Dirk J Schaefer

Dirk J Schaefer
Universitätsspital Basel · Dept. of Plastic, Reconstructive, Aesthetic and Hand Surgery

Prof. Dr.

About

359
Publications
60,000
Reads
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4,627
Citations
Additional affiliations
January 2010 - October 2015
Universitätsspital Basel
Position
  • Full professor and Head of Department
April 2002 - May 2016
Universitätsspital Basel
Position
  • Head of Department
April 2002 - May 2016
Universitätsspital Basel
Position
  • Head of Department

Publications

Publications (359)
Article
Zusammenfassung Deutsch Brustkrebs und die damit verbundenen chirurgischen Eingriffe haben grosse Auswirkungen auf die Lebensqualität der betroffenen Patientinnen. Die Studienlage zeigt, dass der Verlust der Brust und die damit verbundene Veränderung des Körperbildes für viele Frauen grosse Auswirkungen auf das weibliche Selbstverständnis haben. Da...
Article
Purpose To determine the outcomes of diagnostic and therapeutic arthroscopy in patients with chronic wrist pain who are younger than 16 years of age. Methods We retrospectively analyzed collected data from medical records of patients who had undergone wrist arthroscopy by the senior author between 2015 and 2017 for longstanding wrist pain and were...
Article
Full-text available
Rapid vascularization of clinical-size bone grafts is an unsolved challenge in regenerative medicine. Vascular endothelial growth factor-A (VEGF) is the master regulator of angiogenesis. Its over-expression by genetically modified human osteoprogenitors has been previously evaluated to drive vascularization in osteogenic grafts, but has been observ...
Article
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Background Seroma formation is the most common donor site complication following autologous breast reconstruction, along with hematoma. Seroma may lead to patient discomfort and may prolong hospital stay or delay adjuvant treatment. The aim of this study was to compare seroma rates between the deep inferior epigastric perforator (DIEP), transverse...
Article
Zusammenfassung Ziel Diese Studie untersucht, ob das vaskularisierte Knochentransplantat aus der medialen Femurkondyle (MFC) auch erfolgreich bei kleinen (< 4 cm) Knochendefekten an der oberen Extremität eingesetzt werden kann, die nicht das Skaphoid betreffen. Patienten und Methoden Achtmal wurde bei 7 Patienten mit einem Alter zwischen 28 und 66...
Article
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Cells of the stromal vascular fraction (SVF) of human adipose tissue have the capacity to generate osteogenic grafts with intrinsic vasculogenic properties. However, cultured adipose-derived stromal cells (ASCs), even after minimal monolayer expansion, lose osteogenic capacity in vivo. Communication between endothelial and stromal/mesenchymal cell...
Article
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Background: Devitalized bone matrix (DBM) is currently the gold standard alternative to autologous bone grafting in maxillofacial surgery. However, it fully relies on its osteoconductive properties and therefore requires defects with healthy bone surrounding. Fractionated human adipose tissue, when differentiated into hypertrophic cartilage in vitr...
Article
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As part of the engineering of bone grafts, wrapping constructs in well-vascularized tissue, such as fascial flaps, improves bone formation. Our aim was to understand the cross-sectional vascularization pattern of human adipofascial flaps for this application. Methods: Seven adipofascial anterolateral thigh (ALT) flaps were harvested from five hum...
Article
Study design: Retrospective cohort study. Objectives: To analyze characteristics and treatment of osteomyelitis (OM) in the treatment of grade IV pressure injury (PI) in patients with spinal cord injury/disorder (SCI/D) following the Basel Decubitus Concept. Setting: Acute care and rehabilitation clinic specialized in SCI/D. Methods: Patient...
Article
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Background/aim: The use of sternocleidomastoid muscle (SCM) flap for facial reanimation was established in the 1980s by the senior author of this paper. We aimed to analyze long-term outcome and complications of this procedure. Patients and methods: We conducted a retrospective chart review of all patients undergoing SCM reanimation for longstan...
Article
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The reconstruction of complex midface defects is a challenging clinical scenario considering the high anatomical, functional, and aesthetic requirements. In this study, we proposed a surgical treatment to achieve improved oral rehabilitation and anatomical and functional reconstruction of a complex defect of the maxilla with a vascularized, enginee...
Article
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In this randomized controlled pilot trial, we compared three-dimensional (3D)-printed made-to-measure splints to conventional custom-made thermoplastic splints. In a clinical setting, we evaluated their general applicability and possible benefits for immobilization in hand surgical patients. We included 20 patients with an indication for immobiliza...
Article
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Aim: To compare therapeutic benefits of different immunophilin ligands for treating nerve injuries. Materials & methods: Cyclosporine, FK506 and rapamycin, were evaluated first in vitro on a serum-free culture of embryonic dorsal root ganglia followed by a new in vivo model of chronic nerve compression. Results: Outcomes of the in vitro study have...
Article
Background:. A variety of complications after injection of nonpermanent fillers for facial rejuvenation have been reported so far. However, to date, the overall complication rate is still a matter of debate. The aim of this study was to perform a systematic review of literature to assess the type and severity of associated complications following i...
Article
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Reduction mammoplasty is the gold standard procedure for symptomatic breast hypertrophy and it is also used for contralateral breast symmetrisation following breast cancer surgery. We aim at introducing a new procedure, which uses an omega resection pattern to simplify the inferior pedicle breast resection technique. A retrospective review of all p...
Article
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Aim: To develop a consistent model to standardize research in the field of chronic peripheral nerve neuropathy. Methods: The left sciatic nerve of 8-week-old Sprague–Dawley rats was compressed using a customized instrument leaving a defined post injury nerve lumen (400 μm, 250 μm, 100 μm, 0 μm) for 6 weeks. Sensory and motor outcomes were measured...
Article
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In recent years, the demand for genital plastic procedures has increased. Of those, the reduction of the labia minora has become very popular. Several techniques are described, with all its advantages and disadvantages. The aim of this study is to introduce a novel approach combining de-epithelialization with wedge resection. Methods: In this ret...
Article
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Osteoarthritis (OA) is the most prevalent joint disorder, causing pain and disability predominantly in the aging population but also affecting young individuals. Current treatments are limited to use of anti-inflammatory drugs to alleviate symptoms or degenerated joint replacement by a prosthetic implant at the end stage of the disease. We hypothes...
Article
Prospective observational cohort study. First, describe pressure injury (PI) and associated risk factors in individuals with spinal cord injury/disorder (SCI/D) during first rehabilitation. Second, evaluate a prediction model for hospital acquired PI (HAPI) development. Acute care and rehabilitation clinic specialized in SCI/D. Patients ≥18 years o...
Article
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Introduction: Fracture-related infection (FRI) is a severe post-traumatic complication which is occasionally accompanied by a deficient or even avital soft-tissue envelope. In these cases, a thoroughly planned orthoplastic approach is imperative as a vital and intact soft-tissue envelope is mandatory to achieve fracture union and infection eradicat...
Article
Zusammenfassung Der tiefe sternale Wundinfekt (TSWI) ist eine seltene Komplikation nach Sternotomie, die mit hoher Morbidität und Mortalität behaftet ist und Krankenhausaufenthalt sowie die Behandlungskosten signifikant ansteigen lässt. Eine mikrobiologische Besonderheit ist die Ausbildung von Biofilmen auf Implantatmaterial und/oder Knochensequest...
Article
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Zusammenfassung Hintergrund Im Rahmen des ELF der ESPRAS wurde die Notwendigkeit standardisierter Richtlinien zur Brustrekonstruktion auf europäischer Ebene definiert. Ziel dieser Studie ist es, zunächst einen Überblick über den aktuellen Status, Entwicklungen und mögliche regionale Unterschiede der Brustrekonstruktion in Europa zu geben, wobei ein...
Article
Demand has increased for complex lower-extremity reconstruction in the steadily growing elderly patient group in many highly developed countries. Microsurgery is indispensable for soft tissue reconstruction and osseous consolidation salvaging leg function and preventing amputation, with its devastating consequences. Microvascular reconstruction can...
Article
Background: The Executive Committee (ExCo) of the Euro- pean Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS) organized a first ESPRAS European Leadership Fo- rum (ELF) to facilitate international exchange and to provide a platform for international leaders and delegates of national societies of Plastic Surgery to discuss common ch...
Article
Introduction: Avascular necrosis of bone (AVN) leads to sclerosis and collapse of bone and joints. We have previously shown that axially-vascularized osteogenic constructs, engineered by combining human stromal vascular fraction (SVF) cells and a ceramic scaffold, can revitalize necrotic bone of clinically relevant size in a rat model of AVN. For a...
Article
Background: Since 2015/16 the DGPRÄC collects, evaluates and publishes the research activities of academic sections, departments and clinics for plastic surgery at university hospitals in Germany, in order to raise the awareness of plastic surgical research performance. Materials and methods: The directors of plastic surgical academic institutio...
Article
Background/aim: Free flap reconstruction with damaged or diseased vessels is a challenging problem. We describe our case series using an arteriovenous loop or bypass surgery with free flaps for complex defect reconstructions at the lower extremity and the pelvic region. Patients and methods: In this single-center retrospective cohort study 11 co...
Article
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Functional recovery after neurotmesis, a complete transection of the nerve fiber, is often poor and requires a surgical procedure. Especially for longer gaps (>3 mm), end-to-end suturing of the proximal to the distal part is not possible, thus requiring nerve graft implantation. Artificial nerve grafts, i.e., hollow fibers, hydrogels, chitosan, col...
Article
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We report on a potential strategy involving the exogenous neurotrophic factors (NTF) for enhancing the neurotrophic capacity of human adipose stem cells (ASC) in vitro. For this, ASC were stimulated for three days using NTF, i.e., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), NT4, glial cell-derived neur...
Article
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Microsurgical abdominally-based reconstruction is considered the gold standard in autologous breast reconstruction. Despite refined surgical procedures, donor-site complications still occur, reducing patient satisfaction and quality of life. Recent work has outlined the potential of morphometric measurements in risk assessment for postoperative her...
Article
Zusammenfassung Das perioperative Management in der Mikrochirurgie ist ein wesentlicher Bestandteil einer erfolgreichen rekonstruktiven Chirurgie. Im deutschsprachigen Raum herrschen hierzu keine einheitlichen Konzepte und die individuellen Schemata unterscheiden sich wie in der Expertenbefragung erhoben deutlich voneinander. Im Zuge der 41. Jahres...
Article
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This case report highlights the importance of a wide differential diagnosis in transgender patients. A 77-year-old transgender (female-to-male) with recurrent urinary tract infections (UTI) and obstructive voiding difficulties presented with a perineal cyst. Further examinations, including computed tomography (CT) and puncture, revealed that the pa...
Article
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Bone infection represents a serious complication of orthopedic surgery and Staphylococcus aureus is the most common pathogen. To improve the understanding of host‐pathogen interaction, we developed a biospecimen registry (AO Trauma CPP Bone Infection Registry ) to collect clinical data, bacterial isolates, and serum from patients with S. aureus bon...
Article
Zusammenfassung Im Zuge des zunehmenden Kostendrucks im Gesundheitssystem werden Therapien neben ihrer Qualität zunehmend auch hinsichtlich ihrer Wirtschaftlichkeit bewertet. Mikrochirurgische Eingriffe haben sich vor allem im Langzeitverlauf in vielen Bereichen als funktionell und ästhetisch überlegen gezeigt. Im Vergleich zu Alternativeingriffen...
Article
In addition to outcome assessments, cost effectiveness of surgical treatments becomes increasingly important. Both, insurance companies and hospital administrations aim for short and efficient procedures to reduce costs.Microsurgical procedures are often surpassing traditional treatment options in terms of function and aesthetics. However, they are...
Article
Full-text available
Case: Post-traumatic defects of the metacarpophalangeal joint (MCPj) remain challenging for hand surgeons. Restoration of stability and motion are difficult to achieve because of the complex anatomy and kinematics. The Robert Mathys (RM) semiconstrained prosthesis offers good intrinsic stability and mobility and therefore seems suitable. We report...
Article
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The first choice for reconstruction of clinical-size bone defects consists of autologous bone flaps, which often lack the required mechanical strength and cause significant donor-site morbidity. We have previously developed biological substitutes in a rabbit model by combining bone tissue engineering and flap pre-fabrication. However, spontaneous v...
Article
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Introduction: Reconstruction of composite soft-tissue defects with extensor apparatus deficiency in patients with periprosthetic joint infection (PJI) of the knee is challenging. We present a single-centre multidisciplinary orthoplastic treatment concept based on a retrospective outcome analysis over 20 years. Methods and Results: One-hundred sixty...
Article
The present article provides an overview of the current and expected effects of plastic surgery in Europe. It presents the experience of departments for plastic and reconstructive surgery, as evaluated by interviews with members of the Executive Committee (ExCo) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS). The...
Article
Full-text available
Peripheral nerve injuries often result in lifelong disabilities despite advanced surgical interventions, indicating the urgent clinical need for effective therapies. In order to improve the potency of adipose-derived stem cells (ASC) for nerve regeneration, the present study focused primarily on ex-vivo stimulation of ASC by using growth factors, i...
Article
Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory dermatosis characterized by abscesses, deep-seated nodules, sinus tracts and fibrosis in skin lesions around hair follicles of the axillary, inguinal and anogenital regions. While the exact pathogenesis remains poorly defined, clear evidence suggests that HS is a multifactorial infl...
Conference Paper
Full-text available
Background & Aim Osteoarthritis (OA) is the most prevalent joint disorder causing pain and disability predominantly in the ageing population but also in young individuals. Current treatments are limited to alleviate symptoms, e.g. with anti-inflammatory drugs, until at the end stage of the disease the degenerated joint is replaced by a prosthetic i...
Article
Aim: We investigated a potential strategy involving human platelet lysate (HPL) as a media additive for enhancing the neurotrophic potency of human adipose stem cells (ASC). Materials & methods: Dorsal root ganglion explants, ASC and Schwann cells were used for in vitro axonal outgrowth experiments. Results: Remarkably, HPL-supplemented ASC promote...
Article
Full-text available
Background: Little is known about the sensate recovery of skin grafts over free non-neurotized muscle flaps. The aim of this study was to evaluate the sensitivity of free gracilis muscle flaps and meshed skin grafts without nerve coaptation. Methods: Thirteen consecutive patients with a median age of 55 years (range, 21-70 years) who underwent l...
Article
Zusammenfassung Hintergrund Die Bildung von beruflichen Netzwerken und Kooperationen ist neben einer guten Weiterbildung für eine erfolgreiche Karriere meist grundlegend. In etlichen Fachdisziplinen existieren hierfür bereits kleinere Symposien oder Konferenzen. Im Forschungszweig der Mikrochirurgie gab es bislang jedoch noch keine dezidierte Mögli...
Chapter
The use of autologous fat grafting (AFG) is widely used in plastic surgery for both reconstructive and aesthetic indications, in particular for breast and buttock augmentation and facial rejuvenation. AFG is a simple and effective procedure presenting several advantages. Among them, the possibility of combining liposuction of areas with unpleasant...
Preprint
Full-text available
Background Bone infection is a serious complication associated with orthopedic surgery, and Staphylococcus aureus (S. aureus) is a common pathogen. As the optimal treatment requires an understanding of the patient-specific host-pathogen interaction, we developed a biospecimen registry (the AO Trauma CPP Bone Infection Registry) to collect clinical...
Article
Full-text available
Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue‐engineered constructs and to treat ischemic conditions. Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis. However, uncontrolled expression can lead to aberrant vascul...
Article
Full-text available
Background: Management of post-traumatic open fractures resulting from severe injuries of the lower extremity continues to challenge orthopedic and reconstructive surgeons. Moreover, post-traumatic osteoarticular infections due to Clostridium species are rare, with few reports in the literature. We describe possible pathomechanisms and propose tre...
Chapter
In Medizin, Psychologie und Pflege werden trans Personen marginalisiert. Geschlechtliche Diversität wird oft mit sexueller Vielfalt zusammen betrachtet - die gelebte Erfahrung von trans Personen wird dadurch jedoch verdeckt. Dieser Band beschäftigt sich erstmals daher nicht nur mit der aktuellen Lage von trans Personen in diversen Versorgungssystem...
Article
Full-text available
Study design: Retrospective chart analyses as part of a quality improvement project. Objectives: To demonstrate treatment of pressure injury (PI) in patients with spinal cord injuries (SCI) and analyse costs using the "modified Basel Decubitus Concept". Setting: Inpatient setting of a specialised acute care and rehabilitation clinic for SCI....
Article
Zusammenfassung Die Wirtschaftlichkeit von Therapien hat im Gesundheitswesen zunehmenden Stellenwert erlangt und wird dadurch auch für Mikrochirurgen ein relevanterer Aspekt ihrer Arbeit. Vor allem der verbundene Kostendruck, langfristig wirtschaftlich zu agieren, nötigt Mikrochirurgen ihre oftmals komplexen Behandlungen gegenüber Krankenversicheru...