full-text available
N6-methyladenosine (m6A) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it remains unknown whether the m6A modification controls the differentiation of normal and/or malignant myeloid hematopoietic cells. Here we show that shRNA-mediated depletion of the m6A-forming en...
Article
ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG)n ATRX mutations are found in nearly all tumours that maintain their telomeres via the alternative lengthening of telomere (ALT) pathway, and ATRX is known to suppress this pathway. Here, we show that recruitment of ATRX to telome...
Article
Full-text available
Background We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to overexpression of the microRNA miR-125b, and we showed that transplantation of mice with murine stem/ progenitor cells overexpressing miR-125b is able to induce leukemia. In this study, we inv...

Questions

Questions (3)
Question
I've integrated a construct into the FRT site in this cell line but now would like to know where exactly my integration is in the genome. Unfortunately, according to the company (Invitrogen), this site is unmapped. I was just wondering if anyone has the same problem and has tried something.
Question
Do you think a PhD in Molecular Biology can apply for a postdoc in Neurosciences? What are the hot topics in this field? Can you tell me where the top labs are ?
Question
I'm trying to get rid of R-loops in my cell line by overexpressing recombinant RNase H, but have no luck so far.

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