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Dinorah Marisabel Prada Hernández

Dinorah Marisabel Prada Hernández
Centro de Referencia de Enfermedades Reumáticas. Cuba · Departamento docente

Doctor of Medicine

About

37
Publications
5,484
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257
Citations
Introduction
Ensayo Clínico. Fase II. Eficacia y seguridad del CIGB 814 en administración sudcutánea combinado con metotrexate en pacientes con artritis reumatoide. Investigador principal
Education
January 2019 - December 2021
Universidad de Ciencias Médicas de la Habana
Field of study
  • Tratamiento biológico en Artritis Reumatoide

Publications

Publications (37)
Article
Full-text available
Rheumatoid arthritis (RA) is a chronic T cell-mediated autoimmune disease. Serum autoantibodies against cyclic citrullinated peptides (anti-CCP) are significant markers for diagnosis and prognosis of this disease. Induction of immune tolerance as therapeutic approach for RA constitutes a current research focal point. In this sense, we carried out a...
Article
Introducción: La artritis reumatoide es una enfermedad autoinmune caracterizada por la presencia de anticuerpos contra péptidos citrulinados, que constituyen indicadores para el diagnóstico de la enfermedad. Es necesario determinar la utilidad de diferentes métodos de determinación de estos anticuerpos para el diagnóstico de pacientes cubanos con a...
Article
Systemic lupus erythematosus is an inflammatory disease that mainly affects women of childbearing age. There are multiple implications of this entity on pregnancy, and pregnancy can be an activator of disease activity. It has advanced by leaps and bounds in the clinical management of patients suffering from this condition, as well as in the monitor...
Article
Full-text available
Rhupus syndrome is a rare combination of rheumatoid arthritis and systemic lupus erythematosus, and is characterized by the presence of erosive arthritis together with symptoms and signs of systemic lupus erythematosus. Among its complications, is the presence of rheumatoid nodules, and neurological and renal involvement that further complicates it...
Preprint
Full-text available
Background: CIGB 814 is an Altered Peptide Ligand (APL) from a CD4 + T-cell epitope of human heat shock protein 60 (HSP60), an auto-antigen involved in the pathogenesis of rheumatoid arthritis (RA). It induced mechanisms associated with restoration of peripheral tolerance in preclinical studies. This clinical trial was conducted to assess safety an...
Article
Full-text available
Background: CIGB 814 is an Altered Peptide Ligand (APL) from a CD4 + T-cell epitope of human heat shock protein 60 (HSP60), an auto-antigen involved in the pathogenesis of rheumatoid arthritis (RA). It induced mechanisms associated with restoration of peripheral tolerance in preclinical studies. This clinical trial was conducted to assess safety an...
Article
Full-text available
Itolizumab is a humanized anti-CD6 monoclonal antibody (mAb) that has previously shown encouraging results, in terms of safety and positive clinical effects, in a 6-week monotherapy clinical trial conducted in RA patients. The current phase I study evaluated the safety and clinical response for a longer treatment of 12 itolizumab intravenous doses...
Article
Full-text available
Resumen El síndrome de Rhupus es una rara superposición de artritis reumatoide y lupus eritematoso sistémico, que se caracteriza por la presencia de una poliartritis erosiva asociada a síntomas y signos de lupus eritematoso sistémico. Entre sus complicaciones destaca la presencia de nódulos reumatoideos, afectación neurológica y renal que complican...
Article
Introduction: Rheumatoid arthritis is a chronic and progressive inflammatory disease characterized by inflammation of synovial joints and systemic manifestations. Objective: To describe some risk factors for atherosclerosis in patients with rheumatoid arthritis. Methods: A descriptive, cross-sectional study was performed in 112 patients diagnosed w...
Article
Full-text available
Systemic lupus erythematosus is an inflammatory disease that mainly affects women of childbearing age, although sometimes its debut comes at early ages of life. Multiple are the clinical manifestations that can appear in the course of the disease and that affect all organs and organ systems of the human body. Various forms of disease debut are desc...
Article
The uveitis are a heterogeneous group of clinical entities, from very different causes, which have in common the intraocular inflammation. They can be the manifestation of disease widespread as established, be a process limited to the eyeball, or even be the first clinical sign of an entity that will develop over time. Therefore, rheumatologist, wi...
Article
Full-text available
Smoking produces substances that activate proinflammatory, prothrombotic and vasoconstrictive mediators via posttranslational carbamylation of proteins. As a new consequence of carbamylation, induction of anti-carbamylated autoantibodies were observed in rheumatoid arthritis (RA) patients, sometimes prior to onset of the disease. The overall aim of...
Article
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by a chronic relapsing-remitting joint inflammation. Perturbations in the balance between CD4 + T cells producing IL-17 and CD4 + CD25highFoxP3 + Tregs correlate with irreversible bone and cartilage destruction in RA. APL1 is an altered peptide ligand derived from a CD4+ T-cel...
Article
Full-text available
Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation that affects approximately 1% of the general population. Itolizumab, a monoclonal antibody specific for the human CD6 molecule mainly expressed on T lymphocytes, has been shown to inhibit proliferation of T cells and proinflammatory cytokine production in psoriasis pa...
Article
Evaluación de la calidad de vida en pacientes con artritis reumatoide
Article
The deformity of Klippel-Feil is an anomaly of the development that commonly affects to the cervical vertebras. The entity associates in general with other deformities with anomalies or without them so much of the nervous system as of other systems of organs. A 35 year-old mature patient is reported with diagnostic of illness from Klippel-Feil to w...
Article
The osteoarthritis it is the affection to articulate more frequently observed in the mature population of any region of the world, it is characterized by the presence of mechanical pain that frequently associates to rigidity. This illness leads to a loss or decrease of the function progressively to articulate, he/she atrophies muscular, affectation...
Article
A transversal descriptive study about Rheumatoid Arthritis patients with labor disability was performed in the National Center of Rheumatology from January 2011 to January 2012. The samples count 151 patients. Labor status, clinical activity, functional capacity and disability were classified. Results: Female was high (92.7 %), with middle age of 5...
Article
Rheumatoid arthritis during pregnancy is not a rare condition, considering higher prevalence of this disease in women during fertile period. The coexistence of both clinical conditions (rheumatoid arthritis and pregnancy) is always an important challenge for physicians in charge to these patients. It is accepted both that pregnancy has a protective...
Article
Polymyositis-dermatomyositis is a diffuse inflammatory disease of skeletal muscle of unknown etiology existing evidence of immunological factors in its pathogenesis .The incidence of the disease is low and involves mainly skin and muscles. It could be an acute ,sub acute and chronic illness which produces atrophy and degeneration of muscles .The id...
Article
Rheumatic diseases may be active during pregnancy necessitating drug treatment in order to control maternal disease activity and ensure a successful pregnancy outcome. The great majority of patients with autoimmune rheumatic diseases are young females in their reproductive years, willing to have babies. Patients with systemic lupus erythematosus an...
Article
Pregnancy is an important condition that can affect and can be affected by ankylosing spondylitis. In general, ankylosing spondylitis does not appear to interfere negatively with fertility, pregnancy, the fetus or breastfeeding. It is estimated that about 85-90 % of ankylosing spondylitis patients have a term pregnancy. On the other hand, an increa...
Article
Primary Sjögren's syndrome is an autoimmune exocrinopathy of slow progression and chronic, that causes sicca symptoms due to lymphocytic T infiltration that leads to the destruction of the exocrine glands. Clinically it is characterized by ocular and oral dryness However, more than half of the patients develop extraglandular manifestations that can...
Article
Systemic sclerosis is a not common disease, which is frequent in women with ages from 30 to 50 years old, generally after reproductive life, however, is not an exception that pregnancy will outcome because there is not any affection of fertility ability among this patients. It is well known that in those patients there is a higher incidence of pre-...
Article
Full-text available
T cells are involved in the pathogenesis of rheumatoid arthritis (RA). CD6 is a co-stimulatory molecule, predominantly expressed on lymphocytes, that has been linked to autoreactive responses. The purpose of this study was to evaluate the safety, immunogenicity and preliminary efficacy of itolizumab, a humanized anti-CD6 monoclonal antibody, in pat...
Article
Full-text available
La perdida de la capacidad funcional es junto con el dolor la consecuencia más temida de los pacientes con artritis reumatoide, por lo que la valoración de la discapacidad es un desenlace muy importante en la evaluación de estos enfermos. Objetivos: Determinar los beneficios clínicos en pacientes con artritis reumatoide que recibieron inicialmente...
Article
Full-text available
The inflammatory articular síndrome (IAS) is present in nearly all the diseases affecting the osteomyoarticular system (OMAS), and it develops different characteristics according to the affection originating it. In this paper, a review of the pathogenesis of the inflammatoy process is made. Its steps and the functions of different elements influenc...
Article
Full-text available
The inflammatory articular sindrome (IAS) is present in nearly all the diseases affecting the osteomyoarticular system (OMAS), and it develops different characteristics according to the affection originating it. In this paper, a review of the pathogenesis of the inflammatoy process is made. Its steps and the functions of different elements influenc...

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