Denis Zaslavsky

• Professor
• Saint Petersburg State Pediatric Medical University, Russia,

The significant proportion in the structure of childhood disability determines the relevance of assessing the incidence rates of newly diagnosed diseases of the nervous system in the child population of the metropolis. Purpose: t o analyze the primary incidence of diseases of the nervous system in children and adolescents in a metropolis. Materials...

Актуальность. Как известно, в патогенезе синдрома «сухого глаза» (ССГ) существенную роль играет повышение испаряемости слезы, которое наиболее часто развивается на почве дисфункции мейбомиевых желез (ДМЖ). В свою очередь, среди многочисленных причин ДМЖ большое значение имеет патология сальных желез кожи, имеющих общее эволюционное происхождение с...

Introduction: The priority tasks of protecting reproductive health include the reduction of reproductive losses and improvement of sexual well-being of the population, both impossible without resolving the problem of the spread of sexually transmitted infections. Objective: To study the rates, structure, and dynamics of the incidence and prevalence...

Emollients are an integral part of the therapy for patients with atopic dermatitis. The most effective will be the new generation of emollients – emollients plus, which normalize the skin microbiome. Their effectiveness can be assessed by determining the parameters of the epidermal barrier (hydratation, sebum level, pH) and skin elasticity. Objecti...

A clinical case of lymphomatoid papulosis in a 10-year-old boy is described, clinically characterized by the presence of ulcerating nodes that resolve with the atrophy formation. The patient’s differential diagnostic workup included cutaneous anaplastic large cell lymphoma, cutaneous tuberculosis, polyarteritis nodosa, erythema nodosum, deep lupus...

Psoriatic onychodystrophy is observed in about 80% of patients with psoriasis. Psoriasis can affect two nail structures ― the matrix and the nail bed. Involvement of the nail matrix in the pathological process can lead to the formation of leukonychia, thimble symptom, red spots in the area of the hole and destruction of the nail plate. On the other...

In order to investigate frequency of occurrence and features of the clinical course of dry eye syndrome (DES) in children of various ages with certain types of chronic dermatoses, 80 patients aged 4 to 17 years were examined. The criteria for their inclusion in the study were the presence of a verified diagnosis of atopic dermatitis (in the acute s...

The search for modern and affordable methods for the treatment of dermatoses remains an urgent problem in domestic dermatology. The results of recent studies indicate the high therapeutic efficacy of various types of magnetotherapy. The course application of a local low-frequency magnetic field reduces the inflammatory response and helps to restore...

Granuloma annulare (GA) is a chronic inflammatory necrobiotic granulomatous skin disease, which is based on a delayed hypersensitivity reaction caused by the production of interferon-(IFN-) by tissue macrophages and Th1-limocytes, tumor necrosis factor-(TNF-) and matrix metalloproteinases (MMP), which leads to the degradation of connective tissue....

BACKGROUND: Dupilumab is a drug from the group of biological therapy approved for use in children from 6 years of age in Russian Federation. Due to the recent introduction into clinical practice, appear new reports about various clinical effects that may be associated with the use of the drug, but are not listed in the instructions. Thus, cases of...

In order to investigate the possible presence and features of the clinical course of dry eye syndrome (DES) in children of various ages with certain types of chronic dermatoses, 65 patients aged 4 to 17 years were examined. The criteria for their inclusion in the study were the presence of a verified diagnosis of atopic dermatitis (in the acute sta...

Today, the development and implementation of modern physiotherapeutic treatment options, including those safe for home use by patients, is promising. Purpose of the study. Studying the safety and effectiveness of transcranial magnetotherapy with mild and moderate severity of atopic dermatitis. Material and methods . The study was attended by 104 pa...

BACKGROUND: Atopic dermatitis is a chronic, relapsing and severely itchy dermatitis that usually occurs in childhood and has a characteristic age-related distribution. Atopic dermatitis is relatively frequent, affecting 1020% of children in developed countries. Atopic dermatitis in children associated with poor school performance, low self-esteem a...

Purpose. To study the possible presence and features of the clinical course of dry eye syndrome (DES) in children of various ages with chronic dermatoses. Material and methods. 50 patients aged 4 to 17 years were examined. The criteria for their inclusion in the study were the presence of a verified diagnosis of atopic dermatitis (in the acute stag...

Background. In developed countries more than 20% of children have atopic dermatitis (AD). Clinical guidelines unite in the recommendation to use moisturizers/emollients as therapy mainstay. Deeper understanding of AD pathogenesis stimulates development of new, therapeutic moisturizers. To such moisturizers belong ceramide-containing moisturizers, i...

Schimmelpenning Feuerstein Mims syndrome is a rare congenital hereditary syndrome characterized by the presence of one or more sebaceous nevi, structural and functional disorders of the visual, cardiovascular, bone and central nervous systems. The main marker of Schimmelpenning syndrome is the presence of sebaceous nevi on the skin of the face and...

Psoriasis is a chronic immune-associated skin disease of a multifactorial nature with phenotypic diversity in the general population, as well as a large number of comorbid diseases in patients. The generalized pustular psoriasis, historically was considered one of the variants of the course of psoriasis. Today some authors classify it as a genetica...

An urgent aspect of scientific research in atopic dermatitis is the development of new complex methods of pathogenetic and symptomatic therapy and alternative treatment options that can effectively relieve exacerbations of the disease and prolong remission between them. As a therapeutic physical factor, magnetotherapy has long been successfully use...

Background. A key link in the pathogenesis of atopic dermatitis is a violation of the barrier function of the skin. Artificial skin moisturizing with emollients is the basis of palliative therapy for the disease. Aims. The purpose of the study was to assess the effectiveness and tolerability of the cosmetic product Admera. Materials and methods. Th...

Введение. Мастоцитоз — заболевание с разнообразными вариантами течения, характеризующееся клональной пролиферацией тучных клеток. Описание симптомов, терапии и прогноза в больших группах пациентов актуально в связи с редкостью заболевания. Цель исследования. Охарактеризовать половую и возрастную структуру, симптомы, терапию и прогноз мастоцитоза в...

Introduction . Mastocytosis occurs due to clonal mast cells proliferation and may have different clinical course. As the disease only rarely occurs in pediatric population there are very few clinical observations describing its symptoms, prognosis and therapy response in pediatric cohorts. Aim of the study — characterization of gender, sympthoms, p...

BACKGROUND: Because of the low specificity morphea clinical manifestations in early stages, the differential diagnosis is difficult. AIMS: The purpose of the research is to propose a new diagnostic method for early stages of localized scleroderma. MATERIALS AND METHODS: During 20112020, 77 patients with clinical manifestations of morphea and 127 co...

The pharmacological effects of tannins are mainly related to their astringent action. Several medical studies in recent decades have shown additional antimicrobial and anti- inflammatory properties of tannins. Purpose of the study. To evaluate the efficacy and safety of fixed tannin combinations, including spray / lotion (suspension) and cream «neo...

Each year in the developed countries of the world 100 million patients acquire scars; and there are 11 million keloid scars among them. Aim of the study. Evaluate the effectiveness of treatment and dynamics of scar condition when using self-adhesive dressings (silicone sheet; silicone patch) with a layer of soft silicone. Patients and methods. A...

Введение. Мастоцитоз – заболевание, обусловленное пролиферацией и накоплением клональных тучных клеток в одном или нескольких органах. Часто заболевание протекает в ассоциации с другими гемобластозами. Пациенты с агрессивными формами мастоцитоза (АФМ) нуждаются в специфической терапии. Пациентам с неагрессивными формами (НФМ) – кожным, тлеющим, инд...

Целью работы являлась оценка антропометрических показателей молодежи в возрасте 21–26 лет, родившихся в период максимального использования пестицидов и до 17 лет проживавших в Приаралье – регионе экологического бедствия, в зависимости от степени экологического неблагополучия территории проживания. Методы. В ходе поперечного исследования проведено...

Работа посвящена проспективному наблюдению за группой детей с мастоцитозом.

Enteropathic acrodermatitis is a rare hereditary form of zinc deficiency, characterized by periorial and acral dermatitis, alopecia and diarrhea. Refers to congenital disorders of zinc metabolism, inherited as an autosomal recessive disease resulting from mutations in the gene for the zinc transporter SLC39A4. The prevalence ranges from 1 to 9:1,00...

Among skin diseases in children and adolescents, the most common pathology is acne. The main pathogenetic link of acne in adolescents is hormonal imbalance. The effect on the sebaceous glands of high concentrations of dihydrotestosterone causes a change not only in the quantitative but also in the qualitative composition of the sebaceous secretion....

This article presents a case of clinical observation of a 5-year-old child with herpetiformis dermatitis (Duhrings). This rare dermatosis is characterized by a chronic relapsing course, the presence of itching polymorphic rashes, typical histological and immunomorphological signs. The diagnosis was made on the basis of the clinical picture, histolo...

BACKGROUND:Recently there has been an increase in the number of patients with scleroderma. AIM:This study aimed to investigate the pathogenesis and course and present the immunopathogenesis of localized scleroderma (LS) or morphea. MATERIALS AND METHODS:From 2010 to 2019, a prospective study of 77 patients with LS was conducted on the basis of the...

Background: Lichen ruber planus (LP) and lichenoid skin reaction (LSR) are clinically and histologically similar. The performance of histological diagnosis in these diseases remains controversial. Materials and methods: We prospectively studied 33 patients with clinical manifestations and histological signs of the classic form of LP and LSR to asse...

Aim. In this paper we present anthropometric characteristics of young adults permanently living in three areas with different ecological risks in the Aral Sea region. The main hypothesis is that the exposure to organochlorine pesticides (OCPs) in early childhood combined with factor associated with Aral Sea disaster (ASD) may have consequences for...

The differential diagnosis between lichenoid drug eruption (LDE) and lichen planus (LP) is difficult due to similar clinical and histological signs, but important for treatment and prognosis. The purpose of this study was to propose the new diagnosis method for differentiate LDE from lichen planus. During 2015‐2018, 20 patients with confirmed LDE,...

The epidemiology of neurosyphilis is presented in article. The pathogenetic mechanisms of involvement in the syphilitic process are described already in the early stages of the disease of the central and peripheral nervous system and, in particular, of the auditory and vestibular analyzers. Described classical clinical forms of neurosyphilis. Stati...

Biological molecules are increasingly becoming part of therapeutic arsenal of dermatologist. This is due to their high safety profile, efficacy, and specificity in relation to key targets of disease pathogenesis. However, due to the complexity of their structure and heterogeneity, such drugs can be recognized by the host’s immune system as foreign....

The article is devoted to the assessment of such indicators of the availability of dermatological care as the provision of the population with medical personnel and cots. In 2015–2017, in the North–West Federal District, in comparison with the average Russian indicators, there is a higher provision of doctors with dermatovenereologists and a lower...

The article is devoted to the problem of sebaceous gland diseases in infants. The activity of sebaceous glands and associated inflammatory diseases are determined by the age of the child and related hormonal rearrangements in the body. The role of fungal and bacterial flora in pathogenesis of diseases is described in detail in the article. Clinical...

NEW GENE OF PSORIATIC ERYTHRODERMA AND PROBABLE PATHOGENESIS OF THE DISEASE

The therapeutic effects of synthetic tannins are based on their binding action, as well as on their anti-pruritic, antimicrobial and anti-inflammatory effects. Materials and methods. A clinical study of Neotanin spray, Neotanin lotion (suspension) and Neotanin cream was carried out in 8 clinical centres during the period from June, 2017 to January,...

Mycosis fungoides (MF) is a clinical‐pathologically heterogeneous group of Cutaneous T‐Cell Lymphomas (CTCLs) primarily developing and affecting the skin. PUVA is the gold standard of treatment in early disease reaching up to 71.4% of complete remission. Upon insufficient response or immediate relapse PUVA can be combined with systemic therapies, m...

Erythroderma - the term used for the description intensive and usually widespread reddening of the skin which has arisen owing to activation of the previous inflammatory dermatosis. The aim is to study and compare clinical manifestations of various forms of an erythroderma and also to develop an algorithm of their diagnostics and therapy. We observ...

In recent years, there has been an increasing incidence of atopic dermatitis in children. This paper provides a literature review on the skin microbiome in atopic dermatitis, and the pharmacological features of various background skin care products.

Erythroderma is a skin lesion characterized by redness, swelling, infiltration, and desquamation of greater than 90% of the skin. The etiology of erythroderma is not completely clear and the lesion can be manifestations of various chronic dermatoses, including atopic dermatitis, psoriasis, eczema, and toxicodermia, and be represented by erythroderm...

In recent years, there has been an increase in atopic dermatitis all over the world. The disease is more common in highly developed countries, in cities, less often in rural areas and with a higher socioeconomic status, which implies insufficient exposure to infectious agents. Children attending preschool institutions with extensive contacts with t...

Erythroderma represents one of the most complex problems of dermatology. First of all, it is explained by variety of reasons, a pathogenesis ambiguity, monotonous clinical picture, tendency of many forms of an erythroderma to a long and heavy current and resistance to therapy. The erythroderma doesn’t represent a certain disease, it is, most likely...

Skin manifestations of diffuse large B-cell lymphoma are characterized by solitary, large dense cyanotic tumors most oftenly localized in the lower extremities. Erythroderma is the inflammatory disease of skin involving more than 90% of the body. There are a lot of etiological factors of eryhtroderma, however most often this state is preceded by an...

The article describes the clinical case — girl with lichen sklerosus. The disease has a familial, presence of similar disease in mother, girl's elder sister. Disease has widespread characteristics with lesion in anogenital region, back and extrimities.

Erythroderma is inflammation ofpart or all of the skin. The diagnosis of an erythroderma puts the doctor in very difficult situation as he should solve a problem with many unknowns. The commonly accepted classification of an erythroderma doesn’t exist, and classification by Louis An Jeanne Brock based on separation of erythroderma on primary and se...

Background: Erythroderma is a serious medical condition characterized by inflamed red skin involving over 90% of the body. It can be the common presentation of different diseases, therefore clinical diagnosis can be problematic. Controversial data are reported regarding the diagnostic value of histological examination in erythroderma subjects. Me...

Squamous cell carcinoma of the skin (SSCC) is one of the most common malignant skin tumors. Syphilis is a sexually transmitted disease caused by Treponema pallidum, with human beings as the only host. The combination of syphilis and squamous cell carcinoma of the skin is not uncommon, particularly if the lesions are located on different parts of th...

The article presents an analysis of a clinical case of a patient of 76 years, describes the key links in the pathogenesis of Kaposi’s sarcoma virus, and the modern concept of participation in the pathogenesis of the disease. A feature of this clinical observation was the development of the disease on the background of the functional immunosuppressi...

Background: Erythroderma is a serious medical condition characterized by inflamed red skin, involving over 90% of the body. It can be a common presentation of different diseases, therefore clinical diagnosis can be problematic. Controversial data are reported regarding the diagnostic value of histological examination in erythroderma subjects. Metho...

Onychomycosis - one of the most frequent diseases with defeat of a nail bed, matrics and nail plate of a fungal origin. Frequency of an onychomycosis in Russia reaches 5% (to 15 million people), and practically every tenth visit of the dermatologist is connected with this pathology. Treatment of an onychomycosis still remains very difficult task. A...

The research objective is investigation of clinical manifestations of neurosyphilis in women of reproductive age. The diagnoses were based on complaints, anamnestic information, neurological examinations, dermatovenerology consultations, serological blood and liquor tests. All the patients underwent psychometric tests. The following methods were us...

This article presents the modern concept of major therapeutic algorithms Sézary syndrome, and the case of our own observation.

Atopic dermatitis (AD) is a multifactorial disease. The implementation of blood pressure plays an important role genetic determinism, which leads to disruption of the skin barrier, defects of the immune system (stimulation of Th2-cells with subsequent overproduction of IgE), hypersensitivity to allergens and nonspecific stimuli, the colonization of...

Objective. To estimate efficiency and safety of application of a preparation of Aldara (imiquimod, 5% external application cream) it is independent or in combination with cryotherapy in therapy of the basal cell carcinoma of the skin (BCC). Material and methods. Research included 78 patients (22 women and 56 men) with various forms of a basal cell...

A growth in the incidence rate for atopic dermatitis (AD) in infants has been observed for this decade. Early formation of AD (at the age of 3-6 months) is observed in 45% of infants, and in 60% of infants - during the first year of life. As many as 65% of children (by the age of 7) and 74% of children (by the age of 16) suffering from AD have a sp...

Clinical and morphological heterogeneity of malignant lymphoproliferative lesions of the skin is explained by the peculiarities of their pathogenesis and organization of the lymphoid tissue in the skin. These features determine the authenticity of therapeutic approaches to patients with this pathology and exclude the use of standard regimens of pol...

The article presents a case study of cutaneous leishmaniasis in a child. The patient stayed for several months in a leishmaniasis endemic area - in Tajikistan. This case is interesting from the point of view of verification of the infection that is not endemic in Russia.

This article considers the modern approaches to terminology, classification, diagnosis, clinical manifestation and the treatment of the erythroderma. Authors touch upon questions about the meaning of the terminology “erythroderma”, with understanding pathogenesis, methods of making diagnosis and the treatment of the erythroderma.

The authors provide a case study of Langerhans cell histiocytosis (histiocytosis X) in a two-year-old girl. They describe major stages of the etiology and pathogenesis as well as clinical forms of the disease. Langerhans cell histiocytosis (histiocytosis X) is a rare disease characterized by lesions of the skin and internal organs.

Cell differentiation affections substantiate the urgency of the problem related to studying mutual impact of primary or secondary endocrine pathology and hyperproliferative skin diseases. Psoriasis is one of the most demonstrative pathologies for this study for being a prevalent and genetically predetermined disease with a chronic and relapsing cou...

This article gives historical overview of the development of international and European dermatovenereological societies. The first European Dermatological Society and the first world Venereological Society open in Russia. Taking into consideration the fact that it was the first officially registered national dermatological society whereas Municipal...

During Peter the Great syphilis and gonorea had such a wide spread, that so called spinning houses for easy virtues were established in Saint Petersburg. One of this spinning yard established in 1718 by Peter the Great, later on was turned into the medical facility and called Kalinkinskaya Hospital under the rein of Elizaveta Petrovna. Her decree d...

The article describes up-to-date data on mechanics of epigenetic effects of system retinoid - isotretinoin (Roaccutane). It is noted, that modern acne therapy is able not only to pathogenetically influence consequences of the process, but effect genetical causes of desease, leading to persistant changes and normalization of regulatory segments DNA...