Disha Chakraborty

• MD Dermatology
• Post doctoral fellow at VA Medical Centre Sacramento (University of California)

Elevated Cytokine Levels and Their Correlation with Disease Activity in Chronic Spontaneous Urticaria: A Detailed Analysis in the Indian Demographic Authors: Dr. Abhishek De, Disha Chakraborty, Professor Kiran Godse Affiliation Department of Dermatology, DY Patil University, Navi Mumbai. Abstract Background: While the inflammatory impact of cyt...

Objectives: Atopic dermatitis (AD) and contact dermatitis (CD) have a complicated and debatable correlation. A large number of studies have suggested that AD patients have a higher prevalence of contact allergy than non-AD patients. In this study, we aimed to compare the prevalence and patterns of CD in AD and non-AD patients using patch testing. W...

Atopic dermatitis (AD) is a chronic inflammatory skin disorder that profoundly affects quality of life, particularly in patients with moderate-to-severe disease that is refractory to conventional treatments. Cyclosporine is a cornerstone of systemic therapy for severe AD; however, its long-term use is hindered by toxicity, and effective alternative...

Foreword Dr. Christian Vestergaard MD.PhD.DMSc. Clinical Chairprofessor Department of Dermatology Aarhus University Hospital Aarhus, Denmark Atopic dermatitis is one of the most common inflammatory skin conditions, affecting not only children but also adults. While its pathogenesis remains incompletely understood, both environmental and genetic f...

Engagement of microribonucleic acids (miRNA) in the regulation of cutaneous cellular health and diseases is a rapidly advancing niche in dermatology basic research. miRNAs have been identified to play a key role in the pathogenesis of various cutaneous inflammatory, autoimmune and neoplastic conditions, among others. In addition, their purported ro...

Dupilumab is the first US FDA-approved biologic for moderate to severe atopic dermatitis (AD) in adults and children of age more than six months. It is a fully monoclonal antibody that inhibits interleukin (IL)-4 and IL-13 signal transmission. The initial product monograph mentioned major side effects like hypersensitivity reactions and eye problem...

A boy of 11 years, born of a consanguineous marriage, presented with silvery gray hair, which he has had since birth, along with insidious onset hyperpigmentation all over the body for the past 10 years. Similar changes were found in his maternal uncle. On cutaneous examination, diffuse hyper-pigmentation was seen on the face, trunk, and lower limb...

33rd EADV Congress, Amsterdam

Abstract Background Studies revealed patients with chronic spontaneous urticaria (CSU) had lower vitamin D3 levels. Some studies indicated that high-dose vitamin D3 supplementation for 4-12 weeks may reduce disease activity. However, the results of different trials were inconsistent and there is a paucity of well-designed clinical trials especially...

This book reviews the most fascinating research articles on urticaria from the past 12 months, offering valuable insights and updates in the field.

Background Chronic spontaneous urticaria (CSU) is a distressing skin condition characterized by the recurrent appearance of itchy hives. A subset of CSU patients remains resistant to conventional treatment with high-dose antihistamines. Tofacitinib, a Janus kinase inhibitor, has shown promise in various inflammatory skin diseases. We aimed to evalu...

The remarkable characteristics of stem cells (SCs), particularly their potency, capacity for self-renewal, and clonality, are well known. In recent years, there have been notable advancements in the field of cell therapy. Due to its distinctive qualities and versatility, this innovative therapy is already turning into a potentially helpful remedy f...

Preface It is with great pleasure and deep gratitude that I write this preface for our book titled "Urticaria," published by GJS Publications Pvt. Ltd. This book is the culmination of extensive research, collaboration, and dedication, and if brings together a series of intriguing and insightful cases of urticaria that we believe will provide valuab...

Atopic dermatitis (AD) a chronically relapsing dermatosis characterized by pruritus and a significant impact on the quality of life. Emollient and moisturizers are an integral part of its management and those containing natural moisturizing factors (NMF) and pseudoceramides are known to be efficacious barrier repair agents. Conventionally topical c...

Simulium dermatitis following blackfly bites in Northeastern India: a case report Within the diverse Simulidae family, key genera such as Simu-lium, Prosimulium, and Gigantodax stand out for their medical significance. These typically small black flies range from 1 to 5 mm and feature distinctive traits like prominent eyes and 11-segmented antennae...

The nose is a common site for many dermatological disorders and even skin cancers. Herein, we report a case of an elderly man who presented with papular lesions on his nose. A 64-year-old man presented with a cluster of four to five skin-colored papules on his nose for the last two years which were gradually increasing in size. He also had rhinophy...

Pattern recognition receptors (PRRs), which are found in microorganisms but not in hosts, allow Leprae bacilli to be recognized as foreign. Several kinds of pattern recognition receptors, such as toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-1-like receptors (RLRs), are present in the innate immune system. Sen and Baltimore (1986) d...

Introduction The treatment options for chronic spontaneous urticaria (CSU) primarily include second generation non-sedative antihistamine (SGAHs). Bilastine is a newer, nonsedating SGAH approved for urticaria in February 2019 by the Drugs Controller General of India. Its major advantages are in terms of superior efficacy, lack of drug interactions...

Exposure to external environmental stimuli can lead to skin aging, pigmentation, hair loss, and various immune-mediated as well as connective tissue diseases. Although conventional treatments are routinely used and favoured, they fail to achieve an adequate balance between clinical and cosmetic outcomes. Exosomes are vesicles with a lipid bilayer r...

Objectives Managing mild-to-moderate atopic dermatitis (AD) often necessitates topical therapies, and one such recently introduced option is crisaborole ointment. This study sets out to assess the efficacy and safety of crisaborole ointment in pediatric cases of AD over four weeks. Material and Methods Nineteen children between 2 and 16 years old...

We conducted a cross sectional institutional study to compare the serum levels of vitamin D in CSU patients with healthy controls and to assess the correlation between the disease severity and vitamin D deficiency. We also tried to evaluate the effect of vitamin D supplementation to the standard dose of levocetirizine in CSU patients with low serum...

Introduction Leprae bacilli are identified as foreign by pattern recognition receptors (PRRs) present in the microbes but absent in the host. The Nucleotide oligomerization domain (NOD)-like receptor (NLR) family comprises the nucleotide-binding oligomerisation domain (NOD1 and NOD2) proteins, which are two well-known PRRs. The objectives of this s...

Bilastine is a newer second-generation anti-histamine. Our trial results suggest that antihistamines have a unique mechanism of action by reducing systemic autoimmunity in chronic spontaneous urticaria patients by decreasing the level of pro-inflammatory cytokines, IL-6, IL-17. We chose Bilastine as it is much less sedating than other SGAHs.

Introduction Itraconazole follows non-linear pharmacokinetics and hence is recommended once daily, but in real-world practice, is commonly prescribed as twice daily. Hence, this study aimed to evaluate the efficacy and safety of super-bioavailable-itraconazole-130 mg (SB-130) and conventional-itraconazole-200 mg (CITZ-200) once daily compared with...

Researchers are making all out efforts worldwide, to find a serological marker to monitor the disease severity and/or measure efficacy of the drug. There are many potential molecular targets being investigated as a candidate marker. However, till date there has been no significant breakthrough. Thus, various scoring systems have been devised to eva...

It is well known that Mycobacterium leprae tends to target the cooler parts of the body and can involve the oral cavity. Despite this, macrocheilia-a condition where the lips become enlarged-caused by leprosy is rarely documented. There are few reported cases of leprous macrocheilia in India. We present a unique case of an elderly woman with border...

Background: Vitamin D analogues and NBUVB are both well-recognised modes of therapy in the treatment of chronic stable plaque psoriasis. The objective of this open label intraindividual, left right study was to compare two different vitamin D analogues, calcipotriol and calcitriol, in combination with NBUVB phototherapy in psoriasis. Methods: Th...

My article is about a case series of two rare cases of targetoid hemosiderotic hemangioma, also known as hobnail hemangioma. It should be kept as a differential for all acquired vascular tumors.

The next-generation high affinity monoclonal immunoglobulin E (IgE) inhibitor Ligelizumab is being tested in clinical studies to treat chronic spontaneous urticaria (CSU). In 2020, the US Food and Drug Administration (FDA) designated Ligelizumab (QGE031) as a breakthrough therapy for patients with chronic idiopathic urticaria; however, FDA clearanc...