Dimitri Daldegan-Bueno

University of Auckland · School of Pharmacy

Cocaine use entails severe health-and social-related harms globally. Treatment options for cocaine dependence are highly limited. Benefits of cannabinoids for addiction have been documented , making it opportune to examine existing data on the possible outcomes associated with cannabinoids and cocaine co-use. We conducted a systematic scoping revie...

Ayahuasca is a psychoactive brew from the decoction of different Amazonian plants, traditionally used in several cultures, religions, and rituals. Scientific studies with ayahuasca are rapidly increasing due to its subjective effects and therapeutic potential. Although ayahuasca is traditionally used in its liquid presentation, lyophilized (freeze-...

Rationale Smoking-related disease is a major problem globally. Effective smoking cessation treatments are however limited. Increasing evidence suggests that psychedelics have potential as treatments for substance use disorders and may therefore prove an option in aiding smoking cessation. Objectives To establish which factors predict smoking cessa...

Considering the long-lasting effects of ayahuasca in the brain and emotional processing, the objective of this study was to evaluate the behavioural and neurobiological effects of repeated ayahuasca administration in an animal model of exploratory behaviour related to novel-environment anxiety. Male Wistar rats received water, 120, 240, 480 or 3,60...

Data on cannabis use patterns and health outcome indicators for Brazil are limited. We undertook a cross-sectional internet-based survey assessing socio-demographics, cannabis use frequency, other drug use, quality-of-life (QOL), affective states (i.e. anxiety and depression), and cannabis use disorder among adult respondents in Brazil. A multinomi...

Background Globally, an estimated 260 million people suffer from depression [1], and there is a clear need for the development of new, alternative antidepressant therapies. In light of problems with the tolerability and efficacy of available treatments [2], a global trend is emerging for patients to self-treat depression with microdoses of psychede...

Language has been explored as a window into the mind. Psychedelics, known to affect perception and cognition, seem to change language, but a systematic, time-dependent exploration is lacking. Therefore, we aimed at mapping the psychedelic effects on language over the time course of the acute and sub-acute effects in an explorative manner. For this,...

Rationale: The psychedelic brew ayahuasca is increasingly being investigated for its therapeutic potential. Animal models are essential to investigate the pharmacological effects of ayahuasca since they can control factors influencing it, such as the set and setting. Objective: To review and summarise data available on ayahuasca research using a...

The therapeutic potential of the psychedelic brew ayahuasca has been investigated in preclinical and clinical studies. Currently, the most consistent evidence refers to depression. However, various studies suggest that ayahuasca may comprise therapeutic benefits in other health conditions. This narrative review provides a comprehensive, up-to-date...

Issues: Cannabis use and related health/social outcome indicator data for Brazil-where non-medical cannabis is generally illegal-are limited. Approach: Towards a comprehensive overview of relevant indicators, we searched primary databases by combining MeSH-index terms related to cannabis, geographic location and subtopic terms (e.g., use, health...

In neuroscience research, longitudinal data are often analyzed using ANOVA and MANOVA for repeated measures (rmANOVA/rmMANOVA). However, these analyses have special requirements: the variances of the differences between all possible pairs of within-subject conditions (i.e., levels of the independent variable) must be equal. They are also limited to...

The psychedelic brew ayahuasca is increasingly being investigated for its therapeutic potential. To review and summarize data available on ayahuasca research using animal models, we systematically searched five databases (PubMed, Web of Science, EMBASE, LILACS and PsycInfo) for peer-reviewed studies in English, Portuguese or Spanish up to July 2022...

In recent decades, we can see a trend in several countries to regulate the medicinal and recreational use of cannabis, which can generate a huge global market. However, the history of almost a century in the condition of illegality, in practically the entire planet, contributes to the scientific literature on the subject being severely limited. Bas...

Background Cannabis use disorder (CUD) affects one-in-five cannabis users, presenting a major contributor to cannabis-associated disease burden. Epidemiological data identify the frequency of cannabis use as a risk factor for CUD. This review aimed to determine quantifiable risk-thresholds of the frequency of cannabis use for developing CUD. Metho...

Public health-oriented frameworks for cannabis use of control, including legalization, are evolving. Most frameworks aim to reduce cannabis-related health harms that materialize among users; there has been comparably limited focus on cannabis-related “harm-to-others”. A longstanding issue for other psychoactive substances, and increasingly recogniz...

There has been a revival of research that studies the subjective effects of psychedelic drugs on humans. Areas of health science have been studying their possible therapeutic benefits, and psychological measurement instruments are being developed as the studies progress. However, these instruments currently suffer criticism regarding their number a...

Rationale The growing prevalence of psychostimulant (including amphetamine) use and associated health harms, with limited treatment options, present a global challenge. There is an increasing availability and medical applications of cannabinoids, and growing interest in their therapeutic potential for addictive disorders. Objectives The objective...

Background: Preliminary evidence suggests that long-term ayahuasca use is associated with better psychosocial outcomes and less drug use; however, available data on the association between ayahuasca intake frequency and psychosocial outcomes is limited. Objectives: We sought to characterize and investigate the association of regular ayahuasca use,...

Background: Controversy surrounds psychedelics and their potential to boost creativity. To date, psychedelic studies lack a uniform conceptualization of creativity and methodologically rigorous designs. Aims: This study aimed at addressing previous issues by examining the effects of lysergic acid diethylamide (LSD) on creativity using multimodal...

Introduction. The involvement of the striatal system in S-R learning is usually based on neural plasticity related to immediate early-genes (IEGs). Previous studies also have shown that the dorsal striatum plays a role in tone fear conditioning (TFC). Objectives. Given that IEg expression in dorsal striatum supports S-R learning we analyzed early m...

North America (i.e., the United States and Canada) and select other wealthy Commonwealth countries (e.g., Australia, the UK) have been experiencing marked ‘opioid epidemics’, consisting of elevated opioid use and related (e.g., mortality and morbidity) harms involving both prescription and, increasingly, illicit opioid substances. Multiple commenta...

In the early 2000s, increasing prevalence of psycho-stimulant (e.g., crack/cocaine, methamphetamine) use and related harms, including severe adverse health outcomes, was observed among - mostly marginalized - populations of persons using illicit drugs in North America, underscoring an urgent need for interventions options towards improved preventio...

Background Global opioid consumption increased multifold post-2000, disproportionately in high-income countries, with severe mortality/morbidity consequences. Latin America features comparatively low opioid availability; Brazil, the region’s most populous country, makes an interesting case study concerning opioid use/harms. In this comprehensive ov...

Diseases that threaten life raise existential questions that can be a source of psychological distress. Studies with psychedelics demonstrate therapeutic effects for anxiety and depression associated with life-threatening illnesses. Ayahuasca has been proposed as a possible therapeutic agent in the treatment of psychiatric disorders. Preliminary st...

North America and select other Commonwealth jurisdictions have been experiencing unprecedented opioid epidemics characterized by excessive and persistently high levels of opioid misuse, morbidity and mortality, and related disease burden. Recent discussions have considered whether New Zealand might undergo or needs to expect a similar ‘opioid crisi...

Cannabis control policies in a few countries have recently shifted from criminal prohibition-based regimes to legalization of use and supply. While cannabis’ newly emerging status of legality may suggest a coming “end” for criminology-based interest in the drug, these fundamental changes rather open a window to a new set of criminological research...

Cannabis use is common, especially among young people, and associated with risks for acute and chronic adverse health and social outcomes. New Zealand features overall high cannabis use levels, yet may soon follow other jurisdictions and implement legalization of non-medical cannabis use and supply towards public health objectives. While existing c...

New Zealand will hold a public referendum in 2020 on the possible replacement of current cannabis prohibition with legalisation of use and supply policy. Cannabis legalisation policies have been implemented-albeit with heterogeneous regulatory frameworks-in several (eg, North/South America) jurisdictions, with yet inconclusive evidence on main heal...

Issues Non‐medical cannabis policies are changing, including towards legalisation‐with‐regulation frameworks. New Zealand will hold a public referendum on cannabis legalisation in 2020. We reviewed data on cannabis use and health/social harms; policy reform options; experiences with and outcomes of reforms elsewhere; and other relevant consideratio...

O presente artigo tem como objetivo caracterizar as queixas relacionadas ao trabalho de pacientes que realizaram acolhimento no Serviço de Psicologia Aplicada/SPA de uma universidade federal da região Amazônica, entre os anos de 2011 e 2014, de modo a identificar aqueles que apresentam queixas de sofrimento relacionados ao trabalho. O estudo caract...