Dipanjan Karati

• Master of Pharmacy
• Assistant Professor at School of Pharmacy Techno India University West Bengal

Airborne transmission of the bacterial illness tuberculosis (TB) is attributed to Mycobacterium tuberculosis (Mtb). Mycobacterium tuberculosis, a multidrug-resistant strain, spreads quickly and is the cause of multidrug-resistant tuberculosis (MDRTB). A study was conducted to investigate the possible antitubercular interactions between produced 4-a...

Breast cancer is still one of the major causes of cancer‐related death worldwide, which highlights the need for cutting‐edge therapeutic strategies. An alkaloid called piperine, which comes from Piper longum, has demonstrated encouraging anticancer effects. Piperine modulates different cancer signaling pathways and enzymes such as P53, apoptosis, a...

Purpose of Review In healthcare, biomarkers are essential for personalised medicine, prognosis, therapy response, and disease diagnosis. They make it possible for better patient outcomes, early detection, and intervention. They support customised treatment programs, anticipate the progress of diseases, and direct treatment decisions. Different type...

In immunotherapy, peptide-based medications are showing great promise as a new class of therapies that can be used to treat autoimmune diseases, cancer, and other immune-related conditions. Peptides are being created for use in immunotherapy as vaccines, immunological modulators, and adjuvants because of their capacity to precisely alter immune res...

Objective: Flavonols have different pharmacological actions that render them highly promising therapeutic targets. However, their water solubility and bioavailability are low, which restricts their therapeutic potential. ABNPs, albumin-based nanoparticles, are potential nanocarriers that enhance flavonol solubility, stability, and targeted deliver...

Cancer is a disease that is considered one of the worst in the world, and as a result, researchers are constantly looking for natural remedies to alleviate the negative effects of conventional cancer therapy. p53, a tumor suppressor protein, and its inhibitor, MDM2, an oncogenic protein, are becoming increasingly important in cancer therapy. Comput...

Lawsone is the primary compound in the Henna plant, known for its medicinal and colouring properties. This study aimed to design and evaluate new derivatives of bis-2-hydroxy-1,4-naphthoquinone with promise anti-malarial, anti-HIV, and diuretic properties by targeting specific enzymes: Plasmepsin II, HIV protease I, and carbonic anhydrase I. Using...

With 60–70% of all occurrences of dementia, Alzheimer’s disease (AD), an advancing neurological illness, is one of the most frequent causes of dementia. Even though the exact etiology of AD is still unidentified, persons who have the disease have been found to have a number of abnormalities in their brains. Apart from the buildup of amyloid-β plaqu...

The favourable results of Chimeric Antigen Receptor (CAR) T-cell therapy in the management of hematologic malignancies have heightened the formerly unparalleled enthusiasm for employing this novel strategy in the treatment of diverse types of human malignancies. Although there has been a lot of study on increasing the effectiveness of these cells i...

Central nervous system disorders are likely to have a substantial effect on the worldwide healthcare demands of humanity in this era. Alzheimer’s disease (AD) is a senile decay of neurons. Extracellular beta-amyloid accumulation and intracellular tau hyperphosphorylation are two key characteristics of the pathogenesis of AD. Because of the multifac...

Even with recent advancements in surgery and multimodal adjuvant therapy, brain cancer treatment is still difficult. The blood-brain barrier and the potentially deadly medications' nonspecificity have made pharmacological treatment for brain cancer particularly ineffective. The nanoparticle has surfaced as a viable brain delivery vector that can so...

As a bioactive heterocyclic congener, isatin has a wide range of pharmacological and biological uses. Due to their numerous potential uses, it is becoming increasingly important to design inventive isatin and its analogs. Additionally, it is essential to disclose groundbreaking techniques for synthesizing this nucleus, examine the various potencies...

This study demonstrates the scope for N-(5-cyano-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4-yl)-2-(phenylamino)acetamide to develop as promising anticancer agents. Several N-(5-cyano-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4-yl)-2-(phenylamino)acetamide derivatives were synthesized by reflux method and assessed their anticancer activity by in silico r...

Alzheimer’s disease (AD), the most common type of dementia among older adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive functioning with a decline of rational skills. It is well known that AD is multifactorial, so there are many different pharmacological targets that can be pursued. According to estimates...

Cancer involves the uncontrolled, abnormal growth of cells and affects other tissues. Kinase has an impact on proliferating the cells and causing cancer. For the purpose of treating cancer, PIM kinase is a potential target. The pro-viral Integration site for moloney murine leukaemia virus (PIM) kinases is responsible for the tumorigenesis, by phosp...

Pharmaceutical research is increasingly focusing on transdermal drug delivery due to its potential for improved compliance and bioavailability. However, it is challenging due to the tight intracellular junctions present in the skin. Researchers have developed noninvasive methods, like transfersomes, to overcome these challenges. Transfersomes are u...

Nanotechnology exhibits a wide range of applications in the domain of disease therapy, diagnosis, biological detection, and environmental safeguards. The cross-linked polymeric nanosponges (NSs) are a nanoscale drug carrier system with a 3D porous structure and high entrapment efficacy. NSs up to the fourth generation are currently accessible and c...

Cubosomes, a novel drug delivery system, have gained significant attention in recent years due to their unique self-assembled structures and enhanced drug encapsulation capabilities. They are administered by oral, ophthalmic, transdermal, and chemotherapeutic routes, to name a few. Due to their many potential benefits—which include high drug disper...

Alzheimer’s disease, characterized by the accumulation of abnormal protein aggregates and neuronal damage in the brain, leads to a gradual decline in cognitive function and memory. As a complex neurodegenerative disorder, it involves disruptions in various biochemical pathways and neurotransmitter systems, contributing to the progressive loss of ne...

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most prevalent form of senile dementia, causing progressive deterioration of cognition, behavior, and rational skills. Neuropathologically, AD is characterized by two hallmark proteinaceous aggregates: amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) formed of hyperphosphory...

Cancer is a life-threatening disease, and there are very few options to treat it almost completely, with a high percentage of success rates. Proton therapy is a very unique and one of the latest techniques to treat cancer with a very promising percentage of success rate. In this therapy, a proton particle with high velocity is used, and it is super...

Background: Worldwide, cancer is the second most common cause of death. Chemotherapy and other traditional cancer treatments have toxicities that affect normal cells in addition to their intended targets, necessitating the development of novel approaches to enhance cell-specific targeting. Methods: The present work summarizes the scientific inform...

The meninges serve as a protective layer, and the fluid around the brain and spinal cord can become inflamed, known as meningitis. Lipid-based pharmaceutical formulations, by their high lipophilicity, can negotiate the Blood-Brain Barrier (BBB). The current mode of treatment of meningitis is mainly through antibiotics, which, at best, is partially...

Background New nanoparticles (NPs) and biomaterials are utilized more frequently in biological research for vaccinations, diagnostic procedures, and drug administration. Nanomaterials are materials with d50 value from 1 to 100nm. They are also found in various consumer goods, the environment, and work. Thus, it has become crucial for the appropriat...

Cancer, a widespread challenge to global health, remains a puzzle of intricate molecular dynamics. This review article delves into the mystery of cancer, with a keen focus on understanding the contributory role of thymidylate synthase (TS) in cancer. TS, a vital enzyme in DNA synthesis and repair, emerges as a significant player in the narrative of...

In developing new cancer medications, attention has been focused on novel epigenetic medicines called histone deacetylase (HDAC) inhibitors. Our understanding of cancer behavior is being advanced by research on epigenetics, which also supplies new targets for improving the effectiveness of cancer therapy. Most recently published patents emphasize H...

Chalcone derivatives continue to captivate medicinal chemists due to their modest chemistry, facile synthetic method, and promising biological activities. They have become wellknown in the therapeutic and pharmaceutical industries due to their diverse biological actions. These complexes offer different features and applications in a human biologica...

Innovative colloidal preparations that can alter the pharmacological properties of drugs have been made possible by the advancement of nanotechnology. Recent advances in the sciences of the nanoscale have led to the creation of new methods for treating illnesses. Developments in nanotechnology may lessen the side effects of medicine by using effect...

Background Polycystic ovarian syndrome (PCOS) has emerged as one of the most common endocrine and metabolic disorders seen in women of childbearing age throughout the whole world. The complex pathophysiology, different diagnostic criteria, and various manifestations attached to several environmental factors, including lifestyle influences, have mad...

Mitosis of somatic cells produces a daughter cell. Apoptosis, a naturally programmed cellular death mechanism, kills abnormal cells produced by mitosis. Cancer can develop when this equilibrium is disrupted, either by an upsurge in cell propagation or a reduction in tissue demise. Cancer therapy aims to cause cancer cells to die while inflicting li...

The book summarizes the role of multiple enzyme targets and strategies to design and develop novel drug candidates for Alzheimer's disease (AD). Insights from researchers across the globe from diverse fields are presented in a thematic volume. The chapters highlight current information scientists have unraveled about the origin, pathogenesis and pr...

Ocular infirmities significantly influence a person’s routine process by impairing vision to the point of blindness. Effective ocular drug administration with significant bioavailability is challenging due to physiology and defensive mechanisms, which is majorly due to inadequate epithelial permeability and quick removal of the drug from the eye af...

Cancer is one of life's most difficult difficulties and a severe health risk everywhere. Except for haematological malignancies, it is characterized by unchecked cell growth and a lack of cell death, which results in an aberrant tissue mass or tumour. Vascularization promotes tumor growth, which eventually aids metastasis and migration to other par...

In an uncontrolled inflammatory environment, the complex process of lung carcinogenesis occurs. Lung cancer remains the leading cause of cancer-related mortality worldwide. The average 5-year survival rate is still low despite significant advancements in our knowledge of lung carcinogenesis and the development of innovative therapies in recent deca...

A human-machine interface (HMI) is all the hardware and software components that allow a human user and a machine to engage in an interactive system to complete a specific task. HMI technologies can be referred to as a particular type of information technology because they include all equipment used to transfer and present data and commands inside...

Age-related macular degeneration (AMD) is a leading cause of permanent blindness globally. Due to the various obstacles, highly invasive intravitreal (IVT) injections are the prima-ry method used to deliver medications to the tissues of the posterior eye. An utmost patient-friendly topical ocular delivery approach has been extensively researched in...

Multiple genetic, environmental, and immunological variables cause neuropsychiatric disorders (NPDs). The induced inflammatory immune response is also connected to the severity and treatment outcomes of various NPDs. These reactions also significantly impact numerous brain functions such as GABAergic signaling and neurotransmitter synthesis through...

Research into drug delivery and tissue engineering (TE) has made great strides in the current era because of its limitless potential to enhance human health. In the meantime, the advancement of nanotechnology offers chances to categorize, control, and arrange orderly arrangements of materials at the nanoscale ranking. Biomaterials with the nanoscal...

Nanotechnology augmentation have enabled the creation of innovative colloidal preparations that can modify the pharmacological characteristics of medications. Numerous effective applications in the treatment of cancer have been made possible by the distinctive physicochemical and technological characteristics of therapies based on nanomaterials. To...

In the recent era, developments in the field of bio-inorganic chemistry have improved interest in Schiff base complexes (imine scaffolds) for their pharmacological excellence in different areas. Schiff bases are a kind of synthetic molecule that is synthesized by the condensation reaction between a 1o amine and a carbonyl compound. Imine derivative...

All biological tissues and bodily fluids include the autacoid adenosine. The P1 class of purinergic receptors includes adenosine receptors. Four distinct G-protein-coupled receptors on the cellular membrane mediate the effects of adenosine, whose cytoplasmic content is regulated by producing/degrading enzymes and nucleoside transporters. A2A recept...

Background: A novel human virus called coronavirus, SARS-CoV-2, or COVID-19, has become a pandemic disease. It was started last week of November 2019 in Wuhan, a city in China. It causes severe respiratory tract infections and other diseases. It is transmitted from human to human within incubation times between two to ten days. It is spread via dro...

Background: The primary driving force behind the development of several small molecules for the treatment of tuberculosis is multi-drug resistance. A new fluorinated heterocyclic benzimidazole derivative gives extensive pharmacological activity against the FtsZ protein. FtsZ is a new validated target for tuberculosis drug design. It is a cell divis...

Background: The World Health Organization describes traditional medicine as a variation of health practises, approaches, knowledge, and beliefs that include manual techniques, exercises, spiritual therapies, and medications derived from plants, animals, or minerals that are used separately or in combination to promote health and prevent disease. Ap...

The delivery of drugs to different parts of the eye through conventional approaches has been a troublesome task for years, and the urge to overcome the disadvantages of these formulations leads to the discovery of nanosized particle-based ocular formulations that are provided with numerous advantages over the previous attempts. Medical applications...

Chromatography is a method for the isolation of a mixture into separate sections. It is usually based on the principle of partition of solute between two phases. It usually consists of a mobile phase and a stationary phase. The advancement of the mobile process in the planar stationary stage is evoked by different external or internal forces. Capil...

Bio-responsive polymers are the cornerstone of the creation of keen structures which, after getting unique stimuli like biotic indications as well as pathological irregularities, exhibit engineered biomedical functions. The creation of innovative products in precision medicine (a type of medicine that uses a person's own gene or protein knowledge t...

The World Health Organization defines traditional medicine as a variety of health practises, approaches, knowledge, and beliefs that include manual techniques, exercises, spiritual therapies, and medications derived from plants, animals, or minerals that are used singly or in combination to promote health and treat or prevent disease. Traditional C...

Glycogen synthase kinase-3 beta (GSK-3β) is a desired pharmacological target for cancer treatment. Despite its role in the development of various cancers, any target directing GSK-3 inhibitors have not been authorized for cancer treatment. The therapeutic importance of this enzyme is reflected in its monitoring character in autophagy, genetic mater...

Disorders of the central nervous system are expected to have a profound impact on the global healthcare needs of the human community in this era. Alzheimer disease (AD) is senile decay of neurons. The hallmark of pathophysiology of AD disease has two pivotal features example- extracellular beta amyloid deposition and intracellular tau hyper phospho...

Aim The research aims to develop a sustainable microwave-assisted scheme for synthesizing 5-(benzylidene amino)-1-phenyl-1H-pyrazole-4-carbonitrile congeners. Background 5-(benzylideneamino)-1-phenyl-1H-pyrazole-4-carbonitrile scaffolds are novel molecules having various pharmacological activities such as neurodegenerative, anti-microbial, anti-ca...

Bio-responsive polymers are the cornerstone of the creation of keen structures which, after getting unique stimuli like biotic indications as well as pathological irregularities, exhibit engineered biomedical functions. The creation of innovative products in precision medicine (a type of medicine that uses a person’s own gene or protein knowledge t...

Background : As the unique value of medicinal Dendrobium species has gradually been recognized, the growing demand is causing pressure on wild populations. The present work aimed to perform in-silico study of a novel phytosterol isolated from Dendrobium ochreatum. From phytochemical analysis, the presence of steroids was observed only in chloroform...

Skeletal muscle mass responds rapidly to growth stimuli, precipitating hypertrophies (increased protein synthesis) and hyperplasia (activation of the myogenic program). For ages, muscle degeneration has been attributed to changes in the intracellular myo ber pathways. ese pathways are tightly regulated by hormones and lymphokines that ultimately pa...

The genus Ficus is a very useful and significant group of trees with various therapeutic properties. Ficus racemosa linn. is a standard-sized tree in the Moraceae family, often known as the cluster fig tree. Ficus racemosa is also known as yajnayoga, udumbara, goolar, dumar, bodda, heibong, jantuphalam, dimri, yogga dumur, and many more names. Ficu...

Cyclin Dependent Kinase 9 (CDK9), which controls transcriptional elongation, is a promising pharmacological target for a variety of cancerous cells, specifically those characterized by transcriptional dysregulation. CDK9 promotes the pause or release of RNA polymerase II, a rate-limiting stage in normal transcriptional regulation that is often dist...

Cancer is the second most reason for huge mortality in human life which has attributed to a drastic drift in anticancer drug discovery and development. Small molecules as anticancer agents have contributed tremendously for the treatment of cancer however plants based natural products have the cardinal foundation for traditional medicine schemes and...

Background - The present work aimed to isolate one steroidal molecule from Dendrobium ochreatum. From phytochemical analysis, the presence of steroids was observed only in chloroform extracts of the stem, and the antimicrobial activities supported the extracts to be the most significant one, so work was aimed at isolating the chloroform extracts of...

Aim The research work aims to develop sustainable microwave-assisted scheme for the synthesis of 4-(benzylidene amino)-6-phenylpyrimidine-5-carbonitrile congeners. Background 4-(benzylidene amino)-6-phenylpyrimidine-5-carbonitrile scaffolds are novel molecules having various pharmacological activities such as neurodegenerative, anti-microbial, ant...

Background: Pyrazole is a component of a diversity of bioactive heterocyclic congeners with a broad-spectrum range of biological and pharmacological uses. Designing novel pyrazole and its analogues, revealing new routes for synthesizing this nucleus, exploring various potencies of that heterocycles, and looking for possible applications of pyrazol...

Background Pyrazole is a bioactive heterocyclic congener found in a wide range of biological and pharmacological applications. Due to their multiple prospective uses, developing innovative pyrazoles and analogues, disclosing revolutionary ways for synthesizing this nucleus, investigating diverse potencies of that heterocycle, and seeking for possib...

Cancer is a leading cause of death worldwide. The Janus kinase (JAK) signal transducer and activator of transcription (STAT) signalling pathway is activated abnormally, which promotes carcinogenesis. Several cytokines are important cancer drivers. These proteins bind to receptors and use the Janus kinase (JAK) and STAT pathways to communicate their...

Pyrimidine nucleus has a wide spectrum use in medicinal chemistry. Based on structure activity relationship of pyrimidine nucleus we are going to synthesize 4-amino-2-methyl-6-phenylpyrimidine-5-carbonitrile derivatives. In this structure one primary amine group is free at 4th position. Schiff base has excellent antibacterial, antifungal, antiviral...

Cancer is considered one of the gruelling challenges and poses a grave health hazard across the globe. According to the International Agency for Research on Cancer (IARC), new cancer diagnoses increased to 18.1 million in 2018, with 9.6 million deaths, bringing the global cancer rate to 23.6 million by 2030. In 1942, the discovery of nitrogen musta...

COVID-19 through all the world in extreme tension. Gradually thousands of people are being affected day by day. Some of them are cured and some face death. No medicine is discovered till today. One thing is noticeable that the persons having proper immunity power are the winner of COVID-19. There are so many ways-proper nutrition and diet-to increa...