Deog-Hwan Oh

Kangwon National University · Department of Food Science and Biotechnology

Obesity is a condition that leads to increased health problems associated with metabolic disorders. Synthetic drugs are available for obesity treatment, but some of these compounds have demonstrated considerable side effects that limit their use. Polyphenols are vital phytonutrients of plant origin that can be incorporated as functional food ingred...

Soy consumption may reduce hypertension but the impact of food processing on the antihypertensive effect is unclear. Hence, we ascertained the effects of lacto-fermented (FSB) and unfermented soybean (USB) consumption on serum atherogenic lipids, hypertension and gut microbiota of spontaneous hypertensive rats (SHR). FSB displayed a strong in vitro...

Alternative bio-refinery technologies are required to promote the commercial utilization of plant biomass components. The fructooligosaccharide (FOS) obtained after hydrolysis of the hemicellulose fractions was mainly applied in the pharmaceutical and food industries. Agricultural bi-product is a rich constituent in dietary fibres, which have prebi...

Naturally occurring phytochemicals from plants or grains are crucial in reducing various metabolic disorders. Bioactive phytonutrients are abundant in the Asian dietary staple, brown rice. This research evaluated the impact of lactic acid bacteria (LABs) bioconversion and fermentation on antioxidant and antiobesity activities and ferulic acid conte...

The gamma amino butyric acid (GABA) is a chemical messenger and is essential for the health of the brain and muscles. Some lactic acid bacteria (LAB) have the potential to function as psychobiotic cultures because they can produce significant amounts of neuroactive compounds like GABA. Psychobiotics are known to alter bidirectional communication be...

ANCA-associated vasculitis (AAV) is characterized by granulomatous and neutrophilic tissue inflammation, and is commonly accompanied with the development of antibodies that target neutrophil antigens. The two major antigens targeted by ANCAs are leukocyte proteinase 3 (PR3) and myeloperoxidase (MPO). The development of AAV has been linked to a numb...

Ecofriendly disinfectants are being extensively investigated for their potential sanitiser efficacy and food industry application.This study aimed to explore the inhibitory effect of slightly acidic electrolyzed water (SAEW) combined with essential oil (EO) based on surfactant monolaurin (ML) on the growth of Escherichia coli O157:H7 43894, Salmone...

Industrial hemp (Cannabis sativa L.) is a crop with potential applications in the food industry. Hemp seed is the most promising functional food item from hemp plant, which displays a number of applications in foods. However, there is a limited knowledge regarding its health benefits. This study aimed to investigate the metabolite profile and in vi...

Hemp is a valuable crop with a wide range of use, from applications in foods and textiles to pharmaceuticals. Over recent years, the use of hemp as food and food ingredients has drastically increased. The growth is driven by numerous health benefits hemp possesses and its wide range of applications in the food industry. This review provides the sci...

The plant endosphere is full of an assorted group of the microbial population. There is general concurrence that this microbial population makes considerable effects to plant health. Detection of these endophytic microbes can be performed by both classical (culturing methods and visualization methods) and recently adopted genomic approaches. Among...

Crevice corrosion accounts for 62% of the recorded breakdown of insulators utilized in transmission lines, which may interfere with the reliability of power utilities. To address these challenges, sustainable and resilient slippery lubricant-infused porous surfaces (SLIPS) are developed on insulators to prevent electrochemically/biochemically induc...

Oxidative stress is known to cause cell apoptosis, tissue damage, and pathological changes in the body, but antioxidant peptides are renowned radical scavengers. This study investigated the antioxidative and protective effect of six novel peptides obtained after microbial fermentation of brown rice. The selected peptides (MW ≤8 KDa), namely AVPYPQ...

The COVID-19 outbreak again underlined plastic items’ importance in our daily lives. The public has widely utilized disposable face masks constructed of polypropylene polymer materials as effective and inexpensive personal protective equipment (PPE) to inhibit virus transmission. The consequences of this have resulted in millions of tons of plastic...

Human health is threatened worldwide by microbial infections. Antibiotic overuse and misuse have resulted in antimicrobial-resistant bacteria. To battle such resistant microbes, we are looking for safe and alternative antimicrobial treatments, and the advent of nanotechnology holds promise in this regard. Metal oxide nanoparticles have emerged as a...

In the present study, white (Baegilmi), brown (hyunmi) and black (chalheugmi) Korean local rice varieties ethanol extracts were analyzed for in-vitro antioxidant assays (ABTS, FRAP and DPPH), cellular antioxidant activities (CAAs) and phenolic phytochemicals content. The highest antioxidant assays, phenolic, flavonoid and anthocyanins content were...

Black soybean is one of the nutritious crops and is being used in traditional medicines in Asian countries. In the present study, we fermented black soybean and screened against in vitro Alzheimer’s disease (AD) biomarkers such as cholinesterase enzymes, inflammatory factors, oxidative stress, and presence of γ-aminobutyric acid (GABA) levels. Firs...

In recent years, the health benefits of the pigmented rice varieties have been reported due to the richness of their bioactive compounds. Therefore, this study evaluated the antioxidant, total flavonoid, total phenolic, anthocyanin content, amino acid and individual phenolic compound quantification of nine Korean-grown rice varieties using spectrop...

In recent years, the health benefits of the pigmented rice varieties have been reported due to the richness of their bioactive compounds. Therefore, this study evaluated the antioxidant, total flavonoid, total phenolic, anthocyanin content, amino acid and individual phenolic compound quantification of nine Korean-grown rice varieties using spectrop...

The acidic niche of dental plaque can lead to caries expression over time. In this study, we attempted to design an eco-sustainable oral care formulation, and to determine its effect on caries-related pathogens in the presence and absence of lactic acid. We investigated the inhibitory effect of slightly acidic electrolyzed water (SAEW) combined wit...

Streptococcus mutans (S. mutans) can promote the establishment of high acidic biofilms and therefore have contribution to the development of dental caries. Alleviating the acidic environment and/or disrupting the structure of S. mutans biofilm are effective approaches against dental caries, rather than killing the microorganisms. The anti-biofilm e...

Diet is an essential factor determining the ratio of pathogenic and beneficial gut microbiota. Hydrolysates and bioactive peptides have been described as crucial ingredients from food protein that potentially impact human health beyond their roles as nutrients. These compounds can exert benefits in the body, including modulation of the gut microbio...

Hypercholesterolemia is a risk factor for cardiovascular diseases, and hence, reducing serum cholesterol levels could reduce the incidence. In this study, we ascertained the cholesterol-reducing potential of lactic acid bacteria (LAB) isolated from Korean fermented soybean paste. Live, resting, and dead cells of all the bacteria reduced cholesterol...

Black soybeans contain several bioactive compounds and commonly consumed due to their health-related activities but rarely cultivated as edible sprouts. The present study investigated the changes that occurred during germination in two new genotypes black soybeans. Raw and germinated seeds were tested against in vitro Alzheimer’s disease (AD) bioma...

Aquatic products are becoming increasingly popular as a source of high-quality protein with low levels of saturated fat but are highly perishable due to microbial proliferation and enzymatic and chemical reactions. Effective processing or preservation is required to maintain food quality and prolong shelf life. Cold plasma (CP), a nonthermal techno...

The gradually growing resistant strains to existing drugs and latent TB in tuberculosis (TB) considered being a significant concern. In order to extend the antimicrobial potential, prevent the development of drug resistant mutants, and reduce toxicity, a combination of traditional drugs and medicinal plants therapies can serve. The research was per...

In many sectors, biofilms can be produced, one of which is the agricultural sector. In this sector, the biofilms could cause enormous financial damage and jeopardize public health. The development of biofilms is regulated by quorum sensing. A creative approach to inhibiting the formation of biofilms may therefore be the inhibition of quorum sensing...

Actinomycetes were tested for antibacterial and anti-mycobacterial activity from less studied environments. By cultivating these strains via shake flask fermentation using soybean meal medium, crude bio-active molecules were developed. Cell free supernatant and mycelia were removed, respectively, with ethyl acetate and methanol. The antibacterial a...

Worldwide industry, however, is constantly struggling to overcome the obstacles, one of which is bacterial outbreaks. Furthermore, due to the biofilm produced by most of the pathogens and the effect of increased antibiotic resistance, the emergence of outbreaks has enhanced. Therefore, research protocols needed to classify and describe bioactive co...

Oxidative stress has been related to disease as a result of the accumulation of reactive oxygen species. Risk factors associated with widely accessible synthetic antioxidants render the hunt for natural antioxidants of plant origin essential. The goal of the experiment was to determine the antioxidant activity of the bacterial (Actinobacterial) ext...

To evaluate the efficiency of the actinobacterial extract, a precise and reliable method was developed against dengue virus, based on the dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) protocol. Dextran sulfate applied as a positive control to determination of cell viability, based on the spectrophotometer optical density of formazan...

Cancer is the world’s second major cause of death, and despite significant advances in drug distribution, bacteria-based therapies still need to be developed. Bacterial cell free supernatant (CFS) remedies have many advantages relative to the use of traditional therapeutic agents to mitigate the side effects caused by therapies. The objective of th...

Actinomycetes were tested for antimicrobial and antimycobacterial activity with less known habitats. Crude extracts have been evaluated against normal Mycobacterium tuberculosis strain and drug-sensitive and drug-resistant clinical isolates were tested with crude extract of Actinobacteria by luciferase reporter phage (LRP) assay. Significant change...

Melanins are common biopolymers reported to contribute to various metabolic processes and to defend species against environmental stresses. Melanins have gained growing attention in the last decade for their application in organic semiconductors and bioelectronics, drug delivery, photoprotection and bioremediation of the environment. In this analys...

Tuberculosis (TB) is a significant threat to public health and infectious disease caused by mycobacterium (MTB). In addition, some non-tuberculous mycobacterial (NTM) organisms often lead to infection in humans with immune deficiency and even immunocompetence. In this regard, the research investigated the antimycobacterial effects of endophytic act...

The protocol is based on screening actinomycete strains for utilizing carbon as a sole source for extracellular biosurfactant activity by a drop-collapse process. The strains were selected based on generating biosurfactants. The hemolytic activity of actinobacteria strains were ranged approximately 8–20 mm, by the drop-collapsing method and by the...

Cancer is one of the world’s major causes of deaths. Using high-level lactic acid fermentation synthesized by lactate dehydrogenase (LDH), which transforms pyruvic acid to lactic acid, several tumor cells generate ATP. In the Warburg effect, LDH plays a major role, wherein aerobic glycolysis over oxidative phosphorylation is preferred. LDH-targetin...

The depletion of hydrogen peroxide (H2O2) at a bandwidth of 230 nm was calculated, and the standard method for assessing the H2O2 scavenging activity of bacterial extracts is assessed. Since this approach strains from the interaction of phenolics with heavy uptake in the UV region, a simple and accurate colorimetric assay was developed, whereas bac...

Curcumin is a polyphenolic natural compound with diverse and attractive biological properties, which may prevent or ameliorate pathological processes underlying age-related cogni-tive decline, Alzheimer's disease (AD), dementia, or mode disorders. AD is a chronic neurodegen-erative disorder that is known as one of the rapidly growing diseases, espe...

This study evaluated the impact of thermal treatment and lactic acid bacteria fermentation of sorghum on the antioxidant, antidiabetic, nutritional and metabolite profiles. Wet cooking and pressurized cooking improved the antioxidant capacity compared to raw. Fermentation of wet cooked (H95F) and pressurized cooked samples (H121F) further enhanced...

The scientific community has been releasing whole genomic sequences of SARS-CoV-2 to facilitate the investigation of molecular features and evolutionary history. We retrieved 36 genomes of 18 prevalent countries of Asia, Europe and America for genomic diversity and mutational analysis. Besides, we studied mutations in the RBD regions of Spike (S) p...

The face mask introduction in SARS-CoV-2 pandemic situation, one of the precautionary measure to reduce the rate of transmission of infection from person to person. There are many type of of face masks enter into our global market with various size and designs. Among those, surgical mask belongs to secure an important place and this aimed to evalua...

Germination can be used to enhance nutritional value and health functions of edible seeds. Sprouts are considered healthier than raw seeds because they are richer in the basic nutritional components (carbohydrates, protein, vitamins, and minerals) and also contain more bioactive components responsible for various biological activities. The effect o...

Bioactive peptides are present in most soy products and eggs and have essential protective functions. Infection is a core feature of innate immunity that affects blood pressure and the glucose level, and ageing can be delayed by killing senescent cells. Food also encrypts bioactive peptides and protein sequences produced through proteolysis or food...

Gut microbiota (GM) play a role in the metabolic health, gut eubiosis, nutrition, and physiology of humans. They are also involved in the regulation of inflammation, oxidative stress, immune responses, central and peripheral neurotransmission. Aging and unhealthy dietary patterns, along with oxidative and inflammatory responses due to gut dysbiosis...

Oxidative stress has been postulated to play a role in several diseases, including cardiovascular diseases, diabetes, and stress-related disorders (anxiety/depression). Presently, natural plant-derived phytochemicals are an important tool in reducing metabolomic disorders or for avoiding the side effects of current medicinal therapies. Brown Rice (...

In the present study, we screened for potential probiotic yeast that could survive under extreme frozen conditions. The antimicrobial and heat-stable properties of the isolated yeast strains Saccharomyces boulardii (S. boulardii) (KT000032, KT000033, KT000034, KT000035, KT000036, and KT000037) was analyzed and compared with commercial probiotic str...

The initiation and development of cariogenic (that is, caries-related) biofilms are the result of the disruption of homeostasis in the oral microenvironment. There is a daily accumulation of dental biofilm on the surface of teeth and its matrix of extracellular polymers supports the host in its defense against invading microbes, thus helping to ach...

Shiga toxin-producing Escherichia coli (STEC) is a global foodborne bacterial pathogen that is often accountable for colon disorder or distress. STEC commonly induces severe diarrhea in hosts but can cause critical illnesses due to the Shiga toxin virulence factors. To date, there have been a significant number of STEC serotypes have been evolved....

The antioxidant and antidiabetic properties and metabolite profiling of ethanol extracts of red cabbage (RC) and broccoli (BR) seeds and sprouts were investigated in this study. The total phenolic, flavonoid, and saponin contents were in the ranges of 385.4–480.4 mg FAE/100 g, 206.9–215.6 mg CE/100 g, and 17.8–27.0 mg soysaponin BE/100 g, respectiv...

Free radical-induced oxidative stress is the root cause of many diseases, such as diabetes, stress and cardiovascular diseases. The objective of this research was to screen GABA levels, antioxidant activities and bioactive compounds in brown rice. In this study, we first fermented brown rice with different lactic acid bacteria (LABs), and the best...

The study aimed to investigate the antibacterial activity of Mustard (Brassica juncea) and Moringa (Moringa oleifera) leaf extracts and coagulant protein for their potential application in water treatment. Bacterial cell aggregation and growth kinetics studies were employed for thirteen bacterial strains with different concentrations of leaf extrac...

This work evaluated the effect of slightly acidic electrolyzed water (SAEW), fumaric acid (FA) and antioxidant solution treatments on the quality of red and yellow fresh-cut bell pepper (FCBP) challenged with foodborne pathogens (L. monocytogenes and Salmonella sp.). The quality of the FCBP was determined in terms of the microfloral contamination,...

The prevalence of metabolic syndrome (MetS) is presently an alarming public health problem globally. Oxidative stress has been postulated to be strongly correlated with MetS, such as type 2 diabetes, obesity, hypertension, cardiovascular diseases, and certain cancers. Cereals are important staple foods which account for a huge proportion of the hum...

Shiga toxin-producing Escherichia coli (STEC) is an enteric pathogen associated with human gastroenteritis outbreaks. Extensive use of antibiotics in agriculture selects resistant bacteria that may enter the food chain and potentially causes foodborne illnesses in humans that are less likely to respond to treatment with conventional antibiotics. Du...

The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest that the GM can influence the health of the host, and several factors can modify the GM composition, such as diet, drug intake, lifestyle, and geographical l...

The advent of omic technology has made it possible to identify viable but unculturable micro-organisms in the gut. Therefore, application of multi-omic technologies in gut microbiome studies has become invaluable for unveiling a comprehensive interaction between these commensals in health and disease. Meanwhile, despite the successful identificatio...

The quality and intensity of light can have a huge influence on plant growth and bioactive compound production. Compared to conventional lighting, very little is known about the influence of light emitting diodes (LED) irradiation on the antioxidant and antimicrobial properties and resveratrol content of peanut sprouts. This study was aimed at unde...

The treatment of peptides has played an important role in clinical practice since the discovery of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States (US and other regional mar-kets, and peptides continue to undergo drug discovery steadily. Peptide research and development has lev-eraged a wider range of structure...

Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables , and they are the most abundant antioxidant in the human diet. Studies are suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes that may contribute in the prevention of several chronic disorders like diabetes, obesity, hyperte...

As the situation of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is still deteriorating, there has been a huge increase in the demand and use of disinfectants. Electrolyzed water (EW), as a novel broad-spectrum disinfectant and cleaner, has been widely used for several years. EW can be produced in an electrolysis chamber which...

Biofuel and bioenergy production are envisioned as a promising future to meet the dramatically growing global energy demands. Fossil fuels played a significant role in meeting the energy needs in the last century, only to start becoming depleted around the turn of this century. However useful, burning fossil fuels comes with a heftier price-tag, na...