Diego Halabí

Diego Halabí
Universidad Austral de Chile · Institute of Dentistry

DDS, PhD

About

19
Publications
4,397
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203
Citations
Introduction
I am a dentist DDS (PhD) fully dedicated to clinical and translational research
Additional affiliations
March 2018 - present
Universidad Austral de Chile
Position
  • Professor (Assistant)

Publications

Publications (19)
Article
PURPOSE: To assess risk factors for alveolar osteitis. MATERIALS AND METHODS: A prospective nested case-control study was conducted in an urban community dental clinic in Valdivia, Chile. A cohort of 1,355 patients who underwent dental extractions was included. Eight predictor variables (risk factors), namely patient gender, hygiene, tooth location...
Article
Full-text available
Compelling evidence in rats support the idea that gestational chronodisruption induces major changes in maternal circadian rhythms and fetal development and that these changes impact adult life at many physiological levels. Using a model of chronic photoperiod shifting throughout gestation (CPS), in which pregnant female rats (Sprague–Dawley strain...
Article
Full-text available
The interaction of the maternal and fetal circadian systems is recognized as a crucial crosstalk for fetal development, which may be a key factor determining fitting health in adulthood. Unfortunately, in our modern societies the relevance of regular light/dark cycles has been dangerously disregarded, generating a disarray of the internal temporal...
Article
Full-text available
Objective: To determine the effectiveness of chlorhexidine 0.12% mouthwash (CHX) after tooth extraction for the prevention of alveolar osteitis (AO). Material and methods: We conducted a double-blind randomised clinical trial stratified by risk factors. We enrolled a cohort of 822 patients who underwent dental extractions, and were considered to b...
Article
Full-text available
Synchronization to periodic cues such as food/water availability and light/dark cycles is crucial for living organisms’ homeostasis. Both factors have been heavily influenced by human activity, with artificial light at night (ALAN) being an evolutionary challenge imposed over roughly the last century. Evidence from studies in humans and animal mode...
Article
Full-text available
Adverse prenatal conditions are known to impose significant trade-offs impinging on health and disease balance during adult life. Among several deleterious factors associated with complicated pregnancy, alteration of the gestational photoperiod remains largely unknown. Previously, we reported that prenatal manipulation of the photoperiod has advers...
Article
Full-text available
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Upon demyelination, oligodendrocyte progenitor cells (OPCs) are activated and they proliferate, migrate and differentiate into myelin-producing oligodendrocytes. Besides OPCs, neural stem cells (NSCs) may respond to demyelination and generate oligo...
Article
Full-text available
The aim of this study was to design and validate the Dental Psychomotor Skills (DePS) test as an instrument to assess dental students’ psychomotor skills and to help educators adapt their academic practices to students’ needs. The DePS test was created considering three of the main skills needed for dental study and practice. The dimensions measure...
Article
Full-text available
Key points: Light at night is essential to a 24/7 society, but it has negative consequences on health. Basically, light at night induces an alteration of our biological clocks, known as chronodisruption also during pregnancy. Here we explored the developmental impact of gestational chronodisruption (chronic photoperiod shift -CPS-) on adult and fe...
Article
Full-text available
Objetivo: Determinar la calidad metodológica de los estudios clínicos de ortodoncia de las seis revistas con mayor factor de impacto indexadas en ISI, entre enero del 2012 y diciembre del 2016. Metodología: Se realizó una búsqueda en PubMed, se analizó el resumen y metodología de todos los estudios seleccionados. Se clasificó como ensayo clínico a...
Article
Chronic exposure to light at night, as in shift work, alters biological clocks (chronodisruption), impacting negatively pregnancy outcome in human. Actually, the interaction of maternal and fetal circadian systems could be a key factor determining a fitting health in adult. We propose that chronic photoperiod shifts (CPS) during pregnancy, alter ma...
Article
Full-text available
Aim: To determine differences in marginal adaptation between a conventional composite resin and a monoincremental resin with sonic activation. Materials and methods: 32 composite resin discs of 2.5mm in diameter and 2mm thick were fabricated in a propylene matrix and distributed in 2 groups of 16 samples each. Groups 1 FiltekTMZ350XT resin; Group 2...
Article
Full-text available
Aim: To determine the prevalence of neuropathic symptoms in the orofacial region in patients referred for painful temporomandibular disorder at Hospital Base Valdivia in 2014 and 2015. Materials and method: An observational study was conducted on patients referred for painful temporomandibular disorder by general dentists working in primary dental...
Article
Full-text available
Introduction: The aim is to determine the association between abdominal obesity and periodontal disease by a multivariate analysis. Material and methods: A cross-sectional observational study was carried out. From March to April 2014, patients admitted to Dental Sciences Building, at Universidad Austral de Chile, were subjected to a clinical perio...
Conference Paper
The adrenal gland is a peripheral circadian clock, required for fine-tuning to the environment and stress adaptation. Recent results of our group support that the fetal adrenal function is set by the maternal photoperiod, probably through melatonin signaling. Here, we explored the effects of chronic photoperiod shifting throughout pregnancy on the...
Article
Full-text available
PURPOSE: To assess risk factors for alveolar osteitis. MATERIALS AND METHODS: A prospective nested case-control study was conducted in an urban community dental clinic in Valdivia, Chile. A cohort of 1,355 patients who underwent dental extractions was included. Eight predictor variables (risk factors), namely patient gender, hygiene, tooth location...

Questions

Question (1)
Question
Has anyone performed flow cytometry on adipose tissue?
I want to use the protocol published by Bernstein et al. (1989), but the paper isn't as detailed as I would like. My main question is how to disaggregate the cells with collagenase; dose, incubation time, temperature, etc..
If anyone would like to share another protocol, any tips or discuss the technique, I'd really appreciate it.

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Projects

Projects (2)
Project
To determine the risk factors for the main pathologies of the stomatognathic system, and what are the best treatments to prevent their development.