Derek Allen

Derek Allen
University of Nebraska at Lincoln | NU · Department of Biological Sciences

Doctor of Philosophy

About

2
Publications
132
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3
Citations
Citations since 2017
2 Research Items
3 Citations
20172018201920202021202220230.00.51.01.52.0
20172018201920202021202220230.00.51.01.52.0
20172018201920202021202220230.00.51.01.52.0
20172018201920202021202220230.00.51.01.52.0
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Introduction
Skills and Expertise
Cell Culture
PCR
Gel Electrophoresis
DNA Extraction
Western Blot Analysis
Immunofluorescence
Electrophoresis
SDS-PAGE
Cloning
DNA

Publications

Publications (2)
(A) Hind paw withdrawal threshold of C57Bl/6 J male mice after incision...
(A) Hind paw withdrawal threshold of C57Bl/6 J female mice after...
(A) Hind paw withdrawal threshold of C57BI/6 J male mice after incision...
(A). Hind paw withdrawal threshold of C57BI/6 J female mice after...
(A) The pharmacokinetics of N-001 was determined through IP injections...
Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment
Article
Full-text available
  • Jul 2023
Inhibition of actin remodeling in nerves modulates action potential propagation and therefore could be used to treat acute pain. N-001 is a novel protein analgesic engineered from several C. Botulinum toxins. N-001 targets sensory neurons through ganglioside GT1b binding and ADP-ribosylates G-actin reducing actin remodeling. The activity and effica...
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Figure 2. Inhibition and reversibility of calcium influx. Calcium...
Figure 3. In vitro specificity of C2C. a Primary sensory and motor...
Figure 5. Effect of C2C on pain-like behaviors in BALB/c mice. The...
Inhibition and reversibility of actin polymerization. Polymerized...
In vivo targeting of mouse sensory nerve fibers by C2C. Latissimus...
Intracellular G-actin targeting of peripheral sensory neurons by the multifunctional engineered protein C2C confers relief from inflammatory pain
Article
Full-text available
  • Jul 2020
The engineered multifunctional protein C2C was tested for control of sensory neuron activity by targeted G-actin modification. C2C consists of the heptameric oligomer, C2II-CI, and the monomeric ribosylase, C2I. C2C treatment of sensory neurons and SH-SY5Y cells in vitro remodeled actin and reduced calcium influx in a reversible manner. C2C prepare...
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