Dimitris N. Metaxas

Rutgers, The State University of New Jersey | Rutgers · Department of Computer Science

Prevailing Multimodal Large Language Models (MLLMs) encode the input image(s) as vision tokens and feed them into the language backbone, similar to how Large Language Models (LLMs) process the text tokens. However, the number of vision tokens increases quadratically as the image resolutions, leading to huge computational costs. In this paper, we co...

Multi-planar tagged MRI is the gold standard for regional heart wall motion evaluation. However, accurate recovery of the 3D true heart wall motion from a set of 2D apparent motion cues is challenging, due to incomplete sampling of the true motion and difficulty in information fusion from apparent motion cues observed on multiple imaging planes. To...

Generalization remains a central challenge in machine learning. In this work, we propose Learning from Teaching (LOT), a novel regularization technique for deep neural networks to enhance generalization. Inspired by the human ability to capture concise and abstract patterns, we hypothesize that generalizable correlations are expected to be easier t...

Current cardiac cine magnetic resonance image (cMR) studies focus on the end diastole (ED) and end systole (ES) phases, while ignoring the abundant temporal information in the whole image sequence. This is because whole sequence segmentation is currently a tedious process and inaccurate. Conventional whole sequence segmentation approaches first est...

Discrete diffusion models have achieved success in tasks like image generation and masked language modeling but face limitations in controlled content editing. We introduce DICE (Discrete Inversion for Controllable Editing), the first approach to enable precise inversion for discrete diffusion models, including multinomial diffusion and masked gene...

Multimodal large language models (MLLMs) equip pre-trained large-language models (LLMs) with visual capabilities. While textual prompting in LLMs has been widely studied, visual prompting has emerged for more fine-grained and free-form visual instructions. This paper presents the first comprehensive survey on visual prompting methods in MLLMs, focu...

Looking up an unknown sign in an ASL dictionary can be difficult. Most ASL dictionaries are organized based on English glosses, despite the fact that (1) there is no convention for assigning English-based glosses to ASL signs; and (2) there is no 1-1 correspondence between ASL signs and English words. Furthermore, what if the user does not know eit...

While diffusion models have significantly advanced the quality of image generation their capability to accurately and coherently render text within these images remains a substantial challenge. Conventional diffusion-based methods for scene text generation are typically limited by their reliance on an intermediate layout output. This dependency oft...

Large Language Models (LLMs) have significantly enhanced Information Retrieval (IR) across various modules, such as reranking. Despite impressive performance, current zero-shot relevance ranking with LLMs heavily relies on human prompt engineering. Existing automatic prompt engineering algorithms primarily focus on language modeling and classificat...

While diffusion models have significantly advanced the quality of image generation, their capability to accurately and coherently render text within these images remains a substantial challenge. Conventional diffusion-based methods for scene text generation are typically limited by their reliance on an intermediate layout output. This dependency of...

Adapting large-scale pre-trained generative models in a parameter-efficient manner is gaining traction. Traditional methods like low rank adaptation achieve parameter efficiency by imposing constraints but may not be optimal for tasks requiring high representation capacity. We propose a novel spectrum-aware adaptation framework for generative model...

Since American Sign Language (ASL) has no standard written form, Deaf signers frequently share videos in order to communicate in their native language. However, this does not preserve privacy. Since critical linguistic information is transmitted through facial expressions, the face cannot be obscured. While signers have expressed interest, for a va...

We propose a multimodal network using skeletons and handshapes as input to recognize individual signs and detect their boundaries in American Sign Language (ASL) videos. Our method integrates a spatio-temporal Graph Convolutional Network (GCN) architecture to estimate human skeleton keypoints; it uses a late-fusion approach for both forward and bac...

In-context Learning (ICL) empowers large language models (LLMs) to adapt to unseen tasks during inference by prefixing a few demonstration examples prior to test queries. Despite its versatility, ICL incurs substantial computational and memory overheads compared to zero-shot learning and is susceptible to the selection and order of demonstration ex...

The key to dynamic or multi-contrast magnetic resonance imaging (MRI) reconstruction lies in exploring inter-frame or inter-contrast information. Currently, the unrolled model, an approach combining iterative MRI reconstruction steps with learnable neural network layers, stands as the best-performing method for MRI reconstruction. However, there ar...

Local hemodynamic forces play an essential role in determining the functional significance of coronary arterial stenosis and understanding the mechanism of coronary disease progression. Computational fluid dynamics (CFD) has been widely performed to simulate hemodynamics non-invasively from coronary computed tomography angiography (CCTA) images. Ho...

Since American Sign Language (ASL) has no standard written form, Deaf signers frequently share videos in order to communicate in their native language. However, since both hands and face convey critical linguistic information in signed languages, sign language videos cannot preserve signer privacy. While signers have expressed interest, for a varie...

Overcoming barriers on the use of multi-center data for medical analytics is challenging due to privacy protection and data heterogeneity in the healthcare system. In this study, we propose the Distributed Synthetic Learning (DSL) architecture to learn across multiple medical centers and ensure the protection of sensitive personal information. DSL...

This chapter presents methods to address the problem of deception detection in videos. Current approaches to detect deception in videos are limited since they (1) are used in short videos focusing only on a small act of deception; (2) are hard to interpret; and (3) do not make use of any human model or insights that could help in the detection task...

The task of shape abstraction with semantic part consistency is challenging due to the complex geometries of natural objects. Recent methods learn to represent an object shape using a set of simple primitives to fit the target. \textcolor{black}{However, in these methods, the primitives used do not always correspond to real parts or lack geometric...

Accurate 3D cardiac reconstruction from cine magnetic resonance imaging (cMRI) is crucial for improved cardiovascular disease diagnosis and understanding of the heart's motion. However, current cardiac MRI-based reconstruction technology used in clinical settings is 2D with limited through-plane resolution, resulting in low-quality reconstructed ca...

Recent studies show promising performance in open-vocabulary object detection (OVD) using pseudo labels (PLs) from pretrained vision and language models (VLMs). However, PLs generated by VLMs are extremely noisy due to the gap between the pretraining objective of VLMs and OVD, which blocks further advances on PLs. In this paper, we aim to reduce th...

Survival outcome assessment is challenging and inherently associated with multiple clinical factors (e.g., imaging and genomics biomarkers) in cancer. Enabling multimodal analytics promises to reveal novel predictive patterns of patient outcomes. In this study, we propose a multimodal transformer (PathOmics) integrating pathology and genomics insig...

We propose a novel neural deformable model (NDM) targeting at the reconstruction and modeling of 3D bi-ventricular shape of the heart from 2D sparse cardiac magnetic resonance (CMR) imaging data. We model the bi-ventricular shape using blended deformable superquadrics, which are parameterized by a set of geometric parameter functions and are capabl...

Language-based object detection is a promising direction towards building a natural interface to describe objects in images that goes far beyond plain category names. While recent methods show great progress in that direction, proper evaluation is lacking. With OmniLabel, we propose a novel task definition, dataset, and evaluation metric. The task...

The success of training computer-vision models heavily relies on the support of large-scale, real-world images with annotations. Yet such an annotation-ready dataset is difficult to curate in pathology due to the privacy protection and excessive annotation burden. To aid in computational pathology, synthetic data generation, curation, and annotatio...

Contrastive learning-based vision-language pre-training approaches, such as CLIP, have demonstrated great success in many vision-language tasks. These methods achieve cross-modal alignment by encoding a matched image-text pair with similar feature embeddings, which are generated by aggregating information from visual patches and language tokens. Ho...

Federated Learning has gained popularity among medical institutions since it enables collaborative training between clients (e.g., hospitals) without aggregating data. However, due to the high cost associated with creating annotations, especially for large 3D image datasets, clinical institutions do not have enough supervised data for training loca...

Diffusion models have achieved remarkable success in text-to-image generation, enabling the creation of high-quality images from text prompts or other modalities. However, existing methods for customizing these models are limited by handling multiple personalized subjects and the risk of overfitting. Moreover, their large number of parameters is in...

Neural architecture search (NAS) techniques can discover outstanding network architecture while saving tremendous labor from human experts. Recent advancements further reduce the computational overhead to an affordable level. However, it is still cumbersome to deploy NAS in real-world applications due to the fussy procedures and the supervised lear...

Modern medical imaging techniques, such as ultrasound (US) and cardiac magnetic resonance (MR) imaging, have enabled the evaluation of myocardial deformation directly from an image sequence. While many traditional cardiac motion tracking methods have been developed for the automated estimation of the myocardial wall deformation, they are not widely...

Can a text-to-image diffusion model be used as a training objective for adapting a GAN generator to another domain? In this paper, we show that the classifier-free guidance can be leveraged as a critic and enable generators to distill knowledge from large-scale text-to-image diffusion models. Generators can be efficiently shifted into new domains i...

Recent works on diffusion models have demonstrated a strong capability for conditioning image generation, e.g., text-guided image synthesis. Such success inspires many efforts trying to use large-scale pre-trained diffusion models for tackling a challenging problem--real image editing. Works conducted in this area learn a unique textual token corre...

Generalization to previously unseen images with potential domain shifts and different styles is essential for clinically applicable medical image segmentation, and the ability to disentangle domain-specific and domain-invariant features is key for achieving Domain Generalization (DG). However, existing DG methods can hardly achieve effective disent...

Building robust and generic object detection frameworks requires scaling to larger label spaces and bigger training datasets. However, it is prohibitively costly to acquire annotations for thousands of categories at a large scale. We propose a novel method that leverages the rich semantics available in recent vision and language models to localize...

Whole abdominal organ segmentation is important in diagnosing abdomen lesions, radiotherapy, and follow-up. However, oncologists’ delineating all abdominal organs from 3D volumes is time-consuming and very expensive. Deep learning-based medical image segmentation has shown the potential to reduce manual delineation efforts, but it still requires a...

Despite the success of fully-supervised human skeleton sequence modeling, utilizing self-supervised pre-training for skeleton sequence representation learning has been an active field because acquiring task-specific skeleton annotations at large scales is difficult. Recent studies focus on learning video-level temporal and discriminative informatio...

Advancements in AI will soon enable tools for providing automatic feedback to American Sign Language (ASL) learners on some aspects of their signing, but there is a need to understand their preferences for submitting videos and receiving feedback. Ten participants in our study were asked to record a few sentences in ASL using software we designed,...

Models should have the ability to adapt to unseen data during test-time to avoid performance drop caused by inevitable distribution shifts in real-world deployment scenarios. In this work, we tackle the practical yet challenging test-time adaptation (TTA) problem, where a model adapts to the target domain without accessing the source data. We propo...

Top-down instance segmentation framework has shown its superiority in object detection compared to the bottom-up framework. While it is efficient in addressing over-segmentation, top-down instance segmentation suffers from over-crop problem. However, a complete segmentation mask is crucial for biological image analysis as it delivers important morp...

Joint 2D cardiac segmentation and 3D volume reconstruction are fundamental in building statistical cardiac anatomy models and understanding functional mechanisms from motion patterns. However, due to the low through-plane resolution of cine MR and high inter-subject variance, accurately segmenting cardiac images and reconstructing the 3D volume are...

Combining information from multi-view images is crucial to improve the performance and robustness of automated methods for disease diagnosis. However, due to the non-alignment characteristics of multi-view images, building correlation and data fusion across views largely remain an open problem. In this study, we present TransFusion, a Transformer-b...

Overcoming barriers of multi-center data analysis is challenging due to privacy protection and data heterogeneity in the healthcare system. In this study, we propose Distributed Synthetic Learning (DSL) architecture to learn across multi-medical centers without leaking sensitive personal information. DSL emphasizes the building of a homogeneous dat...

Examination of pathological images is the golden standard for diagnosing and screening many kinds of cancers. Multiple datasets, benchmarks, and challenges have been released in recent years, resulting in significant improvements in computer-aided diagnosis (CAD) of related diseases. However, few existing works focus on the digestive system. We rel...

Despite the success of fully-supervised human skeleton sequence modeling, utilizing self-supervised pre-training for skeleton sequence representation learning has been an active field because acquiring task-specific skeleton annotations at large scales is difficult. Recent studies focus on learning video-level temporal and discriminative informatio...

Multi-modality images have been widely used and provide comprehensive information for medical image analysis. However, acquiring all modalities among all institutes is costly and often impossible in clinical settings. To leverage more comprehensive multi-modality information, we propose privacy secured decentralized multi-modality adaptive learning...

Magnetic Resonance (MR) image reconstruction from highly undersampled k-space data is critical in accelerated MR imaging (MRI) techniques. In recent years, deep learning-based methods have shown great potential in this task. This paper proposes a learned half-quadratic splitting algorithm for MR image reconstruction and implements the algorithm in...

Recent advances in magnetic resonance imaging are enabling the efficient creation of high-dimensional, multiparametric images, containing a wealth of potential information about the structure and function of many organs, including the cardiovascular system. However, the sizes of these rich data sets are so large that they are outstripping our abili...

Scene-understanding is an important topic in the area of Computer Vision, and illustrates computational challenges with applications to a wide range of domains including remote sensing, surveillance, smart agriculture, robotics, autonomous driving, and smart cities. We consider the active explanation-driven understanding and classification of scene...

Joint 2D cardiac segmentation and 3D volume reconstruction are fundamental to building statistical cardiac anatomy models and understanding functional mechanisms from motion patterns. However, due to the low through-plane resolution of cine MR and high inter-subject variance, accurately segmenting cardiac images and reconstructing the 3D volume are...

Neural architecture search (NAS) algorithms save tremendous labor from human experts. Recent advancements further reduce the computational overhead to an affordable level. However, it is still cumbersome to deploy the NAS techniques in real-world applications due to the fussy procedures and the supervised learning paradigm. In this work, we propose...

Despite that Convolutional Neural Networks (CNNs) have achieved promising performance in many medical image segmentation tasks, they rely on a large set of labeled images for training, which is expensive and time-consuming to acquire. Semi-supervised learning has shown the potential to alleviate this challenge by learning from a large set of unlabe...

Bidirectional skeleton-based isolated sign recognition using graph convolution networks This work was made openly accessible by BU Faculty. Please share how this access benefits you. Your story matters. Abstract To improve computer-based recognition from video of isolated signs from American Sign Language (ASL), we propose a new skeleton-based meth...