Diego Rosselli

Pontificia Universidad Javeriana · Clinical Epidemiology and Biostatistics Department

Background: In Colombia, the best strategy to establish indication for adjuvant chemotherapy in early breast cancer (EBC) remains unknown. This study aimed to identify the cost-utility of Oncotype DX™ (ODX) or Mammaprint™ (MMP) tests to establish the necessity of adjuvant chemotherapy. Methods: This study used an adapted decision-analytic model to...

Introduction Psoriatic arthritis is an inflammatory arthritis with a wide range of manifestations. The complexity of the disease is a barrier to understanding it, however knowledge about the disease has increased considerably over time, due to advances in genetics, immunology, imaging, and a better understanding of epidemiology. The exact prevalenc...

Objectives To evaluate the cost-effectiveness of the nonsurgical periodontal treatment (NSPT) compared with supragingival therapy in type II diabetics with periodontitis. Methods A decision tree analysis was used to estimate the costs and health outcomes of two periodontal therapies in a hypothetical cohort of type II diabetics with periodontitis....

Objetivo: establecer la estrategia más costo-útil para Colombia entre ofrecer el tratamiento de quimioterapia adyuvante (QT-A) a todas las pacientes (estrategia estándar) con cáncer de mama temprano, receptor hormonal (RH) positivo, Her 2 neu negativo, sin compromiso ganglionar (N0), con criterios clínicos de alto riesgo de recurrencia o definir la...

Objectives to assess the burden of disease of chronic pain in Colombia. Methods we estimated disability adjusted life years (DALYs) attributable to chronic pain using Global Burden of Disease (GBD) method. We identified diagnostic codes related to chronic pain considering lumbar pain, osteoarthritis, post-herpetic neuralgia, diabetic neuropathy, c...

Background: The impact of immunosuppression in solid organ transplant recipients with SARS CoV-2 infection is unknown. The knowledge about the behavior of different immunosuppression schemes in clinical outcomes is scarce. This study aimed to determine the risk of death in kidney transplant recipients with COVID-19 under two different schemes of im...

Para muchas personas, la Economía en general, incluso la Economía de la Salud, es percibida como la ciencia que se ocupa de estudiar el dinero. Esa es una interpretación errada. Como ciencia social, la Economía va mucho más allá, y en sus análisis, así como en sus recomendaciones, incorpora además de la asignación de los recursos (de los cuales el...

Introducción: La N-acetilcisteína (NAC) es uno de los medicamentos que se ha propuesto en el manejo de pacientes con covid-19. Este fármaco cuenta con más de cincuenta años de uso en profilaxis y terapia de varias condiciones clínicas. Objetivo: Revisar la literatura que recoja la evidencia disponible sobre el uso de NAC como adyuvante en inmunizac...

Objective To describe the relation between corruption indicators and statistics on noncommunicable diseases and their risk factors by continent. Methods An ecological study was conducted to examine the relation of the GINI coefficient, the Country Policy and Institutional Assessment (CPIA), and the Corruption Perception Index (CPI) with noncommuni...

Objectives Azathioprine has been the therapy of choice for the maintenance of remission in patients with antineutrophil cytoplasm antibody (ANCA)-associated systemic vasculitis, but recent studies show that rituximab could be more effective. To evaluate the cost-effectiveness of azathioprine, fixed-schedule rituximab, and tailored-dose rituximab fo...

Objectives Advanced melanoma accounts for 4% of malignant skin tumors, and approximately 80% of deaths are attributed to it. The most frequent mutation of the RAF gene is BRAFV600, which has been associated with a worse prognosis. The objective of the research was to evaluate the cost-effectiveness of the combined regimen of dabrafenib plus trameti...

Introducción. La causa más común de estenosis laringotraqueal benigna es iatrogénica, secundaria a intubación orotraqueal. El manejo quirúrgico sigue siendo la alternativa que ha mostrado mejores resultados a largo plazo. El objetivo de este estudio fue analizar la experiencia en el manejo quirúrgico de la estenosis laringotraqueal durante 15 años...

Objectives: (1) To estimate the prevalence, geographic distribution, and demographic characteristics of patients diagnosed with mental and behavioral disorders due to the use of opioids in Colombia, between 2009 and 2018. (2) To describe the opioid sales trends in Colombia over the last few years. Methods: We conducted an observational study ana...

Background and Objective Prostate cancer is a multifactorial disease and is among the top five causes of death in men worldwide. The Colombian Ministry of Health has adopted the Integrated Information System on Social Protection (Sistema Integrado de Información de la Protección Social, SISPRO, by its Spanish acronym) registry to collect comprehens...

Objective Using data from the Ministry of Health of Colombia, we performed an analysis of prevalence and general demographic characteristics of patients with inflammatory myopathies, with data from 2012 to 2018. Design A descriptive cross-sectional study based on data from the Ministry of Health of Colombia. We used as key terms the diagnostic cod...

Introduction Many authors have highlighted the management and outcomes of liver transplant patients with SARS -CoV2, however, there is a reduced experience identified with Hispanic or Latino patients [1]. We would like to share our experience with liver transplantation and SARS-CoV-2 infection (Real-time PCR identification) during 2020. Objectives...

Objectives: (1) To estimate the prevalence, geographic distribution, and demographic characteristics of patients diagnosed with mental and behavioral disorders due to the use of opioids in Colombia, between 2009 and 2018. (2) To describe the opioid sales trends in Colombia over the last few years. Methods: We conducted an observational study analyz...

For centuries, cannabis has been used with many different purposes, including medicinal use, usually bypassing any formal approval process. However, during the last decade, interest in cannabis in medicine has been increasing, and several countries, including the United States and Canada, have produced their own legislation about marihuana and cann...

Introduction Osteoporosis is considered a healthcare problem due to the increased risk of fractures and high cost of care. In Colombia, the Ministry of Health introduced SISPRO, a tool to collect nationwide information from the health system. The information collected from SISPRO is available for scientific analysis. This article presents an analys...

Corruption in healthcare is on the rise. When corruption infiltrates global health, causes embezzlement of public health funds, malfunctioning medical equipment, fraudulent or ineffective health services such as expired medicines and fake vaccines that could have life-or-death consequences. A corrupt healthcare system, amid global health crises lik...

Objectives We designed and conducted a narrative review consistent with the PRISMA guidelines (PROSPERO registration number: CRD42018099498) to evaluate the association between environmental metals (manganese, mercury, iron) and Parkinson’s Disease (PD) in low and middle-income countries (LMIC). Methods Data sources: A total of 19 databases were s...

Background The best strategy to establish indication for adjuvant chemotherapy in early breast cancer (EBC) in Colombia is unknown. This study aimed to identify the cost-effectiveness of various strategies to establish the necessity of adjuvant chemotherapy.Methods This study used an adapted decision-analytic model to compare cost and outcomes of c...

Background: In Colombia, the best strategy to establish indication for adjuvant chemotherapy in early breast cancer (EBC) remains unknown. This study aimed to identify the cost-effectiveness of various strategies to establish the necessity of adjuvant chemotherapy. Methods: This study used an adapted decision-analytic model to compare cost and outc...

This article analyses scientific publishing trends in engineering in Colombia during the decade from 2010 to 2019. Methodology: All publications classified under engineering affiliated to a Colombian institution in Scopus database were selected. Number of publications, citations, self-citations as well as H indexes were collected for the country's...

Perfil clínico y costos directos de la atención de asma

Objectives To characterize at a global level the concept of therapeutic value (TV) and describe the experience of value-based pricing (VBP) policies in 6 reference countries. Methods We conducted a rapid review of the literature that addressed 2 exploratory research questions. A systematic and exhaustive search was carried out up to July 2018 in M...

Introduction Osteoporosis is considered a healthcare problem due to the increased risk of fractures and high cost of care. In Colombia, the Ministry of Health introduced SISPRO, a tool to collect nationwide information from the health system. The information collected from SISPRO is available for scientific analysis. This article presents an analys...

Background: Valle del Cauca is the region with the fourth-highest number of COVID-19 cases in Colombia (>50,000 on September 7, 2020). Due to the lack of anti-COVID-19 therapies, decision-makers require timely and accurate data to estimate the incidence of disease and the availability of hospital resources to contain the pandemic. Methods: We adap...

Algunos han tratado de disminuir la importancia de la mortalidad de la pandemia COVID-19 porque compromete, sobre todo, a adultos mayores [1]. El comportamiento de la enfermedad en América La na, sin embargo, ha sido diferente, y tanto el número de casos confi rmados como el de fallecidos incluye muchos más adultos jóvenes [2] , de manera que las c...

The current systematic review aimed to evaluate the efficacy and safety of dabrafenib plus trametinib (dabrafenib‐trametinib) with those of other therapeutic alternatives in the treatment of patients with BRAF V600 mutation unresectable or metastatic melanoma. The search was carried out on four databases up to July‐2018. Two separate network meta‐a...

Las epidemias han acompañado a la humanidad desde tiempos remotos. Se ha visto que su comportamiento sigue unos patrones matemáticos que poco a poco se han ido precisando. En este artículo se revisan las seis fases que la OMS ha establecido para clasificar las pandemias, se revisan la última gran pandemia, la gripa española de 1918 y su impacto en...

RESUMEN La epidemia de covid-19 se inició en Colombia el 6 de marzo 2020, cuatro meses después de los primeros casos en China, y cuando ya la enfermedad empezaba a ocasionar serios estragos en Europa. En este artículo se describen y se presentan los registros gráficos de algunas características epidemiológicas de la epidemia en nuestro medio, anali...

Objective To calculate the prevalence and describe the main demographic characteristics of Sjögren's syndrome in adults in Colombia. Material and methods Descriptive cross-sectional study which utilised data from the Integral Information System of Social Protection of the Ministry of Health of the Republic of Colombia during the years 2012 to 2016...

Since its emergence in Wuhan, China, on November 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been progressively invading every corner of the world. As of today (April 30), it is responsible for more than 3.2 million confirmed cases and more than 220 thousand deaths in 186 countries (1). SARS-CoV-2 belongs to the envel...

Objectives. The aim of this paper was to compare both the OOP and the proportion of Peruvian households with Catastrophic Health Expenditure (CHE), as well as to evaluate income related inequalities in CHE and their changes between 2008 and 2017 in Peru. Methods. Data from the 2008 and 2017 National Household Survey on Living and Poverty Conditions...

OBJECTIVE: To estimate the cost-effectiveness of first line tyrosine kinase inhibitors (TKI), afatinib and osimertinib, for the treatment of epidermal growth factor receptor (EGFR) mutation-positive (Exon 19 deletion or L858R) non-small cell lung cancer (NSCLC), stages IIIB - IV in Colombia. METHODS: A partitioned survival model was designed, using...

Since its emergence in Wuhan, China, on November 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been progressively invading every corner of the world. As of today (April 30), it is responsible for more than 3.2 million confirmed cases and more than 220 thousand deaths in 186 countries (1). SARS-CoV-2 belongs to the envel...

Background and Aims Azathioprine has been for decades the drug of choice for maintenance therapy in patients with generalized ANCA vasculitis in remission. However, recent studies show that rituximab, a high-cost biological agent, which can be administrated in two different schedules, might be more effective, so it is necessary to know the cost- ef...

In a past issue of the journal, Schroeder et al.1 discuss the experience and prospects of hepatitis C in different countries; Colombia, however, was left out. Our country has had an agreement with the Pan American Health Organization (PAHO) since 2010 to participate in a regional fund for the acquisition of strategic public health products. Hepatit...

Epilepsy is a common neurological disorder that affects approximately 1% of the world’s pop7u-lation. About one third of those patients suffer from treatment-resistant epilepsy (TRE8), defined as failure to stop seizures despite adequate trials of at least two medications at therapeutic dosa-ges. There has been a growing interest in the development...

El 13 de febrero, 2020, con su bautizo oficial por la Orga-nización Mundial de la Salud, nació una nueva enfermedad: el covid-19 (1). Ya venían ocupando páginas en la prensa internacional los estragos del coronavirus causal (a su vez bautizado como SARS-CoV-2) en China, su país natal, más propiamente en la ciudad de Wuhan, capital de la provincia d...

There are few published real-world studies on hepatitis C in Latin America. This paper describes a cohort of Colombian subjects treated with direct-acting antiviral agents. A total of 195 patients from 5 hepatology centers in 4 Colombian cities were retrospectively studied. For each patient, serum biomarkers were obtained, and Child-Pugh, MELD, cir...

Covid-19 epidemic began in Colombia on March 6, 2020, four months after the first cases in China, and when the disease was already starting to have serious consequences in Europe. This article presents graphic records and describes epidemiological characteristics of the epidemic in our country, analyzing its growth rate, its behavior in different a...

Resumen Objetivo Estimar la costo-efectividad de las cintas de uretra media comparada con la colposuspensión retropúbica y el cabestrillo pubovaginal en pacientes con incontinencia urinaria femenina de esfuerzo en Colombia. Métodos Se construyó un árbol de decisión donde se comparó las cintas de uretra media con la colposuspensión retropúbica y el...

Letter to the editor about a group discussion which was held during the XXXIII Colombian Congress of Anesthesiology under the title of "Women as pioneers and leaders in anesthesiology".

Introducción: si bien los cannabinoides se han utilizado durante varios años, apenas recientemente se han descrito los descubrimientos sobre sus mecanismos de acción y blancos terapéuticos, así como las alteraciones en el sistema endocannabinoide, observadas en diversas enfermedades y condiciones que se manifiestan con dolor, inflamación, patología...

The current systematic review aimed to evaluate and compare the efficacy and safety of dabrafenib–trametinib with those of other therapeutic alternatives in the treatment of patients with unresectable advanced/metastatic melanoma with BRAF‐V600 mutation. The search was carried out on four databases up to July 2018. Two separate network meta‐analyse...

Introduction Registries are essential to keep track of inflammatory bowel disease (IBD) and related arthritis epidemiology, and to provide better care to patients. In Colombia, the health ministry has adopted a tool, SISPRO, to gather all information coming from the whole health system structure. Given that the information collected from SISPRO is...

Introduction The Delphi method is a technique for reaching consensus by a group of experts that express their opinion on a particular issue. It has been widely used in different areas of knowledge, including health sciences. Rheumatology is one of the medical specialties that has most widely used this consensus technique. Objectives To review the...

Resumen Introducción Los registros son esenciales para seguir la epidemiología de la enfermedad inflamatoria intestinal (EII) y el compromiso articular asociado y brindar mejor atención a los pacientes. En Colombia, el Ministerio de Salud y de la Protección Social utiliza la herramienta SISPRO para recolectar información del sistema de salud, la c...

Objectives: Multiple sclerosis (MS) is a degenerative neurological disorder. Treatment aims to avoid relapses and disability progression. The purpose of this study was to evaluate the cost-effectiveness of natalizumab compared with fingolimod for treating highly active relapsing-remitting MS (RRMS) patients from the Colombian third-party payer per...

Rabies encephalitis is a fatal zoonotic viral disease transmitted to humans either by domestic animals like dogs and cats or by wild animals like bats, skunks and raccoons. We present the case of a 25-year-old woman admitted due to behavioral disorders, generalized paresthesiasand acute respiratory deterioration compatible with a respiratory distre...

Objective: To evaluate the cost-effectiveness of ceftolozane/tazobactam + metronidazole (C/T+M) and ceftolozane/tazobactam (C/T) compared with 8 alternatives used in the treatment of complicated intraabdominal infection (cIAI) and complicated urinary tract infection (cUTI) respectively. Methods: A Monte Carlo simulation decision model was used for...

Generalized myasthenia gravis (GMG) is a neuromuscular transmission disorder that creates a fluctuating weakness of the voluntary muscles. This study is aimed at understanding the effect that refractory GMG has on the quality of life of patients who suffer from it, and the effect of eculizumab on it. A systematic literature search was conducted in...

Objectives: To evaluate the public health benefits and economic value of live-attenuated yellow fever (YF) 17D vaccine in Colombia. Methods: A decision tree model was used to assess the theoretical impact of routine YF vaccination of 1-year-olds (no "catch-up") during the interepidemic period from 1980 to 2002, avoiding capturing the impact of Y...

Objectives: To estimate the burden of disease attributable to obesity and overweight conditions using disability-adjusted life-years (DALYs) in Colombia. Methods: The burden of disease was estimated following an adapted methodology published by the World Health Organization. A selection of diseases was performed in which overweight and obesity a...

OBJECTIVES: Chickenpox, a viral disease with particularly high incidence in children under 10 years of age, generates direct costs to the health system and indirect costs due to the expenses that the family must assume in terms of out-of-pocket resources and caregiver time. Chickenpox vaccine was introduced in Colombia in July 2015 for children at...

To estimate prevalence and describe the main demographic characteristics of Behcet disease in Colombia. Cross-sectional study, based on official Ministry of Health registry data. 523 cases of Behcet disease (ICD-10 code: M352) were reported between 2012 and 2016, for a prevalence in people over 18 years old of 1.10 per 100,000 inhabitants, of which...