Dian Handayani

Brawijaya University · Department of Nutrition Science

The prevalence of diabetes mellitus has been increasing. This study aimed to develop Food for Special Dietary Use (FSDU) for individuals with diabetes. Different combinations of food ingredients were added to the basic formula, consisting of brown rice and mushroom flour in a ratio of 70% and 11%. The combinations used in the formulation were F1 =...

Diabetes Melitus Tipe 1 atau defisiensi insulin absolut yang terjadi pada anak saat ini semakin meningkat jumlahnya. Buku Pintar Diabetes Melitus (DM) Tipe 1 ini ditulis dengan harapan semakin meningkatkan pengetahuan masyarakat mengenai DM Tipe 1. Sayangnya di Indonesia, penegakan diagnosis diabetes pada anak ini terlambat dilakukan. Tidak jarang...

Moringa (Moringa oleifera) is a plant that easily to find and can grow in lowlands and highlands such as Lombok island relatively inexpensive , and can thrive in almost all parts of Indonesia, such as Lombok island, West Nusa Tenggara province. All parts of this plant can be used as food and traditional medication such as diabetes mellitus. This st...

BACKGROUND: Brown rice contains nutrients that significantly reduce the incidence of obesity. This study aimed to investigate the effect of brown rice as a functional food on the reduction of obesity incidence through the pathways of gut microbiota dysbiosis. METHODS: In this study, we used white rats (Rattus norvegicus albus), which were divided i...

Background: Consumed fructose enters enterocytes of the intestinal epithelial apical membrane mediated by glucose transporter 5 (GLUT5). Aim: To determine the effects of Lombok Island's local Moringa leaf powder on reducing liver fructose levels and GLUT5 expression in the small intestine of albino rats (Rattus novergicus) fed a high-fructose di...

Purpose During Plasmodium berghei (P. berghei) infection, infected erythrocytes are sequestered in gut tissues through microvascular circulation, leading to dysbiosis. This study aimed to investigate the effect of Lactobacillus casei (L. casei) and Bifidobacterium longum (B. longum) administration on the parasitemia level, gut microbiota compositio...

Goat milk kefir (GMK) refers to fermented products, generated through fermenting milk with microbial culture called kefir grains. Prior studies have reported the changes in kefir quality properties during aging process in which fermentation continues, resulting in changes of the peptide content. This research aims to investigate the effect of aging...

Adolescence is a period of rapid growth that a healthy lifestyle must support. School as an environment where teenagers spend most of their time has a School Health Unit (UKS), an essential part of health services at school. UKS can be used as a health education for adolescents at school. However, in reality, UKS needs to be actively used and invol...

Background: The spectrum of non-alcoholic fatty liver disease (NAFLD), known as non-alcoholic steatohepatitis (NASH), can lead to advanced liver disease. It is known that a variety of diets play a significant role in the development of NAFLD/NASH. The goal of this study was to determine the most appropriate composition of diet to induce NASH in an...

Introduction: The increasing consumption of high-fat and high-fructose foods contributes to the increasing prevalence of global obesity. Low-grade chronic inflammation in obesity is a significant risk factor for insulin resistance and type 2 diabetes. Therefore, this study aimed to determine the effect of β-(1,3)-D-glucan from oyster mushroom (Pleu...

Introduction: The increased quantities of inflammatory biomarkers such as C-Reactive Proteins (CRP), Tumour Necrosis Factor-α (TNF-α), and Interleukin-6 (IL-6) have been reported to be associated with an increased risk of metabolic syndrome including type 2 diabetes mellitus (T2DM). However, brown rice is an alternative dietary food source that is...

Gestational diabetes mellitus induces insulin resistance. This condition is an outcome of delayed glucose metabolism throughout pregnancy that leads to a reduction of glucose uptake facilitated by glucose transporter (GLUT), including GLUT1, produces imbalance of antioxidant expression, and induces abnormal production of ROS. Salacca zalacca (SZ) p...

Ulcerative colitis (UC) is an inflammation of the large intestine characterized by diarrhea with blood. UC has a more extensive manifestation in children. Current therapy has not given satisfactory results. This is the basis for the need for preventive therapy to reduce the morbidity and mortality of UC in children. Virgin coconut oil (VCO) is a vi...

Terapi gizi medis (MNT) sangat penting dalam rencana manajemen diabetes secara keseluruhan. Beras coklat berpotensi mengendalikan kadar glukosa darah, karena indeks glikemiknya yang lebih rendah, serat dan magnesium yang lebih tinggi dibandingkan dengan beras putih. Namun, masih belum diketahui perbedaan pengaruh nasi coklat dan nasi putih terhadap...

Obesitas menjadi salah satu penyebab utama sindrom metabolik dislipidemia, yang dapat sebagai komorbid berbagai penyakit. Penggunaan obat-obatan untuk mengurangi obesitas memiliki akibat yang merugikan, oleh karena itu dikembangkan produk komplementer dari susu fermentasi sebagai strategi non-farmakologis untuk pengelolaan dislipidemia. Pemecahan m...

This study aimed to analyze the effect of 'Sintanur' brown rice on Lee's index, fasting blood glucose levels, and HOMA-IR administered to male Sprague Dawley rats. This research was an experimental laboratory study with a post-test-only control group design. The subjects were thirty-five male Sprague Dawley rats divided into five groups. Group 1 co...

Obesity is characterized as a chronic inflammation with progressive infiltration of immune cell into adipose tissue. Adipose tissue macrophages play an important role in the establishment of chronic inflammatory and metabolic dysfunctions such as type 2 diabetes mellitus and insulin resistance. Diet-induced adipose expansion increases macrophage ac...

The rapid development of the prevalence of diabetes mellitus (DM) has been shown in low and middle-economic countries. For a Muslim with diabetes, the obligation to fast during the month of Ramadan will certainly be a challenge. Recent research by some researchers from several countries states that Muslims with diabetes commonly continue to fast re...

Latar Belakang : Diabetes Mellitus (DM) merupakan penyakit metabolik yang sampai saat ini masih menjadi masalah terbesar di dunia dan Indonesia. Penatalaksanaan diet dianggap sebagai komponen penting dalam manajemen diabetes. Diet ketogenik (DK) dilaporkan memiliki efektivitas yang baik dalam manajemen terapi pasien DM Tipe 2 dengan memperbaiki par...

Background: Diabetes mellitus is a metabolic disorder whose prevalence increases globally. Medical nutrition therapy (MNT) is one of the DM management pillars to control blood glucose. Local Indonesian brown rice is proven to contain high fiber and magnesium levels thus could improve obesity, fasting blood glucose, and HbA1c This study aims to prov...

Background: The Type 1 Diabetes Melitus (T1DM) is a disease which is occurred because of autoimmune destruction in pancreas islet (insulin-producing ß cells). A Failure mechanism of immunoregulator causes inflammatory process in the islets and continue to damage the pancreatic β cell. Vitamin D deficiency may increase the risk of autoimmune disease...

p align="justify"> Pendahuluan: Kurangnya pengetahuan menyebabkan perilaku makan yang tidak sehat pada remaja. Pemberian edukasi melalui media video terbukti dapat meningkatkan pengetahuan secara signifikan. Penenelitian ini bertujuan untuk mengetahui perbedaan pengetahuan gizi sebelum dan setelah diberikan edukasi melalui video. Metode: Desain pen...

p>Beras coklat memiliki kandungan magnesium, serat lebih tinggi dan indeks glikemik lebih rendah dari beras putih, diduga dapat mencegah kenaikan glukosa darah dan menurunkan lemak tubuh. Tujuan penelitian ini untuk mengetahui hubungan antara kepatuhan diet berbasis beras coklat dengan kadar glukosa darah puasa dan komposisi lemak tubuh pada pasien...

Backgrounds: Carbohydrate intake is a major determinant of blood glucose stability in patients with type 1 diabetes. Carbohydrate counting as a meal planning approach for patients with type 1 diabetes is known to have flexibility in controlling blood glucose by regulating the amount of carbohydrate intake and insulin dose, yet a good understanding...

This study investigated the agriculture contribution to the nutritional status of children from farming families by comparing situation of the annual crop with agroforestry and mixed farming systems. A survey was conducted from December 2015 to January 2016 in Buol, Central Sulawesi, Indonesia. Household socioeconomic and agricultural data were col...

Gestational diabetes is a glucose intolerance level first identified during pregnancy. This condition is caused by hormone secretion that hinders insulin action from the placenta which caused insulin resistance that will cause hyperglycemia. This condition will increase oxidative stress, and in consequence increasing inflammation and cell death whi...

Obesity is excessive body fat condition due to differences in energy consumption and expenditure. In Indonesia, the prevalence of obese women >18 years old is 32.9%. Interventions are performed with control eating and increased physical activity through an educational approach. A Leaflet is a print media containing some information, while my weight...

Background: Dietary fats and fructose have been responsible for inducing obesity and body tissues damage due to the consequence of metabolic syndrome through several mechanisms. The body fat index (BFI) is one of the anthropometric measures used to detect obesity in rats. This study aims to examine the correlation between high-fat high-fructose di...

Background: Previous research state the correlation between vitamin D deficiency and Type 1 diabetes. The deficiency of Vitamin D is caused by vitamin D intake, sunlight exposure, or nutritional status. Indonesia, as a tropical country, is close to the equator and receives sunlight all year long. Little research has been done on vitamin D levels in...

Objective: This study aimed to analyze the effect of a high-fat and high-fructose diet (HFFD) on the digesta weight and short-chain fatty acid (SCFA) levels of cecaldigesta in rats. Method: This study was an experimental study with a posttest-only control group design with male Sprague Dawley strain rats as the samples. A total of 36 rats were d...

Malnutrisi adalah masalah yang umum terjadi pada pasien sirosis hati. Kurangnya pengetahuan tentang gizi sehingga menyebabkan adanya pembatasan diet yang tidak perlu dan kemudian berkontribusi pada kejadian malnutrisi. Penelitian ini bertujuan untuk mengetahui adanya pengaruh pemberian edukasi gizi terhadap status gizi dan asupan pasien sirosis hat...

BACKGROUND: Obesity can cause oxidative stress due to the release of free radical components or reactive oxygen species. The accumulation of excess fat in obesity also causes the occurrence of non-alcoholic fatty liver. Brown rice is a functional food with higher fiber, vitamin, mineral, and antioxidant contents than those in white rice. AIM: This...

Obesity is characterized by excessive accumulation of fat in the body, which causes changes in body composition and endothelial dysfunction due to impaired production of nitric oxide (NO). The common means of managing obesity is through functional food, such as brown rice, which has high fiber and antioxidant content. Therefore, the purpose of this...

The obesity prevalence in the world continues to increase yearly, which further cause clinical problems related to metabolic syndrome and lipid peroxidation. This study aims to determine the effect of ß-glucan extract from oyster mushrooms on lipid peroxidation markers, namely serum MDA levels in rats. Therefore, Sprague dawley rats were divided in...

BACKGROUND: Cardiovascular disease (CVD) is one the cause of mortality in patients with type 1 diabetes (T1D). The development of CVD is mainly triggered by atherosclerosis, which is associated with the inflammatory process. AIM: The current study was aimed to investigate the association of Vitamin D level and premature atherosclerosis in adolescen...

Background Public interest and awareness of the use of functional food as an obesity nutrition therapy are increasing. Objective This study aims to analyze the content of energy, macronutrients, minerals (magnesium, manganese, and potassium), and bioactive components (fiber, β-glucan) in Indonesian varieties of brown rice compared to white rice, t...

The provision of nutrition care process (NCP) in diabetes mellitus (DM) patients is very important in determining the patient's diet to control blood glucose and to prevent complications. This study aimed to determine the diff erences in levels of intake and blood glucose levels before and after the implementation of NCP for type 2 DM (T2DM) inpati...

BACKGROUND: Consumption of foods and drinks high in energy, fat, and/or sugar beyond the recommended quantities can cause obesity, which triggers the incidence of brain nerve cell death related to oxidative stress, high levels of tumor necrosis factor (TNF)-α and triglycerides, and low high-density lipoprotein (HDL) levels. Progressive nerve cell d...

p>Satiety hormones play a role in obesity metabolism. The satiety response to similar nutrients in food in healthy and obese men remains undefined. The research was aimed to determine the satiety response differences by comparing the effect of isocaloric fast-food consumption on reducing appetite-related gut hormones, such as glucagon-like fullness...

Metabolic inflammation (low-grade inflammation) remains an etiopathogenic key factor in the development of metabolic syndrome. Nuclear Factor Kappa Beta (NF-κβ) is a transcription regulator of genes having a role in immunity, the inflammatory response which can be associated with obesity-related pathological conditions like nonalcoholic fatty liver...

Aim The study aimed to investigate the effect of serum mineral (Mg, Mn, and K) levels to obesity in rat model. Methods A posttest-only control group design was used in this research. This research tested the feed type in Sprague-Dawley rats. A total 36 rats were divided into two groups (18 rats for normal feeding intervention (N) and 18 rats for h...

Obesitas adalah peningkatan berat badan akibat asupan yang melampaui kebutuhan fisik dan skeletal yang ditandai dengan penimbunan lemak tubuh yang berlebih. Obesitas dapat meningkatkan resiko kematian. Selain hal tersebut, peningkatan indeks Massa Tubuh (IMT) berkaitan dengan tingginya tekanan darah dan terjadinya peningkatan total kolesterol menja...

Abstrak Label informasi gizi adalah informasi kandungan nilai gizi yang wajib dituliskan pada makanan kemasan untuk memudahkan konsumen memilih produk yang tepat sesuai kebutuhan gizi. Pengetahuan cara membaca label informasi gizi sangat diperlukan konsumen karena akan memengaruhi perilaku pemilihan makanan kemasan yang dikonsumsinya sehingga dapa...

Background: The incidence of obesity increases regardless of age. It may happen because these students like to consume snacks/ packaged foods and rarely pay attention to the contents of Nutrition Facts label. Personal education method is a method of education conducted on individuals, while lecture method conducted in groups, each methods has their...

Diabetes Melitus merupakan penyakit yang bisa menyebabkan resiko gangguan kognitif melalui gangguan pada pembuluh darah termasuk diantaranya pembuluh darah di otak. Lama menderita DM dan kadar glukosa darah akan mempengaruhi fungsi kognitif penderita DM. Skrining fungsi kognitif diperlukan untuk pencegahan komplikasi seperti penyakit alzheimer. Tuj...

Controlling the blood sugar level of DM patients is an approach to suppress morbidity and mortality. This study aims to know the relationship of four pillars of DM management with blood glucose levels and nutritional status in patients with type 2 DM in East Java. This study is a cross-sectional study with a sample of middle-aged type 2 DM outpatie...

Background and Objective: The desire for food is regulated by appetite-associated hormones such as ghrelin and glucagon-like peptide-1 (GLP-1). Hormone release is influenced by the energy density of and macro-nutrients in food. This study assessed the effects of international and Indonesian fast food on ghrelin and GLP-1 levels, which contribute to...

Dyslipidemia that could be affected by hypercholesterol diet is a contributing factor in millions of deaths worldwide and a risk factor for ischemic heart disease and stroke. High soluble fiber diet is used as one of the non-pharmacological treatments to control hypercholesterolemia. Black Grass Jelly (Mesona palustris BL) also known as black cinca...

Background and objectives: The prevalence of obesity in Indonesia has increasing. We have assessed the relationship between plasma acylated ghrelin hormone and self-reported appetite ratings (hunger and desire to eat) in obese and normal weight men. Methods and study design: Thirty-two men participated in an experimental study, where acylated gh...

Penyakit DM tipe 2 pada perkembangannya dapat menimbulkan stres oksidatif yang mengakibatkan terjadinya perubahan aktivitas antioksidan endogen dan juga meningkatnya kerusakan biomolekul secara oksidatif. Kondisi ini menyebabkan penderita DM tipe 2 memerlukan asupan antioksidan eksogen dalam jumlah besar untuk menghambat kerusakan oksidatif di dala...

Background: Fast food comes to a meal that is prepared fast and identically high in energy and fat contents since fast food is prepared using oil and fats. Excessive eating of fast food which is Indonesian typical fast foods and international fast foods will deliver obesity risk. Satiety and hunger are known as the two main keys to obesity preventi...

Protein energy malnutrition problem still exists in developing country. In fact, Indonesia has faced it as double burden of nutrition problems. This study aims to develop a standardized diet for developing protein energy malnutrition (PEM) on the rat to support nutrition research. Low-protein modified AIM-93M diet (LP) has been given to rats for 12...

This study investigated the effects of Black cincau (Mesona palustris BL) effervescent powder (BCEP) on systolic blood pressure and malondialdehyde concentration in hypertensive rats. BCEP were orally administered to hypertensive rats for 4 weeks, and antihypertensive effects were determined. Rats were given 630 mg/kg, 1.260 mg/kg and 1.890 mg/kg B...

Abstrak Obesitas dan diabetes mellitus merupakan masalah kesehatan yang berhubungan erat dengan asupan makanan terutama energi dan karbohidrat. Tingginya prevalensi obesitas dan diabetes mellitus di Jawa Timur, terutama di Kota Malang, tidak diimbangi dengan ketersediaan informasi tentang kandungan energi dan zat gizi pada makanan. Penelitian ini b...

This study aimed to compare the acute effect of different fast food types on appetite regulatory hormones. This was a randomized, cross over design study. After ten-hour fasting, sixteen obese participants (Body Mass Index 33.6 ± 4.8 kg/m2) received Indonesia Fast Food (IFF) followed Western Fast Food (WFF) after 1 week wash out. Both of fast foods...

This study aims to investigate the duration of Ramadan fasting on the daily intake of total foods, body mass index(BMI), plasma lipid profiles (TG, TC, HDL and LDL) and inflammatory markers (TNF α and IL-6) of overweight male subjects. The research method used in this study is an experimental research method with one group pre-test-post-test design...

Abstrak Kejadian aterosklerosis biasa diawali dengan cedera sel endotel yang menyebabkan peningkatan permeabilitas sel sehingga komponen plasma dapat masuk ke dalam dinding arteri, termasuk asam lemak. Akumulasi asam lemak dalam arteri dapat teroksidasi dan membentuk lapisan lemak di dinding arteri sehingga mengakibatkan penebalan dinding arteri da...

The purpose of this study was to determined the role of vegetable protein intake and anaemia incidence among vegan reproductive-aged women. This study was observational research with cross-sectional study design. Sixty-five subjects were selected by simple random sampling method. Data collection for intake was done by 24-hours recall technique, and...

Background: The increased circumference of waist and waist-hip ratio describe intra-abdominal fat which is associated with a number of metabolic disorders such as diabetes mellitus. Objective: The aim of the study is to analyze the correlation between the circumference of waist and waist-hip ratio in plasma glucose levels using the Oral Glucose To...

Objectives: Rice is the staple food with high glycemic index characterization that can cause an increasing blood glucose. The increase of blood glucose levels may be develop to degenerative disease such as cardiovascular disease, diabetes mellitus, cancer, and etc. This research compared the difference between the glycemic index and glycemic load o...

Cincau hitam atau black grass jelly (Mesona palustris BL) adalah bahan minuman tradisional Indonesia yang dipercaya bermanfaat untuk kesehatan. Cincau hitam biasanya dikonsumsi dalam bentuk gel untuk es campur. Pada penelitian ini cincau hitam dibuat serbuk sehingga praktis penggunaannya. Penelitian dilakukan untuk mengetahui efek hipoglikemik serb...

Abstrak. Beras merupakan salah satu jenis makanan pokok dengan karakteristik tinggi indeks glikemik. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan tepung kedelai pada pembuataan beras tiruan instan terhadap mutu fisik, organoleptik dan kadar zat gizi makro. Penelitian ini terdiri menjadi dua tahap. Tahap pertama, adalah pembuatan be...

Overweight and obesity is chronic diseases that promote metabolic syndrome. The prevalence of obesity in Indonesia increases gradually and nowadays it is 20-30%. One of the causes of obesity is long term excessive energy intake. A big portion, frequent meal and high energy density of food take part in positive energy balance. This study was conduct...

Nutrition labeling identified: Indonesian food has lower energy density than international food pilot project for combating community obesity in Malang-Indonesia Handayani, D*; Hanifa, H; Wiedjarningtyas, N; Rahmawati, W University of Brawijaya Eating away from home is demanding now. It induce obesity as fast food is mostly high of energy density....

Shiitake mushroom have been shown to have health benefits including lowering plasma lipids and preventing body weight gain. However, their underlying mechanisms are largely unknown. The study aim was to assess the potential underlying mechanism of Shiitake mushrooms in lowering plasma triacylglycerol (TAG) in rats fed a high fat diet (HFD). Forty W...

TRADITIONAL INDONESIAN FOOD HAS LOWER ENERGY DENSITY BUT NOT ENERGY PER PORTION THAN MODERN FOOD, STUDY IN MALANG INDONESIA N N. Wirawan1, W. Rahmawati1, D. Handayani1 1Department of Nutrition, Faculty of Medicine, University of Brawijaya, Malang, East Java Province, Indonesia Background and objectives: National Survey in Indonesia shows that preva...

ABSTRACT Preventing obesity could be done by lowering plasma TAG that inhibits adipogenesis. Oat and mushroom beta-glucans in the diet has been reported to lower plasma lipid; however the data focusing on their effects on TAG and obesity are insufficient. In the present study, lowering plasma triacylglycerol, fat deposition, body weight gain (BWG)...