Dirk W Lachenmeier

Dirk W Lachenmeier
Chemisches und Veterinäruntersuchungsamt Karlsruhe | CVUA · Plant-based foods

45.9
 · 
Dr. rer. nat. (PhD)
About
420
Research items
122,875
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6,674
Citations
Introduction
State-certified food chemist, toxicologist, head of the department of plant-based foods and co-head of the nuclear magnetic resonance laboratory at Chemical and Veterinary Investigation Agency, Karlsruhe, Germany, which is a governmental food, medicine and alcohol control authority. Avocationally working as scientist at the Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden. PhD in Forensic Toxicology from University of Bonn. Email: DWLachenmeier@gmx.de
Research Experience
Aug 2015
Chemisches und Veterinäruntersuchungsamt Karlsruhe
Position
  • Head of Department
Oct 2013 - Aug 2015
Chemisches und Veterinäruntersuchungsamt Karlsruhe
Position
  • Laboratory Head
Oct 2012 - Oct 2013
Ministry Of Rural Affairs And Consumer Protection Baden-Württemberg
Ministry Of Rural Affairs And Consumer Protection Baden-Württemberg
Position
  • Referent
Education
Oct 1994 - Dec 1999
University of Bonn
Field of study
  • Food Chemistry
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Following
Projects
Projects (24)
Project
Alcohol consumption is both a prevalent behavior and potentially harmful, causally increasing the risk of DSM-5 Alcohol Use Disorder (AUD) development, morbidity, and mortality. Knowledge of alcohol consumption is crucial for steering public health and individual intervention and prevention measures. Unfortunately, consumption self-reports are often biased so that the validity of consumption estimates on individual and population levels is generally diminished. This project 1) examines assessment material characteristics of widely used instruments (M-CIDI Munich Composite International Diagnostic Interview, but also AUDIT Alcohol Use Disorders Identification Test, and TLFB Timeline Follow-Back) as a possible source for bias. Additionally, this projects 2) examines the relevance of consumption information for the identification of risk behavior and AUD diagnoses.
Research
Research items (420)
Article
Full-text available
A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological threshold (benchmark dose) and estimated human intake. Median lethal dose values from animal experiments were used to derive the benchmark dose. The human intake was calcul...
Article
Full-text available
Background Societies tend to accept much higher risks for voluntary behaviours, those based on individual decisions (for example, to smoke, to consume alcohol, or to ski), than for involuntary exposure such as exposure to risks in soil, drinking water or air. In high-income societies, an acceptable risk to those voluntarily engaging in a risky beha...
Article
Background Given the association between alcohol consumption and negative health consequences, there is a need for individuals to be aware of their consumption of ethanol, which requires knowledge of serving sizes and alcoholic strength. This study is one of the first to systematically investigate the ability to discriminate alcoholic strength by t...
Article
In addition to being produced in ethanol metabolism, acetaldehyde occurs naturally in alcoholic beverages. Limited epidemiological evidence points to acetaldehyde as an independent risk factor for cancer during alcohol consumption, in addition to the effects of ethanol. This study aims to estimate human exposure to acetaldehyde from alcoholic bever...
Article
Thirteen samples of authentic absinthe dating from the preban era (i.e., prior to 1915) were analyzed for parameters that were hypothesized as contributing to the toxicity of the spirit, including naturally occurring herbal essences (thujone, pinocamphone, fenchone), methanol, higher alcohols, copper, and antimony. The total thujone content of preb...
Article
The objective of this study is to investigate whether the materials presented during alcohol consumption assessment sufficiently aid interviewees in categorizing the beverages they consumed during their lifetime. In the cross-sectional “AF-CIDI” online survey, N = 162 adult drinkers (61% female, 40% non-students) aged 27 ± 8.2 years assigned bevera...
Article
Full-text available
In cosmetic products, hydrocarbons from mineral oil origin are used as ingredients in a wide variety of consistency, from liquid oil to solid wax. Refined mineral oil hydrocarbons consist of MOSH (mineral oil saturated hydrocarbons) and a low proportion of MOAH (mineral oil aromatic hydrocarbons). MOSH and MOAH comprise a variety of chemically simi...
Article
Both the German and European organic food markets are growing fast, and there is also a rising demand for organic chicken eggs. Consumers are willing to pay higher prices for organic eggs produced in an animal appropriate environment considering animal welfare. Strict labelling requirements do not prevent chicken eggs from being a subject of food f...
Chapter
Furfuryl alcohol is a food borne heat generated compound that occurs in variable amounts in certain foods, typically less than 1mgkg-1. Thermal processing of foods and ageing of alcoholic beverages are the major sources of furfuryl alcohol. The highest contents of furfuryl alcohol have been reported in coffee beans (>100 mg kg-1), fish products (ab...
Article
Full-text available
The four heat-induced coffee contaminants—acrylamide, furfuryl alcohol (FA), furan and 5-hydroxymethylfurfural (HMF)—were analyzed in a collective of commercial samples as well as in Coffea arabica seeds roasted under controlled conditions from very light Scandinavian style to very dark Neapolitan style profiles. Regarding acrylamide, average conte...
Article
Full-text available
Die 1H NMR-Spektroskopie, eine schnelle und effektive „Fingerprint-Methode“, bietet in Kombination mit chemometrischen Analysetechniken eine Möglichkeit der Haltungsüberprüfung von Hühnereiern.
Article
Full-text available
Background: Consumption of very hot (> 65 °C) beverages is probably associated with increased risk of oesophageal cancer. First associations were reported for yerba mate and it was initially believed that high content of polycyclic aromatic hydrocarbons (PAH) might explain the risk. Later research on other beverage groups such as tea and coffee, w...
Chapter
Der Onlinehandel mit Erzeugnissen nach dem Lebensmittel – und Futtermittelgesetzbuch (LFGB) und auch mit Erzeugnissen aus den Rand- und Graubereichen wie Tabakerzeugnissen oder (oft illegalen) Arzneimitteln wächst stetig und stellt die amtliche Kontrolle vor neue Herausforderungen. Aber selbst konventionelle Lebensmittel werden mehr denn je in klas...
Preprint
Full-text available
The three heat-induced coffee contaminants acrylamide, furfuryl alcohol (FA) and 5-hydroxymethylfurfural (HMF) were analyzed in a collective of commercial samples as well as in Coffea arabica seeds roasted under controlled conditions from very light Scandinavian style to very dark Neapolitan style profiles. Regarding acrylamide, average contents in...
Article
Full-text available
Background: Heat-not-burn (HNB) tobacco products are not burnt but instead are inserted into a tobacco-heating system, which heats the tobacco at temperatures below that required to initiate combustion. This mechanism potentially results in significantly reduced concentrations of heat-generated toxicants in the inhalable aerosol. Method: The margin...
Article
Full-text available
Epidemiological studies indicate an increased risk of esophageal cancer from the consumption of very hot foods and beverages. The contact time and the contact temperature are decisive for the risk of injury. However, measuring the contact temperature is not easy in practice. In the present study, a numerical simulation based on the solution of the...
Article
Full-text available
Isoflavones are secondary plant constituents of certain foods and feeds such as soy, linseeds, and red clover. Furthermore, isoflavone-containing preparations are marketed as food supplements and so-called dietary food for special medical purposes to alleviate health complaints of peri- and postmenopausal women. Based on the bioactivity of isoflavo...
Article
Beverage fraud involving counterfeiting of brand spirits is an increasing problem not only due to deception of the consumer but also because it poses health risks e.g. from possible methanol admixture. Suspicious spirit samples from Russia and Kenya were analysed using 1H nuclear magnetic resonance (NMR) spectroscopy in comparison to authentic prod...
Preprint
Full-text available
Epidemiological studies indicate an increased risk of cancer from the consumption of very hot foods and beverages. The International Agency for Research on Cancer (IARC) has already recommended threshold values for the maximum drinking temperature of very hot beverages. The contact time and the contact temperature are decisive for the risk of injur...
Preprint
Full-text available
Epidemiological studies indicate an increased risk of cancer from the consumption of very hot foods and beverages. The International Agency for Research on Cancer (IARC) has already recommended threshold values for the maximum drinking temperature of very hot beverages. The contact time and the contact temperature are decisive for the risk of injur...
Article
Unrecorded alcohol consumption may be assessed by combining data from expert assessments and nationally representative surveys. While such a multivariate approach improves previous knowledge, underestimates may relate to the weak data available in some countries, exclusion of most vulnerable populations in surveys and potential unawareness of consu...
Article
Full-text available
The International Agency for Research on Cancer (IARC) evaluates "very hot" (> 65 °;C) beverages as "probably carcinogenic". This leads to the question how cooling of coffee is influenced by material properties and filling capacity of different mugs and to-go-cups. How long does it take to cool down coffee to less than 65 °C? With three temperature...
Article
Full-text available
Mineral oils (such as paraffinum liquidum or white oil), which consist of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH), are widely applied in various consumer products such as medicines and cosmetics. Contamination of food with mineral oil may occur by migration of mineral oil containing products from packa...
Article
Full-text available
The International Agency for Research on Cancer (IARC) evaluates “very hot (>65 °C) beverages” as probably carcinogenic to humans. However, there is a lack of research regarding what temperatures consumers actually perceive as “very hot” or as “too hot”. A method for sensory analysis of such threshold temperatures was developed. The participants we...
Conference Paper
Background: Several sources for biased alcohol consumption reporting have been identified. However, we still lack knowledge on whether the material of consumption assessment instruments sufficiently aids interviewees in categorizing real-life beverages to the presented beverage categories. Objectives: Validating laymen beverage assignments through...
Preprint
Full-text available
The International Agency for Research on Cancer (IARC) evaluates “very hot (>65 °C) beverages” as probably carcinogenic to humans. However, there is a lack of research regarding what temperatures consumers actually perceive as “very hot” or as “too hot”. A methodology for organoleptical assessment of such threshold temperatures was developed. The p...
Article
The International Agency for Research on Cancer (IARC) has evaluated drinks that are consumed “very hot” (> 65 °C) as “probably carcinogenic to humans”. Therefore, the purpose of this study is to obtain an initial insight into the dispensing and serving temperatures of coffee-based hot beverages in the home and in the food service industry. Overall...
Technical Report
Full-text available
When questioning professionals or consumers about influences on coffee quality, factors such as type, variety and origin, processing, sorting, gentle roasting, fresh grinding or the type of preparation are usually named. Very rarely, however, is the temperature is brought into play. According to popular opinion, the best way to think with coffee is...
Article
Nuclear magnetic resonance (NMR) spectroscopy has achieved increased application in the field of food authenticity control. Its instrumental variability is very low so that it is possible to compile large databases of authentic spectra. Adulterations in food fraud cases can be detected and quantification of compounds for regulatory limits control c...
Chapter
This review covers publications during the period January 2017 to December 2017 on adverse reactions to antiseptic drugs and disinfectants. Specific agents discussed are: aldehydes (glutaraldehyde and formaldehyde), guanidines (chlorhexidine and polyhexamethylene guanidine), benzalkonium compounds, triclosan, halogens (sodium hypochlorite, iodine,...
Article
Fragt man Fachleute oder Verbraucher nach Einflussfaktoren auf die Kaffeequalität, werden in der Regel die Art, Varietät und Herkunft, Sortierung, schonende Röstung, frisches Mahlen und die Zubereitungsart benannt. Sehr selten wird aber die Trinktemperatur ins Spiel gebracht. Nach landläufiger Meinung ist der Kaffee ’je heißer, desto besser‘. Diese...
Chapter
Full-text available
In diesem Programm sollte erneut geprüft werden, ob die Hersteller seitdem wirksame Maßnahmen zur Reduzierung von Benzolgehalten in Karottengetränken für Säuglinge und Kleinkinder getroffen haben. Diese Ergebnisse sollten mit denen des BÜp aus dem Jahr 2011 verglichen werden. Zusätzlich sollte der Status von Kirschgetränken für Säuglinge und Kleink...
Answer
You could either import the integrals, then you do not need bucketing. Otherwise, Uncrambler allows variable reduction as well, using averaging etc
Conference Paper
Background: Self-reports of recent alcohol consumption represents a crucial construct in addiction theories and research [1]. Next to biases in reporting behavior [2,3], also measurement characteristics may impact the validity of measures such as questionnaires and interviews [2,4]. Research question: Which properties of the M-CIDI consumption asse...
Article
Full-text available
A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination of the content of fluorinated pharmaceuticals. ¹⁹ F NMR spectra were either obtained in dimethylsulfoxide- d6 or aqueous buffer, using trifluoroacetic acid as internal standard. Quantification of 13 fluorine-containing pha...
Article
Full-text available
Cheap licit and artisanal illicit spirit drinks have been associated with numerous outbreaks of alcohol poisoning especially with methanol. This study aimed to evaluate the quality of cheap spirit drinks in Kibera slums in Nairobi County, Kenya. The samples consisted of cheap licit spirits (n = 11) and the artisanal spirit drink, 'chang'aa', (n = 2...
Article
The comprehensive phenolic fingerprint of Calligonum azel Maire plant fractions, collected from the Tunisian Desert, have been assessed for the first time as a source of natural antioxidants. Total phenolic content (TPC), Trolox Equivalent Antioxidant Capacity (TEAC) in scavenging DPPH, ABTS and Ferric Reducing Antioxidant Power (FRAP) were determi...
Article
Die Bezeichnung Schwarzwaldforelle ist seit dem 25.11.1997 in das Verzeichnis der geographisch geschützten Angaben (g. g. A.) der EU aufgenommen und darf seither nur noch nach den in den entsprechenden EU-Verordnungen (z. Z. VO (EU) 1151/2012) niedergelegten Regeln erzeugt und in Verkehr gebracht werden. Wenn die Bezeichnung "Schwarzwaldforelle" ve...
Article
Für einen effizienten Verbraucherschutz hat das CVUA Karlsruhe ein ressourcenschonendes Screening-Verfahren auf Basis der quantitativen Nuclear-Magnetic -Resonance-Spektrometrie (qNMR) etabliert, welches in einem Analysengang elf verschiedene wertgebende Bestandteile von Erfrischungsgetränken bestimmen kann. Aufbauend auf dieser Methode wurde vom C...
Article
Full-text available
Mineral hydrocarbons consist of two fractions, mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). MOAH is a potential public health hazard because it may include carcinogenic polycyclic compounds. In the present study, 400 MHz nuclear magnetic resonance (NMR) spectroscopy was introduced, in the context of offici...
Chapter
Full-text available
This review covers publications during the period January 2016 to December 2016 on adverse reactions to antiseptic drugs and disinfectants. Specific agents discussed are formaldehyde, guanidines (chlorhexidine, polyhexamethylene guanidine and polyhexamethylene biguanidine), benzalkonium compounds, triclosan, halogens (sodium hypochlorite and povido...
Article
Full-text available
Counterfeit alcohol belongs to the category of unrecorded alcohol not reflected in official statistics. The internet trade of alcoholic beverages has been prohibited by the Russian Federation since 2007, but various sellers still offer counterfeit spirits (i.e., forged brand spirits) over the internet to Russian consumers, mostly in a non-deceptive...
Article
In June, 2017, 21 scientists from nine countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their critical review and evaluation of the carcinogenicity of melamine, 1-tertbutoxypropan-2-ol, β-myrcene, furfuryl alcohol, pyridine, tetrahydrofuran, and vinylidene chloride. These assessments will be publi...
Article
As a dimension of exposure, alcohol quality (better termed ‘alcohol composition') is currently considered only for liver cirrhosis. However, in relation to methanol admixture, it may be an important factor in causing mortality and morbidity, especially in unrecorded surrogate alcohols.
Article
Zum Gehalt von Morphin, Codein, Noscapin und Papaverin in Mohnsamen stehen ausreichend viele Daten für die Risikobewertung zur Verfügung. Die Datenlage zum Gehalt von Opiaten in Backwaren mit Mohn ist dagegen unzureichend [4]. Gleiches gilt für die Gehalte der Begleit-Opiate Thebain und Oripavin sowie deren toxikologische Beurteilung. Bei der Herst...
Conference Paper
Objectives: Quantity and frequency of alcohol consumption are important in risk assessment as well as epidemiological and clinical research. Over the past decades, several large-scale studies have used the Munich Composite International Diagnostic Interview (M-CIDI) to assess drinking amounts. However, the accuracy of this assessment has rarely bee...
Article
Mineral hydrocarbons consist of two fractions, mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). MOAH is a potential public health hazard because it may include carcinogenic polycyclic compounds. In the present study, 400 MHz nuclear magnetic resonance (NMR) spectroscopy was introduced, in the context of offici...
Article
Counterfeit alcohol belongs to the category of unrecorded alcohol not reflected in official statistics. The internet trade of alcoholic beverages has been prohibited by the Russian Federation since 2007, but various sellers still offer counterfeit spirits (i.e., forged brand spirits) over the internet to Russian consumers, mostly in a non-deceptive...
Article
Nach der Lebensmittelinformationsverordnung sind bestimmte Pflichtangaben auf Lebensmittelverpackungen in einer Mindestschriftgröße mit einer x-Höhe von 1,2 mm anzugeben. Zur Messung ist nach QS-Vorgaben eine Rückführung notwendig. Am CVUA Karlsruhe hat sich dafür ein System aus Präzisionsmessskala mit digitalem Mikroskop bewährt.
Article
Samples of unrecorded opaque beers (n=58; 40 based on maize, 5 on sorghum and 13 on other plants) and recorded wines (n=8) in Kenya were screened for aflatoxins using a rapid ELISA technique followed by confirmation using liquid chromatography-tandem mass spectrometry. Six of the maize beers were obtained from Kibera slums in Nairobi County. Aflato...
Article
Full-text available
In 2013, illegal drug use was responsible for 1.8% of years of life lost in the European Union, alcohol was responsible for 8.2% and tobacco for 18.2%, imposing economic burdens in excess of 2.5% of GDP. No single European country has optimal governance structures for reducing the harm done by nicotine, illegal drugs and alcohol, and existing ones...
Article
Full-text available
For decades, compounds present in foods and beverages have been implicated in the etiology of human cancers. The World Health Organization (WHO) International Agency for Research on Cancer (IARC) continues to classify such agents regarding their potential carcinogenicity in humans based on new evidence from animal and human studies. Furfuryl alcoho...
Article
Nuclear magnetic resonance (NMR) spectroscopy is evaluated as an efficient analytical technique for simultaneous identification and quantitation of multiple compounds in alcohol-free beverages. The method was validated for three different types of soft drinks, including a beverage with high sugar content, a diet product and an energy drink. The sam...
Article
Full-text available
Humans are cumulatively exposed to acetaldehyde from various sources including alcoholic beverages, tobacco smoke, foods and beverages. The genetic-epidemiologic and biochemical evidence in ALDH2-deficient humans provides strong evidence for the causal relationship between acetaldehyde-exposure due to alcohol consumption and cancer of the upper dig...
Article
Full-text available
The quantity and frequency of alcohol consumption are crucial both in risk assessment as well as epidemiological and clinical research. Using the Munich Composite International Diagnostic Interview (M‐CIDI), drinking amounts have been assessed in numerous large‐scale studies. However, the accuracy of this assessment has rarely been evaluated. This...
Article
This is a comment to the previous rapid response of Sergei V. Jargin: Dr. Jargin is correct regarding the risk of poisoning from the illegal admixture of methanol into various products that may be consumed as surrogate alcohol. We have recently detected methanol in antifreeze products on the market in Novosibirsk [2]. It is of note that methanol i...
Article
A simple, isocratic and robust RP-HPLC method for the analysis of azithromycin was developed, validated and applied for the analysis of bulk samples, tablets and suspensions. The optimum chromatographic conditions for separation were established as a mobile phase comprised of acetonitrile-0.1 M KH2PO4 pH 6.5–0.1 M tetrabutyl ammonium hydroxide pH 6...
Article
Aktuelle Untersuchungsergebnisse aus dem CVUA Karlsruhe zeigen, dass es derzeit keinen Grund zur Sorge um einen verbotenen Einsatz von Melamin in Proteinpulvern und Nahrungsergänzungsmitteln gibt. Mit einer neuen Untersuchungsmethode wurden verschiedene Proben auf Melamin untersucht. Dabei konnten keine Verunreinigungen oder Verfälschungen mit dies...
Project - NMR analysis for quality control of foods, beverages, cosmetics and medicinal products
Project - Unrecorded alcohol: Composition and health consequences
Project - Authentication of saffron
Article
Vor 500 Jahren, am 23. April 1516, wurde in Ingolstadt durch den bayerischen Herzog Wilhelm IV. und seinen Bruder Herzog Ludwig X. eine Landesverordnung erlassen, die einen Passus enthielt, der heute als „Reinheitsgebot des Bieres“ bekannt ist. Nach dieser Verordnung durfte zur Bierherstellung nur Gerste, Hopfen und Wasser verwendet werden. Hefe wu...
Data
Supplementary Figures S1-S13 (19F NMR spectra of all investigated compounds).
Chapter
Full-text available
Nanomaterials are typically defined as compounds, the size of which is less than 100 nm in one or more dimensions of space. However, this definition has been controversially discussed. For example, some regulatory agencies, scientific institutes and scientists have suggested different sizes. Besides the size of the particles, their origin (natural...
Article
Full-text available
During the XIII International Conference on the Applications of Magnetic Resonance in Food Science, which was held in Karlsruhe, Germany, from 7th to 10th of June 2016, a discussion session entitled “Quantitative nuclear magnetic resonance (qNMR)” was organized. The conference participants had the opportunity to submit written questions as well as...
Article
Full-text available
Saffron, the dried stigmata of the plant Crocus sativus L., is a spice used for colouring and flavouring food. It is considered to be the most expensive spice, which can be explained by the laborious way the stigmata have to be harvested. There is a considerable profit to be made by adulterating saffron, e.g. by mixing it with other saffron plant m...
Article
Nuclear magnetic resonance (NMR) spectroscopy was applied to the analysis of alcoholic products in the context of health and safety control. A total of 86 samples of unrecorded alcohol were collected in Novosibirsk and nearby cities in Russia. Sampling was based on interviews with alcohol dependent patients, and unrecorded alcohol thus defined incl...
Article
2004 kam erstmals durch die Isle of Wight Study [1] die Vermutung auf, dass einige Lebensmittelfarbstoffe einen Einfluss auf die Aufmerksamkeit und Aktivität von Kindern haben könnten. Die daraufhin erstellte Southampton-Studie [2] konnte diese Vermutung weder belegen noch widerlegen. Als Reaktion auf diese Studien entschloss sich der Gesetzgeber d...