Devora Aharon

• Fellow at Icahn School of Medicine at Mount Sinai

Reproductive success relies on proper establishment and maintenance of biological sex. In many animals, including mammals, the primary gonad is initially ovary biased. We previously showed the RNA binding protein (RNAbp), Rbpms2, is required for ovary fate in zebrafish. Here, we identified Rbpms2 targets in oocytes (Rbpms2-bound oocyte RNAs; rboRNA...

Reproductive success relies on proper establishment and maintenance of biological sex. In many animals, including mammals, the primary gonad is initially ovary in character. We previously showed the RNA binding protein (RNAbp), Rbpms2, is required for ovary fate in zebrafish. Here, we identified Rbpms2 targets in oocytes (Rbpms2-bound oocyte RNAs;...

Reproductive success relies on proper establishment and maintenance of biological sex. In many animals, including mammals, the primary gonad is initially ovary in character. We previously showed the RNA binding protein (RNAbp), Rbpms2, is required for ovary fate in zebrafish. Here, we identified Rbpms2 targets in oocytes (Rbpms2-bound oocyte RNAs;...

Objective: To assess whether open and minimally invasive myomectomy are associated with changes in postoperative ovarian reserve as measured by serum anti-müllerian hormone (AMH) level. Methods: This prospective cohort study included patients who were undergoing open abdominal myomectomy that used a tourniquet or minimally invasive (robot-assist...

Objective: To assess whether coronavirus disease 2019 (COVID-19) mRNA vaccination is associated with controlled ovarian hyperstimulation or early pregnancy outcomes. Methods: This retrospective cohort study included patients who underwent controlled ovarian hyperstimulation or single euploid frozen-thawed embryo transfer at a single academic cen...

Zebrafish have emerged as a major model organism to study vertebrate reproduction due to their high fecundity and external development of eggs and embryos. The mechanisms through which zebrafish determine their sex have come under extensive investigation, as they lack a definite sex-determining chromosome and appear to have a highly complex method...

Objective: To determine if pregnancy rates (PRs) or pregnancy loss rates (PLRs) were altered in patients undergoing single, euploid frozen-thawed embryo transfer (FET) during the initial peak of the Coronavirus Disease 19 (COVID-19) pandemic. Materials and Methods: This was a retrospective cohort study performed in a single academic center. Patient...

Objective The current study aimed to evaluate perinatal outcomes from transfers of euploid embryos that required trophectoderm (TE) biopsy on day 7 due to delayed cavitation. Design Retrospective study Materials and Methods This study included euploid embryos that underwent IVF and preimplantation genetic testing for aneuploidy (PGT-A) from 2011 to...

Objective Recent studies have demonstrated that extended culture of blastocysts to day 7 leads to satisfactory pregnancy outcomes in patients with slow-growing embryos.1,2 However, even when confirmed to be euploid by preimplantation genetic testing for aneuploidy (PGT-A), day 7 embryos have lower rates of implantation, clinical pregnancy, and live...

Infertility is defined as the inability to achieve a successful pregnancy after 12 months or more of regular unprotected intercourse, or after 6 months among women over 35 years of age. This chapter provides the background and causes of infertility in the infertile couple. Fecundability for healthy young couples is estimated to be 0.25, meaning the...

Aim This study aimed to evaluate the unique phenotype of the Vietnamese polycystic ovarian syndrome (PCOS) population. Methods In this multicenter cross‐sectional descriptive study, a total of 901 reproductive‐age women were recruited at three medical centers in Vietnam from June 2016 to May 2018. Group I included 479 patients with PCOS (Rotterdam...

Objective: The alpha2C adrenoreceptor deletion 322-325 (ADRA2C del 322-325) polymorphism has been associated with autonomic activity and thermoregulation, which are implicated in the vasomotor symptom (VMS) mechanism. The ADRA2C del (322-325) has higher prevalence in African American women, a group known to experience more frequent and bothersome...

Study objective: Data are limited regarding optimal timing between operative hysteroscopy and embryo transfer (ET). This study aimed to assess whether the time interval from operative hysteroscopy to ET affects implantation and clinical pregnancy rates. Design: Retrospective cohort study (Canadian Task Force classification II-2). Setting: Priv...

Objective To report a finding of persistently elevated estradiol (E2) after prolonged mifepristone use for treatment of progesterone-receptor positive meningioma, an association which has not previously been reported. Design This is a case report. Setting Outpatient Reproductive Endocrine clinic at a tertiary referral center. Case Report A 48-ye...

This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field.

Background Cervical cancer is the most prevalent cancer among Peruvian women. Female sex workers (FSW) in Peru are at elevated risk for HPV infection, and receive annual Papanicolaou screening. The objective of this study was to identify barriers to follow-up for abnormal Pap smears among FSW in Peru. Methods 97 FSW attending the Alberto Barton He...

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Background: Despite decrease in child mortality in Jamkhed, more data is needed to evaluate and address factors relevant to infant (below age of one year) death. We assess the causes of infant mortality to provide potential appropriate recommendations. Methods: We applied a verbal survey adapted from the World Health Organization's standard verbal...