Diego Rasskin-Gutman

Diego Rasskin-Gutman
University of Valencia | UV · Instituto Cavanilles de Biodiversidad y Biología Evolutiva

PhD

About

74
Publications
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Introduction
Diego Rasskin-Gutman currently works at the Instituto Cavanilles de Biodiversidad y Biología Evolutiva, University of Valencia. Diego does research in Evolutionary Biology, Paleobiology and Developmental Biology. Their current project is 'Development of Skull Networks'.

Publications

Publications (74)
Article
Morphological EvoDevo is a field of biological inquiry in which explicit relations between evolutionary patterns and growth or morphogenetic processes are made. Historically, morphological EvoDevo results from the coming together of several traditions, notably Naturphilosophie, embryology, the study of heterochrony, and developmental constraints. A...
Article
Network models of the tetrapod skull in which nodes represent bones and links representsutures have recently offered new insights into the structural constraints underlying theevolutionary reduction of bone number in the tetrapod skull, known as Williston’s Law.Here, we have built null network model-derived generative morphospaces of the tetrapodsk...
Article
The tetrapod skull has undergone a reduction in number of bones in all major lineages since the origin of vertebrates, an evolutionary trend known as Williston’s Law. Using connectivity relations between bones as a proxy for morphological complexity we showed that this reduction in number of bones generated an evolutionary trend toward more complex...
Article
Riedl's concept of burden neatly links development and evolution by ascertaining that structures that show a high degree of developmental co-dependencies with other structures are more constrained in evolution. The human skull can be precisely modeled as an articulated complex system of bones connected by sutures, forming a network of structural co...
Chapter
The concept of burden was developed around the 1970s by Austrian zoologist Rupert Riedl, based on morphological insights rooted in Karl Ernst von Baer’s embryological tradition. Burden’s main tenet is that as a morphological character evolves, it develops more relationships with other characters, becoming more and more interconnected. Through this...
Chapter
This chapter introduces the reader to anatomical network analysis (AnNA): a conceptual framework for the tolopological analysis of organismal form. AnNA focuses on the structural relations among anatomical parts, which allows for an evaluation of morphological organization in comparative analyses for both development and evolution. The nodes of the...
Article
Full-text available
We analyze the connectivity patterns and fusion events among bones leading to the adult skeletal organization during the development of the superaltricial monk parakeet (Myiopsitta monachus, Psittaciformes), providing insights about the functional and evolutionary significance in the avian structural design. By using whole mount specimens stained f...
Article
Full-text available
Network analysis provides a quantitative tool to investigate the topological properties of a system. In anatomy, it can be employed to investigate the spatial organization of body parts according to their contiguity and patterns of physical contact. In this study, we build a model representing the spatial adjacency of the major regions of the human...
Article
The origin of the mammalian middle ear ossicles from the craniomandibular articulation of their synapsid ancestors is a key event in the evolution of vertebrates. The richness of the fossil record and the multitude of developmental studies have provided a stepwise reconstruction of this evolutionary innovation, highlighting the homology between the...
Chapter
Brain mapping has always been a priority in neurobiology and evolutionary neuroanatomy. In the last century, methodological issues and technical advances have generated a vivid debate on the parcellation and functions of the cortical territories. Brain structure is generally analyzed by considering the network of connections associated with neural...
Chapter
The concept of burden was developed around the 1970s by Austrian zoologists Rupert Riedl, based on morphological insights rooted in Karl Ernst von Baer’s embryological tradition. Burden’s main tenet is that, as a morphological character evolves, it develops more relationships with other characters, becoming more and more interconnected. Through thi...
Chapter
This chapter introduces the reader to anatomical network analysis (AnNA): a conceptual framework for the tolopological analysis of organismal form. AnNA focuses on the structural relations among anatomical parts, which allows for an evaluation of morphological organization in comparative analyses for both development and evolution. The nodes of the...
Article
Full-text available
The premature fusion of cranial bones, craniosynostosis, affects the correct development of the skull producing morphological malformations in newborns. To assess the susceptibility of each craniofacial articulation to close prematurely, we used a network model of the skull to quantify the link reliability (an index based on stochastic block modeli...
Article
Chondrichthyan teeth are capped with a hypermineralized tissue known as enameloid. Its microstructure displays a hierarchical organization that has increased in structural complexity from a homogenous single-crystallite enameloid (SCE) in early Chondricthyans to the complex multilayered enameloid found in modern sharks (consisting of bundles of cry...
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Full-text available
How do the various anatomical parts (modules) of the animal body evolve into very different integrated forms (integration) yet still function properly without decreasing the individual's survival? This long-standing question remains unanswered for multiple reasons, including lack of consensus about conceptual definitions and approaches, as well as...
Article
Bone fusion has occurred repeatedly during skull evolution in all tetrapod lineages, leading to a reduction in the number of bones and an increase in their morphological complexity. The ontogeny of the human skull includes also bone fusions as part of its normal developmental process. However, several disruptions might cause premature closure of cr...
Article
Full-text available
Modularity and complexity go hand in hand in the evolution of the skull of primates. Because analyses of these two parameters often use different approaches, we do not know yet how modularity evolves within, or as a consequence of, an also-evolving complex organization. Here we use a novel network theory-based approach (Anatomical Network Analysis)...
Article
Full-text available
The different manifestations of equivalence and similarity in structure throughout evolution suggest a continuous and hierarchical process that starts out with the origin of a morphological novelty, unit, or homologue. Once a morphological unit has originated, its properties change subsequently into variants that differ, in magnitude, from the orig...
Article
Full-text available
Mosaic evolution is a key mechanism that promotes robustness and evolvability in living beings. For the human head, to have a modular organization would imply that each phenotypic module could grow and function semi-independently. Delimiting the boundaries of head modules, and even assessing their existence, is essential to understand human evoluti...
Data
Raw adjacency matrices of the skull of human newborns with normal and craniosynostosis conditions.
Article
Full-text available
The enameloid microstucture of chondrichthyan teeth has been studied for decades and it has proven to be a useful taxonomic tool. Changes in enameloid organization have been related to the emergence of new trophic strategies and Mesozoic radiation of the neoselachian crown group. However, in contrast to the abundance of these data on tooth enameloi...
Article
Craniofacial sutures and synchondroses form the boundaries between bones in the human skull, providing functional, developmental and evolutionary information. Bone articulations in the skull arise due to interactions between genetic regulatory mechanisms and epigenetic factors such as functional matrices (soft tissues and cranial cavities), which m...
Article
Despite the many reconstructions of fossil material that have recently appeared in the literature, dinosaur eggshells have never been reconstructed using computing techniques. Using the EMAC 3-D modelling methodology, we reconstruct a section of the Late Cretaceous Megaloolithus siruguei eggshell, which has a particularly complex pore system, exhib...
Article
Despite the many reconstructions of fossil material that have recently appeared in the literature, dinosaur eggshells have never been reconstructed using computing techniques. Using the EMAC 3-D modelling methodology, we reconstruct a section of the Late Cretaceous Megaloolithus siruguei eggshell, which has a particularly complex pore system, exhib...
Article
Ever since the appearance of the first land vertebrates, the skull has undergone a simplification by loss and fusion of bones in all major groups. This well-documented evolutionary trend is known as “Williston’s Law”. Both loss and fusion of bones are developmental events that generate, at large evolutionary scales, a net reduction in the number of...
Article
Full-text available
Network theory has been extensively used to model the underlying structure of biological processes. From genetics to ecology, network thinking is changing our understanding of complex systems, specifically how their internal structure determines their overall behavior. Concepts such as hubs, scale-free or small-world networks, common in the complex...
Article
Evo‐Devo, the science that puts together in a common framework the dynamics of evolution with the processes of embryonic development is inherently multiscale. The hierarchical organization of life phenomena also contributes to the possibility of reducing its complexity to workable modules. However, the emphasis on a compositional, or blocks‐within‐...
Article
Evo-Devo, the science that puts together in a common framework the dynamics of evolution with the processes of embryonic development is inherently multiscale. The hierarchical organization of life phenomena also contributes to the possibility of reducing its complexity to workable modules. However, the emphasis on a compositional, or blocks-within-...
Chapter
El concepto de cambio morfológico direccional jugó un papel clave en los orígenes de la teoría evolutiva. Su vigencia hoy en día se ha visto menoscabada por el neutralismo y el equilibrio puntuado, dos teorías procedentes de campos tan distantes como la genética de poblaciones y la paleontología. Sin embargo, el estudio del cambio direccional sigue...
Chapter
Full-text available
Pere Alberch's work did not take the path of molecular biology. As a result, his contributions to a morphological evo-devo have been neglected by the molecular evodevo community. I will show, in the following sections, the key elements that, in my opinion, form the core of how molecular biologists embraced this specifi c kind of evodevo, which, at...
Article
The theory of Punctuated Equilibria challenges the neo-Darwinian tenet that evolution is a uniform process. Recently, an article by Hunt has found that directional change during the evolution of a lineage is relatively small (occurring only in 5% of 250 analyzed traits). Of those traits that were shown to follow a trend, size was more likely to sho...
Article
Full-text available
We describe a new methodology for rapid 2D and 3D computer analysis and visualisation of gene expression and gene product pattern in the context of anatomy and tissue architecture. It is based on episcopic imaging of embryos and tissue samples, as they are physically sectioned, thereby producing inherently aligned digital image series and volume da...
Article
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Gradient formation is a fundamental patterning mechanism during embryo development, commonly related to secreted proteins that move along an existing field of cells. Here, we mathematically address the feasibility of gradients of mRNAs and non-secreted proteins. We show that these gradients can arise in growing tissues whereby cells dilute and tran...
Article
Nodal cilia dynamics is a key factor for left/right axis determination in mouse embryos through the induction of a leftward fluid flow. So far it has not been clearly established how such dynamics is able to induce the asymmetric leftward flow within the node. Herein we propose that an asymmetric two-phase nonplanar beating cilia dynamics that invo...
Article
Full-text available
We present a vector field method for obtaining the spatial organization of three-dimensional patterns of gene expression based on gradients and lines of force obtained by numerical integration. The convergence of these lines of force in local maxima are centers of gene expression, providing a natural and powerful framework to characterize the organ...
Article
Full-text available
We present a vector field method for obtaining the spatial organization of three-dimensional patterns of gene expression based on gradients and lines of force obtained by numerical integration. The convergence of these lines of force in local maxima are centers of gene expression, providing a natural and powerful framework to characterize the organ...
Article
Morphospaces are theoretical tools to explore the morphological organization of living and fossil organisms. They have been used mostly by the paleontological community in an effort to get the most out of one of the only pieces of evidence that fossil material usually provide: the morphology of hard parts. The expectation with the establishment of...
Article
Full-text available
During vertebrate embryo development, the breaking of the initial bilateral symmetry is translated into asymmetric gene expression around the node and/or in the lateral plate mesoderm. The earliest conserved feature of this asymmetric gene expression cascade is the left-sided expression of Nodal, which depends on the activity of the Notch signallin...
Article
Full-text available
El Bauplan de los animales bilaterales se caracteriza por la demarcación en estadíos tempranos de tres ejes embrionarios. Uno de estos ejes define el plano de simetría bilateral del futuro adulto, el cual divide a estos organismos, en teoría, en dos mitades especulares: izquierda y derecha. Las especies de este grupo se distancian de un modo signif...
Article
Full-text available
[EN] The body plan of bilateral animals is characterized by the early specification of three embryonic axes. One of these axes defines the plane of bilateral symmetry of the future adult, ideally dividing these organisms in two mirror-image halves, left and right. Most species of this group exhibit significant and robust departures from this ideal...
Article
Full-text available
Theoretical models of skeletal structures provide suitable frameworks to assess macroevolutionary patterns of form change. We discuss three theoretical approaches to account for morphological patterns of the pelvic girdle in archosaurs. Every approach targets a different level of organization within the concept of morphospace. First, we build a mor...
Chapter
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Article
THEORETICAL MORPHOLOGY: THE CONCEPT AND ITS APPLICATIONS, by George R. McGhee, 1999. Columbia University Press, New York, 316 p. ISBN 0–231–10616–5 (hardback), $60.00; ISBN 0–231–10617–3 (paperback), $26.50
Article
The comparison of bone homology between the manus of an Early Cretaceous fossil crocodile and that of the extant species Alligator mississippiensis supports explicidy, for the first time, the hypothesis of carpal loss in crocodilian limb evolution. This hypothesis, based on a developmental model of the organization of the tetrapod limb, is in accor...
Article
The comparison of bone homology between the manus of an Early Cretaceous fossil crocodile and that of the extant speciesAlligator mississippiensissupports explicitly, for the first time, the hypothesis of carpal loss in crocodilian limb evolution. This hypothesis, based on a developmental model of the organization of the tetrapod limb, is in accord...
Article
Full-text available
A feathered skeleton of a Lower Cretaceous enantiornithine bird from Spain indicates that the modified diapsid skull of modern birds did not evolve until late in their evolution: Basal birds retained an essentially primitive diapsid design. The fossil provides data clarifying long-standing debates on the cranial morphology of the basalmost bird, Ar...
Chapter
Full-text available
Affine change might be used to seek general patterns of variation or to envisage new ways of describing and evaluating form change. In this paper, we assume a theoretical perspective and show a strategy for generating affine morphospaces (ordered collections of affine-transformed images of a base form), by means of a new computer program called D’A...
Article
Full-text available
THE Lower Cretaceous lithographic limestones from Las Hoyas (province of Cuenca, Spain) have yielded important vertebrate fossil remains. We report here a new specimen, the first ornithomimosaur theropod found in Europe. Pelecanimimus polyodon gen. et sp. nov., has some striking elements preserved, such as the hyoid, sternum and integumentary impre...

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Projects

Projects (6)
Project
Compile materials on the use of network models to study problems in anatomy and morphology.