Derrick G Lee

Derrick G Lee
St. Francis Xavier University · Department of Mathematics, Statistics, and Computer Science

23.19
 · 
Doctor of Philosophy

About

19
Publications
1,237
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191
Citations
Introduction
Assistant Professor with the Department of Mathematics, Statistics, and Computer Science at St. Francis Xavier University (Antigonish, NS). Experienced epidemiologist with a history of working in various cancer and healthcare related industries. Strong research professional with a PhD focused in Biostatistics and Epidemiology from The University of British Columbia and the BC Cancer Research Centre. Skilled in various statistical and analytical languages, Bioinformatics, and Data Analysis.

Publications

Publications (19)
Article
Cure rates for primary mediastinal large B-cell lymphoma (PMBCL) have improved with the integration of rituximab. However, the type of primary therapy and role of radiotherapy (RT) remains ill-defined. Herein, we evaluated the outcome of PMBCL primarily treated with R-CHOP and the impact of an end-of-treatment (EOT) FDG-PET scan to guide consolidat...
Article
A novel prognostic score (IPS‐3), comprised of only three of the seven IPS‐7 indicators (age ≥45, stage IV, haemoglobin <105 g/l), was recently proposed as a simplified model for advanced‐stage classic Hodgkin lymphoma (cHL). We aimed to validate this model in advanced‐stage cHL patients treated with doxorubicin, bleomycin, vinblastine, dacarbazine...
Preprint
Full-text available
Background: Genome-wide association studies have identified over 170 common breast cancer susceptibility loci, many of them with differential associations by estrogen receptor (ER). How these variants are related to other tumor features is unclear. Methods: Analyses included 106,571 invasive breast cancer cases and 95,762 controls of European ances...
Article
Full-text available
Background Inflammation contributes to breast cancer development through its effects on cell damage. This damage is usually dealt with by key genes involved in apoptosis and autophagy pathways. Methods We tested 206 single nucleotide polymorphisms (SNPs) in 54 genes related to inflammation, apoptosis and autophagy in a population-based breast canc...
Data
SNPs for which genotyping was attempted and whether they passed Q/C. (PDF)
Data
Logistic regression and interaction analysis results for European samples for SNPs with p<0.05 before FDR. (PDF)
Article
Full-text available
Objective To estimate the association between occupational polycyclic aromatic hydrocarbon (PAH) exposure and female breast cancer. Methods Lifetime work histories for 1130 cases and 1169 controls from British Columbia and Ontario (Canada) were assessed for PAH exposure using a job-exposure matrix based on compliance measurements obtained during U...
Article
Purpose Since its publication in 1998, the International Prognostic Score (IPS-7) has been widely adopted as a risk stratification tool in patients with advanced stage classical Hodgkin lymphoma (cHL).1 In this study, the 5-y freedom-from-progression (FFP) ranged from 42 to 84% and 5-y overall survival (OS) from 56 to 89%. This index has demonstrat...
Article
Objectives There is limited research on the association between sedentary behaviour and breast cancer risk, particularly whether sedentary behaviour is differentially associated with premenopausal and postmenopausal breast cancer. We pooled data from 2 case–control studies from Australia and Canada to investigate this association. Methods This poo...
Article
Objective Tumors that metastasize to the brain are associated with poor survival and tend to recur at the original site after treatment. Adjuvant whole brain radiation therapy (WBRT) is recommended after surgical resection in order to decrease recurrence rates. However, prognostic factors that determine which patients may benefit from WBRT remain l...
Article
Full-text available
Polycyclic aromatic hydrocarbons (PAHs) are a group of pollutants with multiple variants classified as carcinogenic. The Occupational Safety and Health Administration (OSHA) provided access to two PAH exposure databanks of United States workplace compliance testing data collected between 1979 and 2010. Mixed-effects logistic models were used to pre...
Article
Epidemiologists typically collect narrative descriptions of occupational histories because these are less prone than self-reported exposures to recall bias of exposure to a specific hazard. However, the task of coding these narratives can be daunting and prohibitively time-consuming in some settings. The aim of this manuscript is to evaluate the pe...
Article
Full-text available
Long-term night work has been suggested as a risk factor for breast cancer; however, additional studies with more comprehensive methods of exposure assessment to capture the diversity of shift patterns are needed. As well, few previous studies have considered the role of hormone receptor subtype. Relationships between night shift work and breast ca...
Article
Objectives: We identified the most effective mix of school-based policies, programs, and regional environments associated with low school smoking rates in a cohort of Canadian high schools over time. Methods: We collected a comprehensive set of student, school, and community data from a national cohort of 51 high schools in 2004 and 2007. Hierar...
Article
H. W. Robertson et al. [Order restricted statistical inference. Chichester: Wiley (1988; Zbl 0645.62028), Theorem 1.5.2] discussed order restricted maximum likelihood estimation for exponential families of distributions under three conditions. We obtain the same result under its two conditions by using the H. W. Kuhn ad A. W. Tucker equivalence the...
Article
Pulmonary surfactant provides for a lipid rich film at the lung air-water interface, which prevents alveolar collapse at the end of expiration. The films are likely enriched in the major surfactant component dipalmitoylphosphatidylcholine (DPPC), which, due to its saturated fatty acid chains, can withstand high surface pressures up to 70 mN/m, ther...

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