Destanie Rose

Destanie Rose
University of California, Davis | UCD · Department of Medical Microbiology and Immunology

Doctor of Philosophy

About

25
Publications
7,389
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744
Citations
Introduction
Destanie Rose currently works at the MIND Institute in the Department of Medical Microbiology and Immunology, University of California, Davis. Destanie does research in Neuroscience, Cell Biology and Immunology. Their most recent publication is 'Cytokine alterations in first-episode schizophrenia and bipolar disorder: Relationships to brain structure and symptoms'. Currently working on projects that explore the role of immune regulation in neurodevelopmental disorders.
Additional affiliations
November 2018 - November 2019
University of California, Davis
Position
  • PostDoc Position

Publications

Publications (25)
Article
Autism spectrum disorder (ASD) is a class of neurodevelopmental disorders characterized by impaired social interactions and communication skills and repetitive or stereotyped behaviors. Rates of ASD diagnosis continue to rise, with current estimates at 1 in 44 children in the US (Maenner 2021). Epidemiological studies have suggested a link between...
Article
Full-text available
Epidemiological and animal research shows that maternal immune activation increases the risk of autism spectrum disorders (ASD) in offspring. Emerging evidence suggests that maternal immune conditions may play a role in the phenotypic expression of neurodevelopmental difficulties in children with ASD and this may be moderated by offspring sex. This...
Article
Full-text available
Background Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted repetitive behavior. In addition, many affected individuals display metabolic imbalances, immune dysregulation, gastrointestinal (GI) dysfunction, and altered gut microbiome compo...
Preprint
Full-text available
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with hallmark behavioral manifestations including impaired social communication and restricted repetitive behavior. In addition, many affected individuals display metabolic imbalances, immune dysregulation, gastrointestinal (GI) dysfunction, and altered gut microbiome compositions. We...
Article
Full-text available
Children with ASD are more likely to experience gastrointestinal (GI) symptoms than typically-developed children. Numerous studies have reported immune abnormalities and inflammatory profiles in the majority of individuals with ASD. Immune dysfunction is often hypothesized as a driving factor in many GI diseases and it has been suggested that it is...
Article
Full-text available
In autism spectrum disorders (ASD) many individuals have co-morbid immune dysregulation that can lead to inflammation in the brain and periphery. The novel cytokine interleukin (IL)-35 has described anti-inflammatory properties; however, the plasma levels of IL-35 in children with ASD have never been investigated. The plasma levels of IL-35 were me...
Article
Full-text available
Over half of all children with autism spectrum disorders (ASD) have gastrointestinal (GI) co-morbidities including chronic constipation, diarrhea, and irritable bowel syndrome. The severity of these symptoms has been correlated with the degree of GI microbial dysbiosis. The study objective was to assess tolerability of a probiotic (Bifidobacterium...
Data
Proportion of hard and soft stools with treatment. Mean ± SD proportion of total recorded stools that were A) hard consistency (1 or 2 on Bristol Stool Scale) or B) soft consistency (6 or 7 on Bristol Stool Scale) based on stool log data (n = 8 for each group). Significant differences in means (p<0.05) are denoted by an asterisk. D123, days 1, 2 an...
Data
Wilcoxon P-values gastrointestinal and behavioral questionnaire data. (DOCX)
Data
Non-parametric statistics for stool consistency from stool log data. (DOCX)
Article
Full-text available
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that are highly variable and are clinically characterized by deficits in social interactions, communication, and stereotypical behaviors. Prevalence has risen from 1 in 10,000 in 1972 to 1 in 59 children in the United States in 2014. This rise in prevalence could be...
Article
Full-text available
Purpose of Review There is a growing body of evidence indicating the gut microbiota influence neurodevelopment and behavior. The purposes of this review are to provide an overview of studies analyzing the microbiota and their metabolites in autism spectrum disorders (ASD) and to discuss the possible mechanisms of action involved in microbial influe...
Article
Full-text available
Background: Over the past 30 years, evidence has been accumulating for an immunological component to schizophrenia etiology, including genetic links to the major histocompatibility complex, microglia activation, and dysregulated cytokine profiles. However, the degree of similarity in cytokine profiles for schizophrenia and bipolar disorder, as wel...
Article
Objectives: Many studies have reported the increased presence of gastrointestinal (GI) symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles, pro-inflammatory responses and impaired intestinal permeability have been observed in children with ASD and co-morbid GI symptoms, yet few studies have compared these finding...
Article
Infection during pregnancy can lead to activation of the maternal immune system and has been associated with an increased risk of having an offspring later diagnosed with a neurodevelopmental disorders (NDD) such as autism spectrum disorder (ASD) or Schizophrenia (SZ). Most maternal immune activation (MIA) studies to date have been in rodents and u...
Article
Children with an autism spectrum disorder (ASD) are 6–8 times more likely to have persistent gastrointestinal (GI) symptoms. In addition, intestinal and peripheral inflammation, altered microbiome profiles, and impaired intestinal permeability have also been observed in children with ASD who exhibit GI issues. To further assess immune dysfunction a...
Article
Recent population-based studies of expecting mothers identified a unique profile of immune markers that are associated with an increased risk of having a child diagnosed with autism spectrum disorder (ASD). This immune profile, including increased levels of maternal and placental interleukin (IL)-4 and IL-5, is consistent with an immune response fo...
Article
Full-text available
Associative studies across a range of neurodevelopmental disorders have revealed a relationship between immune system function and behavioral deficits. These correlations are particularly evident in individuals with autism spectrum disorders (ASD), a developmental disorder characterized by social behavior deficits and noted for its high instances o...
Chapter
Autism spectrum disorders (ASD) are developmental disorders characterized by behavioral deficits in verbal and nonverbal communication as well as social interactions, and are accompanied by repetitive or stereotyped behaviors and interests. Numerous studies over the last forty years have recognized altered immune responses in individuals with ASD;...
Article
Autism spectrum disorders (ASD) are complex neurodevelopmental disorders characterized by impairments in three core behavioral areas. As prevalence rates for ASD continue to rise there is also increasing interest in finding biomarkers associated with ASD. The use of biomarkers could help identify those at risk for ASD or ASD-associated comorbid con...
Article
Full-text available
Increased rates of autoinflammatory and autoimmune disorders have been observed in female premutation carriers of CGG repeat expansion alleles of between 55-200 repeats in the fragile X mental retardation 1 (FMR1) gene. To determine whether an abnormal immune profile was present at a cellular level that may predispose female carriers to autoinflamm...

Questions

Question (1)
Question
We currently use a standard PBMC protocol, first centrifuging the citrate blood tubes and collecting plasma, followed by laying the remaining blood components diluted with HBSS over lymphoprep. This protocol has worked well for us, however, we were hoping to save time by trying the Sepmate tubes; we still would like to remove plasma before using the sepmate tubes, to keep the plasma data comparable with past studies. Has anyone done this before?

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