Dennis R A Mans

Dennis R A Mans
Anton de Kom University · Department of Pharmacology

Full Professor

About

352
Publications
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Publications

Publications (352)
Chapter
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Diabetes represents one of the most frequent causes of morbidity and mortality in the world. Despite the availability of a wide range of efficacious forms of treatment, many patients use traditional (plant-derived) preparations for treating their disease. The Republic of Suriname (South America) has a relatively high prevalence of diabetes. Due to...
Book
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Fungi are unicellular or multicellular thick-walled eukaryotic organisms that are not capable of photosynthesis and are placed in a biological kingdom of their own. They are ubiquitous in our environment, and include tens of thousands, perhaps even millions of species of yeasts, rusts, smuts, mildews, molds, and mushrooms. Together with bacteria, f...
Article
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Tanshinones found in Salvia species are the main active compounds for the treatment of cardiovascular and cerebrovascular diseases, but their contents are hugely different in different species. For example, tanshinone IIA content in Salvia castanea Diels f. tomentosa Stib. is about 49 times higher than that in Salvia miltiorrhiza Bunge. The molecul...
Article
Salvia miltiorrhiza is a traditional medicinal plant mainly used for cardiovascular and cerebrovascular disease treatment. Tanshinones are the main bioactive constituents of S. miltiorrhiza, which mainly accumulate around its root periderm tissue. Endophytic fungi are important bioelicitors or probiotics that can promote the accumulation of seconda...
Article
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The patterns of prescription drug use in Suriname in the year 2017 have been determined with the purpose of obtaining indications about the distribution of disease in the country. The claims database of the State Health Foundation (Staatsziekenfonds, SZF) of Suriname was used for calculations of prescription rates of the fifty most prescribed drugs...
Article
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Abstract The main objective of the current study was to investigate the components and antioxidant activity of essential oil extracted from Purple Eleutherococcus leaves (identified as Eleutherococcus simonii) (PEEO) by hydrodistillation (HD) and solid-phase microextraction (SPME). Fourteen chemical components were identified in PEEO using gas chro...
Article
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Background: Using the claims database of the State Health Foundation from 2017, the prevalence and safety of prescription medicines given to pregnant women in Suriname (South America) have been determined. Methods: Prescription rates and proportions of the total number of prescriptions were calculated, overall and stratified for subgroups of age...
Article
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Scutellaria meehanioides C.Y.Wu is a medicinal perennial herb native to China. The complete chloroplast genome sequence of the S. meehanioides was determined and assembled using next generation sequencing methodologies. The complete genome is 152,484 base pairs (bp) in length and has an overall GC content of 38.4%. The chloroplast genome contains,...
Chapter
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The Republic of Suriname (South America) is among the culturally, ethnically, and religiously most diverse countries in the world. Suriname’s population of about 600,000 consists of peoples from all continents including the Javanese who arrived in the country between 1890 and 1939 as indentured laborers to work on sugar cane plantations. After expi...
Chapter
Full-text available
The Republic of Suriname (South America) is among the culturally, ethnically, and religiously most diverse countries in the world. Suriname’s population of about 600,000 consists of peoples from all continents including the Javanese who arrived in the country between 1890 and 1939 as indentured laborers to work on sugar cane plantations. After expi...
Article
Full-text available
Introduction New drug discovery and development programs have historically relied on the identification of novel lead compounds from plant origin. This is understandable when considering that plants have been the main, if not the only sources of therapeutics for managing human diseases for millennia [1]. Only in 1806, a pharmacologically active ing...
Article
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Plant-based preparations are commonly used in Suriname (South America) as adaptogens. In this study, fifteen alleged adaptogenic Surinamese plants have been assessed for their antioxidant activity (AA), total phenolic contents (TPC), and total flavonoid contents (TFC). The investigated plants were Anacardium occidentale, Spondiasdulcis, Annona muri...
Conference Paper
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PURPOSE Delays across the entire cancer care continuum are not uncommon. This cross-sectional study explored the health care trajectories of Surinamese women with breast cancer and identified predictors of timely diagnosis and treatment initiation. METHODS One hundred women age 30 years or older who were newly diagnosed with breast cancer in 2017...
Article
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Objective Vaginal steam baths with herb leaves (herb use) is practised by some Surinamese women. We assessed herb use among women from the five most prevalent ethnic groups, and if herb use is associated with Chlamydia trachomatis infection. Setting Participants were recruited at a sexually transmitted infection (STI) clinic and a family planning...
Article
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Background The Amazonian Amerindian populations living in the southern and southwestern hinterlands of Suriname (South America) have come into contact with western health care since approximately fifty years ago. In this study, secondary data were used to assess the impact of Medical Mission’s fifty-year old primary health care program on the healt...
Article
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Plant-based antihypertensive preparations are abundantly used in traditional medicinal practices in many parts of the world including the Republic of Suriname (South America). In some cases, their apparent blood pressurelowering activity may be related to inhibition of the angiotensin-converting enzyme (ACE). In this literature review, 12 plants th...
Chapter
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Despite much progress in our understanding of the essence of cancer, remarkable advances in methods for early diagnosis, the expanding array of antineoplastic drugs and treatment modalities, as well as important refinements in their use, this disease is among the leading causes of morbidity and mortality in many parts of the world. In fact, the nex...
Conference Paper
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The Republic of Suriname (South America) is located on the Guiana Shield, one of the regions with the highest biodiversity and the largest expanse of undisturbed tropical rain forest in the world. The population of almost 570,000 consists of an unique blend of ethnic groups and cultures from all continents. These include Indigenous Amerindians, the...
Chapter
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Hypertension is the most important modifiable risk factor for cardiovascular, cerebrovas-cular, and renal diseases which are together among the most frequent causes of morbidity and mortality in the world. Despite the availability of a wide range of effective medicines, many individuals suffering from hypertension use plant-derived preparations for...
Article
Full-text available
Drug discovery and development programs have historically mainly focused on plants with medicinal properties and the extensive knowledge of traditional healers about these plants. More recently, the vast array of marine invertebrates and insects throughout the world have been recognized as additional sources for identifying unusual lead compounds t...
Article
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Background: The indigenous Amerindian populations living in the southern interior part of Suriname have to date largely maintained their traditional hunter-gatherer lifestyle. In this study we compared the prevalence of metabolic syndrome (MeTS) and its component risk factors between indigenous Amerindian women of the interior of Suriname, with ind...
Article
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Agricultural pesticides are widely used in Suriname, an upper middle-income Caribbean country located in South America. Suriname imported 1.8 million kg of agricultural pesticides in 2015. So far, however, national monitoring of pesticides in crops is absent. Reports from the Netherlands on imported Surinamese produce from 2010 to 2015 consistently...
Article
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The parasitic disease leishmaniasis is caused by protozoa of the genus Leishmania which are transmitted by sand fly vectors of the genus Phlebotomus in the Old World and Lutzomyia in the New World. Transmission can either be anthroponotic (human to human) or zoonotic through mammalian reservoirs such as dogs and rodents. Leishmaniasis has three pri...
Chapter
Full-text available
The Republic of Suriname (South America) is located on the Guiana Shield, one of the regions with the highest biodiversity and the largest expanse of undisturbed tropical rain forest in the world. The population of almost 570,000 consists of a unique blend of ethnic groups and cultures from all continents. These include Indigenous Amerindians, the...
Article
Full-text available
Abstract Background: To provide evidence that besides the common known causes of pterygium, horizontal ocular version exerts chronic intermittent tension on predisposed limbal area, possibly initiating this affliction. Methods and findings: Tensile force on the conjunctiva was assessed through the measurement of intraocular pressure during outward...
Article
Aims To provide an overview of cataract data in Suriname and to describe and evaluate a programme to control cataract blindness in a developing country. Design Evaluation of hospital data and findings from a population-based cross-sectional survey. Methods The implementation of a new cataract surgical intervention programme was described and retr...
Article
Full-text available
The parasitic disease Leishmaniasis in its various clinical manifestations is one of the most serious public health threats in many parts of the world, its global prevalence and yearly incidence rates exceeding 12 million and 2.