Denisa Čelovska

Comenius University in Bratislava, Slovakia · 1st Department of internal medicine

Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) are recommended in the treatment of arterial hypertension in patients with peripheral arterial disease (PAD). The aims of our study were: (a) to analyse the extent of reinitiation and subsequent discontinuation in older hypertensive PAD patients non-persistent...

Perfusion patterns of cutaneous tissue represent a valuable source of information about the state of the patient’s cardiovascular system and autonomic nervous system (ANS). This concept aims to observe the perfusion changes in the foot sole in two healthy individuals and two subjects affected by diabetes mellitus (DM). We use photoplethysmography i...

Cancer and COVID-19 are both well-established risk factors predisposing to thrombosis. Both disease entities are correlated with increased incidence of venous thrombotic events through multifaceted pathogenic mechanisms involving the interaction of cancer cells or SARS-CoV2 on the one hand and the coagulation system and endothelial cells on the oth...

The beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in hypertensive patients with peripheral arterial disease (PAD) depends on long-term persistence. The aims of our study were to analyse gender differences in non-persistence with ACEIs/ARBs, and to identify the characteristics associa...

The increasing volume of the data and experience with direct oral anticoagulants (DOACS) in the primary and secondary prevention of venous thromboembolism in oncologic patients (CAVTE) has recently lead to changes in several international guidelines. We reflect these changes within the conditions in Slovak republic. In the primary prevention of CAV...

Secondary prevention of peripheral arterial disease (PAD) includes administration of antiplatelet agents, and adherence to medication is a requirement for an effective treatment. The aim of this study was to analyse adherence measured using the proportion of days covered (PDC) index separately in persistent and non-persistent patients, and to ident...

The successful treatment of peripheral arterial disease (PAD) depends on adequate adherence to medications including antiplatelet agents. The aims of this study were (a) to identify the proportion of nonpersistent patients who reinitiated antiplatelet therapy and how many of them discontinued therapy after reinitiation, and (b) to identify patient-...

Introduction: Antiplatelet therapy needs to be administered life-long in patients with peripheral arterial disease (PAD). Our study was aimed at 1) the analysis of non-persistence with antiplatelet medication in older PAD patients and 2) identification of patient- and medication-related characteristics associated with non-persistence. Methods: The...

The relationship between baroreflex sensitivity (BRS) and inflammatory vascular biomarker Lipoprotein associated phospholipase A2 (Lp-PLA2) in subjects with high normal blood pressure (HNBP, prehypertensives) with a positive family history of hypertension (FHH+) and hypertension history free control subjects (FHH-) was evaluated. A total of 24 HNBP...

Autonomic dysfunction is associated with a shift in autonomic balance towards sympathetic dominance, which leads to initation and progression of cardiovascular continuum in the long term. Examination of baroreflex sensitivity (BRS) is a noninvasive marker of autonomic dysfunction. BRS characterises efficacy of blood pressure (BP) regulation in the...

Via practica | 2019;16(1) | www.solen.sk 6 Prehľadové články Periférne artériové ochorenie dolných končatín v ambulancii všeobecného lekára Doc. MUDr. Denisa Čelovská, PhD., MUDr. Marek Kučera, PhD., MHA, MPH, prof. MUDr. Viera Štvrtinová, CSc. I. interná klinika LF UK a UNB, Bratislava Periférne artériové ochorenie dolných končatín (PAO DK) je čas...

Efektívne ovplyvnenie celkového kardiovaskulárneho (KV) rizika u pacientov s periférnym artériovým ochorením dolných končatín (PAD) je často v klinickej praxi podceňované napriek významnému zvýšeniu kardio-cerebro-vaskulárnej morbidity a mortality. Zákaz fajčenia, dlhodobo dobrá metabolická kontrola diabetu, kontrola tlaku krvi, zdravý životný štýl...

Den i sa Čelovsk á, Viera Št v r t i nová, M i roslav Ma l í k , Dáša Mesá rošová, Si lv ia St reča nsk á, Ma r í na A r pášová, Soňa K i ňová Vaskulitídy predstavujú heterogénnu skupinu ochorení, ktoré sú charakterizované zápalom a nekrózou cievnej ste-ny. Pre vaskulárnu medicínu sú doménou vaskulitídy veľkých ciev, Takayasuova arteritída a obrovs...

Giant cell arteritis (GCA) is quite frequent form of vasculitis in adults characterized by systemic immune mediated granulomatous inflammation of the large and medium-sized arteries. Association with atherothrombotic events is well known, while risk of venous thromboembolism (VTE) is being underestimated. The role of thromboprophylaxis is still deb...

Polymyalgia rheumatica (PMR) may be associated with vascular complications for a number of reasons: 1/the inflammatory nature of the disease itself, 2/strong association with giant cell arteritis (GCA – which has a direct inflammatory effect on arteries and may result in either stenosis or aneurysm within affected segments), 3/side effect of the co...

AtheroRev 2016; 1(3): 000–000 Čelovská D. Periférne artériové ochorenie dolných končatín a dyslipidémia 27 Úvod Periférne artériové ochorenie dolných končatín (PAO DK) predstavuje predominantne manifestáciu aterotrombo-tického procesu. Klaudikácie nie sú lokálny problém, ale často upozorňujú na postihnutie viacerých cievnych rie-čísk. Starnutím pop...

1 www.solen.sk | 2016; 8(3) | Vaskulárna medicína Pôvodné práce & kazuistiky Riziko venózneho tromboembolizmu u pacientov s obrovskobunkovou arteritídou MUDr. Denisa Čelovská, PhD., MUDr. Janka Krahulcová, prof. MUDr. Viera Štvrtinová, PhD. I. interná klinika LF UK a UNB, Bratislava Úvod do problematiky: Obrovskobunková arteritída (OBA) je charakte...

Introduction Impaired baroreflex function is associated with a shift in autonomic balance towards sympathetic dominance, which may play important role in the development of arterial hypertension and consequent target organ damage. Aim To determine the effect of treatment on the cardiovascular autonomic modulation expressed by baroreflex sensitivity...

BACKGROUNDː The aim of the study was to evaluate the clinical significance of baroreflex sensitivity (BRS) and carotid intima media thickness (IMT) in risk stratification of hypertensives and subjects with high normal blood pressure (SHNBP). METHODSː A total of 20 patients (61±13 years of age, 10 female/10 male) with essential, treated hypertension...

Background: Our goal was to investigate the effect of short term exercise on fasting and postprandial lipoprotein profile. Methods: Healthy sedentary men exercised 20 min for four days. The intensity of exercise was modulated to maintain 75-80 % of a calculated HRmax. Before and after the exercise program, fasting and postprandial (4 h after sta...

Aim: Baroreflex sensitivity is a noninvasive marker of autonomic nervous system integrity, which characterises efficacy of blood pressure regulation. The aim of study was to evaluate differences and clinical significance of baroreflex sensitivity in risk stratification of patients with primary, well controlled hypertension and resistant hypertensio...

II. interná klinika LF UK a UN Bratislava, Slovenská republika Celovska D, Gonsorcik J, Dukat A, Gaspar L. Baroreflex sensitivity and resistant hypertension. Cardiology Lett. 2015;24(4): Abstract. Aim: Baroreflex sensitivity is a noninvasive marker of autonomic nervous system integrity, which characterises efficacy of blood pressure regulation. The...

Isolated nocturnal hypertension, as the new clinical entity in the field of hypertension was described just recently. Knowledges came from ambulatory blood pressure monitorings, mainly from epidemiologic population studies. As tight correlations to target organ damage and cardiovascular mortality have been found, diagnosis of this clinical unit can...

Objective: Impaired baroreflex sensitivity (BRS) is a non-invasive marker of autonomic dysfunction which has been observed in acute stroke and is associated with a higher risk of long-term poststroke mortality and disability. The aim of the present study was to evaluate the clinical significance of baroreflex sensitivity in hypertensives ≥ 6 months...

Examination of baroreflex sensitivity (BRS) is a non-invasive marker of autonomic dysfunction. Reduced BRS is associated with a shift in autonomic balance towards sympathetic dominance, which leads to initiation of arterial hypertension, disease progression as well as complications related to global cardio-vascular risk in the long term. The aim of...

Objective: Several organizations including the ESH, ESC, and NCEP ATP III have risk based guidance for the treatment of cardiovascular risk factors and target organ damage. Each guideline recommends treatment decisions based on patients estimated risk of cardiovascular disease. However, each guideline recommends a different risk assessment tool and...

Impaired baroreflex sensitivity (BRS) is a marker of autonomous dysfunction, which may play an important role in the long-term development of arterial hypertension, disease progression as well as complications related to global cardiovascular risk. The aim of the study was to evaluate the clinical significance of baroreflex sensitivity in hypertens...

Extremitovascular ischemic disease (peripheral arterial disease of extremities - PAD) is an important manifestation of systemic atherosclerosis and other arterial diseases of vascular system. The lower the anklebrachial pressure index, the greater the risk of serious cardiovascular events (e.g., acute myocardial infarction, stroke). Prevention and...

The relationship between baroreflex sensitivity expressed in ms/mm Hg (BRS) or in Hz/mm Hg (BRSf) in hypertensives with stroke in comparison with a group of stroke-free patients was evaluated. Twenty-six patients (aged 66+/-10 years, 11 females/ 15 males) with a history of the first ever ischemic stroke (6 months and more after stroke onset), which...

Aim: To evaluate the clinical significance of baroreflex sensitivity in subjects with high normal blood pressure and hypertensive patients with or without major cardiovascular events. Patients and Methods: A total of 114 patients were studied (58 males/56 females, 65 ± 13 years of age, body mass index 30 ± 3,4 kg/m2), of whom 26 patients (15 males/...

Aim: To compare the parameters of baroreflex sensitivity and some clinical and echocardiographic parameters in patients with ischaemic and nonischaemic etiology of heart failure. Patients and methods: We analyzed spontaneous baroreflex sensitivity in 107 patients (58 men/49 women, age 66 ± 12 years) with heart failure and sinus rhythm. Patients wer...

The improvement of socio-economic situation in developed countries is associated with the growth of senior population. The incidence of arterial hypertension in this group of population reaches as much as 90 % and is accompanied with polymorbidity in majority of them. It is usually present in a form of isolated systolic hypertension associated with...