Dhina Fitriastuti

• Islamic University of Indonesia

This study describes the development of N-benzyl-1,10-phenantrolinium salt as an antiplasmodium agent. The salt, that is, 1-(4-ethoxy-3-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide, was prepared using vanillin as the starting material in four simple synthetic steps. First, the alkylation of vanillin using diethyl sulfate produced 4-ethoxy-3- met...

E-learning services are ’weapons’ or ’tools’ that are very powerful in college education in the 21st century. The characteristics of e-learning are students who need to learn and seek as much information as possible. The purpose of implementing e-learning in essential oil chemistry lectures which is supported by practicum is to improve understandin...

Application of retrosynthesis module in Synthetic Organic Chemistry Course using Student Centered Learning (SCL) method is expected to encourage and direct students to find the right way of learning and facilitated by the availability of supporting modules so that the above problems are expected to be resolved. The application of this retrosynthesi...

Curcuma mangga Val. is one of Indonesian herbs from Zingiberaceae family that is under explored and could contain potentially active substances to serve as an antimalarial. This research intends not only to examine the antimalarial activity by means of heme polymerization inhibitor mechanism by using the ethanolic extract and fraction of Curcuma ma...

This study describes simple synthetic method to prepare 1-(2-methoxybenzyl)-1,10-phenanthrolin-1-ium bromide from gandapura oil. The salt were synthesized in four steps. Initially, commercial gandapura oil was directly subjected to the alkylation reaction under basic condition using dimethyl sulfate to give methyl 2-methxybenzoate in 86% yield. Nex...

Andrographis paniculata Ness is one of the plants that is under explored and could contain potentially active substances to serve as an antimalarial. Structure investigation of major compounds that have responsibility for the antimalarial activity of Andrographis paniculata Ness ’s n-hexane extract is very important so that it is known whether the...

Globally in 2010, the prevalence of patient with diabetes mellitus (DM) in 20-79 years old is 6.4% (285 million) and will increase until 7.7% (439 million) in 2030. DM is a disease characterized by hyperglycemia due to abnormality insulin secretion, insulin action, or both. If it uncontrolled can causes complications such as retinopathy, nephropath...

A monoacylglycerol compound, 1-monoolein, was successfully synthesized by using green one-step synthesis through the ethanolysis reaction of Kabate Larva Oil. Kabate Larva Oil was reacted using dry ethanol with ratio of oil to ethanol for 1: 4 (w/w). The reaction using lipase enzyme TL IM (5% w/w of total weight of the reactant) as catalyst. The mi...

Curcuma mangga, locally known as “temu mangga” or “kunyit mangga”, is a rhizomatous herb of the Zingiberaceae family. The rhizomes of C. mangga are used in Java as a seasoning for food and treatment for stomach aches, fever and cancer-related diseases. In the present paper, the antiplasmodial activity of extract and fraction of C. mangga rhizome ha...

An improvement of method for synthesizing 1-monolaurin from lauric acid and glycerol has been done. The reaction was carried on mol ratio between lauric acid and glycerol 1:1 at 130 °C for 6 h with variation of pTSA catalyst of 2.5%, 5%, 7.5% (w/w of lauric acid). The purification of 1-monolaurin was conducted only by extracting with alcoholic solu...

The therapy for invasive candidiasis related to biofilms infection remains a difficult medical problem. To overcome this problem, efforts have been made to search for novel antibiofilm agents from various sources. This study investigated the in vitro antibiofilm activity of (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide (FEN) against Candida a...

Phytochemistry is one of the course in Chemistry Department's curriculum which discusses about biosynthetic path of secondary metabolite compound in a plant, classification of secondary metabolite compound, isolation technique, and identification analysis. This course is expected to be able to bridge the generations of a nation that has expertise i...

Xanthone is a phenolic secondary metabolite of Garcinia and Calophyllum herbs which has been clinically proven to display anti malaria activity. In the present paper, 2,3,4-trihydroxy-5-methyl xanthone which has been synthesized from gallic acid and o-cresol in Eaton’s reagent was tested for its activity as antimalarial. Thus, HPIA assay of the syn...

Metal-based drugs, such as 1,10-phenanthroline, have demonstrated anticancer, antifungal and antiplasmodium activities. One of the 1,10-phenanthroline derivatives compounds (1)-N-2-methoxybenzyl-1,10-phenanthrolinium bromide (FEN), which has been demonstrated an inhibitory effect on the growth of Candida spp. This study aimed to explore the in vitr...

Ethanolysis reaction triglyceride from coconut oil using enzyme from lipozymeTL IM has produced a mixture of 2-mono acyl glycerol. Product 2-mono acyl glycerol with a yield of 35% has been achieved in the ratio by weight of triglyceride from coconut oil to dry ethanol is 1:4, temperature of 35°C, the number of lipozymeTL IM 5% (w/w) of the total we...

Synthesis of xanthone derivatives had been conducted to obtain new antimalaria active compounds. The characterization of the synthesized xanthones was also conducted.Synthesis of xanthone was conducted from the raw material of hydroxybenzoic acid and phenol derivatives using Eaton’s reagent via acylation-dehydration reaction by modified Grover, Sha...

The synthesis of (1)-N-(3,4-dimethoxy-benzyl)-1,10-phenanthrolinium bromide had been conducted from vanillin. Heme polymerization inhibitory activity assay of the synthesized antiplasmodium has also been carried out. The first step of reaction was methylation of vanillin using dimethylsulfate and NaOH. The mixture was refluxed for 2 h to yield vera...