Dilek Gogas Yavuz

Marmara University · School of Medicine Section of Endocrinology and Metabolism

Objective: We aimed to evaluate adherence to insulin treatment in terms of treatment persistence and daily adherence to insulin injections among insulin-naïve type 2 diabetic patients initiating insulin therapy with basal (long acting), basal-bolus, and premixed insulin regimens in a tertiary endocrinology outpatient clinic. Methods: A total of 433...

Amaç: Vitamin D eksikliğinin Tip 2 diyabetes mellitus (T2DM) gelişiminde bir risk faktörü olduğu ve vitamin D’nin insülin sekresyonu ve insülin direnci üzerinde rolü olduğuna dair güçlü veriler vardır.Vitamin D eksikliği olanlarda, olmayanlara göre T2DM gelişme riski daha yüksek bulunmuştur.Bu çalışmada; D vitamin eksikliği olan prediyabetik ve T2D...

Kemiğin Paget hastalığı osteoklastların morfolojik ve foksiyonel anomalisi ile ilişkili kemik döngüsünde bozulma ile karakterizedir. Kemiğin tutulum bölgelerine göre kırık,sağırlık ,deformite gibi sonuçlar oluşturmakta tutulum 3 vaka kırık sonrasıtanı almıştır. Multipl kemik tutulumu baskındır uzun kemikler ve kranial kemikler sıklıkla tutulmuştur....

endokrinoloji vakalari 2014

Osteoporosis in men is recently recognized as a major underestimated public health problem. In 2050, the incidence of hip fracture in men is expected to increase by 310% worldwide. After the age of 50, one out of three osteoporotic fractures are seen in men. Men suffering any major fracture have a higher mortality rate than women osteoporotic fract...

Epicardial adipose tissue (EAT) thickness is a novel cardiovascular risk indicator, whereas carotid intima media thickness (CIMT) is a known marker of subclinical atherosclerosis. The aim of this study was to measure EAT thickness and CIMT in subclinical hypothyroid (SCH) patients and to determine the effect of restoration of the euthyroid state on...

AlthoughBMD is in normal range risk of fracture increased in both diabetic and obese patients. Accumulating evidence suggest that advanced glycation end products (AGEs) could adversely affect the fracture resistance of bone in type 2 diabetic patients it is unclear whether a relationship between increased AGE levels and bone density in obesity. Thi...

Introduction: It has been shown that face classification software can help distinguish between subjects with and without acromegaly on regular photographs. In this project we have shown that this method can be provided to the medical public in a first clinical application. Methods: Face classification was based on nodes placed on frontal and side...

Objective: To determine the association of serum paraoxonase concentration with serum lipid levels and bone mineral density in early postmenopausal Turkish women. Design: One hundred healthy postmenopausal women were included in a cross-sectional study in a University hospital clinic. Blood was drawn from women who had bone mineral density (BMD)...

Background/objective: Artificial sweeteners were thought to be metabolically inactive, but after demonstrating that the gustatory mechanism was also localized in the small intestine, suspicions about the metabolic effects of artificial sweeteners have emerged. The objective of this study was to determine the effect of artificial sweeteners (aspart...

Marmara Üniversitesi Tıp fakültesi Endokrinoloji ve Metabolizma BD 8. Aile hekimliği güz okulu 26 eylül 2014-Antalya

Background and aims: The aim of the present study was to assess the efficacy of telephone support on insulin treatment adherence in insulin naive type 2 diabetic patients using different insulin treatment regimens (basal, basal-bolus and premix ) in third care medical centers in Turkey Materials and methods: In this 12 week-open label randomized mu...

Hiperprolaktinemi yetişkinlerde en sık rastlanan nöroendokrin hastalıktır. Fizyolojik nedenler ekarte edilerek patolojik hiperprolaktinemi ve bunun nedeni tespit edilmelidir. Prolaktinoma belirlenirse prolaktin düzeyini normale getirmek, tümör kitlesini küçültmek amacıyla dopamin agonistleri ile medikal tedavi başlanması önerilir. En az 3 yıl Dopam...

Diabetic polyneuropathy is a major source of morbidity in patients with diabetes. Effective, easy to use and objective diagnostic methods are necessary to diagnose the condition. Quantitative determination of vibration perception threshold (VPT) by a neurothesiometer is more reliable because the device minimizes the subjectivity of the examiner. In...

Background Although patients with familial Mediterranean fever (FMF) are symptom-free between the attacks, subclinical inflammation may continue. Vitamin D (vit D) plays an important role in the modulation of immune system and might also influence the course of FMF. Endothelial dysfunction is previously demonstrated in Behcet's disease (BD) and vit...

Introduction: Obesity is a condition with multifactorial etiologies. Type 2 diabetes mellitus (DM), hypothyroidism and Cushing syndrome are among the hormonal etiologies. The aim of the study was to determine the ratio of hormonal etiologies in morbid obese patients. Methods: Morbid obese patients evaluated preoperatively for bariatric surgery were...

AMAÇ: İlaç tedavisine uyumsuzluk kronik hastalıklarda tedavi hedeflerine ulaşmayı engelleyen önemli problemdir.Bu kesitsel çok merkezli çalışmanın amacı 3. basamak sağlık kuruluşlarında izlenen levotiroksin(LT4) replasmanı alan primer hipotiroidi hastalarının LT4 kullanma alışkanlıkları ,ilaç uyumu, TSH düzeyleri ve ilaç dozlarını incelemektir. Met...

RADYOCERRAHİ UYGULANAN AKROMEGALİ HASTALARININ KLİNİK VE LABORATUVAR İZLEMİ

Introduction The purpose of this study is to evaluate the possible predictors of thyroid disorders after neck radiotherapy, with a focus on radiation dose-volume factors. Methods Thyroid function was measured in 100 patients who had received radiotherapy to the neck, including the thyroid. All radiation-induced thyroid dysfunctions were determined...

ABSTRACT Hyperprolactinaemia is the most frequent neuronedocrine disorder in adults. It is essential to differentiate pathological hyperprolactinaemia Once prolactinoma is established medical therapy is recommended with a dopamine agonist in order to control Prolactin levels levels and reduce tumour size. Responsive patients can be followed at leas...

Introduction: Increased mortality in morbid obesity is related to atherosclerosis. Carotid intima media thickness (CIMT) is a sign of early atherosclerosis. The aim of the study is to determine CIMT in morbid obese patients that did not have hormonal etiologies. Methods: Morbid obese patients evaluated preoperatively for bariatric surgery were inc...

Non adherence to medication schedules by patients with chronic illnesses has long been recognized as a problem. The aim of this study is to evaluate levothyroxine (L-T4) compliance, daily dosage and TSH levels under treatment in primary hypothyroid patients. We included 1636 primary hypothyroid patients over 1 year under L-T4 (F/M: 1469/167, 46±13...

Objective: Although risk of bone fracture increased, BMD isincreased rather than decreased in type 2 diabetes. Accumulating evidence suggest that advanced glycation end products (AGEs) could adversely affect the fracture resistance of bone in type 2 diabetic patients. Skin autofluorescence (SAF) is a validated noninvasive measure of tissue AGEs. We...

Background Takayasu arteritis (TAK) is a chronic, large-vessel arteritis predominantly affecting aorta, its major branches and the pulmonary arteries. Vitamin D, as a steroidal hormone, has recently been shown to have immunoregulatory and immunosuppressive effects. Low vitamin D levels are demonstrated in various autoimmune disorders. Objectives Th...

AIM: To investigate the potential association between serum sialic acid and diabetic retinopathy and its several grades. METHODS: We studied the level of serum sialic acid in 70 patients. Thirty control vs 40 type 1 diabetics and with different levels of diabetic retinopathy as well. RESULTS: We found higher levels of serum sialic acid level in dia...

Objective: To determine the association of osteopenia with levels of serum 25-hydroxyvitamin D and HOMA-IR values in postmenopausal women. Methods One hundred healthy postmenopausal women were included in a cross-sectional study. Venous blood was collected after an overnight fast and 25-hydroxyvitamin D, glucose and insulin levels were measured. H...

Aim: Previous studies have suggested an influence of vitamin D receptor polymorphisms on the development of autoimmune thyroid disease in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in a group of Turkish patients with Hashimoto's thyroiditis (HT). Methods: One hundred and eleven pati...

AMAÇ: İnfra pertosal sinüs örneklemesi ( İPSS ) Cushing hastalığının santral ve ektopik ayrımında kullanılan altın standart olarak kabul edilen yöntemdir. Kateterizasyon ve örneklem veya biyokimya yöntemlerinden kaynaklanan problemlerden dolayı testin yanlış yorumlanması önemli sorunlardan birisidir. Bu çalışmanın amacı örneklem güvenilirliği için...

Amaç: Sürrenal adenomların çoğunluğunun nonsekretuvar olduğu bilinmektedir. Sekresyon saptanan adenomlarda Cushing sendromu, Conn sendromu ve Feokromasitoma gözlenmektedir. Bunun yanında giderek artan oranda subklinik Cushing sendromu olgularına rastlanmaktadır. Bu hastalarda metabolik sendrom benzeri bir tablo görülmekte olup kardiyovasküler morta...

ana sebebi kardiyovasküler ölümlerdir. Primer hiperparatiroidismde hipertansiyon, sol ventrikül hipertrofisi ve renin-anjiotensin sisteminde anormallikler gösterilmiştir. Hiperparatiroidi hastalarında damar duvarında olabilecek yapısal değişikliklere ait veriler değişkendir. Çalışmanın amacı hiperparatiroidi hastalarında karotis intima medya kalınl...

GEBELİKTE HİPOTİROİDİ TANI VE TEDAVİSİ

Acromegaly is a chronic disease with an important impact on patients, health-related quality of life (HRQoL). Acromegaly quality of life questionnaire (AcroQoL) is a disease-generated QoL questionnaire comprising 22 questions each having five possible responses scored 1–5, the maximum score of 110 reflecting best possible QOL, and quoted as a perce...

Aim: Nonenzymatic advanced glycation and oxidation end-products, advanced glycation end-products (AGEs), impart a potent impact on vessels in diabetic state and in euglycaemic conditions with increased oxidative stress. The aim of this study is to measure AGEs and its relationship with carotid intimae media thickness (CIMT) in acromegaly patients....

Introduction Increasing evidence suggesting an integral role of vitamin D in skeletal muscle function. The relationship between muscle strength and vitamin D status has been investigated to some degree in older populations, however there has been very little research in younger adult women. This study aims to measure the effects of vitamin D on han...

Introduction.– Takayasu's arteritis (TAK) is a chronic, inflammatory vasculitis of the aorta and its major branches. Vitamin D (Vit D) is increasingly implicated in the pathogenesis of autoimmune diseases. The immune-regulatory role of Vit D affects both the innate and adaptive immune systems, contributing to the immune-tolerance of self-molecules....

Introduction It has been shown that face classification software might help distinguishing between subjects with and without acromegaly on regular photographs. In this project, we investigated several aspects that will be necessary and helpful to bring this recognition method closer to clinical application. Methods Face classification was based on...

tıpta uzmanlık seçimi

Introduction: It has been shown that face classification software might help distinguishing between subjects with and without acromegaly on regular photographs. In this project we investigated several aspects that will be necessary and helpful to bring this recognition method closer to clinical application. Methods: Face classification was based o...

ABSTRACT Objectives: Hyperglycemia affects mortality and morbidity in hospitalized patients. About half of the cases represent a new- onset of hyperglysemia, the aim was to determine the frequency of hyperglycemia in hospitalized patients on the first and last days of their hospital stay and to determine the relationship of hyperglycemia with...

Objectives: Endothelial dysfunction is previously demonstrated in Behçet's disease (BD) and vitamin D is implicated to affect endothelial functions. We aimed to evaluate the status of serum 25(OH)Vit D3 levels and its association with disease activity, endothelial function and carotis intima media thickness (CIMT) in patients with BD. Methods: T...

To evaluate the frequency of the estrogen receptor (ER) gene PvuII and XbaI polymorphisms and their associations with bone mineral density (BMD) in a group of postmenopausal Turkish women. A total of 125 healthy postmenopausal women and 125 premenopausal healthy young women as controls were included in the study. The PvuII and XbaI polymorphisms in...

Adipokines are markers of insulin resistance and play a role in the atherosclerotic process. The association of adipokines with the macrovascular complications of type 1 diabetes mellitus (DM) needs to be determined. The aim of this study was to measure serum adiponectin, leptin, and resistin levels in type 1 DM patients and investigate their relat...

Paraoxonase is an esterase bound to high-density lipoproteins which by metabolizing lipid peroxides, prevents their accumulation on low-density lipoproteins. It also hydrolyzes various organophosphorus compounds. Considering the role of PON1 in hydrolyzing phospholipids and cholesteryl-ester hydroperoxides and thus protecting lipoproteins against o...

Atherosclerosis and osteoporosis share some common pathophysiological pathways. Increase in oxidative stress and activation of cytokines that increase osteoclastogenesis were reported in postmenopausal period. The aim of this study was to determine the link between these two states. A total of 32 female adult Wistar albino rats were included in the...

Insulin resistance is getting important in the course of type 1 diabetes mellitus. Visceral fat depot is associated with insulin resistance and assessment of epicardial fat thickness is a way of measuring visceral fat. The aim of the study was to measure epicardial adipose tissue (EAT) thickness and to determine its relationship with waist-hip-rati...

Previous studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a grou...

Aim: Diabetes is a systemic disease with increased oxidative damage, lipid oxidation and decreased prevention of LDL oxidation. Some of the preventive effects of HDL is thought to be mediated by paraoxanase. Paraoxonase activity is reduced in diabetes. Aminoguanidine, inhibits the formation of advanced glycation endproducts by reacting with interme...

Zollinger-Ellison syndrome is characterized by elevated levels of serum gastrin associated with increased gastric acid secretion, gastrointestinal ulcerations and diarrhea. Most gastrinomas (75%) occur sporadically and are located within the gastrinoma triangle. Extraduodenal, extrapancreatic and extranodal gastrinomas have been shown in 5.6% of th...

albrights herediter osteodystrophy in conjuction wiıth growth hormone deficiency and adrenal insufficiency

To determine the frequency of the vitamin D receptor (VDR) gene polymorphisms BsmI, ApaI, TaqI and FokI and their associations with bone mineral density (BMD) in postmenopausal Turkish women. One hundred and thirty healthy postmenopausal women and 130 premenopausal healthy women acting as controls were included in the study. The BsmI, FokI, ApaI an...

Ülkemizde tıp eğitimi ve tıbbi araştırmaların büyük bölümü tıp fakültelerince yürütülmektedir. 2010 yılı itibarı ile Türkiye'de tıp eğitimi veren 75 tıp fakültesi bulunmaktadır. Türkiye'nin yirminci tıp fakültesi olarak kurulan Marmara Üniversitesi Tıp Fakültesi (MÜTF), İngilizce eğitim yapan ilk fakültelerinden biri olması nedeni ile klasik tıp fa...

Aim: Medical education and an important part of clinical research is carried out by medical faculties in Turkey. By 2010, 75 medical faculties are available in Turkey. Marmara University School of Medicine (MUTF) established as the twentieth medical faculty of Turkey represents a different model from conventional medical faculties because it was on...

Objective: C-reactive protein (CRP) is considered to be a cardiovascular risk marker and changes in its level have been attributed to genetic factors. The aim of the study was to determine CRP 1059G/C gene polymorphism frequency and its relationship with CRP levels and carotid artery intima-media thickness (CIMT) in type 2 diabetic patients (DM). M...

Diabetic cardiomyopathy is an important complication of type 1 diabetes mellitus. Diastolic heart failure is an early manifestation of diabetic cardiac disease. Nt-proBNP is a valuable marker of ventricular dysfunction. The aim of this study was to determine Nt-proBNP concentrations in type 1 diabetic patients and determine their relationship with...