Devesh U. Kapoor

• PhD Pharmaceutics
• Professor at Dr. Dayaram Patel Pharmacy College

Brain disorders, encompassing neurodegenerative conditions and intracranial neoplasms, present formidable obstacles in the realm of pharmacological delivery due to the existence of athe blood–brain barrier (BBB) and the restricted bioavailability of therapeutic agents. Alginate-derived nanoformulations have emerged as highly promising systems for d...

Posaconazole (POS) drug is widely used as an antifungal effective against Candida infections falls under the Biopharmaceutics Classification System (BCS) Class II. Because of its very low water solubility and hydrophobic properties, solubility is the rate limiting step which affects the absorption rate, to overcome these problems the current resear...

Bacterial infections continue to pose significant global health challenges, particularly with the rise of antibiotic resistance and multi-drug resistant strains. Current treatment options are often associated with limitations such as toxicity, poor drug bioavailability, and limited specificity. Liposomes, as versatile drug delivery systems, offer p...

Opinion Statement Ocular cancers, though rare, present significant therapeutic challenges due to their aggressive nature, high metastatic potential and anatomical constraints that limit drug delivery. Conventional therapies, including radiation, enucleation, and chemotherapy, often result in significant side effects and suboptimal outcomes. Recent...

Prostate cancer is a condition characterized by the uncontrolled proliferation of abnormal cells inside the prostate gland, part of the male reproductive system. Prostate cancer is the most common cancer among men and the second largest cause of cancer-related mortality in the United States. A novel approach to treating advanced Prostate cancer has...

A mesoporous silica-based nanoparticulate drug delivery system encapsulating curcumin was designed to enhance the targeted delivery of the therapeutic agent to tumor tissues in oral cancer. The drug was entrapped within functionalized mesoporous material, MCM 41, by solvent evaporation technique, and folic acid was used as a targeting agent. The op...

Posaconazole (POS) is widely used as an antifungal agent effective against Candida infections. Because of its very low water and high fat solubility, it falls under the Biopharmaceutics Classification System (BCS) Class II. It showed considerable differences in absorption rates among individuals when administered orally. To overcome these obstacles...

The field of drug delivery has witnessed significant advancements with the emergence of nanocarriers and advanced delivery devices for parenteral administration. Nanocarriers, a prominent topic in drug delivery, are introduced with an emphasis on their significance and diverse applications A critical analysis compares conventional injectables with...

Pancreatic cancer stands as one of the most aggressive and deadly malignancies, characterized by a limited array of treatment options and unfavorable patient outcomes. Recent strides in the realm of nanotechnology have introduced advanced approaches to increase the delivery of anti-cancer agents and intensify their effectiveness. The lipid-based na...

Osteoporosis presents a significant clinical and public health challenge due to its link with fractures that commonly occur with aging. The objective of current investigation was to formulate and characterize the Lactoferrin Nanoparticles loaded in situ gel for vaginal delivery of bisphosphonates for postmenopausal osteoporosis. The nanoparticles w...

In the 21st century, 75 % of women encounter vaginal malfunctions (cervicitis, mucoid ectopy, aerobic vaginitis, candidiasis, bacterial vaginosis, degenerated vaginitis, desquamative chronic vaginitis, and sexually transmitted infections) that clinically manifest as irritation, awkwardness, irregular bleeding, or evacuation. Vaginal drug delivery,...

The biocompatible and biodegradable polysaccharide starch is a great platform for the development of nanoparticles (NPs). Due to its special qualities, which include high stability, low toxicity, and ease of modification, it is a desirable option for the administration of anticancer drugs. Targeted cancer therapy has found a potential carrier in st...

Polymeric nano-discs offer a promising and adaptable nanocarrier platform for topical applications involving the targeted administration of drugs. These biocompatible polymer-based, disc-shaped, nanoscale structures have drawn interest due to their exceptional capacity to encapsulate a diverse range of theranostics. Theranostics, the concept of com...

The growth of nanostructured lipid carriers for brain targeting shows a promising strategy for escalating the therapeutic efficacy of antiepileptic drugs such as carbamazepine (CBZ). CBZ is a drug of choice in the management of epilepsy and trigeminal neuralgia. However, CBZ oral administration is associated with poor bioavailability, successive do...

Diabetes is a medical condition, which belongs to the group of chronic diseases that affects how body processes glucose, the primary source of energy for cells. Glucose comes indirectly from the consumed food and is carried by bloodstream to various cells in body. Insulin, a hormone synthesized by pancreas play a vital role in conversion of glucose...

This study aimed to develop and optimize glimepiride microparticles (GM) using the solvent evaporation technique, employing polymers like ethyl cellulose, Eudragit RL100, and RS100 in various ratios. The optimized GM formulation (F2) demonstrated a mean particle size of 1.75 μm, a polydispersity index (PDI) of 0.59, and a zeta potential of 1.396 mV...

This study focuses on the formulation, optimization, and characterization of a water-in-oil (W/O) Pickering emulsion (PE) containing capecitabine (CAP), which is self-stabilized using polysarcosine (Psar) nanoparticles (NPs), to create a topical treatment for squamous cell carcinoma (SCC). The polysarcosine nanoparticles (Psar-NPs) were prepared us...

Nanoparticle-based drug delivery systems represent a transformative advancement in targeted therapeutics, providing meticulous drug delivery, enhanced bioavailability, and diminished side effects. However, designing nanoparticles (NPs) optimal for specific drugs and diseases remains a complex challenge. The advancements in artificial intelligence (...

Cancer is characterized by a highly intricate pathophysiology and stands as a chief cause of mortality and illness globally. Traditional treatments for cancer such as chemotherapy, targeted & radiation therapy, and immunotherapy. Despite their widespread use, these therapies have significant limitations. They often suffer from a lack of selectivity...

An ideal drug carrier system should demonstrate optimal payload and release characteristics, thereby ensuring prolonged therapeutic index while minimizing adverse effects. The field of drug delivery has undergone significant advancements, particularly within the last two decades, owing to the revolutionary impact of biomaterials. The use of biomate...

Herbal medicines, integral to human history, remain vital in developing countries owing to the high costs of synthetic drugs, with 80% of the population relying on traditional practices. There has been an escalating focus within the scientific community on the exploration of phytoconstituents. This growing interest is due to the diverse benefits of...

Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 1–3 % results from uncon�trolled proliferation of keratinocytes and affects millions of people. While there are various treatment options available, some of them may come with potential side effects and limitations. Recent research has shown that using bioactive compounds...

Polymeric nanoparticles are one of the emerging drug delivery systems in the field of oncology. Ellagic acid is a polyphenolic compound with vast effects like anti-cancer, anti-viral, and anti-oxidant. The ellagic acid nano particles was prepared by desolvation method. Formulating ellagic acid NPs using BSA enhances the stability and solubility o...

Nanoflowers, an innovative class of nanoparticles with a distinctive flower-like structure, have garnered significant interest for their straightforward synthesis, remarkable stability, and heightened efficiency. Nanoflowers demonstrate versatile applications, serving as highly sensitive biosensors for rapidly and accurately detecting conditions su...

Fluorescent liposomes are pivotal in cancer research, serving as adaptable vehicles for imaging and therapeutics. These small lipid vesicles, capable of encapsulating fluorescent dyes, offer precise visualization and monitoring of their targeted delivery to cancer cells. This review delves into the critical role fluorescent liposomes play in enhanc...

Purpose Although the resistance to decomposition is caused by varied conformation and rigidity, lignocellulose is consid- ered a potential feedstock for the development of substitute fuels, chemicals, fabricating pharmaceutical dressing, and food packaging components. Lignocellulose has been regarded as an essential resistance element in the exploi...

Oral cancer retains one of the lowest survival rates worldwide, despite recent therapeutic advancements signifying a tenacious challenge in healthcare. Artificial intelligence exhibits noteworthy potential in escalating diagnostic and treatment procedures, offering promising advancements in healthcare. This review entails the traditional imaging te...

Effectively managing inflammatory bowel disease (IBD) poses difficulties due to its persistent nature and unpredictable episodes of exacerbation. There is encouraging evidence that personalized medication delivery systems can improve therapy efficacy while reducing the negative effects of standard medicines. Zein, a protein produced from corn, has...

The biotechnology field has witnessed rapid advancements, leading to the development of numerous proteins and peptides (PPs) for disease management. The production and isolation of bioactive milk peptides (BAPs) involve enzymatic hydrolysis and fermentation, followed by purification through various techniques such as ultrafiltration and chromatogra...

Carbon nanodots represent a burgeoning class of nanomaterials renowned for their remarkable adaptability and multifunctionality. In the realm of cancer research, carbon nanodots emerge as a potent avenue for drug delivery, offering precision and efficacy. This review explores various methods employed in the fabrication of nanodots. The review also...

Parkinson's disease (PD) is a common and progressively worsening neurodegenerative disorder characterized by abnormal protein homeostasis and the degeneration of dopaminergic neurons, particularly in the substantia nigra pars compacta. The prevalence of PD has doubled in the past 25 years, now affecting over 8.5 million individuals worldwide, under...

Psoriasis, recognized as a chronic inflammatory skin disorder, disrupts immune system functionality. Global estimates by the World Psoriasis Day consortium indicate its impact on approximately 130 million people, constituting 4 to 5 percent of the worldwide population. Conventional drug delivery systems, mainly designed to alleviate psoriasis sympt...

Nanotechnology as a field in material science has continued to grow in leaps and bounds, with efficacious applications in quite challenging areas of human endeavors. Consequently, the application of nanomaterials has eased life generally for humanity, through engaging research outputs, with cumulative simplification of initially knotty and overwhel...

Chitosan (CT), a natural, cationic, chemically stable molecule, biocompatible, biodegradable, nontoxic, poly-saccharide derived from the deacetylation of chitin, has very uniquely surfaced as a material of promise for drug delivery and biomedical applications. For the oral, ocular, cutaneous, pulmonary, and nose-to-brain routes, CT-coated nanoparti...

Polyelectrolytes represent a unique class of polymers abundant in ionizable functional groups. In a solution, ionized polyelectrolytes can intricately bond with oppositely charged counterparts, giving rise to a fascinating phenomenon known as a polyelectrolyte complex. These complexes arise from the interaction between oppositely charged entities,...

Konjac glucomannan (KG) is a dietary fiber hydrocolloid derived from Amorphophallus konjac tubers and is widely utilized as a food additive and dietary supplement. As a health-conscious choice, purified KG, along with konjac flour and KG-infused diets, have gained widespread acceptance in Asian and European markets. An overview of the chemical comp...

The flexible functionalization of gelatin provides opportunities for easy and efficient cross-linking as well as combining with other materials (such as metal nanoparticles (MNPs), carbonaceous materials, and polymeric materials showing desired functional properties) to create hybrid materials with improved physicochemical, biological, and thermome...

Pediatric pharmacotherapy presents distinctive challenges compared with adult pharmacotherapy and encompasses considerations such as drug administration methods, susceptibility to medication-related toxicity, and taste preferences that influence compliance and efficacy. Customizing pediatric medicines is crucial for tailoring formulations to the ag...

Pectin hydrogels have emerged as a highly promising medium for the controlled release of pharmaceuticals in the dynamic field of drug delivery. The present review sheds light on the broad range of applications and potential of pectin-based hydrogels in pharmaceutical formulations. Pectin, as a biopolymer, is a versatile candidate for various drug d...

Biotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less...

The application of Quality Target Product Profile (QTPP) in optimizing nanoemulsion (NEM) shows immense potential in advancing pharmaceutical formulation design for effective drug delivery. By aligning QTPP with nanoemulsion attributes, this approach offers a pathway to tailored formulations that meet specific therapeutic objectives and responses....

The primary goal of drug formulation is to improve a drug’s bioavailability in the body. However, poorly water-soluble drugs present challenging issues related to their solubility and bioavailability factors. Emerging technologies, such as lipid-based drug delivery systems, including micro- or nanoemulsifying drug delivery systems, have become incr...

Nanotechnology plays pivotal role to solve the therapeutic and diagnostic challenges that are associated various neurodegenerative diseases. The Alzheimer's disease (ADs) is one of the chief neurodegenerative disorders. The main hindrance in developing an effectual treatment strategy for ADs is the permeability of the drug at the blood brain barrie...

Alzheimer's disease (AD) is very common type of disorder like dementia. Neurodegeneration that is pathophysiologically progressive is a hallmark of the AD. Amyloid-beta (Aβ) is the name for the amino acid peptides contained in the amyloid plaques observed in the brains of individuals with AD. The consequences of AD are reduced by current medication...

Low aqueous solubility of drug candidates is an ongoing challenge and pharmaceutical manufacturers pay close attention to amorphization (AMORP) technology to improve the solubility of drugs that dissolve poorly. Amorphous drug typically exhibits much higher apparent solubility than their crystalline form due to high energy state that enable them to...

Globally, many individuals struggle with Alzheimer’s disease (AD), an unrelenting and incapacitating neurodegenerative condition. Despite notable research endeavors, effective remedies for AD remain constrained, prompting the exploration of innovative therapeutic avenues. Within this context, silica-based nanoplatforms have emerged with pronounced...

The need for novel approaches to the treatment of colon cancer, a common and deadly disease, is universal. In this compilation, we look at how polymeric nanoparticles (Polymeric nanoparticles) could be used to treat colon cancer. Advantages of Polymeric nanoparticles in Fig.hting this disease include targeted medication administration , enhanced th...

The treatment of brain tumours is often a challenging task due to the low permeability of drugs through the blood-brain barrier and their poor penetration into the tumour tissues. Liposomes enhance the delivery of chemotherapeutics to the brain without using any invasive approach. Liposomes are biomimetic nanocarriers that exhibit good biocompatibi...

One of the major limitations with cancer therapy is lack of targeting, giving rise to serious adverse effects on normal tissues. The delivery of anticancer drugs through nanosystems may assist in achieving control of temporal and spatial release of the drug, although the efficiency of these delivery systems may be limited in cancer treatment due to...

Phytopharmaceuticals, derived from plants, are increasingly recognized for their potential therapeutic benefits. However, their effectiveness is often hindered by challenges such as poor bioavailability, stability, and targeted delivery. In this study, we aimed to address these limitations by developing PCL (phosphatidylcholine) fortified nano-phyt...

Vegetable and natural product utilization are conversely connected with diminished malignant growth rate and mortality. Fruit antioxidants have been extensively studied for their ability to scavenge free radicals, preventing to develop the chronic degenerative diseases. As antiproliferative agents, mixtures of biophenols were more effective than in...

Biogenic metallic nanoparticles (BMNPs) are nanostructure materials synthesized through biological processes that have gained significant attention due to their small size and high surface area-to-volume ratio. BMNPs have several advantages over chemically synthesized ones due to their eco-friendly synthesis regimen, sustainability, biocompatibilit...

Biogenic metallic nanoparticles (BMNPs) are nanostructure materials synthesized through biological processes that have gained significant attention due to their small size and high surface area-to-volume ratio. BMNPs have several advantages over chemically synthesized ones due to their eco-friendly synthesis regimen, sustainability, biocompatibilit...

Metabolic associated fatty liver disorder (MAFLD) characterizes the contributing etiologies (i.e., type 2 diabetes mellitus, metabolic syndrome, overweight) of individuals with fatty liver disease that affects 1/3rd of the world population. In 2020, the coronavirus disease 2019 (COVID-19) crisis was unprecedented, and people with different comorbid...

Background: Animal models for drug discovery and development in Parkinson 's disease have played an important role in the characterization of the pathophysiology of diseases and associated mechanisms of injury, drug target identification, and evaluation of novel therapeutic agents for toxicity/safety, pharmacokinetics, pharmacodynamics, and effica...

Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), are a leading cause of morbidity and mortality. The presence of blood–cerebrospinal fluid (B-CSF) and blood–brain barrier (BBB) causes attenuation of site-specific delivery of therapeutic agents in neurodegenerative disorders. S...

Engineered nano-sized liposomes have attained the highest success rate in commercialization among the reported nanomedicines. However, developing industrially acceptable nanoliposomes is still challenging because the process, formulation factors and even their properties may critically influence the desired attributes of the final nanoliposomal pro...

The disease related to parathyroid glands is mostly occurred due to abnormal serum calcium levels. Hypoparathyroidism mostly occurs due to the removal of the parathyroid gland during neck surgery. Several causes of hypoparathyroidism include postsurgical, postradiation, autoimmune, heavy metal deposition, and metastatic infiltration responsible for...

Objective: Fenofibrate (FNF), an anti-hyperlipidemic agent, suffers from poor water solubility (0.000707 mg/ml) and belongs to class II drug as per BCS, shows a slow dissolution rate. The current investigation aimed to fabricate a fast-dissolving tablet of FNF (not available in the commercial market) using solid dispersion technique employing Vitam...

New liquid chromatographic technique was established for the simultaneous estimation of tinidazole, omeprazole and amoxicillin in the fixed dose combination (HP-KIT by Sun Pharma). RP-HPLC elution has performed by using the Phenomenex Luna column (250 mm x 4.6 mm) having internal diameter and the packing material of size 5µm) in isocratic mobile ph...

Health care is going to be complex due to the arrival of novel treatments, enhancing roles of providers, and changes in legislation, payment methods and healthcare information technology. The generation of big data due to fast adaptation of technology from a change of resources which are simple to complex in their content. The stakeholders of the h...

New RP-HPLC method was developed for the simultaneous estimation of Clarithromycin, tinidazole and lansoprazole in the fixed dose combination (PYLOKIT by CIPLA). RP-HPLC separation was carried out using Ultisil XB-CN column (250 x 4.6 mm) internal diameter and the packing material having 5µm size) using gradient mobile phase of Potassium dihydrogen...

Abstract Pharmaceutical products are meant to be used on the biological system to prevent or cure the diseased conditions. They are administered via different routes in the form of different delivery systems that ultimately reach the bloodstream. Hence, they need to be free from microbes to avoid any unwanted effects due to the product. Sterilizati...

Disintegration and dissolution are the in vitro performance test procedures for a drug to be developed and its formulation to be selected for in vivo studies, specifically for orally administered drugs except for solution dosage forms. Further, these procedures also provide an alternative for in vivo bioequivalence studies with sufficient in vitro–...

Disintegration and dissolution are the in vitro performance test procedures for a drug to be developed and its formulation to be selected for in vivo studies, specifically for orally administered drugs except for solution dosage forms. Further, these procedures also provide an alternative for in vivo bioequivalence studies with sufficient in vitro–...