Dimitrios A Lamprou

Dimitrios A Lamprou
Queen's University Belfast | QUB · School of Pharmacy

Ph.D. MBA

About

122
Publications
35,414
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
3,377
Citations
Introduction
Dimitrios, is the author of over 130 peer-reviewed publications and of over 350 conference abstracts, has over 130 Invited talks in institutions and conferences across the world, and has secure Funding in excess of £2.5M. Has been recognised as world leader in Printing, with PubMed-based algorithms placed him in the top 0.1% of scholars in the world writing about Printing in the last 10 years. Moreover, his research lab is listed in the top 5 labs in UK for research in microfluidics.
Additional affiliations
May 2022 - August 2022
Queen's University Belfast
Position
  • Full Professor
Description
  • Chair of Biofabrication and Advanced Manufacturing
May 2018 - April 2022
Queen's University Belfast
Position
  • Reader
September 2016 - April 2018
University of Kent
Position
  • Senior Lecturer
Education
October 2013 - December 2015
Middlesex University, UK
Field of study
  • Master of Business Administration (MBA)
October 2010 - February 2013
University of Strathclyde
Field of study
  • PgDip in Advanced Academic Studies
October 2006 - September 2009
University of Portsmouth
Field of study
  • Ph.D. in BioSurface Chemistry

Publications

Publications (122)
Article
Cholesterol plays a strategic role in liposome composition, however the quantity used to achieve an appropriate formulation has not been yet clarified. Therefore, by screening arrange of lipids and cholesterol ratio, the main aim of this study is to investigate the most suitable amount of cholesterol in lipids in order to prepare stable and control...
Article
Full-text available
Following our call to join in the discussion over the suitability of implementing a reporting checklist for bio–nano papers, the community responds. Below we report short extracts highlighting the main messages of the correspondences we received.
Article
Full-text available
As process of 3D printing was patented in 1986 the research in the field of 3DP did not become popular until the last decade. However, there has been increasing research into the areas of 3DP for medical applications for fabricating prosthetics, bio-printing and pharmaceutics. This novel method allows manufacture of dosage forms on demand, with mod...
Article
The high demand on medical devices and personal protective equipment (PPE) during the COVID-19 crisis left millions of health care professionals unprotected in the middle of this situation, as governments around the world were not prepared for such pandemic. The three-dimensional printing (3DP) community, from universities to 3DP enthusiasts with p...
Article
Liposomes have been the centre of attention in research due to their potential to act as drug delivery systems. Although its versatility and manufacturing processes are still not scalable and reproducible. In this study, the microfluidic method for liposomes preparation is presented. DMPC and DSPC liposomes containing two different lipid/cholestero...
Article
Full-text available
Bioprinting is an emerging technology with various applications in developing functional tissue constructs for the replacement of harmed or damaged tissues and simultaneously controlled drug delivery systems (DDSs) for the administration of several active substances, such as growth factors, proteins, and drug molecules. It is a novel approach that...
Article
In the recent years, we have encountered significant advances in the manufacturing processes of medicinal products and medical devices, particularly after the recent pandemic and the turmoil in the supply chain. Trends in these technological advances in the diagnosis of diseases and therapeutic treatments heavily relied on new technologies that can...
Article
Introduction: Covid-19, alongside previous pandemics, has highlighted the need for the continued development of technologies that are at our disposal. Emerging technologies are those that show true promise in achieving such a goal and have begun to form sturdy independent research areas. Technological advances in healthcare must continually develop...
Article
Full-text available
3D printing was invented thirty years ago. However, its application in healthcare became prominent only in recent years to provide solutions for drug delivery and clinical challenges, and is constantly evolving. This cost-efficient technique utilises biocompatible materials and is used to develop model implants to provide a greater understanding of...
Article
Full-text available
Breast cancer is the second most common cancer worldwide, characterized by a high incidence and mortality rate. Despite the advances achieved in cancer management, improvements in the quality of life of breast cancer survivors are urgent. Moreover, view the heterogeneity that char-acterizes tumors and patients, focusing on individuality is fundamen...
Article
The utilisation of alginate polymers for wound healing is well explored; however, little attention is paid towards the optimisation of the manufacturing process, especially in regards to the final morphological and rheological properties that are imparted to the alginate matrix. This is important as it helps to establish a set of guidelines for the...
Article
Introduction: Sustainability within the pharmaceutical industry is becoming a focal point for many companies, to improve the longevity and social perception of the industry. Both additive manufacturing (AM) and microfluidics (MFs) are continuously progressing, so are far from their optimisation in terms of sustainability; hence it's the aim of this...
Article
Full-text available
Salmonella is a global health threat with pig production being one of the main sources of human salmonellosis. The current study investigated the antivirulence properties of geraniol for inhibiting the in vitro colonization of Salmonella. The minimum inhibitory (MIC) and bactericidal concentrations (MBC) of geraniol against Salmonella Typhimurium f...
Article
Pulmonary Arterial Hypertension (PAH) is the progressive increase in mean pulmonary arterial pressure (mPAP) (≥ 20 mmHg at rest). Current treatment strategies include the drugs targeting at nitric oxide pathway, endothelin receptors, prostaglandin receptors, thromboxane receptors and phosphodiesterase inhibitors, which provides the symptomatic reli...
Article
“Microneedle drug delivery is a promising approach for transdermal drug delivery (TDD), due to its potential to deliver drug through the skin without causing pain." https://www.ondrugdelivery.com/3d-printed-hollow-microneedles-a-new-frontier-for-transdermal-drug-delivery/
Article
The current study is a preliminary investigation on the use of stereolithography 3D printing technology in the field of personalized medicines and specifically for delivering drugs locally, which can for example usefully be applied to ear infections. The main aim is the development of drug-loaded implants for the treatment of ear diseases, to impro...
Article
Full-text available
The treatment strategy required for the effective healing of diabetic foot ulcer (DFU) is a complex process that is requiring several combined therapeutic approaches. As a result, there is a significant clinical and economic burden associated in treating DFU. Furthermore, these treatments are often unsuccessful, commonly resulting in lower-limb amp...
Article
Full-text available
In conventional drug administration, drug molecules cross multiple biological barriers, distribute randomly in the tissues, and can release insufficient concentrations at the desired pathological site. Controlling the delivery of the molecules can increase the concentration of the drug in the desired location, leading to improved efficacy, and redu...
Article
Recent literature concerning the use of polymer and ceramic coatings for a variety of biomedical applications is surveyed in this review. Applications have been grouped into six broad categories: orthopaedic materials, cardiovascular stents, antibacterial surfaces, drug delivery, tissue engineering and biosensors. Polymer and ceramic coatings add e...
Article
The encapsulation of biologic molecules using a microfluidic platform is a procedure that has been understudied but shows great promise from initial reported studies. The study focusses upon the encapsulation of bovine serum albumin (BSA) under various parameters and using multiple phospholipids to identify optimal conditions for the manufacturing...
Article
Full-text available
3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process with potential for easily exploring different geome...
Article
Current surgical strategies for the treatment of pelvic floor dysfunctions involve the placement of a polypropylene mesh into the pelvic cavity. However, polypropylene meshes have proven to have inadequate mechanical properties and have been associated to the arising of severe complications, such as infections. Furthermore, currently employed manuf...
Article
Objectives: There is a requirement within ear therapeutics for a delivery system capable of safely delivering controlled doses to the inner ear. However, the anatomy and sensitivity of the inner ear make current delivery systems problematic and often ineffective. Therefore, a new delivery system is required to overcome these issues and provide a mo...
Article
Full-text available
3D printing has provided a new prospective in the manufacturing of personalized medical implants, including fistulas for haemodialysis (HD). In the current study, an optimized fused modelling deposition (FDM) 3D printing method has been validated, for the first time, to obtain cylindrical shaped fistulas. Printing parameters were evaluated for the...
Article
Objectives The traditional manufacturing methods of solid oral dosage forms (SODFs) are reported to be time-consuming, highly expensive and not tailored to the patient’s needs. Three-dimensional printing (3DP) is an innovative emerging technology that can help to overcome these issues. The aim of this review is to describe the most employed 3DP tec...
Article
Full-text available
Foams have frequently been used as systems for the delivery of cosmetic and therapeutic molecules; however, there is high variability in the foamability and long-term stability of synthetic foams. The development of pharmaceutical foams that exhibit desirable foaming properties, delivering appropriate amounts of the active pharmaceutical ingredient...
Article
Electrospinning is an innovative technique that allows production of nanofibers and microfibers by applying a high voltage to polymer solutions of melts. The properties of these fibers – which include high surface area, high drug loading capacity, and ability to be manufactured from mucoadhesive polymers – may be particularly useful in a myriad of...
Article
Full-text available
Cardiovascular disease (CVD) is a general term for conditions which are the leading cause of death in the world. Quick restoration of tissue perfusion is a key factor to combat these diseases and improve the quality and duration of patients’ life. Revascularization techniques include angioplasty, placement of a stent, or surgical bypass grafting. F...
Article
Full-text available
Microfluidic technique has emerged as a promising tool for the production of stable and monodispersed nanoparticles (NPs). In particular, this work focuses on liposome production by microfluidics and on factors involved in determining liposome characteristics. Traditional fabrication techniques for microfluidic devices suffer from several disadvant...
Chapter
Implantable and long-lasting drug delivery systems provide sustained delivery of drug over a period of weeks to months. These systems can provide many advantages in the delivery of drugs for conditions in which the patient is required to take medications frequently for an indefinite period of time, such as less frequent dosing and improved quality...
Article
Full-text available
The implementation of peptide-based molecules within the medical field has vast potential, owing to their unique nature and predictable physicochemical profiles. However, peptide ther-apeutic usage is hindered by delivery-related challenges, meaning that their formulations must be altered to overcome these limitations. This process could be propell...
Article
Full-text available
Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles. Polymers of N-(3-aminopropyl) methacrylamide hydrochloride (APMA) are cationic with primary amine groups in their structure, which have been explored in biomedical applications via post-polymerisation modification...
Article
Contrast Induced Nephropathy is the most severe side-effect arising after non-ionic iodinated contrast agents (CAs) intravenous administration. The use of antioxidants (i.e., N-Acetylcysteine; NAC) is one of the attempted prevention approaches. Herein, we describe the microfluidic-assisted synthesis of iodinated polymeric nanoparticles (NPs) as new...
Article
Diabetic foot ulcer (DFU) is a serious complication of diabetes mellitus, affecting roughly 25% of diabetic patients and resulting in lower limb amputation in over 70% of known cases. In addition to the devastating physiological consequences of DFU and its impact on patient quality of life, DFU has significant clinical and economic implications. Va...
Article
The uncharted nature of the Covid-19 pandemic has caused uncertainty globally, resulting in many healthcare professionals and key-workers being left with supply shortages in medical consumables and Personal Protective Equipment (PPE), exacerbated by supply line issues and in some cases, delays resulting from governmental policies. 3D printing (3DP)...
Article
Cardiovascular diseases constitute a number of conditions which are the leading cause of death globally. To combat these diseases and improve the quality and duration of life, several cardiac implants have been developed, including stents, vascular grafts and valvular prostheses. The implantation of these vascular prosthesis has associated risks su...
Article
Current treatment for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) involves transvaginal implantation of surgical mesh, conventionally made of polypropylene (PP). However, it has recently become apparent that the mechanical properties of PP are unsuitable, resulting in serious complications such as tissue erosion. In this study...
Article
Full-text available
Surgical meshes have been employed in the management of a variety of pathological conditions including hernia, pelvic floor dysfunctions, periodontal guided bone regeneration, wound healing and more recently for breast plastic surgery after mastectomy. These common pathologies affect a wide portion of the worldwide population; therefore, an effecti...
Article
Full-text available
Hematopoietic stem cells (HSCs) maintain balanced blood cell production in a process called hematopoiesis. As humans age, their HSCs acquire mutations that allow some HSCs to disproportionately contribute to normal blood production. This process, known as age‐related clonal hematopoiesis, predisposes certain individuals to cancer, cardiovascular an...
Article
There is limited information on how to perform in vitro release tests for intravenously administered parenteral formulations and how to relate the in vitro release with an in vivo pharmacokinetic parameter after the administration of the formulation. In this study, the effect of hydrodynamics (using sample and separate and continuous flow condition...
Article
Core-shell nanofibrous drug delivery systems have increasing attention in the last eyars due to their potential to incorporate two or more active pharmaceutical ingredients (APIs) individually into the desired layer (either core or sheath) and thus finely tune the release profile of even incompatible drugs in one system. This study aimed to formula...
Article
Traditional drug administration methods, including injection, oral and nasal route, have been extensively adopted over the years due to their low-cost and/or easy ways to deliver drugs. However, most of the times, they are not effective and significant drawbacks still compromise their application. In order to overcome the shortcoming associated wit...
Article
Full-text available
Implantable devices are versatile and promising drug delivery systems and their advantages are well established. Of these advantages, long acting drug delivery is perhaps the most valuable. Hydrophilic compounds are particularly difficult to deliver for prolonged times. This work investigates the use of poly(caprolactone) (PCL)-based implant coatin...
Article
Introduction: A pandemic is the worst-case scenario in the field of infectious diseases. Innovative technologies have the potential to address the challenges associated with the manufacture of personalized drug delivery systems, biosensors, and medical devices during a pandemic. 3D-Printing, microfluidics, and Microelectromechanical systems (MEMS)...
Article
Full-text available
Neurodegenerative diseases (NDs) bear a lot of weight in public health. By studying the properties of the blood-brain barrier (BBB) and its fundamental interactions with the central nervous system (CNS), it is possible to improve the understanding of the pathological mechanisms behind these disorders and create new and better strategies to improve...
Book
The 3D printing (3DP) process was patented in 1986; however, only in the last decade has it been used for medical applications, as well as being utilized in the fields of prosthetics, bio-fabrication, and pharmaceutical printing. 3DP or additive manufacturing (AM) is a family of technologies that implement layer-by-layer processes in order to fabri...
Article
Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI) are two prevalent disorders affecting 30-40% of women worldwide. Current strategies to repair or improve these medical conditions are non-surgical options such as physiotherapy, or surgical options such as the use of vaginal meshes. The synthetic material polypropylene (PP), which ha...
Book
Full-text available
Electrospinning is one of the most widely used techniques for the fabrication of nano/microparticles and nano/microfibers, induced by a high voltage applied to the drug-loaded solution. The modification of environmental conditions, solution properties or operation parameters results in different fiber properties, thus enabling the fine-tuning of fu...
Article
In vitro release testing is a useful tool for the quality control of controlled release parenteral formulations, but in vitro release test conditions that reflect or are able to predict the in vivo performance are advantageous. Therefore, it is important to investigate the factors that could affect drug release from formulations and relate them to...
Article
Full-text available
Implantable drug delivery devices offer many advantages over other routes of drug delivery. Most significantly, delivery of lower doses of drug, thus, potentially reducing side-effects and improving patient compliance. 3D printing is a flexible technique, which has been subject to increasing interest in the past few years, especially in the area of...
Article
Full-text available
Current strategies to treat pelvic organ prolapse (POP) or stress urinary incontinence (SUI), include the surgical implantation of vaginal meshes. Recently, there has been multiple reports of issues generated by these meshes conventionally made of poly(propylene). This material is not the ideal candidate due to its mechanical properties leading to...
Article
Full-text available
Electrospinningisoneofthemostwidelyusedtechniquesforthefabricationofnano/microparticles andnano/microfibers,inducedbyahighvoltageappliedtothedrug-loadedsolution. Themodification of environmental conditions, solution properties or operation parameters results in different fiber properties, thus enabling the fine-tuning of functionality-related characteri...
Article
The limited ability to selectively deliver drug molecules at well-defined dosing regimens remains a significant challenge. Therefore, the delivery of effective therapies relies on the improvement of current carriers. Due to the clear lack of novel drugs and patent expiry of blockbuster molecules, novel drug delivery systems need to be used and teac...
Article
Since the discovery of X-rays in the late 1890s, several medical imaging techniques have been developed, such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and Ultrasound Imaging, which are used daily to diagnose, monitor, or treat medical conditions. Some of these techniques include the use of contrast agents to enhance the contras...
Article
The main aim of the research was to synthesize amphiphilic cyclodextrin (AMCD) by substituting C12 alkyl chain to a β-cyclodextrin (βCD) in a single step and to study its self-assembly in an aqueous medium. The drug delivery application of the AMCD was also evaluated by encapsulating tamoxifen citrate as a model hydrophobic drug. AMCD was able to s...
Article
Catheter associated infections are a common complication that occurs in dialysis patients. Current strategies to prevent infection include catheter coatings containing heparin, pyrogallol or silver nanoparticles, which all have an increased risk of causing resistance in bacteria. Therefore, a novel approach for manufacture, such as the use of addit...
Article
Full-text available
The rising rate of individuals with chronic kidney disease (CKD) and ineffective treatment methods for catheter-associated infections in dialysis patients has led to the need for a novel approach to the manufacturing of catheters. The current process requires moulding, which is time consuming, and coated catheters used currently increase the risk o...
Article
3D printed microneedle arrays were fabricated using a biocompatible resin through stereolithography (SLA) for transdermal insulin delivery. Microneedles were built by polymerising consecutive layers of a photopolymer resin. Thin layers of insulin and sugar alcohol or disaccharide carriers were formed on the needle surface by inkjet printing. The op...
Article
Full-text available
The evaluation of biological responses to polymeric scaffolds are important, given that the ideal scaffold should be biocompatible, biodegradable, promote cell adhesion and aid cell proliferation. The primary goal of this research was to measure the biological responses of cells against various polymeric and collagen electrospun scaffolds (polycapr...
Article
The forces experienced by the particles inside a twin screw granulator (TSG) are one of the most difficult parameters to measure quantitatively. However, it is possible to perform accurately this measurement through the use of dye containing calibrated microencapsulated sensors (CAMES) whose rupture is directly dependant on their experienced shear...
Article
Full-text available
Introduction: The field of nanomedicine, utilising nano-sized vehicles (nanoparticles and nanofibres) for targeted local drug delivery, has a promising future. This is dependent on the ability to analyse the chemical and physical properties of these drug carriers at the nanoscale and hence atomic force microscopy (AFM), a high-resolution imaging an...
Article
Full-text available
Nanotechnologies have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery systems and combination therapy strategies are being explored. In this paper, we report the design and...
Article
Full-text available
Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature have led to a major boom in research focus. This review article concentrates on the use of these smart...
Article
The present study investigates effect of linkers [zero length (without linker), short length linker (glycine and lysine) and long length linker (PEG1000, PEG2000 and PEG3500)] on pharmacokinetics and toxicity of docetaxel (DTX) and gemcitabine (GEM) bio-conjugates. Conjugates were synthesized via carbodiimide chemistry and characterized by 1H-NMR a...
Article
In the present study, we have modified bovine serum albumin (BSA) by covalently conjugating with anacardic acid (AA) and gemcitabine (GEM) and further used for development of docetaxel (DTX) loaded nanoparticles (AA-GEM-BSA NPs). AA is supposed to provide tumor targeting through VEGF receptors overexpressed in tumors, while the combination of GEM a...
Article
In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone microneedle designs followed by inkjet print coating of insulin formulations., trehalose and xylitol were used as drug carriers with...