Dilek Tuzun

• Professor
• Professor (Full) at Kahramanmaraş Sütçü İmam University

Aim: Our aim was to investigate the frequency of isolated maternal hypothyroxinemia (IMH) at gestational diabetes mellitus (GDM) Material and method: Fifty women with GDM aged between 20–41 and 100 healthy pregnant aged between 17–41 were involved to study. Patients that have thyroid disease and low free T4 levels at first trimester were ruled out....

This study was designed to evaluate the ultrasonographic and histopathologic features of nodules composed predominantly of Hurthle cells detected during cytological examination. Fifty-seven patients with thyroid nodules composed predominantly of Hurthle cells on fine needle aspiration cytology were retrospectively analyzed. Patients were evaluated...

Purpose: This study evaluated the effectiveness of elastosonography (ES) scoring and strain index (SI) in diagnosing patients with thyroid nodules composed primarily of Hurthle cells. Materials and methods: This study retrospectively analyzed 57 patients with thyroid nodules composed predominantly of Hurthle cells on fine needle aspiration cytol...

We present a case report of a young female patient with hypercalcemia-induced acute necrotizing pancreatitis as first manifestation of a benign parathyroid adenoma. Case: A 46-year-old female presented at the emergency room with a sudden attack of severe epigastric pain and vomiting. Clinical examination revealed a severely ill patient, a silent ab...

AThalassemia is a group of inherited disorders characterized by the reduced or absent synthesis of the globin chains that make up hemoglobin. Transfusion-dependent thalassemia (TDT) is the most severe form, which requires lifelong transfusion. Complications related to the heart, liver and endocrine glands caused by the accumulation of excess iron i...

Objective Subacute thyroiditis is also known as subacute granulomatous thyroiditis, giant cell thyroiditis, painful thyroiditis, and De Quervain’s thyroiditis. Immature granulocytes (IG) and neutrophil-to-lymphocyte ratio (NLR) are new inflammatory markers that are easily detected in routine complete blood count (CBC) tests. The aim of this study w...

Acromegaly is a chronic systemic disease characterized by autonomous and excessive secretion of growth hormone (GH). Acromegaly is most commonly caused by ais a somatotroph adenoma of the anterior pituitary. In acromegaly, mortality primarily results from are cerebrovascular, cardiovascular, respiratory diseases and malignancies. Monocyte/lymphocyt...

Hyperparathyroidism (HPT) is an endocrine disorder characterized by high secretion of parathyroid hormone. Brown tumor is one of the skeletal manifestations of HPT. Its overall prevalence is low (about 0.1%). Involvement of facial bones is extremely rare. The mandible is involved in 4.5% of cases. Primary HPT (PHPT)with vitamin D deficiency worsens...

Objective: Our aim was to compare vaspin and galanin in obese and normal weight individuals, to reveal whether these parameters are related to obesity and other related parameters. Material and Methods: Forty patients with obesity and 40 control subjects were included in the study. Biochemical parameters were recorded from patient’s files. Galanin...

Gestational diabetes mellitus (GDM) is a condition that is very common during pregnancy and has negative consequences for both mother and fetus. Insulin resistance has been shown as an important cause in the pathogenesis of GDM and low-level inflammation is suggested to be one of the underlying causes of insulin resistance. We aimed to investigate...

Glucagon-like peptide-1 is the most potent incretin secreted from the intestinal tract. It is synthesized by L-cells in the jejunum and distal ileum of the gastrointestinal system. Glucose-dependent insulino-tropic polypeptide is a polypeptide released by specialized endocrine cells called K cells, most com-monly in the duodenum and jejunum, in res...

Amaç: Diyabetin mikrovasküler komplikasyonlarında oksidatif stresin belirteçlerini incelemek, prolidazın oksidatif stres göstergeleriyle ilişkisini incelemek, prolidazın prediktif değer olarak kullanılabilirliliğini araştırmaktır. Gereç ve Yöntemler: Çalışmaya 112 tip 2 Diyabetes Mellitusu (DM) olan hasta ve 44 sağlıklı kontrol birey alındı. Hastal...

Background: Thyroid cancer is one of the most common cancers and is especially common in young patients. Therefore, effective recognition and treatment of thyroid cancer are essential for patient survival. Objectives: To compare the effectiveness of standard guidelines for predicting thyroid malignancy. To do so, thyroid nodules were classified...

We aimed to evaluate sarcopenia and sarcopenic obesity (SO) in patients with type 2 diabetes mellitus (T2DM), possible relationships with serum irisin and myostatin levels, and the effect of glycemic control on SO. Ninety T2DM patients were included in this a cross-sectional study. Sarcopenia was determined by evaluating muscle mass (bioelectrical...

Objectives This study aimed to evaluate the current situation of hypoparathyroid patients and to investigate the relationship between treatment adherence and quality of life. Study design Prospective, multicentre study. Methods Adult patients presenting with the diagnosis of hypoparathyroidism to 20 different endocrinology clinics were included. Th...

Objective: This study aimed to investigate the association between insulin resistance (IR) and thyroid volume (TV) along with thyroid nodule in patients with nonfunctional adrenal incidentaloma (NFAI). Material and Methods: Fortyfive NFAI patients with a mean age of 59.00±7.00 and 43 healthy controls of comparable age and body mass index (BMI) were...

Background: Majority of the incidentally discovered adrenal masses, called adrenal incidentaloma (AI), are nonfunctioning adrenal adenomas. The appropriate management of AI is still a matter debate, so it is necessary to investigate their associated morbidity. However, data regarding morphological and functional cardiac alterations are limited in...

Objective: Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone and plays a role in the pathogenesis of myocardial hypertrophy. The aim of this study was to evaluate the association of FGF-23 levels with echocardiographic parameters and insulin resistance (IR) in patients with gestational diabetes. Subjects and methods: Fifty-...

Objective: To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods: 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma...

Aim: It is a diagnostic challenge to differentiate benign and malignant cytology in the presence of Hürthle cells. In our previous study, it was determined that in fine needle aspirations (FNA), the malignancy outcome of the Hürthle cells containing group tend to be papillary thyroid carcinoma (PTC) in a higher percentage. The most common misinterp...

Insulin edema is a rare complication seen in patients with newly diagnosed, poorly controlled diabetes in a short period of time after starting intensive insulin therapy. It frequently limits itself. In this case report, we present an underweight patient with newly diagnosed type 1 diabetes mellitus who presented with diabetic ketosis and developed...

Prolactinomas are the most common pituitary tumors but rarely seen in adolescent males. There is no indication for surgery both in micro-and macro-adenomas unless an urgent treatment is necessary. First line treatment is always medical with dopamine agonists. In this report, we presented a patient with pubertal arrest and giant prolactinoma that di...

Hurthle cells are large epithelial cells producing thyroglobulin and are observed in both nonneoplastic and neoplastic thyroid lesions. Hurthle cell neoplasms are classified as benign Hurthle cell adenoma or malignant hurthle cell carcinomas. These two entities are distinguished according to the presence of thyroid capsular or vascular invasion or...

Background. Antiphospholipid syndrome (APS) characterized by thrombosis and abortus may rarely cause primary adrenal failure. Case Presentations. A 34-year-old male presented with hypotension, hypoglycemia, hyperpigmentation on his skin and oral mucosa, scars on both legs, and loss of consciousness. In laboratory examinations, hyponatremia (135 mmo...

Objective Ectopic thyroid tissue (ETT) is a rare abnormality of the thyroid gland and the true prevalence and importance is not known. The aim of this study was to evaluate ultrasonography (US) guided fine needle aspiration biposy (FNAB) results, sonographic features, and frequency of ETT detected in the midline of the neck. Subjects and methods F...

Objective Our aim was to investigate the thyroid function tests and thyroid volume differences among males with isolated hypogonadotropic hypogonadism (IHH) who take androgen replacement treatment (ART). Materials and methods Forty-four male with IHH with a mean age 33.2 (18-54), diagnosed in Endocrinology and Metabolism Department between Septemb...

To investigate frequency of isolated maternal hypothyroxinemia (IMH) in women with gestational diabetes mellitus (GDM) using both the method specific trimester range (MSTR) and the standard reference range (SRR). Our study included 50 GDM patients (case group) and 60 non-GDM pregnant (control group). Glucose, insulin, HOMA-IR, fT4 and TSH values we...

Body mass index (BMI), waist circumference (WC), serum triglyceride (TG) and HDL-cholesterol (HDL-C) concentrations are evaluated together in calculation of visceral adiposity index (VAI), is a newer described index. We aimed to investigate the relationships of smoking and/or alcohol intake and VAI in healthy adult men in this study. For this purpo...

Aim: In this case report we present a newly diagnosed, underweight type 1 diabetes mellitus (DM) patient developed insulin oedema following high dose insulin therapy. Case: A 18-year-old male patient was admitted to the hospital with a 1-month history of excessive water consumption, pollakiuria, polyuria, and weight loss 6 kg. In laboratory examina...

Aim: Disabilities of the arm, shoulder, and hand (DASH) questionnaire is a self-administered region-specific outcome instrument developed as a measure of self-rated upper-extremity disability and symptoms. The DASH consists mainly of a 30-item disability/symptom scale. In this study, we aimed to evaluate DASH questionnaire in 1000 type 2 diabetes m...

Aim: In this study, we aimed to assess psychiatric symptoms in 1000 type 2 diabetes mellitus (T2DM) patients. Material and methods: 297 patients (mean age 52.13±9.37 years, 190 women and 107 men) who had T2DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytren’s contracture, tinnel sign, and tendinitis was ass...

Aim: Diabetes mellitus is a chronic metabolic condition characterised by persistent hyperglycaemia with resultant morbidity and mortality related primarily to its associated microvascular and macrovascular complications In this study our aim was to investigate the prevalence of the most frequently occurring hand complications in 1000 type 2 diabete...

Introduction: Adrenocortical oncocytomas are rare seen tumours. Most of these tumours are benign and non-functioning. We present here a case of oncocytic adrenocortical tumour, detected incidentally, presented with Cushing’s syndrome. Case: A 41-year-old male patient, while investigating for abdominal pain, bilateral adrenal masses were detected in...

Aim: To evaluate the effect of androgen replacement therapy on lipid profile and platelet aggregation in in male patients with isolated hypogonadotropic hypogonadism (IHH). Material and methods: 36 male patient, mean age 32.2 (18–54)with IHH, admitted to the outpatient clinic of Endocrinology and Metabolism were included to the study. Patients in t...

Introduction: Multiple endocrine neoplasia type-1 (MEN-1) is an autosomal dominant disorder MEN-1 diagnosis is established as the occurrence of two or more MEN-1 associated tumour or one MEN-1 associated tumour in a patient that have 1 MEN-1 family member or positive MEN-1 genetic mutation. MEN-1 associated tumours usually involve the parathyroid g...

Aim: Hyperinsulinaemia is frequent finding in patients with hyperprolactinemia and has associations with thyroid volume. In this study, we evaluated the association between thrombotic markers, insulin resistance, CIMT, and thyroid volume in female patients with prolactinoma. Material and methods: 38 women with prolactinoma and 24 healthy women were...

We report a case of GIST comorbidity with pituitary macroadenoma presenting with gastrointestinal bleeding. Case: A 56-year-old male patient was admitted to the emergency department with complaints of hematemesis. Antral gastritis and a mass about 3 cm in diameter with irregular margins in the ampulla detected in upper gastrointestinal endoscopy. I...

Aim: Disabilities of the arm, shoulder and hand (DASH) questionnaire is a self-administered region-specific outcome instrument developed as a measure of self-rated upper-extremity disability and symptoms. The DASH consists mainly of a 30-item disability/symptom scale. In this study, we aimed to evaluate DASH questionnaire in 1000 type 2 diabetes me...

Objective: Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy resulting from pregnancy associated insulin resistance and impaired insulin secretion. We aimed to investigate the frequency of vitamin D deficiency and its relation with glucose parameters and the incidence of gestational diabe...

Aim: In this study, we aimed to assess psychiatric symptoms in 1000 type 2 diabetes mellitus (DM) patients. Material and methods: 179 patients (mean age 51.73±9.06 years, 117 women and 62 men) who had type II DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytren’s contracture, tinnel sign and tendinitis was a...

Aim: Empty sella is usually an incidental finding. The term primary empty sella (PES) makes reference to the herniation of the subarachnoid space within the sella turcica in patients with no history of pituitary tumor, surgery or radiotherapy. The aim of this study was to evaluate hormonal abnormalities associated with empty sella. Materials and me...

Aim: In this study, our aim was to investigate the prevalence of the most frequently occurring hand complications in 1000 type 2 diabetes mellitus patients. Material and methods: 179 patients (mean age 51.73±9.06 years, 117 women and 62 men) who had type II DM were included as a preliminary in this study. The presence of cheiroarthropathy, dupuytre...

Dear Editor, Sarcoidosis is a systemic granulomatous disease of unknown aetiology. It emerges in the form of hiler adenopathy and interstitial pulmonary disease in most cases. The lungs, eyes, skin, abdominal organs, central nerve system and bones are among the organs involved. 1,2 Although non-caseous granulomas are detected histopathologically in...

Context. The metabolic effects of primary hyperparathyroidism (PHPT) causing increased cardiovascular morbidity have begun to gain importance in medical science, and the number of studies investigating glucose metabolism disorders in asymptomatic PHPT patients is rare. Objective. To evaluate the relationship between glucose metabolism disorders and...

We aimed to determine whether the presence of Hürthle cells altered the distribution of categories in the Bethesda system for reporting thyroid cytopathology, or the expected neoplastic and malignant outcome. Fine needle aspiration (FNA) cytology reports of Hürthle cells in a 2-year period were evaluated. The distribution of Bethesda system categor...

Context. The metabolic effects of primary hyperparathyroidism (PHPT) causing increased cardiovascular morbidity have begun to gain importance in medical science, and the number of studies investigating glucose metabolism disorders in asymptomatic PHPT patients is rare. Objective. To evaluate the relationship between glucose metabolism disorders and...

Insulin stimulates proliferation of thyroid cells in culture. The presence of insulin resistance (IR) is associated with larger thyroid gland volume and an increased prevalence of thyroid nodules. The aim of this study was to investigate the presence of any possible association between IR and thyroid cancer. Forty-one patients with diffuse thyroid...

Introduction: Insulin resistance, refers to decreased response of tissues to insulin, primarily associated with type 2 diabetes and glucose intolerance. Several results were obtained in previous studies about the relation between insulin resistance and thyroid dysfunction. In these studies hepatosteatosis was not an exclusion criteria despite insul...

Aim: DASH questionnaire is a self-administered region-specific outcome instrument developed as a measure of self-rated upper-extremity disability and symptoms. The DASH consists mainly of a 30-item disability/symptom scale. In this study, we aimed to evaluate DASH Questionnaire in 1000 type two diabetes mellitus (DM) patients. Material and methods:...

Aim: To investigate the prevalence of the most frequently occurring hand complications in 1000 type 2 diabetes mellitus patients. Material and methods: patients (mean age 50±9.01 years, 34 women and 24 men) who had type II DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytren’s contracture, tinnel sign and te...

Introduction: Hepatosteatosis is one of the results of insulin resistance. Thyroid dysfunctions effect on insulin sensitivity. The aim of this study was to evaluate insulin resistance in patients with hepatosteatosis and either hypothyroidism or hyperthyroidism. Design: A total of 407 patients with hepatosteatosis were included. These patients were...

Aim: In this study, we aimed to assess psychiatric symptoms in 1000 type 2 diabetes mellitus (DM) patients. Material and methods: Fifty-eight patients (mean age 50±9.01 years, 34 women and 24 men) who had type II DM were included as a preliminary in this study. The presence of cheiroarthropathy, Dupuytren’s contracture, tinnel sign and tendinitis w...

Pituitary adenomas which co-secrete GH and TSH accounts for <0.2% of all adenomas of the pituitary. Symptoms of hypertyroidism are usually masked by clinical manifestations of acromegaly. Here, we have reported the result of the primary one year long medical therapy in a case who was diagnosed to have adenoma co-secreting GH and TSH. Case: Seventy-...

Objective: To investigate prevalence of gestational diabetes mellitus (GDM) in patients with gestational transient thyroxicosis (GTT). Methods: Fifty two patients with GTT and 100 age matched healthy pregnant women were included. Fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), LDL-cholesterol, HDL-cholesterol, triglyceride, thyrotrophin (T...

Background. Antineutrophil cytoplasmic antibodies (ANCA) positivity is usually determined in vasculitis of medium and large arteries. In literature, data related to the prevalence of ANCA positivity and the development of antibodies after antithyroid therapy in Graves' disease are quite rare. Aim. To investigate the titers of myeloperoxidase (MPO)-...

The aim of the present study was to determine alterations in thyroid blood flow parameters and thyroid volume (TV), measured at inferior thyroid artery (ITA), due to changes in sex hormones and thyroid stimulating hormone (TSH) at four different periods of menstrual cycle (MC) showing infradian rhythm in healthy women. Twenty-two women with regular...

Elastosonography (ES) is a newly developed method that is used for the differential diagnosis of benign and malignant thyroid nodules. In different studies, ES scoring has been compared with histopathological findings, and sensitivity and specificity of the scoring were calculated. In this study, it determines the strain index (SI) as well as the E...

It is well known that TSH plays a major role in the secretion of thyroid hormones, maintenance of thyroid specific gene expression, and gland growth. In this study, we aimed to evaluate association between tests of thyroid functions (fT3, fT4, TSH) and differentiated thyroid carcinoma. 441 patients operated for nodular goiter between 2005 and 2008...

Sweet's syndrome or acute febrile neutrophilic dermatosis is associated with several systemic diseases such as malignancies and infectious diseases. We present a 34-year-old woman with Sweet's syndrome associated with both herpes infection and metastatic disease. Skin biopsy showed neutrophilic infiltrates in the dermis confirming the diagnosis of...