Dipasmita Pal-Nath

Dipasmita Pal-Nath
National Institutes of Health | NIH · Center for Cancer Research

PhD Microalgal Biotechnology

About

23
Publications
6,158
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788
Citations

Publications

Publications (23)
Article
Full-text available
We examined responses of batch cultures of the marine microalga Nannochloropsis sp. to combined alterations in salinity (13, 27, and 40 g/l NaCl) and light intensity (170 and 700 μmol photons/m(2)·s). Major growth parameters and lipid productivity (based on total fatty acid determination) were determined in nitrogen-replete and nitrogen-depleted cu...
Article
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We investigated the effects of osmotic downshift induced by the transfer of Nannochloropsis oceanica CCALA 804 from artificial seawater medium (27 g L(-1) NaCl) to the same medium without NaCl or freshwater modified BG-11 medium (mBG-11) as a function of photosynthetically active radiation (170, 350, or 700 μmol photon m(-2) s(-1)). Alterations in...
Article
Full-text available
We investigated effects of irradiance on the relationships between chlorophyll fluorescence transients (OJIP), carotenoid-to-chlorophyll ratio, and fatty acids in a nitrogen-deprived Parietochloris incisa (Chlorophyta, Trebouxiophyceae) Δ5 desaturase mutant accumulating valuable LC-PUFA dihomo-γ-linolenic acid (DGLA). High light (270 μE·m− 2·s− 1 P...
Article
The Δ5 desaturase mutant (P127) of the microalga Lobosphaera incisa is a promising organism for large-scale production of the valuable LC-PUFA dihomo-gamma-linolenic acid (DGLA, 20:3 n-6). We examined the potential of P127 for DGLA production under nitrogen (N) starvation conditions, triggering the deposition of DGLA in triacylglycerols, and develo...
Article
Full-text available
The identification of thrombospondin-1 as an angiogenesis inhibitor in 1990 prompted interest in its role in cancer biology and potential as a therapeutic target. Decreased thrombospondin-1 mRNA and protein expression are associated with progression in several cancers, while expression by nonmalignant cells in the tumor microenvironment and circula...
Article
Full-text available
Elevated CD47 expression in some cancers is associated with decreased survival and limited clearance by phagocytes expressing the CD47 counter-receptor SIRPα. In contrast, elevated CD47 mRNA expression in human melanomas was associated with improved survival. Gene expression data was analyzed to determine a potential mechanism for this apparent pro...
Article
Full-text available
CD47 is a ubiquitous cell surface receptor that directly regulates T cell immunity by interacting with its inhibitory ligand thrombospondin-1 and limits clearance of cells by phagocytes that express its counter-receptor signal-regulatory protein-α. Murine natural killer (NK) cells express higher levels of CD47 than other lymphocytes, but the role o...
Article
Triacylglycerol (TAG) is the major storage lipid in most terrestrial plants and microalgae, and has great nutritional and industrial value. Since the demand for vegetable oil is consistently increasing, numerous studies have been focused on improving the TAG content and modifying the fatty‐acid compositions of plant seed oils. In addition, there is...
Article
The oleaginous microalga Lobosphaeraincisa(Trebouxiophyceae, Chlorophyta)contains arachidonic acid (ARA, 20:4 n-6) in all membrane glycerolipids and in the storage lipidtriacylglycerol.The optimal growth temperature of the wild-type (WT) strain is 25°C; chilling temperatures (≤15oC) slow its growth. This effect is more pronounced in the delta-5-des...

Projects

Project (1)
Project
Insights into the role of LC-PUFA in the green microalga Lobosphaera incisa