Didier Dewailly

Didier Dewailly
Centre Hospitalier Régional Universitaire de Lille · Division of Reproductive Endocrinology

MD

About

492
Publications
88,228
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26,447
Citations
Additional affiliations
January 2003 - present
Centre Hospitalier Régional Universitaire de Lille
Position
  • Head of Department
January 1980 - present
University of Lille Nord de France
Position
  • Professor
Description
  • Teaching and mentoring in reproductive Endocrinology

Publications

Publications (492)
Article
Full-text available
Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in many biological pathways. Since the discovery of their involvement in endocrine signal transduction, myo-Ins and D-chiro-Ins supplementation has contributed to clinical approaches in ameliorating many gynecological and endocrinological diseases. Currently bo...
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Full-text available
Introduction Primary ovarian insufficiency (POI) affects 1% of women under 40 years old. POI is idiopathic in more than 70% of cases. Though many candidate genes have been identified in recent years, the prevalence and pathogenicity of abnormalities are still difficult to establish. Objectives Our primary objective was to evaluate the prevalence o...
Article
Study question: Are serum levels of anti-Müllerian hormone (AMH) normal in patients with functional hypothalamic anovulation (FHA)? Summary answer: Our study confirms that in the general FHA population, serum AMH levels are not decreased, but if patients with polycystic ovarian morphology (PCOM) are excluded, levels become significantly lower, a...
Article
Research question Which clinical and/or biological and/or ultrasound features are the most strongly associated to either high or low AMH levels in patients with PCOS? Design A retrospective cross-sectional study was conducted within a University-affiliated Reproductive Endocrinology Unit in Lille. A total of 639 patients with PCOS according to the...
Article
Purpose Anti-Müllerian hormone (AMH) is a biomarker reflecting ovarian reserve. A low AMH level before 39 years may be associated with a risk of menopause between 40 and 45 years. The risk of onset of premature ovarian insufficiency (POI) is, however, poorly documented. The objective of the study was to determine the prevalence of POI 5–10 years af...
Article
Introduction: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). Areas covered: In view of the recent knowledge, changes in nutritional an...
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Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generat...
Article
Resumen Desde su descripción inicial por Stein y Leventhal en 1935, el síndrome de ovarios poliquísticos (SOP) ha visto evolucionar su definición. Desde 2003, tras la conferencia de consenso de Rotterdam, la definición se ha basado en la presencia de criterios clínicos, de laboratorio y ecográficos, tras descartar otras etiologías que pudieran prod...
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Study question : Does the relative distribution of AMH isoforms differ from one patient to another depending on their BMI and PCOS status in the serum and the follicular fluid (FF)? Design Obese and normal weight (NW) patients (PCOS:70; non-PCOS:37) were selected from a database (2014-1018) for this case-control study in the serum. Between 2018 an...
Article
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P450 oxidoreductase deficiency (PORD) is an autosomal recessive disease caused by bi-allelic mutations of the POR gene. It is responsible for decreased activity of several P450 enzymes including CYP21A2, CYP17A1 and CYP19A1 that are involved in adrenal and/or gonadal steroidogenesis. PORD is typically diagnosed in neonates and children with ambiguo...
Article
It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little ef...
Article
Study question: Can cytochrome P450 oxidoreductase deficiency (PORD) be revealed in adult women with menstrual disorders and/or infertility? Summary answer: PORD was biologically and genetically confirmed in five adult women with chronically elevated serum progesterone (P) who were referred for oligo-/amenorrhea and/or infertility. What is know...
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Introduction: This Experts’ opinion aims to offer an updated scientific support for the therapeutic use of Inositols in Polycystic Ovary Syndrome (PCOS) and non-insulin dependent (type 2) diabetes mellitus (NIDDM), providing a practical support for gynecologists, obstetricians, endocrinologists, nutritionists, developmental and system biologists, n...
Article
This review details the physiologic roles of two insulin sensitizers, myo-inositol (MI) and d-chiro-inositol (DCI). In the human ovary, MI is a second messenger of follicle-stimulating hormone (FSH) and DCI is an aromatase inhibitor. These activities allow a treatment for polycystic ovary syndrome (PCOS) to be defined based on the combined administ...
Article
Objectives Cyproterone acetate is actually the first-line anti-androgenic treatment for severe hyperandrogenism in women. However, as this treatment is currently controversial, the objective of the study was to evaluate the safety and efficacy of spironolactone as a relay for cyproterone acetate. Methods This is a monocentric retrospective study co...
Article
Introduction L’hormone anti-Müllerienne (AMH) dont les taux sont plus élevés dans le syndrome des ovaires polykystiques est connue pour augmenter la sécrétion de LH/GnRH [1], [2]. Par ailleurs, les tanycytes, qui enchâssent les terminaisons des neurones à GnRH [3], [4], expriment le récepteur à l’AMH [2]. Ainsi, notre objectif est de tester les deu...
Article
Research question: Primary ovarian insufficiency (POI) is defined as the early exhaustion of ovarian function, before the age of 40 years. Its origin is genetic in 20-25% of cases. In rare cases, sequence variants of the NR5A1/SF-1 gene may result in POI, or in various disorders of gonadal development (DGD) or adrenal insufficiency. Design: This...
Article
Full-text available
Polycystic ovary syndrome (PCOS) and hyperprolactinemia (HPRL) are the two most common etiologies of anovulation in women. Since the 1950s, some authors think that there is a pathophysiological link between PCOS and HPRL. Since then, many authors have speculated about the link between these two endocrine entities, but no hypothesis proposed so far...
Article
Objectives: The prevalence of ovulation disorder (OD) is 3-fold higher in obese than normal-weight women. Most ODs are associated with concomitant polycystic ovary syndrome (PCOS), but obesity by itself can cause OD, through mechanisms that remain poorly documented. The literature on obese non-PCOS women with OD is sparse. The aim of the present s...
Article
In women, the anti-Müllerian Hormone (AMH) is secreted by the granulosa cells of growing follicles. Its measurement is strongly correlated with antral follicle count and represents a reliable marker of ovarian reserve. It also has the advantage of being highly reproducible since it has little variation within and between cycles. However, although i...
Article
Polycystic ovary syndrome (PCOS) affects 8–13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Müllerian hormone (AMH) is proposed as an alternative. To inform international PCOS guidelines, a systematic review was completed. Key identified gaps incl...
Article
Research question: To determine whether adding intramuscular to vaginal administration of progesterone reduces miscarriage rates compared with those of vaginal administration alone for luteal phase support in women receiving oocyte donation and to determine the best time to introduce intramuscular progesterone. Design: Retrospective analysis of...
Article
Résumé L’imagerie de la femme et en particulier l’échographie pelvienne jouent un rôle majeur dans l’évaluation et le diagnostic d’anomalies de la réserve ovarienne, que ce soit dans les situations d’excès folliculaire tel que le syndrome des ovaires polykystiques, ou dans la situation inverse, c’est-à-dire les baisses de réserve ovarienne, pouvant...
Article
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Background: Maternal virilization during pregnancy is a rare phenomenon. Polycystic ovary syndrome (PCOS), luteoma and luteinic cysts are the most frequent and benign etiologies. This article presents two cases of recurrent maternal virilization during pregnancy. Clinical cases: Our reported cases were young women with Afro-Caribbean and Nigeria...
Article
Résumé Objectifs L’objectif principal de cette étude était de décrire le taux d’ovulation chez des patientes atteintes de syndrome des ovaires polykystiques prises en charge en induction d’ovulation/insémination intra-utérine et traitées par follitropine alfa lors d’une seconde tentative de stimulation par gonadotrophines. Méthodes Une étude obse...
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With the increasing incidence of cancer and survival rates among young women, the development of fertility preservation techniques is of critical importance for those who desire future pregnancy. The pattern of ovarian response and oocyte quality after ovarian stimulation in cancer patients of reproductive age has been studied in several retrospect...
Article
Purpose of review: Polycystic ovarian syndrome (PCOS) is the most common cause of chronic anovulation and hyperandrogenism in young women and represents a true public health concern and an economic burden. Recent findings: The pathophysiology of PCOS is still not fully understood, but progresses have been made and the relationships between anti...
Article
Introduction/objectifs Dans le syndrome des ovaires polykystiques (SOPK), les taux d’hormone anti-Müllerienne (AMH) sont 2 à 3 fois plus élevés [1]. Or, l’AMH augmente la sécrétion de LH via une hyper-activation des neurones à GnRH [2]. Par ailleurs, les tanycytes, qui enchâssent les terminaisons des neurones à GnRH [3], [4], [5], expriment l’AMH e...
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Study Question What is the recommended assessment and management of women with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference? Summary Answer International evidence‐based guidelines including 166 recommendations and practice points, addressed prioritized questions to promote cons...
Article
Full-text available
Study question: What is the recommended assessment and management of women with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise and consumer preference? Summary answer: International evidence-based guidelines, including 166 recommendations and practice points, addressed prioritized questions to promote...
Article
Full-text available
Study question: What is the recommended assessment and management of women with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference? Summary answer: International evidence-based guidelines including 166 recommendations and practice points, addressed prioritized questions to promote...
Article
Full-text available
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and corresponds with a high degree of comorbidities and economic burden. How PCOS is passed on from one generation to the next is not clear, but it may be a developmental condition. Most women with PCOS exhibit higher levels of circulating luteinizing hormone, sugges...
Article
Introduction: The management of posterior deep endometriosis is not consensual. This is due to a great heterogeneity of data from the literature. Many series were small and overall, predictors of pregnancy were not all included and analyzed by multivariate analysis. We conducted this study to evaluate the factors associated with pregnancy during t...
Article
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Study question: Do patient-specific features contribute to the differences between measured serum anti-Müllerian hormone (AMH) concentrations and AMH values expected from the corresponding antral follicle count (AFC)? Summary answer: Patient-specific features contribute to the differences between measured AMH values and AMH values expected from...
Article
Study question: Is the negative correlation between the numbers of 2-5 and 6-9 mm follicles influenced by ovarian and/or metabolic parameter(s) in young control women and in patients with polycystic ovarian syndrome (PCOS)? Summary answer: Our study confirmed that the negative correlation between numbers of follicles sized 2-5 and 6-9 mm was str...
Article
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A lower number of metaphase II oocytes eligible for vitrification after controlled stimulation in cancer patients has recently been reported, suggesting that cancer may impair the dynamics and quality of follicular growth. In this prospective, non-interventional study, the pattern of follicular growth and oocyte cohort after ovarian stimulation in...
Article
La perimenopausia es la fase de transición, más o menos larga, comprendida entre la actividad ovárica «normal» y la menopausia. Se caracteriza por una verdadera desorganización hormonal, en la que primero existe una fase de hiperestrogenia seguida por la alternancia de fases de hipo e hiperactividad ovárica. Su diagnóstico sigue siendo clínico, aun...
Article
This Consensus Opinion summarizes the main aspects of several techniques for performing ovarian antral follicle count (AFC), proposes a standardized report and provides recommendations for future research. AFC should be performed using a transvaginal ultrasound (US) probe with frequency ≥ 7 MHz. For training, we suggest a minimum of 20-40 supervise...
Article
In this issue, Quinn et al. reports their experience on the diagnostic value of the anti-mullerian hormone (AMH) assay for the recognition of polycystic ovary syndrome (PCOS). This subject remains very much debated and, in particular, there is no consensus on a specific threshold discriminating PCOS from normal women. One of the reasons, but certai...
Article
La prévalence de l’obésité augmente massivement depuis plusieurs dizaines d’années dans les pays industrialisés. Les femmes obèses ont une activité sexuelle, non différente des femmes de poids normal, et bénéficieraient d’une couverture contraceptive moindre et d’un risque de grossesse non désirée plus élevé. En outre, l’obésité constitue un facteu...
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Introduction L’insuffisance ovarienne prématurée (IOP) se définit par une aménorrhée et un taux de FSH supérieur à 25 UI/L. Dans environ 70 % des cas, aucune étiologie n’est retrouvée. Ces dernières années, de nombreux gènes candidats ont été identifiés. Cependant, leur imputabilité et leur prévalence restent mal connues. Objectif Évaluer la préva...
Article
Serum AMH measurement became a key element in clinical practice, especially before using Assisted reproductive techniques (ART). However, many AMH kits exist giving different AMH results, leading to a confusion in their interpretation. Until recently, only manual ELISA kits existed (mainly Gen II Beckman, EIA/AMH Immunotech and two Anshlab kits) re...
Article
STUDY QUESTION Can cluster analysis be used to differentiate between normo-ovulatory women with normal ovaries and normo-ovulatory women with polycystic ovarian morphology (PCOM) in a non-subjective manner? SUMMARY ANSWER Cluster analysis can be used to accurately and non-subjectively differentiate between normo-ovulatory women with normal ovaries...
Article
Full-text available
Study question: Can anti-Müllerian hormone (AMH) automated immunoassays (Elecsys® and Access) be used interchangeably as a companion diagnostic for individualisation of follitropin delta dosing? Summary answer: The Access assay gives systematically higher AMH values than the Elecsys® assay which results in over 29% of women being misclassified t...
Article
Study question: Does the use of the serum anti-Müllerian hormone (AMH) assay to replace or complement ultrasound (U/S) affect the diagnosis or phenotypic distribution of polycystic ovary syndrome (PCOS)? Summary answer: Combining U/S and the serum AMH assay to define polycystic ovarian morphology (PCOM) diagnoses PCOS (according to the Rotterdam...
Article
Mono-follicular stimulation in women with poly-microcystic ovary syndrome must follow a well-coded strategy in 3 steps: first Clomifene citrate with follow-up cycle after cycle and dose adjustment as necessary results in pregnancy in about half the cases. In case of failure, one will choose according to its expertise and the local facilities betwee...
Article
Background: Non-classic congenital hyperplasia (NCAH) due to 21-hydroxylase deficiency is a common autosomal recessive disorder characterized by androgen excess. Objective and rationale: We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of...
Article
The relationship between serum anti-Müllerian hormone (AMH) levels, body mass index (BMI) and related metabolic factors were investigated in women with polycystic ovary syndrome (PCOS). A total of 691 women aged between 18 and 35 years, referred to the Department of Gynaecological Endocrinology at the University Hospital of Lille between 2009 and 2...
Article
Objective: Insulin resistance is known to worsen polycystic ovarian syndrome (PCOS). The management of insulin resistance is crucial in the treatment of PCOS and insulin-sensitizing molecule as myo-inositol (MYO) seems to have promising effects. The aim of our pilot study was to study whether supplementation with MYO can improve patients' sensitiv...
Article
Objective: Data on the incidence and severity of ovarian hyperstimulation syndrome (OHSS) in France are limited. Methods: Prospective observational multicentric study (23 French centers of IVF) in a cohort of 421 women treated with highly purified hMG (HP-hMG) for the first or second cycle of IVF with or without ICSI. The primary objective was t...
Article
In France until the end of 2015, oocyte donors must have had at least one child and be aged 18−37 years. This population of fertile women was selected to examine whether serum anti-Müllerian hormone (AMH) concentration could be a reliable correlate of spontaneous pregnancy in women who had proven their fertility before. A cohort of 217 women follow...
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BACKGROUND Androgens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are essential in human ovarian folliculogenesis. However, the interactions between these four players is not fully understood. OBJECTIVES AND RATIONALE The purpose of this review is to highlight the chronological sequence of the appearance and function of androgens, FSH, AM...
Article
In the management of azoospermia, a combination of testicular sperm extraction and intracytoplasmic sperm injection (ICSI) is usually the most successful option for fatherhood. However, an outstanding question remains: How can at least a few spermatozoa be obtained from the ejaculate, thus avoiding the need for a surgical procedure? A 36-year-old m...
Article
The stimulation of spermatogenesis is the best treatment of infertility for male hypogonadotropic-hypogonadism. The results are very pleasing because a real improvement of semen is sometimes obtained with spontaneous pregnants describing in the literature but after a long duration of treatment, often many months. Sometimes, the treatment improves t...
Article
Context: Ovulation induction in patients having both functional hypothalamic amenorrhea (FHA) and polycystic ovarian morphology (PCOM) has been less studied in the literature. As results remain contradictory, no recommendations have yet been established. Objective: To compare pulsatile GnRH therapy versus gonadotropins for ovulation induction in...
Article
Full-text available
Background Pulsatile GnRH therapy is the gold standard treatment for ovulation induction in women having functional hypothalamic amenorrhea (FHA). The use of pulsatile GnRH therapy in FHA patients with polycystic ovarian morphology (PCOM), called “FHA-PCOM”, has been little studied in the literature and results remain contradictory. The aim of this...