Dirk De Ridder

Dirk De Ridder
University of Otago · Department of Surgical Sciences

MD, PhD

About

404
Publications
110,582
Reads
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16,935
Citations
Additional affiliations
February 2013 - present
University of Otago
Position
  • Neurological Foundation chair of Neurosurgery
January 2000 - December 2012
Universitair Ziekenhuis Antwerpen
Position
  • Professor of Neurosurgery
November 1998 - October 1999
Algemeen Ziekenhuis Sint-Lucas
Position
  • Neurosurgen

Publications

Publications (404)
Article
Objective Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome metho...
Preprint
Full-text available
Obesity is a serious issue in the modern society since it associates to a significantly reduced quality of life. Current research conducted to explore the obesity-related neurological evidences using electroencephalography (EEG) data are limited to traditional approaches. In this study, we developed a novel machine learning model to identify brain...
Article
Full-text available
Persistent pain is a key symptom in people living with knee osteoarthritis (KOA). Infra-slow Neurofeedback (ISF-NF) training is a recent development focusing on modulating cortical slow-wave activity to improve pain outcomes. A parallel, two-armed double-blinded, randomized sham-controlled, feasibility clinical trial aimed to determine the feasibil...
Article
Full-text available
Tinnitus is defined as the conscious awareness of a sound without an identifiable external sound source and tinnitus disorder as tinnitus plus associated suffering. Chronic tinnitus has been anatomically and phenomenologically separated into three pathways: a lateral "sound" pathway, a medial "suffering" pathway, and a descending noise-canceling pa...
Article
Full-text available
Introduction Chronic low back pain (CLBP) is a common disabling health condition. Current treatments demonstrate modest effects, warranting newer therapies. Brain imaging demonstrates altered electrical activities in cortical areas responsible for pain modulation, emotional and sensory components of pain experience. Treatments targeting to change e...
Article
Objective The aim of this study was to identify and describe clusters of patients with similar characteristics presenting with sciatica caused by a lumbar disc herniation in secondary care. Methods Forty-six percent (n=163) of the eligible patients (n=352) completed all questionnaires and were included in a hierarchical cluster analysis. The analy...
Article
Full-text available
Introduction Internalizing disorders (IDs), e.g., major depressive disorder (MDD), posttraumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD) are the most prevalent psychopathologies experienced worldwide. Current first-line therapies (i.e., pharmacotherapy and/or psychotherapy) offer high failure rates, limited accessibility, and su...
Article
Full-text available
Acute pain is a physiological response that causes an unpleasant sensory and emotional experience in the presence of actual or potential tissue injury. Anatomically and symptomatically, chronic pathological pain can be divided into three distinct but interconnected pathways, a lateral “painfulness” pathway, a medial “suffering” pathway and a descen...
Conference Paper
Alzheimer’s disease (AD), the most common form of dementia, is a significant and growing health challenge worldwide. Current available treatments for AD have poor efficacy. Decreased activity within default-mode network (DMN) has been demonstrated as a potential biomarker for tracking AD progression and is a recommended target for brain stimulation...
Article
Background and Study Aims: The traditional percutaneous placement of dorsal root ganglion (DRG) electrodes may not be eligible for every patient. In this tertiary spine surgery and interventional pain therapy center, alternative neurostimulation implantation techniques were developed and applied where standard percutaneous approaches failed or were...
Article
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Chronic pain, with a prevalence of 20-30% is the major cause of human suffering worldwide, because effective, specific and safe therapies have yet to be developed. It is unevenly distributed among sexes, with women experiencing more pain and su...
Chapter
Electroencephalography (EEG) is a widely used non-invasive technique to measure multi-channel potentials that reflect the electrical activity of the brain. Over the last few decades, EEG analysis has been an intensively explored research topic due to its potentials in being applied to the diagnosis of neurological diseases, such as epilepsy, brain...
Conference Paper
Persistent pain is a key symptom in people with knee osteoarthritis (KOA). Infra-slow Neurofeedback (ISF-NF) training is a recent development focusing on modulating cortical slow-wave activity to modulate abnormal faster frequencies that are linked to the pain experience. Aim: The study aims to evaluate the feasibility (recruitment rate, retention,...
Conference Paper
Full-text available
Background: Internalizing disorders (IDs; e.g. posttraumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD)) are the most prevalent form of psychopathology experienced worldwide. Current first-line therapies (e.g. pharmacotherapy) offer high failure rates and substantial side-effects. Closed-loop brain training of electrophysiological...
Conference Paper
Dementia, characterised by progressive deterioration of cognitive functions, is a significant and growing health challenge, with a huge social and economic impact. Current available treatments have limited efficacy, warranting new targeted interventions. Several studies demonstrate dysfunctional electrical activity in brain-wide functional networks...
Article
The original version of this chapter unfortunately contained two errors: in author name and order of author.
Chapter
The pathophysiological mechanisms that underlie the generation and maintenance of tinnitus are being unraveled progressively. Based on this knowledge, a large variety of different neuromodulatory interventions have been developed and are still being designed, adapting to the progressive mechanistic insights in the pathophysiology of tinnitus. rTMS...
Article
Full-text available
Background: Mental illnesses are increasing worldwide with the internalizing disorders (IDs; e.g., anxiety disorders, depressive disorders) being the most prevalent. Current first-line therapies (e.g., pharmacotherapy) offer high failure rates and substantial side effects. Electroencephalographic neurofeedback (EEG-NFB) has been shown to be an effe...
Article
Introduction: The International Neuromodulation Society defines neuromodulation as the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body. Areas covered: In the near future (<5 years) increasingly complex implantable neuromodulation syst...
Chapter
This volume has highlighted the many recent advances in tinnitus theory, models, diagnostics, therapies, and therapeutics. But tinnitus knowledge is far from complete. In this chapter, contributors to the Behavioral Neuroscience of Tinnitus consider emerging topics and areas of research needed in light of recent findings. New research avenues and m...
Chapter
As for hypertension, chronic pain, epilepsy and other disorders with particular symptoms, a commonly accepted and unambiguous definition provides a common ground for researchers and clinicians to study and treat the problem. The WHO's ICD11 definition only mentions tinnitus as a nonspecific symptom of a hearing disorder, but not as a clinical entit...
Preprint
Full-text available
Background: The core intrinsic connectivity networks (ICNs), encompassing the default-mode network (DMN), salience network (SN) and central executive network (CEN), have been shown to be dysfunctional in individual’s with internalizing disorders (IDs; e.g. major depressive disorder, MDD; generalized anxiety disorder, GAD; social anxiety disorder, S...
Chapter
It has been increasingly recognized that tinnitus is likely to be generated by complex network changes. Acoustic trauma that causes tinnitus induces significant changes in multiple metabolic pathways in the brain. However, it is not clear whether those metabolic changes in the brain could also be reflected in blood samples and whether metabolic cha...
Article
Full-text available
Chronic pain is pain that persists beyond the expected period of healing. The subjective experience of chronic pain results from pathological brain network interactions, rather than from persisting physiological sensory input of nociceptors. We hypothesize that pain is an imbalance between pain evoking dorsal anterior cingulate cortex and somatosen...
Article
As for hypertension, chronic pain, epilepsy and other disorders with particular symptoms, a commonly accepted and unambiguous definition provides a common ground for researchers and clinicians to study and treat the problem. The WHO's ICD11 definition only mentions tinnitus as a nonspecific symptom of a hearing disorder, but not as a clinical entit...
Preprint
Full-text available
Effective analysis of EEG signals for potential clinical applications remains a challenging task. So far, the analysis and conditioning of EEG have largely remained sex-neutral. This paper employs a machine learning approach to explore the evidence of sex effects on EEG signals, and confirms the generality of these effects by achieving successful s...
Conference Paper
Background: Persistent knee pain is a common presenting complaint in people with knee osteoarthritis (KOA) and is linked to abnormal activity in sensory discriminative, motivational/affective, and anti-nociceptive brain regions. Electroencephalography neurofeedback (EEG-NF) training is a form of non-invasive neuromodulatory intervention targeted to...
Article
Full-text available
Just as the human brain works in a Bayesian manner to minimize uncertainty regarding external stimuli, a deafferented brain due to hearing loss attempts to obtain or “fill in” the missing auditory information, resulting in auditory phantom percepts (i.e., tinnitus). Among various types of hearing loss, sudden sensorineural hearing loss (SSNHL) has...
Chapter
Vagus nerve stimulation is a promising new tool in the treatment of chronic tinnitus. Current protocols involve pairing sounds, which exclude the tinnitus frequency, with simultaneous vagus nerve stimulation (VNS). This is based on extensive preclinical animal studies that demonstrate that pairing non-tinnitus sounds with VNS results in a tonotopic...
Article
Effective analysis of EEG signals remains a challenging task. So far, the analysis and conditioning of EEG have largely remained gender-neutral. This paper explores the evidence of gender effects on EEG signals and confirms the generality of these effects by achieving successful gender prediction through EEG signals. Specifically, we propose a nove...
Chapter
Tinnitus and pain share similarities in their anatomy, pathophysiology, clinical picture and treatments. Based on what is known in the pain field, a heuristic model can be proposed for the pathophysiolgy of tinnitus. This heuristic pathophysiological model suggests that pain and tinnitus are the consequence of an imbalance between two pain/tinnitus...
Article
Full-text available
Although hearing aids (HAs) are sometimes efficacious in abating tinnitus, the precise mechanism underlying their effect is unclear and predictors of symptom improvement have not been determined. Here, we examined the correlation between the amount of tinnitus improvement and pre-HA quantitative electroencephalography (qEEG) findings to investigate...
Article
Abnormal neural activity, particularly in the rostrodorsal anterior cingulate cortex (rdACC), appears to be responsible for intense alcohol craving. Neuromodulation of the rdACC using cortical implants may be an option for individuals with treatment-resistant alcohol dependence. This study assessed the effectiveness and feasibility of suppressing a...
Article
Full-text available
Introduction: Persistent pain is a significant contributor to disability in people living with knee osteoarthritis (KOA). Brain imaging, including electrophysiological studies, confirms altered cortical oscillatory and synchrony patterns in cognitive, affective, and somatosensory areas in individuals with KOA pain. Electroencephalography neurofeedb...
Article
Introduction: Since the introduction of burst spinal cord stimulation for neuropathic pain, several companies have developed their own version of burst stimulation, which is confusing the marketplace and clinicians of what burst stimulation truly is, the value and utilization of the therapy. Areas covered: We review those two burst stimulation d...
Article
Full-text available
Tinnitus, the perception of a phantom sound, is accompanied by loudness and distress components. Distress however accompanies not just tinnitus, but several disorders. Several functional connectivity studies show that distress is characterized by disconnectivity of fronto-limbic circuits or hyperconnectivity of default mode/salience networks. The d...
Conference Paper
Background: Persistent pain is a significant contributor to disability in people living with knee osteoarthritis (KOA). Brain imaging including electrophysiological studies confirm altered cortical oscillatory, and synchrony patterns in cognitive, affective and somatosensory areas in individuals with KOA pain. Electroencephalography neurofeedback (...
Article
Background: The SUNBURST Study, a USA-based controlled cross-over trial demonstrated that burst spinal cord stimulation was superior compared to tonic stimulation in suppressing chronic intractable pain. However, when on burst stimulation, participants preferred lower to higher amplitudes. This led to the hypothesis that lower burst amplitudes wil...
Article
Full-text available
Although tinnitus retraining therapy (TRT) based on Jastreboff’s classical neurophysiological model is efficacious in most patients, its effects on the cortical activity changes responsible for the improvement of tinnitus are still unclear. In this study, we compared pre- and post-TRT resting-state quantitative electroencephalography (rs-qEEG) find...
Article
Full-text available
Introduction: Higher physical activity (PA) and lower sedentary behaviour (SB) levels have demonstrated beneficial effects on temporal summation (TS) and conditioned pain modulation (CPM) in healthy adults. This cross-sectional study investigated the relationships between PA and SB and TS/CPM responses in individuals with chronic musculoskeletal p...
Conference Paper
representations of their pain. Illness perceptions (IPs) are associated with pain severity and physical functioning in people with musculoskeletal pain conditions1. Negative IPs may adversely influence pain modulatory processes, which in turn could affect clinical pain outcomes. Therefore, the primary aim of this cross-sectional investigation was t...
Poster
Full-text available
Background and aims: Social participation has been recommended as an important therapeutic target in clinical trials in individuals with chronic joint pain.1 However, the literature pertaining to the factors influencing social participation is scarce. Therefore, the primary aim of this cross-sectional study was to determine whether demographic, pai...
Poster
Full-text available
The combination of training the infraslow frequency band (0.0-0.1) in a specific brain network is a relatively new NF approach. All possible reported effects should be controlled in order to learn more how it can affect health and well being
Article
Full-text available
In the present study, we use resting state fMRI to investigate whether nucleus accumbens (NAc) and extended frontostriatal networks are involved in the pathology of auditory phantom perception, i.e., tinnitus, through a study of functional connectivity. We hypothesize that resting state functional connectivity involving NAc will be increased relati...
Article
Full-text available
The posteromedial cortex (PMC)—comprising posterior cingulate cortex (PCC), retrosplenial cortex (RSC), and the precuneus (PrC)—is perhaps best known for its involvement in the default mode network. There is no consensus regarding the specific functions of PMC, however, and its component regions each exhibit distinct, but partially overlapping func...
Article
Background Repetitive transcranial magnetic stimulation (rTMS) has become increasingly popular during the last decades mainly driven by the antidepressant effects of dorsolateral prefrontal cortex stimulation with “butterfly” coils. Only recently, alternative targets such as the dorsomedial prefrontal cortex (dmPFC) have been brought into focus and...
Article
Full-text available
The data presented here are functional connectivity analyses based on fMRI scans from a clinical sample of the chronic tinnitus population (n = 75). All data were obtained during an experiment in which subjects listened to auditory stimuli via headphones while undergoing fMRI scanning. The stimuli consisted of tones and bandpass noise presented at...
Article
Full-text available
The posterior cingulate cortex (PCC) is involved in food craving in obese food addicted individuals. This randomised, double-blind, placebo-controlled parallel study explored the potential therapeutic effects of infraslow neurofeedback (ISF-NF) on food craving targeting the PCC in obese women with symptoms of food addiction. Participants received s...
Article
Full-text available
There is a growing research interest in the diagnosis rate of misophonia, a condition characterized by a negative emotional/autonomic reaction to specific everyday sounds. Diagnosis of misophonia requires a thorough case history and audiological test procedures. Associative and non-associative learning models for understanding the underlying mechan...
Article
Full-text available
Tinnitus is the perception of a phantom sound characterized behaviorally by a loudness and a distress component. Although a wealth of information is available about the relationship between these behavioral correlates and changes in static functional connectivity, its relationship with dynamic changes in network connectivity is yet unexplored. The...
Article
As the COMT polymorphism is especially prominent in the prefrontal cortex and has been associated with auditory gating, we hypothesize that tinnitus patients with this polymorphism have altered activity in the ventromedial prefrontal/anterior cingulate areas that modulates the tinnitus percept. To test this, we recruited a total of 40 tinnitus subj...
Article
Full-text available
Background/Objective: Non-invasive neuromodulation techniques, such as repetitive Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation (tDCS), have increasingly been investigated for their potential as treatments for neurological and psychiatric disorders. Despite widespread dissemination of these techniques, the und...
Article
Full-text available
Thalamocortical dysrhythmia (TCD) is a model proposed to explain divergent neurological disorders. It is characterized by a common oscillatory pattern in which resting-state alpha activity is replaced by cross-frequency coupling of low- and high-frequency oscillations. We undertook a data-driven approach using support vector machine learning for an...
Article
Full-text available
Aims: The prevalence of panic disorder (PD) reportedly is up to fivefold higher in people with tinnitus than it is in the general population. The brain networks in the two conditions overlap but the pathophysiological link remains unclear. In this study the electrophysiological brain activity is investigated in adults with non-pulsatile tinnitus w...
Article
Distress is a domain-general behavioral symptom whose neural correlates have been under investigation for a long time now. Although some studies suggest that distress is encoded by changes in alpha activity and functional connectivity between specific brain regions, no study that we know has delved into the whole brain temporal dynamics of the dist...