Diana - Carolina Visan

Carol Davila University of Medicine and Pharmacy | UMF CD · Department of Organic Chemistry

In this article, we present the design and synthesis of novel compounds, containing in their molecules an L-valine residue and a 4-[(4-bromophenyl)sulfonyl]phenyl moiety, which belong to N-acyl-α-amino acids, 4H-1,3-oxazol-5-ones, 2-acylamino ketones, and 1,3-oxazoles chemotypes. The synthesized compounds were characterized through elemental analys...

This study aimed to establish the essential oil (EO) composition from young shoots of Picea abies, Larix decidua, Pseudotsuga menziesii, and Pinus nigra harvested from Romania and evaluate their antimicrobial and anti-virulence activity, as well as potential synergies with currently used antibiotics. The samples’ EO average content varied between 0...

A bidentate NO donor Schiff base, 2‐(((2‐chloro‐5‐ (trifluoromethyl)phenyl)imino)methyl) phenol (HL1) and its complexes [Co(L1)2(H2O)2] (1), [Cu(L1)2] (2), [Mn(L1)2(H2O)2] (3), [Ni(L1)2(H2O)2] (4), [Pd2(L1)2(OAc)2·1.16H2O] (5), [Pt(L1)2] (6) were synthesized and characterized by different physico‐chemical techniques including elemental and thermal...

A series of Cu(II), Co(II), Pd(II), Pt(II), Zn(II), Cd(II) and Fe(III) complexes were designed and synthesized using Schiff base 1‐phenyl‐2,3‐dimethyl‐4‐(N‐3‐formyl‐6‐methylchromone)‐3‐pyrazolin‐5‐one (HL). The new metal complexes were investigated using various physicochemical techniques including elemental and thermal analyses, molar electric con...

The species of Portulaca genus are little known, studied and are not used in Romania for therapy or food purposes. In the world, though, Portulaca oleracea is known for its therapeutic and nutritive value. This research aimed the investigation of some lipophilic compounds from two Romanian native species, P. oleracea and P. grandiflora. The analysi...

New copper(II), manganese(II), cobalt(II), nickel(II) and palladium(II) complexes, [Cu(L)(X)(H2O)] [X= OAc⁻ (1), Cl⁻ (3), ClO4⁻ (4)], [M(L)2(H2O)2] [M= Cu²⁺(2), Mn²⁺(5)], [M(L)(OAc)(H2O)] [M= Co²⁺(6), Pd²⁺(8)], [Ni(L)(OAc)] (7) were synthesized with 2-(5H-dibenzo [a,d][7] annulen-5-ylacetyl)-N-(4-chlorophenyl) hydrazinecarbothioamide (HL). All the...

Searching new antioxidants compounds to prevent or reduce the impact of oxidative stress on cells, we designed and synthesized several N-acylhydrazone derivatives with dibenzo[a,d][7]annulene moiety. In this work, a series of previously synthesized N-acylhydrazone derivatives bearing 5H-dibenzo[a,d][7]annulene moiety 7a-g were evaluated for antioxi...

Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N′-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), ¹H...

New Cu(II), Pd(II) and Pt(II) complexes, (Cu(L)(H₂O)₂(OAc)) (1), (Cu(HL)(H₂O)₂(SO₄)) (2), (Cu(L)(H₂O)₂(NO₃)) (3), (Cu(L)(H₂O)₂(ClO₄)) (4), (Cu(L)₂(H₂O)₂) (5), (Pd(L)(OAc))H₂O (6), and (Pt(L)₂) (7) were synthesized from 8-ethyl-2-hydroxytricyclo(7.3.1.0(2,7))tridecan-13-one thiosemicarbazone (HL). The ligand and its metal complexes were characterize...

A series of 2-amino-1, 3, 4-oxadiazoles 4a-f with 5H-dibenzo[a, d][7]annulene moiety were synthesized by cyclization of 2-acylhydrazinecarbothioamides 3a-f in the presence of mercury oxide. 2-Acylhidrazinecarbothioamide 3a-f were synthesized by nucleophilic addition of 2-(5Hdibenzo[a, d][7]annulen-5-yl)acetohydrazide to different isothiocyanates. A...

The thermal stabilization effect of copper complexes on ethylene-propylene-diene terpolymer (EPDM) is studied during an accelerated degradation of polymer samples by their exposure to c(137Cs)-radiation. These complexes of Cu(II) with two Schiff base ligands provided an efficient improvement in the stabilization of basic polymer. For the evaluation...

A novel Schiff base, ethyl 4-[(E)-(2-hydroxy-4-methoxyphenyl)methyleneamino] benzoate (HL), was prepared and structurally characterized on the basis of elemental analyses, 1H NMR, 13C NMR, UV-Vis and IR spectral data. Six new copper(II) complexes, [Cu(L)(NO3)(H2O)2] (1), [Cu(L)2] (2), [Cu(L)(OAc)] (3), [Cu2 (L)2Cl2(H2O)4] (4), [Cu(L)(ClO4)(H2O)] (5...

This paper presents synthesis of new compounds from 1,3,4-thiadiazole and 1,3,4-oxadiazole class obtained by cyclization of some hydrazinecarbothioamides containing arylsulfonylphenyl and 2,4-difluorophenyl moieties that were described in a previous paper [22]. The structures of these compounds were confirmed by elemental analysis and spectral tech...

In the present investigation, new hydrazinecarbothioamides 4-6 were synthesized by reaction of 4-(4-X-phenylsulfonyl)benzoic acids hydrazides (X= H, Cl, Br) 1-3 with 2,4-difluorophenyl isothiocyanate and further these were treated with sodium hydroxide to obtain 1,2,4-triazole-3-thione derivatives 7-9. The reaction of 7-9 with α-halogenated ketones...

The aim of this paper was to evaluate the chemical composition of volatile oil isolated from the flowers of Lonicera japonica and Lonicera caprifolium cultivated in Romania. One oil sample from Lonicera caprifolium and two oil samples from Lonicera japonica obtained by hidrodistillation were analysed by gas chromatography - mass spectrometry (GC-MS...

While the seeds of Trigonella foenum-graecum (L.) are relatively widely used as a spice and seasoning in food and as a traditional herbal medicinal product, those of T. caerulea have a more limited use and are rather ignored. We report on a comparative study of the surface morphology (investigated by scanning electron microscopy), of alcoholic extr...

The stability of ascorbic acid (AA) in different aqueous solutions was studied for the development of optimal methods and procedures for the HPLC analysis of this compound in young shoots with needles of conifers. The best extraction solvent that offered the maximum stability of AA was aqueous 0.5% acid oxalic. The chromatographic separation was ca...

Urtica dioica (nettle) is one of the most popular and cosmopolitan plants (present in Europe, Africa, Asia, America), whose dietary and therapeutic benefits have been known since ancient times. The therapeutic activity of nettle extracts is related to the presence of phenolic compounds (mainly cafeoil-malic acid, chlorogenic acid, ferulic acid, rut...

2-Furaldehyde-4-phenylthiosemicarbazone (HL) and its nickel(II), palladium(II) and copper(II) complexes: [Pd(L)2] (1), [Ni(L)2] (2), [Cu2(L)2(Et3N)2(H2O)4 ](SO4) (3), [Cu2(L)2(Et3N)2(H2O)4 ](NO3)2 (4), [Cu(L)2(H2O)2] (5), [Cu(L)(OAc)(H2O)] (6) were synthesized and characterized. The ligand has been characterized by elemental analyses, IR, electroni...

The aim of this paper was to evaluate the chemical composition of volatile oil isolated from the flowers of Lonicera japonica and Lonicera caprifolium cultivated in Romania. One oil sample from Lonicera caprifolium and two oil samples from Lonicera japonica obtained by hidrodistillation were analysed by gas chromatography - mass spectrometry (GC-MS...

Six new Cu(II), Ni(II), and VO(II) complexes (1–6) with Schiff base 1-phenyl-2,3-dimethyl-4-(1H-indole-3-carboxaldehyde)-3-pyrazolin-5-one (HL) were synthesized. The Schiff base was prepared through the condensation of 1-phenyl-2,3-dimethyl-4-amino-3-pyrazolin-5-one (antipyrine) with 1H-indole-3-carboxaldehyde. The new obtained compounds were chara...

The paper follows aspects subject to the content in active principles of vegetal products Thymy folium harvested from Thymus vulgaris L. species from Lebanon and Thymy herba harvested from Romania. It was also followed the determination of chemo-variety type through gas-chromatographic analyze of volatile oils obtained in laboratory conditions. Vol...

A novel Schiff base, N-(4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one)pyridoxaldimine (HL·HCl), was prepared and structurally characterized on the basis of elemental analyses, 1H and 13C NMR, and IR spectral data. The synthesis and characterization of several Cu(II) (1–6) and V(IV) (7) complexes with N-(4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5...

Thymus species have been used for centuries as a folk remedy against cancer. The aim of the present study is to highlight some of the molecular mechanisms involved in the anticancer properties of Thymus pulegioides L. The experiments were performed on male Wistar rats, using the volatile oil from Thymus pulegioides L. The modifications of cytochrom...

The aim of this paper was to evaluate the chemical composition, antimicrobial properties of volatile oil isolated from sprouts of Picea abies growing wild in Romania. The essential oil from young sprouts of Picea abies L obtained by hidrodistillation was analysed by gas chromatography-mass spectrometry (GC-MS). Fifty four compounds accounting for 9...

The essential oil from dried leaves, flowers and fruits of Anethum graveolens L. (dill) cultivated in Romania was isolated by hydrodistillation and analysed by gaschromatography coupled with mass spectrometry (GC-MS). The main components in leaves were α- phellandrene (62.71%), limonene (13.28%) and anethofuran (16.42%). The main components in flow...

The species Thymus comosus grows spontaneously in the Romanian flora, at altitudes of 400-700 m, and it is harvested for obtaining the collective herbal drug Serpylli herba. The content of essential oil of this species was assessed and the chemical composition of the essential oil was analysed by gas-chromatography coupled with mass spectrometry. A...

The volatile compounds present in the species belonging to the Thymus genus (Lamiaceae) are responsible for the two well defined therapeutic effects demonstrated for these plants: antiseptic and spasmolytic effects. The essential oil which contains the majority of these compounds is hardly accessible and, as consequence, it is rarely used by the pa...

The ligand N'-acetyl-4-(4-X-phenylsulfonyl)benzohydrazide (I), X=H, Cl, Br, forms complexes (Cu(L-H)2) and (Cu(L-H)2(NH3)2) which have been characterized by elemental analyses, magnetic moments, molar conductance, electronic, ESR and IR spectral measurements. Coordination area and metal ion geometry varies with the working conditions: different sal...