Diane Threapleton

University of Leeds · School of Food Science and Nutrition

Purpose The first 1000 days of life are critical for long-term health outcomes, and there is increasing concern about the suitability of commercial food products for infants, toddlers, and children. This study evaluates the compliance of UK commercial baby food products with WHO Nutrient and Promotion Profile Model (NPPM) guidelines. Methods Betwe...

Optimal nutrition during infancy and early childhood is crucial for promoting healthy growth, development, and overall well-being ⁽¹⁾ . Concerns arise regarding commercially available Food Products for Infants and Young Children (FIYC) due to potential imbalances in sugar, salt, fat content, and inappropriate promotion. The World Health Organizatio...

Ensuring consumption of nutrient‐dense, safe and appropriate complementary foods among older infants and young children (IYC) 6–36 months of age is critical for enabling optimal growth and development. The ubiquitous availability of and high demand for commercially packaged snack foods has culminated in a growing trend of snack food products specif...

In Southeast Asia, the increasing availability of commercially produced complementary foods (CPCF), including dry or instant cereals (CPCF cereals), has been noted, however, concerns exist around their nutrient profile and labelling practices. This 2021 study assessed the nutrient composition, labelling practices, and micronutrient content of CPCF...

Commercially produced complementary foods (CPCF), including ready‐to‐eat CPCF purées and meals, are gaining popularity among caregivers of older infants and young children (IYC) as a convenient alternative to home‐prepared foods in low and middle‐income countries. However, there is growing concern regarding the suitability of these products for old...

There is growing international concern about the suitability of certain commercial food products for infants and young children (FIYC) in Europe, especially those high in free sugars or marketed for infants under 6 months of age. Current regulatory guidelines are outdated and insufficient, resulting in the marketing and sale of unsuitable products....

Monitoring nutritional intake is of clinical value but few existing tools offer electronic dietary recording, instant nutritional analysis and a platform connecting healthcare teams with patients, providing timely, personalised support. This feasibility randomised controlled trial tests usability of ‘myfood24 Healthcare’, a dietary assessment app a...

Iodine is essential for normal thyroid function, supporting healthy fetal and child development. Io-dine requirements increase in pregnancy, but many women in regions without salt iodisation have insufficient intakes. We explored associations between iodide intake and urinary iodine concentra-tion (UIC), urinary iodine:creatinine ratio (I:Cr), thyr...

Background Maternal iodine requirements increase during pregnancy to supply thyroid hormones essential for fetal brain development. Maternal iodine deficiency can lead to hypothyroxinemia, a reduced fetal supply of thyroid hormones which, in the first trimester, has been linked to an increased risk of autism spectrum disorder (ASD) in the child. No...

Background: Maternal iodine requirements increase during pregnancy to supply thyroid hormones essential for fetal brain development. Maternal iodine deficiency can lead to hypothyroxinemia, a reduced fetal supply of thyroid hormones which, in the first trimester, has been linked to an increased risk of autism spectrum disorder (ASD) in the child. N...

Background: Maternal iodine requirements increase during pregnancy to supply thyroid hormones critical for fetal neurodevelopment. Iodine insufficiency may result in poorer cognitive or child educational outcomes but current evidence is sparse and inconsistent. Objectives: To quantify the association between maternal iodine status and child educ...

The aim was to determine whether commercial baby foods marketed within Europe (up to 36 months of age) have inappropriate formulation and high sugar content and to provide suggestions to update European regulations and recommendations as part of a nutrient profile model developed for this age group. The latter was produced following recommended Wor...

Background: Severe iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outcomes, finding inconsistent ev...

WHO guidelines on sugars strongly recommend reducing free sugar intake to below 10% of total energy, also their guidance on ‘Ending the inappropriate promotion of foods for infants and young children (IYC)’ recommends avoiding free sugars. Information on the sugar content of commercially available complementary foods (CACFs) for infants is limited,...

Severe iodine deficiency in mothers is known to impair foetal development. Pregnant women in the UK may be iodine insufficient, but recent assessments of iodine status are limited. This study assessed maternal urinary iodine concentrations (UIC) and birth outcomes in three UK cities. Spot urines were collected from 541 women in London, Manchester a...

Severe iodine deficiency in mothers is known to impair foetal development. Pregnant women in the UK may be iodine insufficient, but recent assessments of iodine status are limited. This study assessed maternal urinary iodine concentrations (UIC) and birth outcomes in three UK cities. Spot urines were collected from 541 women in London, Manchester a...

Objective Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. We conducted network meta-regression within a Bayesian framework to compare and rank different treatment strategies for HCC through direct and indirect evidence from international studies. Methods and analyses We pooled the OR for 1-year, 3-year and 5-ye...

Purpose To examine the barriers that hinder collaboration between health care and social care services and to report recommendations for effective collaboration to meet the growing support and care needs of our ageing population. Methods Data for this qualitative study were obtained from interviews with 7 key informants (n = 42) and 22 focus group...

Patient education and behavioural interventions for self-management of type 2 diabetes mellitus (T2DM) are effective but place demands on manpower resources. This systematic review aimed to investigate the effectiveness of smartphone technologies (STs) for improving glycaemic control among T2DM patients. CENTRAL, MEDLINE, Embase, CINAHL and Science...

Purpose To inform health system improvements for care of elderly populations approaching the end of life (EOL) by identifying important elements of care and implementation barriers and facilitators. Design A scoping review was carried out to identify key themes in EOL care. Articles were identified from MEDLINE, the Cochrane Library, organizationa...

Aims Depression is one of the most common mental disorders and identifying effective treatment strategies is crucial for the control of depression. Well-conducted systematic reviews (SRs) and meta-analyses can provide the best evidence for supporting treatment decision-making. Nevertheless, the trustworthiness of conclusions can be limited by lack...

Purpose: Inform health system improvements by summarizing components of integrated care in older populations. Identify key implementation barriers and facilitators. Data sources: A scoping review was undertaken for evidence from MEDLINE, the Cochrane Library, organizational websites and internet searches. Eligible publications included reviews,...

Background: High blood pressure is a strong risk factor for cardiovascular disease.Objective: The aim of this study was to determine the associations of dietary glycemic index (GI) and glycemic load (GL) with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in healthy individuals.Design: A systematic review and meta-analysis of rand...

Background: High blood pressure is a strong risk factor for cardiovascular disease. Objectives: The aim was to determine the associations of dietary glycemic index (GI) and glycemic load (GL) with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in healthy individuals. Design: A systematic review and meta-analysis of randomized cont...

Objectives: Higher or lower blood pressure may relate to cognitive impairment, whereas the relationship between blood pressure and cognitive impairment among the elderly is not well-studied. The study objective was to determine whether blood pressure is associated with cognitive impairment in the elderly, and, if so, to accurately describe the ass...

Objectives: Estimate the epidermal growth factor receptor (EGFR) mutation prevalence in all non-small cell lung cancer (NSCLC) patients and patient subgroups. Results: A total of 456 studies were included, reporting 30,466 patients with EGFR mutation among 115,815 NSCLC patients. The overall pooled prevalence for EGFR mutations was 32.3% (95% CI...

Scientific Reports 6 : Article number: 18764 10.1038/srep18764 ; published online: 08 January 2016 ; updated: 19 August 2016 . In the original version of this Article, there was an error in Affiliation 1 which was incorrectly given as ‘Department of Health Management, Southern Medical University, Guangzhou 510515, Guangdong, China’.

Background: It is uncertain whether concurrent use of low-dose aspirin removes the gastrointestinal benefit displayed by COX-2 selective inhibitors (coxibs) when compared to traditional nonsteroidal anti-inflammatory drugs (NSAIDs). Aim: To evaluate the gastrointestinal risks associated with coxibs and traditional NSAIDs and the interaction with...

Background: Many strategies are used to prevent nonsteroidal anti-inflammatory drug (NSAID)-associated gastrointestinal toxicity, but the comparative effectiveness remains unclear. Aim: To evaluate the comparative effectiveness of clinical strategies for preventing gastrointestinal toxicity induced by NSAIDs. Methods: MEDLINE, EMBASE and the C...

Atherosclerosis is the primary cause of cardiovascular events and its molecular mechanism urgently needs to be clarified. In our study, atheromatous plaques (ATH) and macroscopically intact tissue (MIT) sampled from 32 patients were compared and an integrated series of bioinformatic microarray analyses were used to identify altered genes and pathwa...

Hepatitis B and hepatitis C are 2 types of potentially life-threatening liver diseases with high infection rate. Body piercing represents a progressively popular sociocultural phenomenon which is also a potential exposure approach for hepatitis B virus (HBV) and hepatitis C virus (HCV). Conclusions from those researches with statistically risk asse...

Objective To determine the most efficacious treatment for eradication of Helicobacter pylori with the lowest likelihood of some common adverse events among pre-recommended and newer treatment regimens. Design Systematic review and network meta-analysis. Data sources Cochrane Library, PubMed, and Embase without language or date restrictions. Study s...

In observational studies, fruit intake is associated with a reduced risk of cardiovascular disease (CVD), though fruit type has been less frequently explored. The aim of the current study was to explore the association between total fruit and fruit subgroup intake according to polyphenol content and CVD mortality in the UK Women’s Cohort Study. Tot...

Background: It is possible that cross-over studies included in current systematic reviews are being inadequately assessed, because the current risk of bias tools do not consider possible biases specific to cross-over design. We performed this study to evaluate whether this was being done in cross-over studies included in Cochrane Systematic Review...

To determine the effect of different types of dietary fibre on SBP and DBP. A systematic review of the literature and a meta-analysis of randomized controlled trials using random-effects models. Eligibility criteria for studies included randomized controlled trials of at least 6 weeks duration, testing a fibre isolate or fibre-rich diet against a c...

Current data on the concordance of KRAS, BRAF, PIK3CA mutation status or PTEN expression status between primary tumors and metastases in colorectal cancer (CRC) are conflicting. We conducted a systematic review and meta-analysis to examine concordance and discordance of the status of these four biomarkers between primary tumors and corresponding me...

Background: Stroke risk is modifiable through many risk factors, one being healthy dietary habits. Fibre intake was associated with a reduced stroke risk in recent meta-analyses; however, data were contributed by relatively few studies, and few examined different stroke types. Methods: A total of 27,373 disease-free women were followed up for 14...

In observational studies, fruit intake is associated with a reduced risk of cardiovascular disease (CVD), though fruit type has been less frequently explored. The aim of the current study was to explore the association between total fruit and fruit subgroup intake according to polyphenol content and CVD mortality in the UK Women's Cohort Study. Tot...

The intake of sugar-sweetened soft drinks has been reported to be associated with an increased risk of type 2 diabetes, but it is unclear whether this is because of the sugar content or related lifestyle factors, whether similar associations hold for artificially sweetened soft drinks, and how these associations are related to BMI. We aimed to cond...

To investigate dietary fibre intake and any potential dose-response association with coronary heart disease and cardiovascular disease. Systematic review of available literature and dose-response meta-analysis of cohort studies using random effects models. The Cochrane Library, Medline, Medline in-process, Embase, CAB Abstracts, ISI Web of Science,...

OBJECTIVE Diets with high glycemic index (GI), with high glycemic load (GL), or high in all carbohydrates may predispose to higher blood glucose and insulin concentrations, glucose intolerance, and risk of type 2 diabetes. We aimed to conduct a systematic literature review and dose-response meta-analysis of evidence from prospective cohorts.RESEARC...

Background Cardiovascular disease (CVD) is a major cause of mortality and morbidity in developed countries. CVD risk can be modified via lifestyle habits and some prospective studies indicate greater fibre intake is associated with lower CVD risk. The aim of this work was to explore this association using data from the UK Women’s Cohort Study. Meth...

We thank Tikhonoff et al for drawing our attention to their article published after our review was submitted for publication , and after the specified cutoff for our literature searches. Although we agree with the principle of increasing population of fiber intake, our results based on much larger numbers (almost 10 000 incident strokes in just und...

and Purpose—Fiber intake is associated with reduced stroke risk in prospective studies, but no meta-analysis has been published to date. Methods—Multiple electronic databases were searched for healthy participant studies reporting fiber intake and incidence of first hemorrhagic or ischemic stroke, published between January 1990 and May 2012. Result...

and Purpose—Fiber intake is associated with reduced stroke risk in prospective studies, but no meta-analysis has been published to date. Methods—Multiple electronic databases were searched for healthy participant studies reporting fiber intake and incidence of first hemorrhagic or ischemic stroke, published between January 1990 and May 2012. Result...

Dietary fibre has been associated with improvements in key risk factors for cardiovascular disease (CVD). Prior research has focussed more on CVD development in men and our aim was therefore to explore the association between dietary fibre intake and CVD mortality using data from the United Kingdom Women's Cohort Study (UKWCS). Dietary fibre intake...

Background and purpose: Fiber intake is associated with reduced stroke risk in prospective studies, but no meta-analysis has been published to date. Methods: Multiple electronic databases were searched for healthy participant studies reporting fiber intake and incidence of first hemorrhagic or ischemic stroke, published between January 1990 and...

Dietary fibre intake and diabetes risk: a systematic review and meta-analysis of prospective studies - Volume 72 Issue OCE4 - D. E. Threapleton, D. C. Greenwood, C. Evans, C. L. Cleghorn, C. Nykjaer, C. Woodhead, V. J. Burley

Background In the UK in 2008, stroke was responsible for over 43,000 deaths. Dietary fibre intake may reduce stroke risk through modifying one or more risk factor such as body weight, blood cholesterol, or blood pressure. Food sources of fibre can be examined in relation to risk as different foods contain different types of fibre which have differi...

Dietary fibre intake and cardiovascular disease: A systematic review and meta-analysis of prospective studies - Volume 71 Issue OCE3 - D. E. Threapleton, D. C. Greenwood, C. Evans, C. L. Cleghorn, C. Nykjaer, C. Woodhead, J. E. Cade, C. Gale, V. J. Burley

Dietary fibre intake and risk of stroke: A systematic review and meta-analysis of prospective studies - Volume 71 Issue OCE3 - D. E. Threapleton, D. C. Greenwood, C. E. Evans, C. L. Cleghorn, C. Nykjaer, C. Woodhead, J. E. Cade, C. Gale, V. J. Burley

Systematic review and meta-analysis to determine the associations between glycaemic index and load on markers of cardiovascular disease - Volume 71 Issue OCE3 - C. E. L. Evans, D. E. Threapleton, C. L. Cleghorn, C. Nykjaer, D. C. Greenwood, V. J. Burley

Coronary heart disease (CHD) remains a significant problem and one of the main causes of death within the United Kingdom today, accounting for over 88,000 deaths per year (1). Dietary fibre is thought to influence CHD risk through changes in key modifiable risk factors such as body weight, blood cholesterol, or blood pressure (2). Exploring intakes...

Vitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires, which can over-report fruit and vegetable intake, the main source of vitamin C. This is the first study to investigate associations between vitamin C intake and breast cancer...

Introduction Vitamin C intake has been inversely associated with breast cancer risk in case-control studies, but not in meta-analyses of cohort studies using Food Frequency Questionnaires. No study has assessed this relationship prospectively using food diaries which may more accurately measure intake. Methods Estimated dietary vitamin C intake wa...