Devi Atukorala

Devi Atukorala
University of Manitoba | UMN · Department of Oral Biology

BDS (Hon), Ph.D.

About

33
Publications
3,090
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207
Citations
Citations since 2017
16 Research Items
139 Citations
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Introduction
Our lab focuses on the craniofacial development. Taking teleost fish, such as zebrafish (Danio rerio) and Mexican tetra fish (Astyanax mexicanus) as model animals, we study the evolutionary development of the dentition, sensory systems, and jaw bones. Formation of these structures involve complex interactions and we are interested in finding the molecular signaling pathways which regulate their development. This research addresses the questions related to the human congenital malformations and c
Additional affiliations
September 2016 - present
Mount Saint Vincent University
Position
  • PostDoc Position

Publications

Publications (33)
Article
The Mexican tetra (Astyanax mexicanus) is one of the fresh water teleost fish models in evolutionary developmental biology. The existence of two morphs: eyed, pigmented surface fish and blind depigmented cavefish from multiple cave populations, provides a unique system to study adaptive radiation. Compared to the adult surface fish, cavefish have l...
Conference Paper
Full-text available
Alcohol is a common addictive substance and prenatal alcohol exposure can caused various birth defects. Craniofacial region which is primarily derived from the neural crest derived ectomesenchyme are adversely affected by alcohol. Small freshwater teleost fish has been identified as a fine animal model to study the craniofacial development, melanoc...
Article
Full-text available
Alcohol is a common addictive substance and prenatal alcohol exposure could cause fetal alcohol spectrum disorder (FASD) and can lead to various birth defects. The small teleost zebrafish (Danio rerio) has been identified as a fine animal model in developmental biology and toxicological research. Zebrafish models are widely used to study the harmfu...
Chapter
Full-text available
Fetal alcohol spectrum disorders (FASD) refer to the entire suite of detrimental consequences resulting from prenatal alcohol exposure. Alcohol is identified as an environmental teratogen competent of inducing a wide range of developmental abnormalities. Embryonic alcohol exposure produces clinically recognizable wide range of congenital malformati...
Article
Full-text available
The chemical senses of olfaction and taste are well developed in fish and play a vital role in its various activities such as navigation, mate recognition, and food detection. The small teleost fish Astyanax mexicanus consists of interfertile river‐dwelling and cave‐dwelling populations, referred to as “surface fish” and “cavefish” respectively. An...
Conference Paper
Full-text available
Vertebrate color patterns are composed of specialized pigment-producing cells, the chromatophores. Melanin is the main pigment type that colors the skin and skin appendages in mammals. Melanin is produced by specialized cells called melanocytes. Melanocytes have embryonic neural crest cells origin and their development and functions are ubiquitous...
Conference Paper
Full-text available
Melanin is the pigment that colors the skin and skin appendages. Melanin is produced by specialized cells called melanocytes. Melanocytes have embryonic neural crest cells origin and their development and functions are ubiquitous across vertebrates. Alcohol is a widely abused teratogenic substance. Fetal alcohol spectrum disorder (FASD) is describe...
Article
Full-text available
Pregnancy is a tightly regulated immunological state. Mild environmental perturbations can affect the developing fetus significantly. Infections can elicit severe immunological cascades in the mother's body as well as the developing fetus. Maternal infections and resulting inflammatory responses can mediate epigenetic changes in the fetal genome, d...
Article
Full-text available
The SARS-CoV-2 virus has shaken the globe with an ongoing pandemic of COVID-19 and has set challenges to every corner of the modern health care setting. The oral mucosa and saliva are high risk sites for higher viral loads and dental health care professionals are considered a high risk group. COVID-19-induced oral lesions and loss of taste and smel...
Article
Human cleft lip and/or palate (CLP) are immediately recognizable congenital abnormalities of the face. Lip and palate develop from facial primordia through the coordinated activities of ectodermal epithelium and neural crest cells (NCCs) derived from ectomesenchyme tissue. Subtle changes in the regulatory mechanisms of NCC or ectodermal epithelial...
Article
A small fresh water fish, the Mexican tetra (Astyanax mexicanus) is a novel animal model in evolutionary developmental biology. The existence of morphologically distinct surface and cave morphs of this species allows simultaneous comparative analysis of phenotypic changes at different life stages. The cavefish harbours many favourable constructive...
Article
The phenotype of lens-ablated Mexican tetra (Astyanax mexicanus) compared to wild-type surface fish has been described and includes, among other effects, eye degeneration, changes in tooth number and cranial bone changes. Here, we investigate the spatiotemporal expression patterns of several key genes involved in the development of these structures...
Chapter
The cavefish, Astyanax mexicanus, is an omnivorous feeder that is also the top predator in its subterranean ecosystem, despite lacking the major sensory organ required to find food, namely eyes. These cavefish have, over the last 1 million years, evolved for successful searching, identification, and consumption of food in these resource-limiting en...
Article
Background: Teeth are integrated into the vertebrate oral jaws to provide a functional unit for feeding, however little is known about how this integration occurs during growth and development. The purpose of this study is to identify the ontogenetic changes in oral jaw shape that are associated with the transition of the oral dentition from unicu...
Article
The Mexican tetra (Astyanax mexicanus), a fresh water teleost fish, is an excellent vertebrate model organism to study tooth development, specifically the spatiotemporal events related to the development of the oral and pharyngeal dentitions. In contrast to the coordinated early tooth development in the premaxilla and mandible, the maxillary teeth...
Article
Full-text available
The Mexican tetra (Astyanax mexicanus) has emerged as a good animal model to study the constructive and regressive changes associated with living in cave environments, as both the ancestral sighted morph and the cave dwelling morph are extant. The cave dwelling morphs lack eyes and body pigmentation, but have well developed oral and sensory systems...
Conference Paper
Background: In teleosts, scales and teeth are elements of dermal skeleton thought to derive from common ancestor, and hence share common signaling pathways in development such as ectodysplasin (Eda) pathway which plays a pivotal role in ectodermal organogenesis. Eda receptor (Edar) mutant medaka fish (Oryzias latipes) known as rs-3 is characterized...
Article
Ectodermal contribution to the induction of pharyngeal teeth that form in the endodermal territory of the oropharyngeal cavity in some teleost fishes has been a matter of considerable debate. To determine the role of ectodermal cell signaling in scale and tooth formation and thereby to gain insights in evolutionary origin of teeth, we analyzed scal...
Conference Paper
Objectives: Ectodysplasin-A (EDA) and ectodysplasin-A receptor (EDAR) are thought to have critical roles in the induction and development of ectodermal organs. The defects on these genes were reported to cause hypohidrotic ectodermal dysplasia in humans characterized by malformations of dermis and its appendages including sweat grand, hair, and tee...
Article
Oral submucous fibrosis (OSMF) is a chronic, insidious, disabling potentially malignant condition of the oral mucosa seen predominantly in south and Southeast Asia. No reports are hitherto available on the aetiological factors of OSMF based on Sri Lankan patients. A total of 74 patients with OSMF and 74 controls who consecutively attended the Oral...

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