Dirk K F Meijer

University of Groningen | RUG · Senior Academy Faculty

Conformational states of living cells have typical spatial arrangements of atoms, that are characteristic for building, homeostasis, decay and apoptosis. We earlier found clear evidence, indicating that such states of biomolecules are related to spectral coherence and decoherence frequency bands, providing a quantitative physical resource. The patt...

In this chapter, we postulate an integral concept of information processing in the universe, on the basis of a new biophysical principle, coined the generalized music (GM)-scale of EMF frequencies. Meta-analyses of current biomedical literature revealed the presence of a distinct pattern of discrete EMF frequency bands in a wide range of animate an...

We submit a generalized interpretation of quantum physics on the basis of resolution of quantum indeterminacy, emerging from an integral and simultaneous change of physical relationships at the Planck scale. This model postulates "space-time instants of now" framed by us as "blinks of change" in the physical world. These "instants of now" can only...

This is the editorial letter devoted to the special issue of Quantum Biosystems, vol. 11, 2020 with the target papers of Meijer, Jerman, Melkikh and Sbitnev om Consciousness in the Universe

Part 2 of this review article provides a novel conceptual bridge between living and non-living systems, being of relevance for the areas of biophysics, brain research, as well as for mechanisms of biological evolution. As to the latter aspect, the potential role of phyllosilicates (clay materials) in the generation of a primordial biofield is treat...

Part 1 of this review article submits an integral concept of information processing in the universe on the basis of a generalized musical (GM)-scale of discrete EMF frequencies. Meta-analyses of current biophysical literature revealed the effects of similar EMF frequency patterns in a wide range of animate and non-animate systems. This provided a n...

In the transition from inanimate-to animate systems in (pre)-biological evolution, clay minerals may have played a crucial role. The current conjecture is that this was due to their structural organization leading to absorption, selection, and protection of organic biological precursor molecules, promoting the polymerization of precursor molecules...

This paper addresses the question whether electromagnetic frequencies associated with pure water are similar to those of biological systems. A literature survey was performed on intrinsic frequencies of water molecules measured across the electromagnetic spectrum using various spectroscopic technologies. The registered frequencies were plotted on a...

Conformational states of living cells have typical spatial arrangements of atoms, that are characteristic for building, homeostasis, decay and apoptosis. We earlier found clear evidence, indicating that such states of biomolecules are related to spectral coherence and decoherence frequency bands, providing a quantitative physical resource. The patt...

Reference list of all of the used publications in the meta-analysis of biological data for the verification of the EMF- coherency hypothesis, called the Generalized Music (GM) scale, that revealed a discrete pattern of alternate electromagnetic frequency bands, that are either beneficial or detrimental for life conditions. March 2020.

The current science scene displays its own basic problems, by some called the “inflation in science”. The particular, evidently counter-productive, elements are generally very well realized by individual scientists, but often are not openly discussed in the scientific community. These calamities include the lack of basic analysis of the current sci...

This paper addresses the question whether electromagnetic frequencies associated with pure water are similar to those of biological systems. A literature survey was performed on intrinsic frequencies of water molecules measured across the electromagnetic spectrum using various spectroscopic technologies. The registered frequencies were plotted on a...

This review article submits an integral concept of information processing in the universe on the basis of a generalized musical (GM)-scale of discrete EMF frequencies. Meta-analyses of current biophyisical literature revealed the effects of similar EMF frequency patterns in a wide range of animate and non-animate systems. This provided a novel conc...

Individual consciousness is considered as an expression of an underlying, non-local, quantum field, that exhibits holographic properties. This paper pays special attention to the interfacing of this field of universal consciousness and our personal brain in relation to potential afterlife. We postulate a toroidal event horizon workspace of the brai...

This compilation of articles describes the developments of medicine research in the Netherlands, with special reference to the Federation for Innovative Drug Research in the Netherlands, with Dirk K.F. Meijer as founding chairman.

Interview of Prof.dr Dirk K.F. Meijer, by Rakefet Tevor, Epoch Times Magazine, Israel. Date: 8th july, 2019. Extended English translation.

The Generalized Music (GM)-scale is an acoustic (octave-like) algorithm of 12 tones that describes the electromagnetic (EM) frequency band pattern discovered from a meta-analysis of in total 468 biomedical research papers. These studies reported either beneficial or detrimental effects of electromagnetic frequencies (EMF) on biological tissues/cell...

Quantum entangled life conditions and graded states of consciousness in the universe are scale invariant and areguided by a quantum wave meta-language in a superfluid quantum space/ zero-point energy field that is instrumental in creating quantum coherent states through pilot wave resonant connectivity. This interacting dynamic EM field is steering...

This paper addresses the question whether superconductive phenomena in superconductive materials and in life systems have common physical grounds. An extensive literature survey was performed with regard to intrinsic energy gap frequencies reported on a range of superconductor materials as measured by different spectroscopic technologies. The regis...

The Generalized Music (GM)-scale is an acoustic (octave-like) algorithm of 12 tones that describes the EM frequency band pattern discovered from a meta-analysis of in total 468 biomedical research papers. These studies reported either beneficial or detrimental effects of electromagnetic radiation (EMF) on biological tissues/cells in vitro or whole...

This paper addresses the question whether electromagnetic frequencies measured in pure water have common physical grounds with conditions in normal life systems. A literature survey was performed with regard to intrinsic frequencies of water molecules reported on different ranges of frequencies measured by a spectrum of various spectroscopic techno...

This paper addresses the question whether superconductive phenomena in superconductive materials and in life systems have common physical grounds. An extensive literature survey was performed with regard to intrinsic energy gap frequencies reported on a range of superconductor materials as measured by different spectroscopic technologies. The regis...

The concept of an Universal Knowledge Field was previously also framed as Universal Consciousness, Cosmic Consciousness, Universal Mind, Universal Memory, Universal Intelligence, Holographic Memory, Collective Consciousness, Implicate order and the Plenum, among many other terms. The concept that information can take a universal character and that...

In this mini-review we describe our recent work, summarizing 13 publications, integrating their concepts and picturing potential perspectives. The history of the discovery of the generalized music (GM)-scale is highlighted in relation to the areas of bio-field research and quantum biology. The central message is that nature may be guided by a discr...

processes in the light of currently defined ideas on the societal flow of knowledge and conservation of information, using the versatile physical concept of toroidal geometry. This should be seen as a heuristic model that is open for further development and evolution. The scientific process, has been often described as a iterative and/or recurrent...

The current geometric and thermodynamic approaches in protein folding studies do not provide a definite solution to understanding mechanisms of folding of biological proteins. A major problem is that the protein is first synthesized as a linear molecule that subsequently must reach its native configuration in an extremely short time. Hydrophobicity...

In 1905 Einstein proposed the idea that electromagnetic radiation is quantized and appears only in defined energy packets. The energy of a photon for a given type of radiation can be computed using the frequency relation published in 1900 by Planck. It is proposed in the present paper that the energy distribution of these packets is according to a...

This is an overview of recent publications (2012-2018) of Dirk K. F. Meijer, University of Groningen, The Netherlands: Titles and abstracts

Abstract Carcinogenesis fits in a frequency pattern of electromagnetic field (EMF) waves, in which a gradual loss of cellular organization occurs. Such generation of cancer features can be inhibited by adequate exposure to coherent electromagnetic frequencies. However, cancer can also be initiated and promoted at other distinct frequencies of elect...

The underlying rules for a natural system describing cellular automata are simple, but produce highly complex behavior. A mathematical basis for the spectra of discrete coherent and non-coherent electromagnetic (EM) frequencies was derived, in which the algorithm exhibits an information distribution according to ratios of 2:3 in 1:2 at a semi-harmo...

A novel biophysical principle: the GM-model was revealed, describing an al-gorithm for coherent and non-coherent electromagnetic (EM) frequencies that either sustain or deteriorate life conditions. The particular frequency bands could be mathematically positioned on a Pythagorean scale, based on information distribution according to ratios of 2:3 i...

Solitons, as self-reinforcing solitary waves, interact with complex biological phenomena such as cellular self-organization. A soliton model is able to describe a spectrum of electromagnetism modalities that can be applied to understand the physical principles of biological effects in living cells, as caused by endogenous and exogenous electromagne...

Solitons or polarons, as self-reinforcing solitary waves, interact with complex biological phenomena such as cellular self-organization. Such soliton models are able to describe a spectrum of electromagnetism (EM) modalities, that can be applied to understand the physical principles of biological effects in living cells, as caused by endogenous and...

Our brain is not a "stand alone" information processing organ: it acts as a central part of our integral nervous system with recurrent information exchange with the entire organism and the cosmos. In this study, the brain is conceived to be embedded in a holographic structured field that interacts with resonant sensitive structures in the various c...

The current protein folding literature is reviewed. Two main approaches to the problem of folding were selected for this review: geometrical and biophysical. The geometrical approach allows the formulation of topological restrictions on folding, that are usually not taken into account in the construction of physical models. In particular, the topol...

Solitons, as self-reinforcing solitary waves, interact with complex biological phenomena such as cellular self-organization. This soliton model is able to describe a spectrum of electromagnetism (EM) modalities, that can be applied to understand the physical principles of biological effects in living cells, as caused by endogenous and exogenous ele...

Physical and biological evidence has been found for the hypothesis that carcinogenesis fits in a frequency pattern of electromagnetic (EM) waves, in which a gradual loss of cellular organization occurs. We find that cancer can be initiated and promoted at typical frequencies of electromagnetic waves positioned in decoherent soliton frequency zones....

The current geometric and thermodynamic approaches in protein folding mechanisms do not provide a definite solution to the modeling of folding of biological proteins. This in spite of the fact that in various studies impressive progress was made. A major problem (the so called Levinthal paradox) is that the protein is first synthesized as a linear...

Solitons, as self-reinforcing solitary waves, interact with complex biological phenomena such as cellular self-organization. This soliton model is able to describe a spectrum of electromagnetism (EM) modalities, that can be applied to understand the physical principles of biological effects in living cells, as caused by endogenous and exogenous ele...

Abstract Processes of Science and Art, Modeled by Toroidal Flux of Information Dirk K.F. Meijer, PhD An attempt is made to model the structure of science and art discovery processes, in the light of currently defined ideas on the societal flow of knowledge and conservation of information, using the versatile physical concept of toroidal geometry...

Recently, a novel biological principle, revealing specific electromagnetic (EM) radiation frequencies that sustain life, was presented by us on the basis of an evaluation of 175 biological articles concerning beneficial effects of electromagnetic waves on the state of living cells. This concept was also based on a very similar range of frequencies...

1. Beeldvorming en informatieverwerking in de cultuur: het memen concept Onze wereld, zoals die zich aan ons voordoet, bestaat uit materie (in al haar gedaanten), energie (in al haar vormen) en informatie (in al haar varianten) (zie ref. 3-10). In de biologische en culturele evolutie, met een steeds toenemende complexiteit, is informatie een zeer c...

Solitons, as self-reinforcing solitary waves, interact with complex biological phenomena such as cellular self-organisation. Soliton models are able to describe a spectrum of electromagnetism modalities that can be applied to understand the physical principles of biological effects in living cells, as caused by electromagnetic radiation. A bio-soli...

We propose a hypothesis of a mathematical algorithm for coherent quantum frequencies, that may create stability of biological order. The concept is based on an extensive literature survey, comprising 175 articles from 1950 to 2015, dealing with effects of electromagnetic radiation on in vitro and in vivo life systems, indicating that typical discre...

This essay highlights the scientific vision of John Archibald Wheeler, a giant of 20th century physics. His ideas provided the important insight that humanity may be in the very center of disclosure and manifestation of the evolution of our universe. This on the basis of scientific reasoning derived from quantum physics rather than simple anthropoc...

The present knowledge of the brain neurology, collectively, is insufficient to explain higher mental processes such as (self)-consciousness, qualia, intuition, meditative states, transpersonal experiences as well as ultra rapid brain responses and functional binding between distant parts of the brain. It is proposed that super-causal space-time con...

Contents: Introduction in Quantum aspects of brain function, p 1-19 Quantum approaches to neurobiology: state of art, p 19-31 David Bohm: Wholeness and the implicate order, p 30-39 Henry Stapp: Attention, intention and quantum coherence, p 39-44 Roger Penrose: Consciousness and the geometry of universe, p 45-54 Stuart Hameroff: Objective reduction...

This essay highlights the scientific vision of John Archibald Wheeler, a giant of 20th century physics. His ideas provided the important insight that humanity may be in the very center of disclosure and manifestation of the evolution of our universe. This on the basis of scientific reasoning derived from quantum physics rather than simple anthropoc...

Immortality, in the personal sense, is defined as the potential to freely choose the moment of individual death, rather than having the meaning of eternal life. Man is a symbol and metaphor-creating being who apprehends the world through his imaginary power. The desire to give a place to an “inevitable“ individual death, has led mankind to many pow...

Information is considered as a fundamental building block of reality, along with matter and energy. Yet the word information is often employed as a container term that represents many different modalities ranging from information constituting a physical parameter to the daily transmission of the news in human culture. Information is particularly kn...

Taking into account the constituting elements of the human brain, such as neuronal networks, individual neurons, trans-membrane ion-fluxes and energy producing cellular metabolism as well as other molecules that promote neural activity, there is clear consensus that the present knowledge of the brain, collectively, is insufficient to explain higher...

There are many good reasons to ask basic questions on the construction of reality. These questions not only concern the structure of the world we live in and how we perceive it, but also the mysteries of how our Universe was born and how it will evolve in the far future. This article aims to highlight the prominent role of information in the manife...

The sections in this article are:

Selective targeting of drugs to the kidney may enable an increased renal effectiveness combined with a reduction of extrarenal toxicity. Intrarenal delivery to the proximal tubular cell can be achieved using low-molecular-weight proteins, such as lysozyme. Administration of high dosages of lysozyme, required to study the effects of such conjugates...

The Rho kinase pathway plays an important role in dedifferentiation of epithelial cells and infiltration of inflammatory cells. For testing of the hypothesis that blockade of this cascade within the kidneys might be beneficial in the treatment of renal injury the Rho kinase inhibitor, Y27632 was coupled to lysozyme, a low molecular weight protein t...

Lactoferrin (Lf) is a potential drug candidate for the treatment of oropharyngeal Candida infections. However, for an effective therapeutic treatment an appropriate dosage form is required. Therefore a mucoadhesive tablet for buccal application was developed. Tablets of sufficient strength could be produced on high speed tabletting machines, but th...

Abstract Pharmacokinetics, biodistribution, and excretion of the α-glucosidase inhibitor and antiviral compound N-benzyl-1-deoxynojiri-mycin (BndNM) were studied in mice, after intravenous, subcutaneous, and oral administration of a single radiolabeled dose. No metabolites were detected in plasma, urine, or feces extracts. BndNM, a lipophilic deriv...

Approximately 80% of the kidney is composed of tubular cells which secret and reabsorb substances to and from the urine. Activated tubular cells play a pivotal role in the etiology of renal fibrosis. During renal injury, these activated tubular cells participate in the initiation of fibrogenic processes which eventually may lead to tubulointerstiti...

Cell culture models have contributed significantly to the study of liver fibrosis, but cannot accurately incorporate in vivo cell-cell and cell-extracellular matrix interactions or account for the heterogeneity of the fibrogenic cell population involved in fibrosis development. Thus, there persists a need for an in vitro model that mimics the in vi...

Activation of tubular epithelial cells by transforming growth factor-beta (TGF-beta) plays an important role in the pathogenesis of renal tubulointerstitial fibrosis. We developed a renally accumulating conjugate of a TGF-beta type-I receptor kinase inhibitor (TKI) and evaluated its efficacy in vitro and in vivo. TKI was conjugated to the protein L...

For non-viral gene delivery we prepared stabilized plasmid lipid particles (SPLPs), to which lactoferrin (LF) was coupled as a hepatocyte specific targeting ligand. LF-SPLPs and untargeted SPLPs labeled with [3H]cholesteryloleyl-ether were injected into rats. About 87% of the LF-SPLPs were eliminated from the blood within 5 min, while 80% of untarg...

1. Beeldvorming en informatieverwerking in de cultuur: het memenconcept Onze wereld, zoals die zich aan ons voordoet, bestaat uit materie (in al haar gedaanten), energie (in al haar vormen) en informatie (in al haar varianten). In de biologische en culturele evolutie, met een steeds toenemende complexiteit, is informatie een zeer centraal aspect. I...

In fibrotic livers, collagen producing hepatic stellate cells (HSC) represent a major target for antifibrotic therapies. We designed liposomes with surface-coupled mannose 6-phosphate (M6P) modified human serum albumin (HSA) to target HSC via the M6P receptor. In this study we determined the pharmacokinetics and target specificity of M6P-HSA-liposo...

Liver fibrosis is characterized by excessive proliferation and activation of hepatic stellate cells (HSC), a process in which platelet-derived growth factor (PDGF) plays an important role. Inhibition of liver fibrosis via specific delivery of a PDGF kinase inhibitor to HSC might therefore be an attractive strategy. The HSC-selective carrier mannose...

Chronic liver injury of various etiologies can cause liver fibrosis, which is characterized by the progressive accumulation of connective tissue in the liver. As no effective treatment for liver fibrosis is available yet, extensive research is ongoing to further study the mechanisms underlying the development of disease- or toxicity-induced liver f...

In the fibrotic liver, hepatic stellate cells (HSC) produce large amounts of collagen and secrete variety of mediators that promote development of fibrosis in this organ. Therefore, these cells are considered an attractive target for antifibrotic therapies. We incorporated the bioactive lipid dilinoleoylphosphatidylcholine (DLPC) into the membrane...

Succinylated human serum albumin (Suc-HAS) is a negatively charged neo-glycoprotein that binds to the positively charged V3-loop of HIV-1 gp120, acting as HIV-1-fusion inhibitor in vitro (IC50: 0.5-5.0 microg/ml). Suc-HSA was safe in rats and monkeys, and showed antiretroviral effect in a human-to-mouse model. We evaluated safety and pharmacokineti...

Hepatic stellate cells (HSC) are a major target for antifibrotic therapies in the liver and in particular gene delivery to these cells would be relevant. Previously, we demonstrated that mannose 6-phosphate human serum albumin (M6P-HSA) coupled liposomes accumulate in HSC in fibrotic livers. Here we prepared a M6P-HSA modified viral vector that all...

Current cell culture models contributed significantly to the study of liver fibrosis and the testing of anti-fibrotic drugs but mimic the complex in vivo milieu poorly. Therefore, we evaluated fibrotic rat liver slices as a new, more physiologic in vitro model to test anti-fibrotic compounds. Precision-cut slices (8 mm diameter, 250 microm thicknes...

During renal injury, activation of p38 mitogen-activated protein kinase (MAPK) in proximal tubular cells plays an important role in the inflammatory events that eventually lead to renal fibrosis. We hypothesized that local inhibition of p38 within these cells may be an interesting approach for the treatment of renal fibrosis. To effectuate this, we...

Hepatic stellate cell (HSC) activation is a key event in wound healing as well as in fibrosis development in the liver. Previously we developed a technique to induce HSC activation in slices from rat liver. Although this model provides a physiologic, multicellular milieu that is not present in current in vitro models it might still be of limited pr...

Hepatic stellate cell (HSC) proliferation is a key event in liver fibrosis; therefore, pharmacological intervention with antiproliferative drugs may result in antifibrotic effects. In this article, the antiproliferative effect of three cytostatic drugs was tested in cultured rat HSC. Subsequently, the antifibrotic potential of the most potent drug...