Dhruv Seshadri

Case Western Reserve University School of Medicine · Department of Biomedical Engineering

Objectives Clinical practice guidelines for rehabilitation following ACL reconstruction (ACLR) emphasize the use of functional and strength testing, patient reported outcomes, chronobiological age, and physician expertise. While there are no current internal measures used to aid in the decision of a safe and timely return to sport, recent literatur...

Ulnar collateral ligament (UCL) tears occur due to the prolonged exposure and overworking of joint stresses, resulting in decreased strength in the flexion and extension of the elbow. Current rehabilitation approaches for UCL tears involve subjective assessments (pain scales) and objective measures such as monitoring joint angles and range of motio...

Wearable devices in sports have been used at the professional and higher collegiate levels, but not much research has been conducted at lower collegiate division levels. The objective of this retrospective study was to gather big data using the Catapult wearable technology, develop an algorithm for musculoskeletal modeling, and longitudinally deter...

The coronavirus disease 2019 (COVID-19) pandemic has enabled the adoption of digital health platforms for self-monitoring and diagnosis. Notably, the pandemic has had profound effects on athletes and their ability to train and compete. Sporting organizations worldwide have reported a significant increase in injuries manifesting from changes in trai...

Objective: The study describes the development and testing of a dry surface stimulation flexible electrode (herein referred to as Flexatrode), a low-cost, flexible, and scalable elastomeric nanocomposite using carbon black (CB) and polydimethylsiloxane (PDMS). Methods: Flexatrodes composed of CB and PDMS were developed and tested for mechanical...

Traditional measures of clinical status and physiology have generally been based in health care settings, episodic, short in duration, and performed at rest. Wearable biosensors provide an opportunity to obtain continuous non-invasive physiologic data from patients with congenital heart disease (CHD) in the real-world setting, over longer durations...

Heat-related illnesses, which range from heat exhaustion to heatstroke, affect thousands of individuals worldwide every year and are characterized by extreme hyperthermia with the core body temperature (CBT) usually > 40 °C, decline in physical and athletic performance, CNS dysfunction, and, eventually, multiorgan failure. The measurement of CBT ha...

Objective: Wound dressings that create and maintain a moist environment provide the optimal conditions for wound healing by increasing the rate of epithelialization and angiogenesis. However, current wound dressings require periodic removal which exposes the wound to the surrounding environment, thereby increasing the likelihood for infection and...

Purpose of the review Commercial wearable biosensors are commonly used among athletes and highly active individuals, although their value in sports cardiology is not well established. In this review, we discuss the evidence for the current applications of wearables and provide our outlook for promising future directions of this emerging field. Rec...

Wearable sensors have gained mainstream acceptance for health and fitness monitoring despite the absence of clinically validated analytic models for clinical decision support. Individual sensors measuring, say, EKG signal and heart rate can provide insight on cardiovascular response, but a more complete picture of health and fitness requires a more...

The Bundesliga made headlines for becoming the first major sports league to return to sport worldwide following COVID-19 lockdown. To-date, there lacks retrospective studies on longitudinal injury rates to elucidate the effect isolation measures had on the health and safety of professional athletes. This study sought to compare injury rates experie...

Wearable sensors enable the real-time and non-invasive monitoring of biomechanical, physiological, or biochemical parameters pertinent to the performance of athletes. Sports medicine researchers compile datasets involving a multitude of parameters that can often be time consuming to analyze in order to create value in an expeditious and accurate ma...

The COVID-19 pandemic has brought into sharp focus the need to harness and leverage our digital infrastructure for remote patient monitoring. As current viral tests and vaccines are slow to emerge, we see a need for more robust disease detection and monitoring of individual and population health, which could be aided by wearable sensors. While the...

In the Apple Heart Study, 34% of individuals who received a notification of arrhythmia were later found to have atrial fibrillation (AF), and the positive predictive value in participants notified of an irregular pulse was 0.84.1 That study relied on optical sensors in Apple Watch Series 1 through 3 to detect an irregular pulse and a proprietary al...

Background Wearable wrist-monitors offer an unobtrusive way to acquire heart rate data in an efficient manner. Previous work in this field has focused on studying healthy subjects during exercise but has yet to assess the efficacy of these devices in patients suffering from common cardiac arrhythmias such as atrial fibrillation. Objective The objec...

Athletes are continually seeking new technologies and therapies to gain a competitive edge to maximize their health and performance. Athletes have gravitated toward the use of wearable sensors to monitor their training and recovery. Wearable technologies currently utilized by sports teams monitor both the internal and external workload of athletes....

The convergence of semiconductor technology, physiology, and predictive health analytics from wearable devices has advanced its clinical and translational utility for sports. The detection and subsequent application of metrics pertinent to and indicative of the physical performance, physiological status, biochemical composition, and mental alertnes...

The digital health field has seen a surge in product development over the last decade, with product introductions ranging from wrist monitors, epidermal electronics, electronic pills and smart garments, much of these precipitated through the commercialisation and commoditisation of sensor technology. The emergence of wearable technology has recentl...

The use of nanomaterials to modulate the tumor microenvironment has great potential to advance outcomes in patients with lung cancer. Nanomaterials can be used to prolong the delivery time of therapeutics enabling their specific targeting to tumors while minimizing and potentially eliminating cytotoxic effects. Using nanomaterials to deliver small-...

Growth of abdominal aortic aneurysms (AAA), localized aortal wall expansions, is driven by the disruption and subsequent loss of aortal wall elastic fibers by matrix metalloproteases (MMPs). Since elastic fibers do not naturally regenerate or repair, arresting/reversing AAA growth has not been possible. Previously, we showed utility of doxycycline...

Elite-level athletes and professional sports teams are continually searching for opportunities to improve athletic performance and gain a competitive advantage on the field. Advances in technology have provided new avenues to maximize player health and safety. Over the last decade, time?motion analysis systems, such as video recording and computer...

Wearable devices have garnered increased attention over the past years by the sports industry, military, and general public for everyday use. Technological advancements have enabled athletes, sports teams, soldiers, and physicians to track functional movements, workload, biometric and bio-vital markers to maximize performance and safety while minim...

Statement of significance: Proactive screening of high risk elderly patients now enables early detection of abdominal aortic aneurysms (AAAs). There are no established drug-based therapeutic alternatives to surgery for AAAs, which is unsuitable for many elderly patients, and none which can achieve restore disrupted and lost elastic matrix in the A...