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Introduction
Vaccinology & Drug discovery
Publications
Publications (23)
Onchocerciasis, caused by the filarial worm Onchocerca volvulus, remains a major public health challenge due to the limitations of ivermectin-based control strategies, thereby, highlighting the need for more innovative tools like vaccines. This study investigated the safety and immunogenicity of a novel multi-epitope chimeric antigen, OvMANE1 formu...
Tuberculosis (TB) remains a major cause of ill health and one of the leading causes of death worldwide, with about 1.25 million deaths estimated in 2023. Control measures have focused principally on early diagnosis, the treatment of active TB, and vaccination. However, the widespread emergence of anti-tuberculosis drug resistance remains the major...
Tuberculosis (TB) remains a major cause of ill health and one of the leading causes of death worldwide, with about 1.25 million deaths estimated in 2023. Control measures have focused principally on early diagnosis, treatment of active TB, and vaccination. However, the widespread emergence of anti-tuberculosis drug resistance remains the major publ...
Background
Gaining a comprehensive understanding of the genetic mechanisms underlying insecticide resistance in malaria vectors is crucial for optimising the effectiveness of insecticide-based vector control methods and developing diagnostic tools for resistance management. Considering the heterogeneity of metabolic resistance in major malaria vect...
Onchocerciasis (river blindness) is a debilitating tropical disease that causes significant eye and skin damage, afflicting millions worldwide. As global efforts shift from disease management to elimination, vaccines have become crucial supplementary tools. The Onchocerciasis Vaccine for Africa (TOVA) Initiative was established in 2015, to advance...
Onchocerciasis (river blindness) is a debilitating tropical disease that causes significant eye and skin damage, afflicting millions worldwide. As global efforts shift from disease management to elimination, vaccines have become crucial supplementary tools. The Onchocerciasis Vaccine for Africa (TOVA) Initiative was established in 2015, to advance...
Onchocerciasis is a devastating tropical disease that causes severe eye and skin lesions. As global efforts shift from disease control to elimination, prophylactic/therapeutic vaccines have emerged as alternative elimination tools. Notably, Ov-RAL-2 and Ov-103 antigens have shown great promise in preclinical studies and plans are underway for clini...
Gaining a comprehensive understanding of the genetic mechanisms underlying insecticide resistance in malaria vectors is crucial for optimising the effectiveness of insecticide-based vector control methods and developing diagnostic tools for resistance management. Considering the heterogeneity of metabolic resistance in major malaria vectors, the im...
Background
The double burden of malaria and helminthiasis in children poses an obvious public health challenge, particularly in terms of anemia morbidity. While both diseases frequently geographically overlap, most studies focus on mono-infection and general prevalence surveys without molecular analysis. The current study investigated the epidemiol...
Almost a decade ago, it was recognized that the global elimination of onchocerciasis by 2030 will not be feasible without, at least, an effective prophylactic and/or therapeutic vaccine to complement chemotherapy and vector control strategies. Recent advances in computational immunology (immunoinformatics) have seen the design of novel multi-epitop...
Background
The double burden of malaria and helminthiasis in children poses an obvious public health challenge particularly in terms of anemia morbidity. While both diseases geographically overlap, most studies focus on mono-infection and general prevalence surveys without molecular analysis. The current study investigated the epidemiological deter...
Onchocerciasis is a skin and eye disease that exerts a heavy socio-economic burden, particularly in sub-Saharan Africa, a region which harbours greater than 96% of either infected or at-risk populations. The elimination plan for the disease is currently challenged by many factors including amongst others; the potential emergence of resistance to th...
A computational approach to design more potent vaccines for onchocerciasis
The increasing prevalence of drug-resistant influenza viruses emphasizes the need for new antiviral countermeasures. The M2 protein of influenza A is a proton-gated, proton-selective ion channel, which is essential for influenza replication and an established antiviral target. However, all currently circulating influenza A virus strains are now res...
The public health goal of onchocerciasis in Africa has advanced from control to elimination. In this light, accurate diagnosis is necessary to determine treatment endpoints and confirm elimination, as well as to conduct surveillance for the identification of any possible recrudescence of the disease. Currently, the monitoring of onchocerciasis elim...
Onchocerciasis is a parasitic disease with a high socio-economic burden, particularly in sub-Saharan Africa. The elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and microfilaria stages of the parasite’s life cycle would be invaluable to achieve the current...
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-Saharan Africa. The elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and microfilaria stages of the parasite’s life cycle would be invaluable to achieve the current eli...
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-Saharan Africa. The elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and microfilaria stages of the parasite’s life cycle would be invaluable to achieve the current eli...
Onchocerciasis is a parasitic disease with a high socio-economic burden, particularly in sub-Saharan Africa the elimination plan for this disease has faced numerous challenges. A multi-epitope prophylactic/therapeutic vaccine targeting the infective L3 and microfilaria stages of the parasite’s life cycle would be invaluable to achieve the current e...
Onchocerciasis (river blindness) is a disabling yet neglected tropical disease with enormous socioeconomic burden mostly on 34 affected African countries. The disease is caused by the parasite Onchocerca volvulus and transmitted by blackflies of the genus Simulium. It is the second leading cause of infectious blindness after trachoma worldwide, wit...
Objective: The present work was set to evaluate the in vivo efficacy and safety of “Afya tea®”, a trademarked antidiabetic herbal preparation commonly sold in Cameroon.
Methods: The tea was acquired from local sale points and different concentrations and doses determined from the prescription by the manufacturer. The antidiabetic activity was asse...
Questions
Questions (3)
Hi Yang,
What you are doing seem to be very novel. If you can fill me in on the details including how the pseudo virus was generated and how you will want it tested (protocols) then I guess I could put up something, as here in Cameroon I have access to our Lab: http://www.mcblbiotechub.com/
All the best
Nebangwa
After going through the IUPAC nucleotide code list, everything now makes sense. It shows that the ambiguous positions could be mutations or not Mutations. Now the purpose of my analysis is to identify SNPs relative to reference sequences.
1)How do I determine whether or not these ambiguous nucleotide positions are mutations or not?
2) which is the best approach to check these SNPs?
Hi there!! I want to do quality check some Sanger sequence reads and realized that the reads contain some odd letters (N, K, Y, B etc) different from the normal 4 DNA base letters (ATGC). What can i do to edit away these strange nucleotides represented by the strange letters?
