Dian Handayani

Dian Handayani
Brawijaya University · Department of Nutrition Science

PhD

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37
Publications
31,219
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152
Citations

Publications

Publications (37)
Article
Full-text available
Metabolic inflammation (low-grade inflammation) remains an etiopathogenic key factor in the development of metabolic syndrome. Nuclear Factor Kappa Beta (NF-κβ) is a transcription regulator of genes having a role in immunity, the inflammatory response which can be associated with obesity-related pathological conditions like nonalcoholic fatty liver...
Article
Aim The study aimed to investigate the effect of serum mineral (Mg, Mn, and K) levels to obesity in rat model. Methods A posttest-only control group design was used in this research. This research tested the feed type in Sprague-Dawley rats. A total 36 rats were divided into two groups (18 rats for normal feeding intervention (N) and 18 rats for h...
Article
Full-text available
Obesitas adalah peningkatan berat badan akibat asupan yang melampaui kebutuhan fisik dan skeletal yang ditandai dengan penimbunan lemak tubuh yang berlebih. Obesitas dapat meningkatkan resiko kematian. Selain hal tersebut, peningkatan indeks Massa Tubuh (IMT) berkaitan dengan tingginya tekanan darah dan terjadinya peningkatan total kolesterol menja...
Article
Full-text available
Abstrak Label informasi gizi adalah informasi kandungan nilai gizi yang wajib dituliskan pada makanan kemasan untuk memudahkan konsumen memilih produk yang tepat sesuai kebutuhan gizi. Pengetahuan cara membaca label informasi gizi sangat diperlukan konsumen karena akan memengaruhi perilaku pemilihan makanan kemasan yang dikonsumsinya sehingga dapa...
Article
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Background: The incidence of obesity increases regardless of age. It may happen because these students like to consume snacks/ packaged foods and rarely pay attention to the contents of Nutrition Facts label. Personal education method is a method of education conducted on individuals, while lecture method conducted in groups, each methods has their...
Article
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Diabetes Melitus merupakan penyakit yang bisa menyebabkan resiko gangguan kognitif melalui gangguan pada pembuluh darah termasuk diantaranya pembuluh darah di otak. Lama menderita DM dan kadar glukosa darah akan mempengaruhi fungsi kognitif penderita DM. Skrining fungsi kognitif diperlukan untuk pencegahan komplikasi seperti penyakit alzheimer. Tuj...
Article
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Controlling the blood sugar level of DM patients is an approach to suppress morbidity and mortality. This study aims to know the relationship of four pillars of DM management with blood glucose levels and nutritional status in patients with type 2 DM in East Java. This study is a cross-sectional study with a sample of middle-aged type 2 DM outpatie...
Article
Background and Objective: The desire for food is regulated by appetite-associated hormones such as ghrelin and glucagon-like peptide-1 (GLP-1). Hormone release is influenced by the energy density of and macro-nutrients in food. This study assessed the effects of international and Indonesian fast food on ghrelin and GLP-1 levels, which contribute to...
Article
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Dyslipidemia that could be affected by hypercholesterol diet is a contributing factor in millions of deaths worldwide and a risk factor for ischemic heart disease and stroke. High soluble fiber diet is used as one of the non-pharmacological treatments to control hypercholesterolemia. Black Grass Jelly (Mesona palustris BL) also known as black cinca...
Article
Background and objectives: The prevalence of obesity in Indonesia has increasing. We have assessed the relationship between plasma acylated ghrelin hormone and self-reported appetite ratings (hunger and desire to eat) in obese and normal weight men. Methods and study design: Thirty-two men participated in an experimental study, where acylated gh...
Article
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Background: Fast food comes to a meal that is prepared fast and identically high in energy and fat contents since fast food is prepared using oil and fats. Excessive eating of fast food which is Indonesian typical fast foods and international fast foods will deliver obesity risk. Satiety and hunger are known as the two main keys to obesity preventi...
Article
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Protein energy malnutrition problem still exists in developing country. In fact, Indonesia has faced it as double burden of nutrition problems. This study aims to develop a standardized diet for developing protein energy malnutrition (PEM) on the rat to support nutrition research. Low-protein modified AIM-93M diet (LP) has been given to rats for 12...
Article
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This study investigated the effects of Black cincau (Mesona palustris BL) effervescent powder (BCEP) on systolic blood pressure and malondialdehyde concentration in hypertensive rats. BCEP were orally administered to hypertensive rats for 4 weeks, and antihypertensive effects were determined. Rats were given 630 mg/kg, 1.260 mg/kg and 1.890 mg/kg B...
Article
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Abstrak Obesitas dan diabetes mellitus merupakan masalah kesehatan yang berhubungan erat dengan asupan makanan terutama energi dan karbohidrat. Tingginya prevalensi obesitas dan diabetes mellitus di Jawa Timur, terutama di Kota Malang, tidak diimbangi dengan ketersediaan informasi tentang kandungan energi dan zat gizi pada makanan. Penelitian ini b...
Article
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This study aimed to compare the acute effect of different fast food types on appetite regulatory hormones. This was a randomized, cross over design study. After ten-hour fasting, sixteen obese participants (Body Mass Index 33.6 ± 4.8 kg/m2) received Indonesia Fast Food (IFF) followed Western Fast Food (WFF) after 1 week wash out. Both of fast foods...
Article
This study aims to investigate the duration of Ramadan fasting on the daily intake of total foods, body mass index(BMI), plasma lipid profiles (TG, TC, HDL and LDL) and inflammatory markers (TNF α and IL-6) of overweight male subjects. The research method used in this study is an experimental research method with one group pre-test-post-test design...
Article
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Abstrak Kejadian aterosklerosis biasa diawali dengan cedera sel endotel yang menyebabkan peningkatan permeabilitas sel sehingga komponen plasma dapat masuk ke dalam dinding arteri, termasuk asam lemak. Akumulasi asam lemak dalam arteri dapat teroksidasi dan membentuk lapisan lemak di dinding arteri sehingga mengakibatkan penebalan dinding arteri da...
Article
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Background: The increased circumference of waist and waist-hip ratio describe intra-abdominal fat which is associated with a number of metabolic disorders such as diabetes mellitus. Objective: The aim of the study is to analyze the correlation between the circumference of waist and waist-hip ratio in plasma glucose levels using the Oral Glucose To...
Conference Paper
Full-text available
Objectives: Rice is the staple food with high glycemic index characterization that can cause an increasing blood glucose. The increase of blood glucose levels may be develop to degenerative disease such as cardiovascular disease, diabetes mellitus, cancer, and etc. This research compared the difference between the glycemic index and glycemic load o...
Article
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Cincau hitam atau black grass jelly (Mesona palustris BL) adalah bahan minuman tradisional Indonesia yang dipercaya bermanfaat untuk kesehatan. Cincau hitam biasanya dikonsumsi dalam bentuk gel untuk es campur. Pada penelitian ini cincau hitam dibuat serbuk sehingga praktis penggunaannya. Penelitian dilakukan untuk mengetahui efek hipoglikemik serb...
Conference Paper
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Abstrak. Beras merupakan salah satu jenis makanan pokok dengan karakteristik tinggi indeks glikemik. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan tepung kedelai pada pembuataan beras tiruan instan terhadap mutu fisik, organoleptik dan kadar zat gizi makro. Penelitian ini terdiri menjadi dua tahap. Tahap pertama, adalah pembuatan be...
Conference Paper
Full-text available
Overweight and obesity is chronic diseases that promote metabolic syndrome. The prevalence of obesity in Indonesia increases gradually and nowadays it is 20-30%. One of the causes of obesity is long term excessive energy intake. A big portion, frequent meal and high energy density of food take part in positive energy balance. This study was conduct...
Conference Paper
Nutrition labeling identified: Indonesian food has lower energy density than international food pilot project for combating community obesity in Malang-Indonesia Handayani, D*; Hanifa, H; Wiedjarningtyas, N; Rahmawati, W University of Brawijaya Eating away from home is demanding now. It induce obesity as fast food is mostly high of energy density....
Article
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Shiitake mushroom have been shown to have health benefits including lowering plasma lipids and preventing body weight gain. However, their underlying mechanisms are largely unknown. The study aim was to assess the potential underlying mechanism of Shiitake mushrooms in lowering plasma triacylglycerol (TAG) in rats fed a high fat diet (HFD). Forty W...
Conference Paper
Full-text available
TRADITIONAL INDONESIAN FOOD HAS LOWER ENERGY DENSITY BUT NOT ENERGY PER PORTION THAN MODERN FOOD, STUDY IN MALANG INDONESIA N N. Wirawan1, W. Rahmawati1, D. Handayani1 1Department of Nutrition, Faculty of Medicine, University of Brawijaya, Malang, East Java Province, Indonesia Background and objectives: National Survey in Indonesia shows that preva...
Article
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ABSTRACT Preventing obesity could be done by lowering plasma TAG that inhibits adipogenesis. Oat and mushroom beta-glucans in the diet has been reported to lower plasma lipid; however the data focusing on their effects on TAG and obesity are insufficient. In the present study, lowering plasma triacylglycerol, fat deposition, body weight gain (BWG)...
Article
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High-fat diet (HFD) induces obesity. This study examined the effects of Shiitake mushroom on the prevention of alterations of plasma lipid profiles, fat deposition, energy efficiency, and body fat index induced by HFD. Rats were given a low, medium, and high (7, 20, 60 g/kg = LD-M, MD-M, HD-M) Shiitake mushroom powder in their high-fat (50% in kcal...
Article
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In Indonesia, the prevalence of coronary heart disease (CHD) was increased. It currently became the main cause of mortality. Unhealthy dietary pattern as the most determinant of atherosclerosis through the increasingof plasma LDL, will be worsen by the presence of free radical such as reactive oxygen species (ROS) that led to accumulation of athero...
Article
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The improving social welfare and food availability has created a shift of consumption pattern that leads to high-fat foodsand low-complex carbohydrate, especially the fibrous foods. As we know,carbohydrate has been considered as the safecomponent of foods, therefore, it is recommended to be consumed more. Recently, more experts have started to thin...
Article
Full-text available
The biggest population of Diabetes Mellitus is type 2 diabetes. Dyslipidemia is frequently found in type 2 diabetic patients, which is characterized by increased TG plasma levels and decreased HDL. Increased TG levels may be due to LPL activity disturbance, which then lead to impaired lipoprotein metabolism, such as decreased hydrolyzing TGs in VLD...

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Penelitian ini dirancang khusus sebagai dasar penelitian selanjutnya yaitu pengaruh pemberian ekstrak beras coklat tergerminasi (GBR) dalam memperbaiki obesitas dan sindroma metabolik. Adapun beberapa tujuan penelitian ini antara lain: 1. Mengetahui efek High Fat Fructose Diet (HFFD) untuk menciptakan kondisi hewan coba (tikus) obesitas. 2. Mendapatkan bukti empirik kondisi obesitas hewan coba yang telah diintervensi HFFD melalui parameter plasma glukosa, insulin, dan leptin.