Dilip Kumar YadavCentre for Cellular and Molecular Biology | CCMB
Dilip Kumar Yadav
Doctor of Philosophy
About
12
Publications
3,114
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Introduction
Currently I am working as Post-Doctoral Associate at Boston University School of Medicine. My focus is mainly on “Investigating the role of Metabolism in Neuronal Regeneration”. I am using laser sever individual axons and quantitative measure of regenerative outgrowth experiments in C. elegans, a well-established and powerful model system for the study of neuronal regeneration, and in primary mouse neuronal culture.
Additional affiliations
August 2019 - present
Boston University School of Medicine Campus
Position
- PostDoc Position
December 2017 - July 2019
June 2012 - December 2012
Education
July 2007 - June 2009
Publications
Publications (12)
Cellular metabolism plays an essential role in the regrowth and regeneration of a neuron following physical injury. Yet, our knowledge of the specific metabolic pathways that are beneficial to neuron regeneration remains sparse. Previously, we have shown that modulation of O-linked β-N-acetylglucosamine (O-GlcNAc) signaling, a ubiquitous post-trans...
Cellular metabolism plays an essential role in the regrowth and regeneration of a neuron following physical injury. Yet, our knowledge of the specific metabolic pathways that are beneficial to neuron regeneration remains sparse. Previously, we have shown that modulation of O-linked β-N-acetylglucosamine (O-GlcNAc), a ubiquitous post-translational m...
Background:
Maternal nutrition in pregnancy has been linked to offspring health in early and later life, with changes to DNA methylation (DNAm) proposed as a mediating mechanism.
Objective:
We investigated intervention-associated DNAm changes in children whose mothers participated in 2 randomized controlled trials of micronutrient supplementatio...
S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production. SAM is hypothesized to link metabolism and chromatin modification, however, its role in acute gene regulation is poorly understood. We recently found that Caenorhabditis elegans with reduced SAM had def...
Background:
Mounting evidence suggests that nutritional exposures during pregnancy influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with implications for disease risk across the life course.
Methods:
We review human intergenerational studies using a three-part search strategy. Search 1 investigates associ...
Background
Mounting evidence suggests that nutritional exposures during pregnancy influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with implications for disease risk across the life course.
Methods
We review human intergenerational studies using a three-part search strategy. Search 1 investigates associati...
Aim:
Identification and functional characterization of cis-regulatory elements in human PPARD gene.
Methods:
We used various bioinformatic tools on the publicly available human genome and Encyclopedia of DNA Elements databases to explore potential cis-regulatory elements in PPARD gene region.
Results:
We predicted an insulator and an enhancer...
Aim:
To investigate the effect of B12 and/or folic acid supplementation on genome-wide DNA methylation.
Methods:
We performed Infinium HumanMethylation450 BeadChip (Zymo Research, CA, USA) assay in children supplemented with B12 and/or folic acid (n = 12 in each group) and investigated the functional mechanism of selected differentially methylat...
Background:
Animal studies have shown that nutritional exposures during pregnancy can modify epigenetic marks regulating fetal development and susceptibility to later disease, providing a plausible mechanism to explain the developmental origins of health and disease. Human observational studies have shown that maternal peri-conceptional diet predi...
Unlabelled:
Maternal nutritional deficiency in-utero is known to predict risk of complex disorders like cardiovascular disease, diabetes and many neurological disorders in the offspring and vitamin B12 is one such critical micronutrient. Here we performed 2D-DIGE followed by MALDI TOF/TOF analysis to identify proteins that are differentially expre...
