Didier RiethmullerUniversity of Grenoble · Faculté de Médecine
Didier Riethmuller
About
423
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4,611
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Citations since 2017
Introduction
Skills and Expertise
Publications
Publications (423)
Objective: To quantify the transplacental transmission of SARS-CoV-2 and antibodies in pregnant women and their new-borns according to the trimester of maternal infection. Design: This was a prospective observational multicentre study including pregnant women with positivity for SARS-CoV-2 by reverse transcription–polymerase chain reaction (RT‒PCR)...
Résumé
L’idée d’utiliser un instrument pour assister la naissance par les voies naturelles ne date pas d’hier et ce sont les 18ème et 19ème siècles qui verront l’essor du forceps. Il faudra attendre l’après 2ème guerre mondiale pour que la ventouse apporte une alternative à l’accouchement instrumental mais toujours basé sur la préhension-traction....
Background:
The objective of this study was to assess the preliminary efficacy and safety of conservative management compared with systematic suture in isolated vaginal or first-degree perineal tears after birth.
Methods:
We conducted a preliminary efficacy, open-label, randomized, controlled, and prospective trial. This study implemented Simon'...
Human papillomavirus (HPV) 16 exhibits different variants that may differ in their carcinogenic risk. In order to identify some high‐risk variants, we sequenced and compared HPV16 whole genomes obtained from a longitudinal cohort of 34 HPV16‐infected women who had either spontaneously cleared their infection (clearance group or “C”), or developed c...
Purpose
To evaluate the effectiveness and safety of temporary proximal uterine artery embolization (UAE) for the treatment of highly vascularized retained products of conception (RPOC).
Materials and methods
This retrospective analysis included women who underwent vaginal bleeding after abortion, miscarriage or delivery with highly vascularized RP...
Background:
Fetal cardiac well-being is essential during labor as the delivery is at risk for fetal distress. Continuous monitoring by cardiotocography (CTG) is daily used to record the fetal heart rate (FHR) but this technique has important drawbacks in clinical use.
Objectives:
We propose to monitor FHR with a non-invasive technique, using mul...
Objective
To evaluate and compare overall survival and progression-free survival in two groups of patients with advanced ovarian cancer, managed by neoadjuvant chemotherapy (3 cycles or more) followed by interval debulking surgery. Secondary objectives regarded surgical morbidity and extent of cytoreduction.
Material and Methods
We conducted a ret...
Contexte
La classification française des « codes couleurs » permet de graduer le degré d’urgence d’une césarienne. Une césarienne est réalisée en « code rouge », ou en extrême urgence, si le pronostic fœtal ou maternel est immédiatement engagé. Ces situations représentent moins de 1 % des accouchements, et cette procédure, non dénuée de risques, do...
Resumen
El mundo médico ha negado durante mucho tiempo la posibilidad de que el feto pudiese sentir dolor. Posteriormente, experimentos realizados en recién nacidos muy prematuros han mostrado que las estructuras necesarias para la percepción del dolor están presentes desde la mitad del segundo trimestre del embarazo. A partir de estos resultados,...
Background:
Cervical dilatation curves are widely used to describe normal and abnormal labor progression for cephalic presentation. Labor curves for breech presentations have never been described.
Objectives:
The aims of this study were to examine the pattern of labor progression in women with a breech presentation and to determine whether the t...
Resumen
Emmanuel A. Friedman propuso normas para el desarrollo del trabajo de parto hace más de 65 años, y estas normas han sido aceptadas a escala internacional. Sin embargo, es sorprendente que haya habido muy poca investigación sobre el trabajo de parto normal hasta principios de la década de 2000. En efecto, son los datos recientes los que han...
Background
Induction of labour, a very common obstetric procedure, affects about one in five pregnant women in most developed countries. Induction of labour is medically indicated, is subject to risks and additional costs, and is often poorly experienced by patients. The practices concerning induction vary widely from centre to centre and therefore...
Femoral fracture is a rare but significant foetal injury, more frequent and likely to happen when the foetus is malpositioned or in a breech presentation. Caesarean section does not appear to be protective and all recent publications report cases occurring during caesarean section. We report a case that occurred in a vaginal delivery of a single fo...
Fetal heart rate (FHR) is the main feature for monitoring fetal well-being as recommended by the International Federation of Gynecology and Obstetrics (FIGO). The ultrasound based cardiotocography (CTG) is nowadays the world-wide non-invasive clinical reference technique for intrapartum FHR monitoring, as stated by FIGO. However, some limitations o...
Résumé
Objectif : Analyser l’introduction de la pratique de la manœuvre de Couder au sein de notre maternité de niveau 3 peu de temps après son introduction en 2019. Puis, évaluer et comparer le taux de lésions périnéales entre 2017, lorsque que la manœuvre n’était pas du tout réalisée, et 2020.
Matériels et méthode : Étude rétrospective monocentri...
The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. The objective of this study was to describe HPV genotype distribution and risk factors in a po...
PurposeTo evaluate the obstetrical prognosis of term breech delivery in case of asymmetric pelvis.Methods
An observational, comparative, retrospective, bi-centric study of 559 patients who had a computer tomography pelvimetry prior to delivery of a term breech presentation was conducted between August 2013 and August 2019. Patients with an attempte...
Resumen
La vacunación antes del embarazo permite transmitir una inmunidad al feto que lo protegerá durante el período neonatal, hasta que desarrolle su propia inmunidad. La vacunación se ha considerado durante mucho tiempo incompatible con el embarazo, a pesar de que la gestación expone a las mujeres a formas a veces más complicadas de ciertas enfe...
Encephalocraniocutaneous lipomatosis (ECCL) or Haberland syndrome (MIM #613001) is a rare congenital neurocutaneous disorder. It is characterized by unilateral ocular, cutaneous and central nervous system anomalies. Key clinical features include hairless fatty tissue nevus of the scalp, choristoma of the eye and intraspinal and intracerebral lipoma...
Résumé
Objectifs: Évaluer la manœuvre de Demelin dans la prise en charge d’une dystocie du relèvement des bras lors de l’accouchement voie basse (AVB) d’un siège après échec de la manœuvre de Lovset.
Méthodes: Nous avons réalisé une étude observationnelle rétrospective dans deux maternités françaises (niveaux IIB et III) entre janvier 2013 et juin...
Contexte
L’exclusion par clips chirurgicaux des anévrysmes intracrâniens est une chirurgie risquée et la formation des plus jeunes est souvent limitée à cause du développement du traitement endovasculaire. L’utilisation d’un modèle de simulation d’anévrisme intracrânien apparaît comme une nécessité. Il existe différents modèles parfois trop éloigné...
High-risk HPV (hrHPV) testing has been implemented as a primary screening tool for cervical cancer in numerous countries. However, there is still a need for relevant triage strategies to manage hrHPV positive women to avoid excessive referral to colposcopy. The objective of this study was to assess, in women infected by hrHPV and presenting no or m...
Résumé
La tumeur de Buschke Lowenstein est un condylome acuminé géant caractérisé par son potentiel dégénératif, son caractère envahissant et récidivant après traitement. C'est une affection rare, transmise essentiellement par voie sexuelle et liée au papillomavirus humain (HPV).
La discussion sera illustrée par un cas clinique. Le traitement reste...
Resumen
El parto por vía vaginal implica el paso de tres obstáculos: el cuello uterino, que está cerrado durante el embarazo y se dilatará durante el trabajo de parto; la pelvis: el paso de este desfiladero, en parte rígido, necesita una adaptación constante de las diversas partes del feto al continente; el periné: su paso constituye la expulsión....
This study aims to analyze, in a population of singletons, the potential confounding or modifying effect of noise on the relationship between fetal growth restriction (FGR) or small for gestational age (SGA) and environmental exposure to air pollution. All women with single pregnancies living in one of two medium-sized cities (Besançon, Dijon) and...
Background
We aimed at developing a core outcome and variables of interest set to investigate the effects of mediolateral episiotomy on Obstetric Anal Sphincter Injury (OASI) during and after operative delivery in nulliparous women in a large-scale one-year observational French study including 15,000 women (INSTRUMODA).
Methods
A list of outcomes...
The Odon DeviceTM is an innovative investigational device for assisted vaginal birth (AVB) and has not yet been granted regulatory approval for sale in any country. It is the first innovation in AVB since the introduction of the vacuum extractor in the 1950’s and the device is designed for use by different level of trained health care providers. Ef...
Neonatal skull fracture is rare and instrumental delivery is one of the risk factors. We present a case of parietal bone fracture in a term newborn with Thierry's spatulas who benefited from a 3D brain scan. If many cases have been reported with the use of forceps whatever their type, our case is to our knowledge the first one described with spatul...
Objectives
In 5 % of vaginal deliveries in case of cephalic presentation there is a persistent occipital posterior position known to be associated with a higher maternal and neonatal morbidity. In these situations, vacuum extractor seems to be the best choice for assisted delivery but it also has limits and contraindications, for example an importa...
The aim of this study was to evaluate an oocyte pick-up (OPU) simulation training program for residents using the high fidelity PickUpSimTM (Accurate, Cesena, Italy) simulator. The authors carried out an observational study during an OPU simulation workshop. A successful scenario was defined as an oocyte retrieval rate ≥70% without any complication...
Purpose:
To evaluate the impact of a selective use of episiotomy combined with Couder's maneuver on the incidence of perineal tears in spontaneous term deliveries.
Methods:
A comparative, retrospective, mono-centric study in a university maternity unit was designed and included all primiparous women who delivered spontaneously after 37 weeks of...
Objective:
To compare neonatal mortality and morbidity of first twins according to the planned mode of delivery when the first twin is in breech presentation, in a country where planned vaginal delivery is an option.
Methods:
This is a planned secondary analysis of the JUMODA (JUmeaux MODe d'Accouchement) cohort, a national prospective populatio...
Resumen
Las presentaciones en extensión, que se oponen a la presentación occipital, de vértex perfectamente flexionada, son tres y se diferencian en función del grado de extensión cefálica. La presentación de cara tiene una extensión completa de tres tercios, la de frente una extensión de dos tercios y, por último, la de bregma una extensión de un...
Résumé
L’Odon DeviceTM est décrit dans la littérature depuis 2013 et l’organisation mondiale de la santé soutient son développement à travers son programme de recherche Human reproduction programme. Ce dispositif innovant pourrait être plus simple d’utilisation que les instruments habituels et pourrait être une alternative à la césarienne lors du d...
Multiple risk factors are associated with adverse pregnancy outcomes (APO), but how all these different factors combine and accumulate remains unknown. The objective of this observational retrospective study was to describe the accumulation of multiple vulnerability markers in pregnant women living in an urban area. Women living in Besançon (France...
Resumen
Las presentaciones transversas y oblicuas son posiciones distócicas del feto en el sentido de un parto aún más difícil, incluso imposible en la gran mayoría de los casos. El eje mayor del móvil fetal es perpendicular al eje materno. Si bien estas presentaciones reflejan a menudo una enfermedad uterina en la primípara, en cambio tienen una c...
Purpose:
The first aim was to evaluate feasibility and reproducibility of 2-dimensional ultrasound (2D) shear wave elastography (SWE) of human fetal lungs and liver between 24 and 34weeks of gestation. The second aim was to model fetal lung-to-liver elastography ratio (LLE ratio) and to assess its variations according to gestational age and matern...
Résumé
Objectif
Évaluer par une revue systématique de la littérature les bénéfices et l’innocuité de la rotation manuelle dans la prise en charge des variétés postérieures en 2019.
Méthodes
Nous avons conduit une revue systématique de la littérature à partir des bases de données MEDLINE et COCHRANE LIBRARY afin d’identifier les articles évaluant...
Purpose
To evaluate spatulas for entrapment of the after-coming head (EAH) during vaginal breech delivery, in the setting of failed usual manoeuvres (Bracht or Mauriceau).
Methods
We led a retrospective cohort study in two tertiary referral hospital in France. From 2003 to 2018, we included all deliveries of live children requiring the use of spat...
Background
The denial of pregnancy is the non-recognition of the state of the current pregnancy by a pregnant woman. It lasts for a few months or for the whole pregnancy, with generally few physical transformations. In this study, we will consider the denial of pregnancy as a late declaration of pregnancy (beyond 20 weeks of gestation) as well as a...
Objective: Our purpose was to evaluate the impact of active delivery of the anterior arm with Couder’s Maneuver (CM) during vacuum-assisted vaginal delivery (VAVD) on perineal tears. This maneuver can be beneficial because it has the advantage of reducing fetal biacromial diameter.
Methods: This monocentric retrospective study compared two non-conc...
Introduction
To evaluate the impact of the mode of delivery of twin pregnancies with the first twin in breech position for all parities combined after introduction of a policy of planned caesarean section in 38 weeks’ gestation in nulliparas.
Material and methods
A retrospective study of the mode of delivery of twin pregnancies with the first twin...
Introduction:
The objective of these clinical practice guidelines was to analyse all of the interventions during pregnancy and childbirth that might prevent obstetric anal sphincter injuries (OASIS) and postnatal pelvic floor symptoms.
Material and methods:
These guidelines were developed in accordance with the methods prescribed by the French H...
Background. Multiple pregnancies (where more than one fetus develops simultaneously in the womb) are systematically excluded from studies of the impact of air pollution on pregnancy outcomes. This study aims to analyze, in a population of multiple pregnancies, the relationship between fetal growth restriction (FGR), small for gestational age (SGA)...
Résumé
Objectif
L’accouchement instrumental (AI) est grevé d’un risque de déchirures périnéales et notamment de lésions obstétricales du sphincter anal (LOSA) qui sont associées à une morbidité importante et une altération de la qualité de vie. L’objectif principal de cette étude était de comparer la proportion de LOSA chez les primipares à terme...
High risk HPV infection is the necessary cause for the development of precancerous and cancerous lesions of the cervix. Among HPV, HPV16 represents the most carcinogenic type. Since the determination of HPV16 DNA load could be clinically useful, we assessed quantitative real-time PCR targeting E6HPV16 and albumin genes on two different platforms. S...
Résumé
Objectif
L’objectif de tout acteur de la naissance qui intervient au cours de la phase du dégagement de la présentation fœtale est de prévenir au mieux les lésions périnéales. Ce travail a donc consisté, au travers d’une analyse de la littérature, à rechercher et à évaluer les interventions qui diminuent ce risque périnéal au cours du dégag...
Introduction: The objective of these clinical practice guidelines was to analyse all of the interventions during pregnancy and childbirth that might prevent obstetric anal sphincter injuries (OASIS) and postnatal pelvic floor symptoms. Material and methods: These guidelines were developed in accordance with the methods prescribed by the French Heal...
We report a case of prenatal exposure to angiotensin II receptor antagonists (ARA II) from the beginning of pregnancy in a patient with a hypokinetic dilated cardiomyopathy. This case report emphasizes the fetal renal impact of prolonged intrauterine exposure to renin-angiotensin system (RAS) blockers, and highlights that this exposure can cause se...
A 5,6 Mb de novo 19q12-q13.12 interstitial deletion was diagnosed prenatally by array-comparative genomic hybridization in a 26 weeks male fetus presenting with intra-uterine growth retardation, left clubfoot, atypical genitalia and dysmorphic features. Autopsic examination following termination of pregnancy identified a severe disorder of sex deve...
Objective:
The aim of the study was to identify the risk factors of post-large loop excision of the transformation zone (LLETZ) recurrent disease and the impact of colposcopic guidance at the time of LLETZ on that risk.
Materials and methods:
From December 2013 to July 2014, 204 patients who had undergone LLETZ for the treatment of high-grade in...
Objectives:
Mortality rates of very preterm infants may vary considerably between healthcare facilities depending on the neonates' place of inclusion in the cohort study. The objective of this study was to compare the mortality rates of live-born extremely preterm neonates observed in two French tertiary referral hospitals, taking into account the...
La incidencia de los embarazos extrauterinos (EEU) se estima en el 2% del total de los embarazos. La trompa y particularmente la ampolla son las localizaciones más frecuentes. Los principales factores de riesgo son todos maternos, a saber, antecedente de EEU, tabaquismo, infección genital, dispositivo intrauterino, más de 35 años de edad, microprog...
Background:
Despite the availability of safe and effective HPV vaccines in France, more than 80% of girls remain unvaccinated.
Setting:
A regional university hospital referral centre in France.
Objective:
To estimate the overall prevalence and distribution of HPV in vaccinated, sexually active young French women who were screened for cervical...
L’objectif était d’analyser le lien entre l’exposition environnementale au bruit et à la pollution de l’air en milieu urbain et la prématurité chez les femmes dont le risque d’accouchement prématuré était augmenté par la présence d’une ou plusieurs comorbidités. Méthode. Une étude cas-témoins a été conduite sur les grossesses uniques accompagnées d...
Objective
Nomograms are statistical models that combine variables to obtain the most accurate and reliable prediction for a particular risk. Fetal heart rate (FHR) interpretation alone has been found to be poorly predictive for fetal acidosis while other clinical risk factors exist. The aim of this study was to create and validate a nomogram based...
Background: The nonavalent HPV (9vHPV) vaccine is indicated for active immunisation of individuals from the age of 9 years against cervical, vulvar, vaginal and anal premalignant lesions and cancers causally related to vaccine HPV high risk types 16, 18, 31, 33, 45, 52 and 58, and to the HPV low risk types 6 and 11, causing genital warts.
Objective...
Purpose:
To evaluate the reliability of pelvimetric measurements performed using stereoradiographic imaging (SRI), and to assess maternal and fetal radiation doses compared to low-dose computer tomography (CT) pelvimetry.
Materials and methods:
Thirty-five pregnant women (mean age, 29.6±5.5 [SD] years; range: 20-41 years) were prospectively incl...
The estimated prevalence of fetal caudal dysgenesis is 1 per 100,000 births. The functional prognosis of sacral agenesis is dominated by the large spectrum of associated caudal malformations. Except for cases associated with hydrocephalus secondary to open spinal dysraphism or chromosomal anomalies, association with mental deficiency is rare. We pr...
Objective:
The aim of the study was to identify the risk factors of post-large loop excision of the transformation zone (LLETZ) inadequate colposcopy.
Materials and methods:
From December 2013 to July 2014, a total of 157 patients who had a LLETZ performed for the treatment of high-grade intraepithelial lesion with fully visible cervical squamoc...