Dhananjay Vithalrao Mane

Yashwantrao Chavan Maharashtra Open University | YCMOU · Regional Center Nashik

Rivaroxaban is Anti-hypersensitive drug. In this study RP-HPLC stability indicating method was developed for Rivaroxaban in Active Pharmaceutical Ingredients. Hemochrom Intsil C18 (250mm X 4.6mm X 5µm) HPLC column was used at temperature 35°C.Gradient elution was achieved with 0.01M KH2PO4 Buffer and Acetonitrile-Water (20:80) v/v. The flow rate wa...

The Woodfordia floribunda Salisb has a very important role in the branch of medicinal chemistry as mentioned in literature. The plant contains a variety of bioactive constituents such as alkaloids, steroids, terpenoids, glycosides, and phenolic compounds, out of these sterols and glycosides show antiinflammatory activity. Non-steroidal anti-inflamm...

A new precise and accurate GC-ALS method was developed and validated for quantitative determination of hazardous high boiling solvents impurities i.e. acetic acid and dimethyl sulphoxide in Linagliptin drug molecule using direct injection technique by GC-ALS with the help of Flame ionization detector (FID). The column used was Agilent J & W DB-FFAP...

The Woodfordia floribunda salisb. plant is significant in the domains of medicinal chemistry and pharmacology. The phyto-constitutents such as diterpene alcohol, alkaloids, tannins and phenolics are qualitatively verified by phytochemical analysis. Literature shows that W. floribunda possess anti-inflammatory, antioxidant as well as anticancer prop...

This study aimed to prepare and evaluate intranasal nano-emulsion of sumatriptan. Methods: The muco-adherent Nano-emulsions were developed by first creating a drug nano-emulsion with the least amount of external phase and then adding the needed amount of concentrated polymer solution to it to get the desired final concentration. Suamtriptan Mucoadh...

The purpose of this study was to make and test an intranasal nanoemulsion of zolmitriptan and almotriptan. The mucoadhsive Nanoemulsions were created by first producing a drug nanomulsion with the least amount of exterior phase and then adding the appropriate quantity of concentrated polymer solution to get the required final concentration. Zolmitr...

The present thesis is an endeavor to explore structural modifications of CdSe nanostructures was carried out by simple and cost-effective chemical bath deposition method to study the vitsl role of structural modifications on the performances of solar cell. I use indium, ruthenium, and thallium as dopants and studied their effect on surface morpho...

Ionic liquids (ILs) have created interest as an environmentally benign media for the catalytic applications due to their unique chemical and physical properties, such as low vapor pressure, high thermal and chemical stability, ease of recyclability and controlled miscibility. In view of this, we have described a highly efficient, safer protocol b...

According to the International Classification of Headache Disorder (ICHD) Migraine is a common neurological disorder, which is characterized by intense, unilateral, throbbing and pulsatile headache attacks, lasting for 4-72 hour and accompanied by anorexia, nausea, vomiting, photophobia and/or phonophobia. Migraine is characterized by recurrent epi...

A N-methyl-2-pyrrolidonium hydrogensulfate [NMP][HSO4] bronsted acidic ionic liquid-promoted cyclocondensation-cyclization pathway has been established using one pot reaction of anilines, aldehydes and mercaptoacetic acid to give 4-thiazolidinone derivatives in good to promising yields using microwave irradiation. Applications for this protocol are...

Advanced nanotechnology is an enormously growing area due to its massive scope of applications for diverse domains of applied science and engineering. Numerous types of synthetic procedures are utilized for the creation of nanoparticles (NPs) due to their myriad application scenarios. However, known conventional physical and chemical strategies hav...

A simple, economical, user-friendly, precise, accurate, robust, rugged and linear analytical method developed and validated for estimation (Assay) of Aceclofenac in Active Pharmaceutical Ingredients or bulk drug form.Isocratic HPLC method developed, flow rate is 1.5 ml/min, and column used Hemochrom C18 Intsil (150mm X 4.6 mm X 5 µm), Column temper...

TiO2 has materialized as an excellent heterogeneous photocatalyst for environmental and energy fields, including air and water splitting. It has 3.2 eV band gap with the absorption edge at near-UV light. Tuning of the band gap of TiO2 into visible region is achieved by the doping of nitrogen. The optimum compositions of N doped TiO2 NPs are prepare...

A [DBN][HSO 4 ] bronsted acidic ionic liquid promoted condensation followed by cyclization protocol has been developed 16 for the first time by a successive reaction of aldehydes, barbituric acid and urea to afford dihydropyrimido [4,5-d] pyrimidine derivatives in high to excellent yields under microwave irradiation (MW=240W). The ionic liquid prov...

In present work, Ruthenium and Indium doped Cdse thin films were synthesized using the chemical bath deposition Technique on the fluorine doped tin oxide (FTO) substrate. The crystal structure and surface composition of the doped CdSe thin film are obtained by X-ray diffraction patterns, energy dispersive X-ray analysis, and FE-SEM images. The opti...

The [DBN][HSO4] -promoted Knoevenagel condensation followed by cyclization protocol has been developed for the first time by a successive reaction of aldehydes, dimedone and malononitrile to afford 2-Amino-4H-pyrans derivatives in high to excellent yields at room temperature. The synergic couple of microwave and ionic liquid provided the capability...

The [DBN][HSO4] -promoted Knoevenagel condensation followed by cyclization protocol has been developed for the first time by a successive reaction of aldehydes, dimedone and malononitrile to afford 2-Amino-4H-pyrans derivatives in high to excellent yields at room temperature. The synergic couple of microwave and ionic liquid provided the capability...

The genus Cochlospermum belongs to Cochlospermaceae family (some classifications place this genus in the family Bixaceae), which consists of about 15 species. Out of which, 3 occur as far north as northern Mexico and southwestern United States. Cochlospermum vitifolium, popularly known as buttercup tree, found widespread in central America and the...

The pure anatase phase tetragonal structured Phosphorous doped TiO2 nanoparticles were successfully synthesized at room temperature by using simple sol–gel method. The structural, optical properties of the materials are investigated thoroughly by various spectral techniques (XRD, EDAX, FT-IR, and UV-DRS) and electron microscopy (FESEM and HRTEM). T...

Titanium dioxide (TiO2) is effective materials in wastewater treatment. It is commonly used as a photocatalyst due to its relatively high photocatalytic efficiency, biological and chemical stability, cost effectiveness, and non-toxicity. However, two main variables limit its application; the quick recombination of photogenerated electron-hole (e−/h...

Selenium nanoparticles (SeNPs) have attracted a great deal of attention in distinctive fields such as anticancer, antioxidant, catalysis, photocopiers, rectifiers, solar cells, and xerography. This has ameliorated an immense development of different synthetic pathways for SeNPs production. Preparation of SeNPs depends largely on the known chemical...

Selenium nanoparticles (SeNPs) have attracted a great deal of attention in distinctive fields such as anticancer, antioxidant, catalysis, photocopiers, rectifiers, solar cells, and xerography. This has ameliorated an immense development of different synthetic pathways for SeNPs production. Preparation of SeNPs depends largely on the known chemical...

The thesis entitled “Research and Development of New Analytical Methods for the Determination of Drugs, Drug Release and Impurities in Different Pharmaceutical Dosage Forms Used in Treatment of Alzheimer’s, Depression and Liver Diseases”. Determination of exact quantity of drug in the drug formulation requires accurate and robust analytical method....

This study is the first phase of an ongoing research project initiated to promote and enhance Forensic Chemistry in India. It is a multidisciplinary investigation combining forensic investigation, chemistry and forensic toxicology to create a unique platform needed by the forensic community of India for the identification of drugs and forensic inte...

Glycyrrhizic acid, the major metabolite of Glycyrrhiza glabra, is a 'Hot Molecule' in view of its sweet tasting properties and potent anti-viral and anti-allergic activities. A fast chromatographic method for its isolation and a rapid, sensitive reproducible high-performance thin-layer chromatography (HPTLC) method for its quantification have been...

ABSTRACT An efficient, high-yielding and rapid protocol has been developed for the synthesis of dihydropyrano[2,3-c]pyrazoles derivatives via one-pot, four-component, C-C and C-N bond forming reaction of aryl aldehydes, , ethyl acetoacetate, malononitrile and hydrazine hydrate or phenyl hydrazine by using PS-DABCO as green reusable heterogeneous ca...

ABSTRACT The utility of Ionic Liquids (ILs) for the environmentally benign synthesis of heterocyclic compounds found important for due to their unique chemical and physical properties viz. low vapor pressure, recyclability, controlled miscibility, high thermal and chemical stability. The synthesis of 2-amino-5,6,7,8-tetrahydro-7,7-dimethyl-4-(3, 4-...

a diphenyl ether herbicide used for broad-spectrum pre- and post-emergent control of annual broad leaf and grassy weeds in a variety of tree fruits, nuts, vines, and field crops. The largest agricultural markets in terms of total pounds of active ingredient are wine grapes and almonds. There are also nonagricultural ornamental and forestry uses. Ox...

Cannabis, also known as Marijuana, and other forms of cannabis plant (bhang, ganja, and Charas) are very frequently submitted to forensic laboratories under THC narcotic drug and psychotropic substances act 1985. In routine cases the identification of Cannabinoids in marihuana is achieved unequivocally by the 'three-parameter approach [Morphology,...

ABSTRACT We have described a highly efficient, safer protocol for the synthesis of tetrahydrobenzo[b]pyran conjugates catalyzed by Bronsted acidic ionic liquid [Et3NH][HSO4] in excellent yields. The protocol offers cost effective, environmentally benign, solvent-free conditions and recycle-reuse of the catalyst. Keywords: Tetrahydrobenzo[b]pyran,...

A novel series of amide derivatives of 4-(3-methyl-5-(piperazin-1-yl)-1H-pyrazol-1-yl)benzonitrile were synthesized, characterized and evaluated biologically. N-boc piperazine and diketene are employed as key raw materials and produced a series of novel amide derivatives by 5 steps reaction pathway with excellent yield and milder reaction condition...

In our research project to develop newer anticancer molecules, we have adopted two different strategies using two different pharmacophores. First we used thieno [2, 3-d] pyrimidine nucleus to designed and synthesized newer amide and hydrazide molecules of target. Secondly, we designed the novel amide and hydrazide molecules combining the two pharma...

In present work, Ruthenium and Indium doped Cdse thin films were synthesized using the chemical bath deposition Technique on the fluorine doped tin oxide (FTO) substrate. The crystal structure and surface composition of the doped CdSe thin film are obtained by X-ray diffraction patterns, energy dispersive X-ray analysis, and FE-SEM images. The opti...

Novel sulfonamide containing diaryl pyrazoles were synthesized and were subsequently tested for their in vitro cyclooxygenase inhibitory assay. Compounds that showed promising in vitro COX-2 IC50 values and selectivity indices were then evaluated for their in vivo anti-inflammatory inhibition assay using standard carrageenan-induced rat paw edema m...

ABSTRACT Purpose: To develop rapid, rugged, precise and an accurate stability indicating analytical method for estimation of related substances in Ursodeoxycholic Acid tablets. Method: The separation of impurities and Ursodeoxycholic Acid drug is achieved by an isocratic chromatographic method on C18, 250 mm x 4.6 mm, 5µm column. The mobile phase...

In the present work, the magnetic properties and catalytic properties of the CuFe2O4 nanoparticles have presented. The wet chemical synthesis technique was employed for the synthesis of CuFe2O4 catalyst. The crystallinity and phase purity of the CuFe2O4 nanoparticles were checked by the X-ray diffraction technique. The magnetic properties of the pr...

An HPLC assay method is developed for quantitative determination of ursodeoxycholic acid in ursodeoxycholic acid tablets. The developed method is a simple, accurate, rugged, precise and stability indicating chromatographic method. The stationary phase used in separation of known impurities and ursodeoxycholic acid drug was C18, 250 mm × 4.6 mm, 5 µ...

An efficient and convenient approach towards the synthesis of nitrogen fused imidazoheterocycles through double C-N bond formation in a single step has been achieved with a good range of substituted phenacyl bromides in the presence of magnetically recoverable Fe3O4 as a green heterogeneous nanocatalyst. The present approach was found to be environ...

Purpose: To develop and validate a rapid, rugged, precise and an accurate stability indicating analytical method for determination of Nortriptyline HCl in Nortriptyline tablets. The separation of impurities and Nortriptyline HCl drug was achieved by an isocratic liquid chromatographic method using Inertsil, C18, 250 mm x 4.6 mm, 5µm column at 45ºC....

In view of extensive applications in the Indian Ayurvedic system of medicine and the increased demand for both as single ingredient and as a major component in multiherbal formulations of Boerhavia diffusa, a rapid, sensitive and reproducible high-performance thin-layer chromatography (HPTLC) method has been developed for its quantitative evaluatio...

Microwav e assisted MicroencapsulatedCu(acac) 2 [MCCu(acac) 2 ] is found an efficient, environmentally benign catalyst for the one pot multicomponent condensation reaction of aromatic aldehyde, β the amidoalkyl naphthols in good yield. Add itionally, the catalyst could be reused upto four times without the significant loss in yield and selectivity...

ABSTRACT Here in we report synthesis and 4dihydro8 methoxy4antibacterial scree ning oxoquinoline3of fourteen novels 7substituted 1 carboxamide derivatives by substituting fluoro group at C heterocyclic amine and substituted heterocyclic amine. All these derivatives wer P. aeruginosa KEYWORDS: and Bacillus subtiliscyclopropyl-- 6 fluoro1, 7 position...

Iron doped titanium nanoparticles have been synthesized by solgel method using chemical bath containing appropriate volume ratio of titanium isopropoxide, oleic acid as a capping agent, conc. HNO3, ferrous ammonium sulphate; kept at temperature of 600C. Synthesized nanoparticles were characterized by X-ray diffraction (XRD), FourierTransorm infra-r...

Abstract: A new and efficient protocol is developed for the synthesis of benzothiazoles using TBAF as catalyst under environmentally friendly conditions. An attempt is made to develop synthetic protocol representing a novel and very simple route for the preparation of 2-substituted benzothiazole derivatives. In addition, a microwave irradiation tec...

The present study was aimed to develop an analytical method for quantification of memantine (MEM) hydrochloride in dissolution samples using high-performance liquid chromatography with refractive index (RI) detector. The chromatographic separation was achieved on C18 (250 × 4.5 mm, 5 μm) column using isocratic mobile phase comprises of buffer (pH 5...

A new and efficient protocol was developed for synthesis of benzothiazoles using Tetra-n-butyl ammonium fluoride (TBAF) as a catalyst under environmentally friendly conditions. The developed synthetic protocol represents a novel and very simple route for preparation of 2-substituted benzothiazole derivatives (3a-i) . In addition, a microwave irradi...

Heterocyclic compounds are of interesting due to their physiological and industrial significance. The versatile application of nitrogen and / or oxygen heterocyclic compounds have made this area of extensive research of synthetic chemists. Nitrogen heterocyclic compounds like triazines, Benzimidazoles, pyrazoles, isoxazoles and pyridines have recei...

Abstract :- Metallophthalocyanines (MPcs) of Ni was synthesized by chemical reaction from phthalic acid, urea and Nickel Chloride by using Ammonium Molybdate as a catalyst. The sample preparation was done by using press technique, in the form of pellets. The synthesized compounds were confirmed by physical analysis. Further characterization were d...

Abstract :- Metallophthalocyanines (MPcs) of Ni was synthesized by chemical reaction from phthalic acid, urea and Nickel Chloride by using Ammonium Molybdate as a catalyst. The sample preparation was done by using press technique, in the form of pellets. The synthesized compounds were confirmed by physical analysis. Further characterization were d...

ABSTRACT: The present paper shows an agro waste of Rice and wheat straw and husk, Cotton stalk, Saw mill waste, ground nut shell, banana stalk and jute, sisal and vegetable residues are produce yearly in millions of tones from Indian agriculture, if we use this waste in energy production and compost manure which is best option for chemical fertiliz...

Kinetics has played vital role in the development of chemistry. Chemical kinetics is gaining importance in pure and applied fields. It helps to find out optimum conditions required to get the value added desired products. 1, 4-Benzothiazines are known for their utility as dyestuff's, photographic developers, ultraviolet light absorbers and antioxid...

Abstract : Pyrazoles are very important heterocyclic compounds which are widely present in the medicinal, pesticide type of molecules. Wide literature for the preparation of pyrazole is present till date. We have synthesized pyrazole using uncommon reagent i.e. Lawesson’s Reagent (LR) with excellent yield and minimum reaction time at room temperatu...

ABSTRACT Microencapsulated-Cu(acac)2 [MC-Cu(acac)2] is found to be an efficient catalyst for the multicomponent condensation reaction of aromatic aldehyde, β-naphthol and amide to form the corresponding amidoalkyl naphtholsin good yield. Moreover, the catalyst could be recycled for four times without the significant loss in yield and selectivity of...

In the present paper, We have made efforts to use a new chromogenic spray reagent for the high-performance thin-layer chromatographic detection of carbamates. In this work, we used 10% aq. sodium hydroxide followed by 5% of toluidine reagent and 10% of aq. sodium nitrate, giving orange and violet spots. Key Words: Insecticides Toxicological High-pe...

Cancer chemotherapy has been one of the major medical advances in the last few decades. The medications involved in treatment have a narrow therapeutic index, and often the responses produced are only just palliative as well as unpredictable. In contrast, targeted therapy such as Tyrosine kinases inhibitors, that has been introduced in recent years...

Rapid one pot synthetic route has been developed for cyclocondensation of 2-aminothiophenol and 1,3- dicarbonyls/diketones using relatively safe oxidants like metaperchlorobenzoic acid (M-CPBA) and 2- iodoxybenzoicacid (2-IBX).The details of synthetic route and characterization of the product carried by spectral analysis are also presented.

Endosulfan (6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro- 6,9-methano-2,4,3-benzodioxathiepine-3-oxide; Figure 1) is an organochlorine pesticide used for agricultural purposes [1]. It is applied as a fumigant for vegetables, fruits, and cotton. Though it is a highly toxic pesticide, it is easily available in the market of all the parts of India...

Manganese (II) Chloride has been used as an efficient catalyst for an improved synthesis of 3-(1H-indol-3-yl)-1, 3-diphenylpropan-1-ones in excellent yields using water as a reaction medium. This aqueous mediated reaction of various Chalcone with indole using catalytic amounts of manganous chloride avoids the use of expensive, corrosive reagents, t...

The structural, magnetic and dielectric properties of ferrites are of great importance to select materials for specific applications. Some factors which affect the properties of ferrites are the type and amount of substitution, chemical composition, methods of preparation and different types of irradiation. Since the research on ferrites is so vast...

Since its introduction, antiretroviral drug therapy has dramatically reduced morbidity and mortality associated with HIV infection. The use of combination drug therapies can significantly improve HIV patients’ chances for long-term survival. Unfortunately, the effectiveness of antiretroviral therapy can be markedly reduced by the emergence of drug...

Chapter I deal with the general introduction and literature survey. Chapter II deals with development of method for isolation and identification of organophosphorus insecticides like monochrotophos (Section A), again another spray reagent developed for monochrotophos (Section B) and dichlorvos (Section C). Chapter III deals with isolation and ident...

The IR spectra shows two main absorption bands n 1 and n 2 are characteristics of spinel ferrites. The shape, size and morphology of synthesized sample studied by transmission electron microscopy and scanning electron microscopy indicates agglomerated nano particles in the range of 9-18 nanometer. The magnetic properties like remanent magnetization...

Analytical toxicology is an important branch of forensic science. The number of fatal poisoning cases received for toxicological analysis is constantly increasing. There is tremendous rise in the use of insecticide; pesticide and other potentially poisonous substances in last five-year for crop protection, their misuse has lead to suicidal, homicid...

A simple rapid and accurate High performance thin layer chromatography (HPTLC) method has been developed for identification of paracetamol from biological material, i.e. blood, gastric larvage, and visceral material. The method is based on HPTLC separation of paracetamol-analgestic drug followed by densitometric measurements of spt at 270 nm. The s...

ABSTRACT: A simple rapid and accurate High performance thin layer chromatography (HPTLC) method has been developed for identification of paracetamol from biological material, i.e. blood, gastric larvage, and visceral material. The method is based on HPTLC separation of paracetamol-analgestic drug followed by densitometric measurements of spt at 270...

ABSTRACT: A sensitive and selective thin layer chromatographic method for the detection and identification of nitrobenzene using furfural as a spray reagent is described. The reduction product of nitrobenzene gives aniline. Which react with furfural reagent to give a red color spot. The reagent does not react with other organo phosphorous (except e...

ABSTRACT A revolution method of microwave assisted organic synthesis is one of the major roles for synthesis of new drug molecules. Considering the benefits of microwave organic synthesis we have synthesized 12 novel Schiff base compounds (10 E-10 P) of 2-amino-N-[3-fluoro-4-(morpholin-4-yl) phenyl] benzene-1-sulfonamide derivatives from commercial...